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Edina Tanović, Adnana Talić-Tanović, Jasminka Ðelilović-Vranić, Amir Rekić, Adnan Papović, Emina Tanović
Aim To investigate the effect of kinesiotherapy on muscle strengthening in patients with Parkinon's disease. Methods This clinical retrospective - prospective study was based on collected data from medical histories and included 40 patients, who, beside medicaments, had undergone kinesiotherapy. This study analysed age, gender, duration of the rehabilitation and estimation of the gross muscle strength at admittance and discharge using Manual Muscle Test (MMT). Results Females was slightly more represented in the total sample without significant statistical difference...
February 1, 2019: Medicinski Glasnik
Eva Siegl, Britta Lassen, Susi Saxer
Parkinson's disease is among the most common neurological diseases. About 4.1 million people are attected worldwide. The course of Parkinson's disease is chronically progressive. With L-Dopa therapy the life expectancy of people being affected by Parkinon's disease is not shortened compared with people who are not affected. Therefore people with Parkinson's disease often suffer from the serious effects for decades which include motor symptoms as well as vegetative disturbance, which concerns bladder function and functions of the gastrointestinal tract...
September 2013: Pflege Zeitschrift
Péter Balicza, Benjamin Bereznai, Annamária Takáts, Péter Klivényi, György Dibó, Eszter Hidasi, István Balogh, Mária Judit Molnár
Parkinson's disease is a promising target of applying personalized medicine. For this purpose it is crucial to reveal the genetic and environmental factors, which contribute to the disease, also to collect epidemiologic data and to preserve the patients samples and data in a proper biobank. In our investigation we examined the prevalence of the most frequent Parkinson's disease causing LRRK2 G2019S mutation in a Hungarian Parkinson-patient group. From 120 patients, we haven't detected this substitution in anyone...
July 30, 2012: Ideggyógyászati Szemle
Juan Esteban Ferrario, Argelia Esperanza Rojas-Mayorquín, Marisa Saldaña-Ortega, Cristiane Salum, Margarete Zanardo Gomes, Stéphane Hunot, Rita Raisman-Vozari
L-DOPA is still the drug of choice to treat Parkinson's disease although adverse side effects appear after several years of treatment. These are thought to be the consequence of plastic re-arrangements of the nigrostriatal connections, such as sprouting of the dopaminergic terminals or post-synaptic changes. Pleiotrophin, a trophic factor that we have shown to be up-regulated in the striatum of parkinsonian rats after long-term L-DOPA treatment may play a role in these plastic changes. To determine whether one of the three known pleiotrophin receptors [N-syndecan, receptor protein tyrosine phosphatase type zeta beta (RPTP-zeta/beta) and anaplastic lymphoma kinase] might be implicated in these putative plastic effects, we quantified their expression levels by real-time RT-PCR in the striatum and mesencephalon of rats with partial lesions of the nigrostriatal pathway undergoing L-DOPA treatment...
October 2008: Journal of Neurochemistry
B Cioni
In 2000, Canavero and Paolotti reported the improvement of symptoms in a case of advanced Parkinson disease (PD), following chronic epidural motor cortex stimulation (MCS). In 2002, the same group reported the results obtained in 2 patients with PD. Unilateral MCS proved to be beneficial bilaterally. They concluded that MCS may represent a cost-effective alternative to deep brain stimulation. In 2003, Pagni promoted an Italian Multicenter Study and in June 2005 the results in the first 29 cases were reported...
2007: Acta Neurochirurgica. Supplement
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March 1960: Connecticut Medicine
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