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spike development

Laura Escobar Fernández, Alejandra Coccolo Góngora, María Vázquez López, Ana Paloma Polo Arrondo, María Concepción Miranda Herrero, Estíbaliz Barredo Valderrama, Pedro Castro de Castro
INTRODUCTION: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. METHODS: A retrospective study was conducted on paediatric patients with CSWS treated in a third-level hospital from November 1997 to November 2017...
February 13, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Iria Rujido-Santos, Lucía Naveiro-Seijo, Paloma Herbello-Hermelo, María Del Carmen Barciela-Alonso, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro
Advances on nanometrology require reliable sample pre-treatment methods for extracting/isolating nanomaterials from complex samples. The current development deals with a discontinuous ultrasonication (60% amplitude, 15 cycles of ultrasound treatment for 59 s plus relaxing stage for 59 s, 20 mL of methanol) method for a fast and quantitative extraction of silver nanoparticles (Ag NPs) from moisturizing creams. Possibilities offered by modern inductively coupled plasma mass spectrometry (ICP-MS) which allow 'single particle' assessment (sp-ICP-MS) have been used for Ag NPs assessment (Ag NPs concentration and Ag size distribution)...
May 15, 2019: Talanta
Piyaluk Nurerk, Christina Shu Min Liew, Opas Bunkoed, Proespichaya Kanatharana, Hian Kee Lee
An environmentally friendly method of etching a stainless steel plunger wire, to replace the conventional hydrofluoric acid approach, was developed for plunger-in-needle liquid phase-microextraction (PIN-LPME). The one-step etching procedure was performed by immersing the plunger wire in a ferric chloride-hydrochloric acid (FeCl3 -HCl) solution. The etched wire was then used for LPME as the organic solvent holder. After solvent coating, the wire was directly exposed to a water sample for extraction of polycyclic aromatic hydrocarbons (PAHs), which were then subjected to thermal desorption in the injector of a gas chromatograph for gas chromatography-mass spectrometric (GC-MS) analysis...
May 15, 2019: Talanta
Xiaolan Liu, Man He, Beibei Chen, Bin Hu
Increasing use of TiO2 nanoparticles (NPs) leads to an accumulation in environment and a risk to human. In this work, an on-line monolithic capillary microextraction (CME)-inductively coupled plasma mass spectrometry (ICP-MS) method was developed for sensitive determination of TiO2 NPs in environmental water samples. With the presence of citric acid, TiO2 NPs can be selectively adsorbed on the poly(acrylamide)-vinylpyridine-methylene bis-(acrylamide) (poly(AA-VP-Bis)) monolithic column at pH 1, whereas Ti ions cannot be adsorbed...
May 15, 2019: Talanta
Yan Zhang, Luqi Zhu, Pingang He, Futing Zi, Xianzhi Hu, Qingjiang Wang
The rapid and cost-effective detection of bacteria is of great importance to ensuring food safety, preventing food poisoning. Herein, we developed a sensitive detection of Escherichia coli (E. coli) using bacteria-specific aptamer in conjunction with microchip capillary electrophoresis-coupled laser-induced fluorescence (MCE-LIF). Based on the differences between charge to mass ratios of free aptamer and bacteria-aptamer complex, which influence their electrophoretic mobilities, the separation of free aptamers and complex peaks by MCE could be achieved...
May 15, 2019: Talanta
M Verlinde, J Gorny, G Montavon, S Khalfallah, B Boulet, C Augeray, D Larivière, C Dalencourt, A Gourgiotis
A new rapid protocol for 226 Ra separation and preconcentration in natural water samples was developed before its determination by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). For this purpose, the commercially available Ra specific resin AnaLig® Ra-01 was used. This resin shows a high selectivity for radium in a large range of acid concentrations and no affinity or possible elution of 226 Ra interfering elements. The distribution coefficients of Ra and other elements over a wide range of acid (HCl and HNO3 ) concentrations were obtained...
February 13, 2019: Journal of Environmental Radioactivity
Minchuan Luo, Zhu Su, Xinyi Wang, Liang Li, Yifeng Tu, Jilin Yan
A fluorimetric method is described for the determination of alkaline phosphatase (ALP) activity. It is based on the use of polyethyleneimine-coated silver nanoclusters (AgNCs), which display an intense blue fluorescence peaking at 450 nm (under 375 nm excitation). ALP catalyzes the dephosphorylation of the thiophosphate amifostine to generate a thiol that binds to the AgNCs and causes its fluorescence to be quenched. Under the optimal experimental conditions, fluorescence linearly drops in the 0.08-2.0 U L-1 ALP activity range, and the limit of detection is 0...
February 15, 2019: Mikrochimica Acta
Fen-Ying Kong, Rong-Fang Li, Lei Yao, Zhong-Xia Wang, Heng-Ye Li, Wei-Xin Lv, Wei Wang
An electrochemical sensor is described for the simultaneous determination of the pollutants catechol (CC) and hydroquinone (HQ). A glassy carbon electrode (GCE) was modified with reduced graphene oxide, Fe3 O4 and gold nanoparticles and then showed a pair of well-defined voltammetric peaks for CC and HQ. Its oxidation peak potentials (located at 0.21 and 0.10 V vs. Ag/AgCl) are well separated, and this makes it suitable for simultaneous determination of the two isomers. Under optimal conditions, the oxidation peak currents of CC and HQ increase linearly in the 0...
February 15, 2019: Mikrochimica Acta
Chaoran Liu, Xinya Liu, Philip J Marriott, Heng Qian, Zilin Meng, Zhirong Yang, Runhua Lu, Haixiang Gao, Wenfeng Zhou
In this work, a method for the analysis of benzoylurea insecticides, including hexaflumuron, flufenoxuron, lufenuron and chlorfluazuron, in tea samples by HPLC with Fe3 O4 - hyperbranched polyester nanocomposite as the adsorbent for magnetic solid-phase extraction was developed. The magnetic nanocomposite was prepared and characterized by infrared spectroscopy, vibrating sample magnetometry and scanning electron microscopy. The as-prepared nanocomposite was used as the sorbent for extraction and preconcentration of pesticide residues in tea samples...
February 15, 2019: Journal of Separation Science
Hafiz Muhammad Jhanzab, Abdul Razzaq, Yamin Bibi, Farhat Yasmeen, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Setsuko Komatsu
Production and utilization of nanoparticles (NPs) are increasing due to their positive and stimulating effects on biological systems. Silver (Ag) NPs improve seed germination, photosynthetic efficiency, plant growth, and antimicrobial activities. In this study, the effects of chemo-blended Ag NPs on wheat were investigated using the gel-free/label-free proteomic technique. Morphological analysis revealed that chemo-blended Ag NPs resulted in the increase of shoot length, shoot fresh weight, root length, and root fresh weight...
February 14, 2019: International Journal of Molecular Sciences
Catherine Leigh, Omar Alsibai, Rob J Hyndman, Sevvandi Kandanaarachchi, Olivia C King, James M McGree, Catherine Neelamraju, Jennifer Strauss, Priyanga Dilini Talagala, Ryan D R Turner, Kerrie Mengersen, Erin E Peterson
Monitoring the water quality of rivers is increasingly conducted using automated in situ sensors, enabling timelier identification of unexpected values or trends. However, the data are confounded by anomalies caused by technical issues, for which the volume and velocity of data preclude manual detection. We present a framework for automated anomaly detection in high-frequency water-quality data from in situ sensors, using turbidity, conductivity and river level data collected from rivers flowing into the Great Barrier Reef...
February 6, 2019: Science of the Total Environment
Steven H Mott, Richard P Morse, Scott A Burroughs, Ashura W Buckley, Cristan A Farmer, Audrey E Thurm, Susan E Swedo, Amara L Krag, Gregory L Holmes
Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. There is increasing evidence that abnormalities of coherence, a measure of the consistency of the phase difference between two EEG signals when compared over time, is an important feature of brain oscillations and plays a role in cognition and behavior...
February 15, 2019: Epileptic Disorders: International Epilepsy Journal with Videotape
Roberto H Caraballo, Pedro Cachia, Gabriela Reyes Valenzuela, Agustin Calvo
A female patient with electroclinical and neuroradiological features compatible with Rasmussen syndrome developed a particular clinical and EEG pattern. As the seizures were refractory to valproate at 750 mg/kg/day, oxcarbazepine (OXC) at 30 mg/kg/day was added. Seizures became more frequent and on neurological examination, no hemiparesis was detected. The interictal EEG showed focal spikes and diffuse paroxysms in the right fronto-temporal regions. Brain MRI revealed right hemiatrophy, mainly at the Sylvian fissure...
February 15, 2019: Epileptic Disorders: International Epilepsy Journal with Videotape
Imke Matthys, Daniel Borsboom, Sophia Steyaert, Delphine Vervloet, Kristoff Cornelis, Erik Vanderstraeten, Sébastien Kindt, Pieter Dewint, Valerie Lambrecht, Peter Sinnaeve, Christophe Van Steenkiste
Mycoplasma pneumoniae infection can present with a plethora of symptoms and result in a systemic vasculitis by activating a cascade of autoimmune reactions. In this case report, a young man without relevant past medical history was admitted to the hospital with diarrhea, abdominal pain and spiking fever. A CT-scan showed terminal ileitis. A 5-day broad spectrum antibiotic treatment (ciprofloxacin/clindamycin) did not result in any clinical improvement. On the contrary, the patient developed a cholestatic hepatitis, bilateral anterior uveitis and a dry cough...
February 15, 2019: Acta Clinica Belgica
Rosalie A Multari, David A Cremers, Ann Nelson, Zohreh Karimi, Stephen Young, Carolyn Fisher, Robert Duncan
AIMS: To investigate the use of a laser-based method of detection as a potential diagnostic test for the rapid identification of infectious agents in human blood. METHODS AND RESULTS: In this study, the successful differentiation of blood spiked with viruses, bacteria, or protozoan parasites to clinically relevant levels is demonstrated using six blood types (O+, O-, AB+, A+, A-, B+) using blood from different individuals with blood samples prepared in two different laboratories...
February 15, 2019: Journal of Applied Microbiology
Zhouyan Feng, Weijian Ma, Zhaoxiang Wang, Chen Qiu, Hanhan Hu
Deep brain stimulation (DBS) traditionally utilizes electrical pulse sequences with a constant frequency, i.e., constant inter-pulse-interval (IPI), to treat certain brain disorders in clinic. Stimulation sequences with varying frequency have been investigated recently to improve the efficacy of existing DBS therapy and to develop new treatments. However, the effects of such sequences are inconclusive. The present study tests the hypothesis that stimulations with varying IPI can generate neuronal activity markedly different from the activity induced by stimulations with constant IPI...
2019: Frontiers in Neuroscience
Venkata Yelleswarapu, Joshua R Buser, Margalit Haber, Jonathan Baron, Eshwar Inapuri, David Issadore
Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnostics but are currently mainly confined to laboratory settings, due to the instrumentation necessary to serially generate, control, and measure tens of millions of droplets/compartments. To address this challenge, we developed an optofluidic platform that miniaturizes digital assays into a mobile format by parallelizing their operation...
February 14, 2019: Proceedings of the National Academy of Sciences of the United States of America
Jon Von Visger, Clarissa Cassol, Uday Nori, Gerardo Franco-Ahumada, Tibor Nadasdy, Anjali A Satoskar
BACKGROUND: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment...
February 14, 2019: BMC Nephrology
Lisa N van der Vorm, Li Li, Dana Huskens, Walid Chayouâ, Hilde Kelchtermans, Philip G de Groot, Mark Roest, Jasper A Remijn, Bas de Laat
BACKGROUND: Interaction of von Willebrand factor (VWF) with platelets requires a conformational change that exposes an epitope within the VWF A1 domain, enabling platelet glycoprotein Ibα binding. Quantification of this ''active" conformation of VWF has been shown to provide pathophysiological insight into conditions characterized by excessive VWF-platelet interaction. METHODS: We developed an immunosorbent assay based on a variable heavy chain antibody fragment against the VWF A1 domain as a capture antibody...
2019: PloS One
Jiao Li, Jie Xu, Wenying Jin, Zhongsheng Yi, Chenbo Cai, Xuefen Huang, Jinfang Nie, Yun Zhang
A method that combines five-way fluorescence kinetics with fourth-order calibration for interference-free quantification of diclofenac sodium in river water was proposed and tested. Traditional fluorescence methods may not be suitable for such measurements since the fluorescence properties of the analyte are highly dependent on both pH and irradiation time in situ. In the method considered here, a five-way emission-excitation-time-pH data array was obtained from the samples by introducing the pH level and irradiation time as two extra modes...
February 13, 2019: Analytical and Bioanalytical Chemistry
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