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Jerald J Nair, Johannes van Staden
Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to already overworked and ailing healthcare structures. Traditional medicine (TM) remains vibrant in most of these regions wherein plants often serve as the first line of defense against malaria. Given this fact as well as the successes elsewhere of therapies such as Artemisia annua emanating from evidence-based TM, interest in plants as a source of new antimalarial drugs has been rejuvenated...
February 11, 2019: Fitoterapia
Dario Bertossi, Giorgio Giampaoli, Alessandra Lucchese, Maurizio Manuelli, Massimo Albanese, Riccardo Nocini, Pier Francesco Nocini
Minimally invasive facial rejuvenation procedures reached an all-time high in the 2016. This reveals a growing interest in a smoother, younger, and tighter look accessible using the esthetic medicine tools like botulinum toxin and dermal filler injections, laser, and microdermabrasion. Forty-five patients from 35 to 52 years old (medium age 43.8), 38 women and 7 men underwent 5 sessions of Fraxel laser, 1 session of very low G prime HA, and Microbotox injection treatments from January 2016 and January 2017, were included in this study...
February 14, 2019: Lasers in Medical Science
Pei Xiong Liew, Paul Kubes
Neutrophils have always been considered as uncomplicated front-line troopers of the innate immune system equipped with limited proinflammatory duties. Yet recently, the role of the neutrophil has been undergoing a rejuvenation of sorts. Neutrophils are now considered complex cells capable of a significant array of specialized functions, and as an effector of the innate immune response, they are able to regulate many processes such as acute injury and repair, cancer, autoimmunity, and chronic inflammatory processes...
April 1, 2019: Physiological Reviews
Michael H Gold, Julie Biron
INTRODUCTION: Skin rejuvenation procedures have become common with sophisticated technologies with reduced downtime and related risks. Recently, microneedling has been paired with radiofrequency to create Fractional Radiofrequency Microneedling (FRFM) to induce neocollagenesis. Frequently, topical products are applied immediately after the needling. This procedure is known as percutaneous collagen induction therapy (PCIT). Postoperative topical wound care is critical for prompt rapid and safe healing, with moist wound healing deemed of primary importance for fast and correct scarring process...
February 12, 2019: Journal of Cosmetic Dermatology
Hao Nguyen Trong, Thao Vu Thi Phuong, Thuong Nguyen Van, Ha Vu Thai, Nghi Dinh Huu, Minh Vu Nguyet, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelastic properties. AIM: To evaluate the efficacy and safety of HA microinjection in skin rejuvenation. METHODS: We enrolled thirty participants underwent three sessions of HA microinjection involving multiple injections in the face or back of the hands at 2-week intervals...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Sandra Pinho, Paul S Frenette
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to emergencies and injury. Improved methods for HSC isolation, driven by advances in single-cell and molecular technologies, have led to a better understanding of their behaviour, heterogeneity and lineage fate and of the niche cells and signals that regulate their function...
February 11, 2019: Nature Reviews. Molecular Cell Biology
Mitsuhiro Ebara
The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called "immunomodulatory biomaterials". Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-inert biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their performance in more traditional applications...
January 2019: Chonnam Medical Journal
Ran Duan, Min Wu, Mathias Tremp, Carlo M Oranges, Feng Xie, Qingfeng Li
BACKGROUND: Over the years, many techniques have been described to correct tear trough deformity (TTD). Fat-repositioning lower blepharoplasty via a transconjunctival approach is increasingly applied due to its satisfactory rejuvenating effect. However, those methods have disadvantages such as a complicated surgical approach, residual scar, and long recovery time. OBJECTIVES: We modified the surgical technique of fat-repositioning transconjunctival lower blepharoplasty with an effective but easy internal fixation method via a supraperiosteal approach...
February 7, 2019: Aesthetic Plastic Surgery
Antonio Casado-Díaz, Gabriel Dorado, Mercè Giner, María José Montoya, Cristina Navarro-Valverde, Adolfo Díez-Pérez, José Manuel Quesada-Gómez
Osteoporosis long-term treatment with nitrogen-containing bisphosphonates, has been associated with uncommon adverse effects, as atypical femoral fractures (AFF). Thus, treatment with teriparatide (TPTD; fragment of human parathyroid hormone; PTH1-34 ) has been proposed for such patients. Besides its anabolizing effect on bone, TPTD may affect stem-cell mobilization and expansion. Bone marrow mononuclear cells (BMMNC) were isolated from five women that had suffered AFF associated to bisphosphonate treatment, before and after 6 months of TPTD therapy...
February 6, 2019: Calcified Tissue International
Sebastian Cotofana, Nirusha Lachman
OBJECTIVE: There has been a significant shift in the understanding of facial anatomy during the last decade. Newer minimally invasive therapeutic options for facial rejuvenation procedures are increasing the need for a better knowledge of anatomy. MATERIAL AND METHODS: The current literature is summarized, analyzed and presented along with the experience of the author for this narrative review, which summarizes the current understanding of the superficial and deep facial fat compartments and their relevance for minimally invasive facial procedures...
January 30, 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Giuseppe Alessandro Digesu, Visha Tailor, Mario Preti, Pedro Vieira-Baptista, Tufan Tarcan, Colleen Stockdale, Sherif Mourad
AIMS: Energy-based devices using radiofrequency and laser technologies have gained popularity as therapies for vaginal atrophy, urinary incontinence, and vaginal prolapse. They have been promoted by cosmetic and aesthetic industries for vaginal "laxity" and vaginal "rejuvenation," both of which are undefined conditions and terms. This article aims to review the current available literature and its quality on this emerging technology. METHODS: An international panel of gynaecologists, urogynaecologists, and urologists undertook a review of the available published literature, identifying articles, guidance, and society statements on the use vaginal energy-based devices...
January 29, 2019: Neurourology and Urodynamics
Robert Douglas Young, Waclaw Jan Kroczek
By definition, a validated supercentenarian is a properly documented centenarian who has lived to be at least the age of 110 years. The tables presented here, based on records maintained by members of the Gerontology Research Group (GRG), continue the series published in Rejuvenation Research in past years1,2 - giving the latest list of living supercentenarians, currently with a cutoff age of 112+. It should be emphasized that this list cannot include all living supercentenarians, only those whose claim can be validated to the required standard bsed on information available to us; we estimate the true population worldwide to be in the range 600-900...
January 30, 2019: Rejuvenation Research
Jacob Bülow, Stanley J Ulijaszek, Lars Holm
No abstract text is available yet for this article.
January 1, 2019: Journal of Applied Physiology
Henning T Langer, Agata A Mossakowski, Keith Baar, Julian Alcazar, Marcos Martin-Rincon, Luis M Alegre, Ignacio Ara, Jose A L Calbet, J Mathew Hinkley, Paul M Coen, Brian A Irving, Timothy D Allerton, Sreekumaran Nair, Ricardo M Lima, Juan Pablo Rey-López, David Scott, Robin M Daly, Peter R Ebeling, Alan Hayes, Anne-Julie Tessier, Stéphanie Chevalier, Brandon A Yates, LeAndra R Brown, Thomas W Storer, Wayne L Westcott, Artemissia-Phoebe Nifli, Robert V Musci, Adam R Konopka, Karyn L Hamilton, Russell T Hepple
No abstract text is available yet for this article.
January 1, 2019: Journal of Applied Physiology
Xuelian Sun, Qiukui Hao, Renjie Tang, Chun Xiao, Meiling Ge, Birong Dong
Frailty, one appealing target for improving successful aging of the elderly population, is a common clinical syndrome based on the accumulation of multisystemic function declines and the increase in susceptibility to stressors during biological aging. The age-dependent senescence, the frailty-related stem cell depletion, chronic inflammation, imbalance of immune homeostasis, and the reduction of multipotent stem cells, collectively suggest the rational hypothesis that it is possible to (partially) cure frailty with stem cells...
January 29, 2019: Rejuvenation Research
Richard S Legro
This introduction reviews the background of mitochondrial transplantation. Its goals are to provide both basic and clinical insights into mitochondria and reproduction. The articles will review the biology of mitochondria, mitochondrial DNA, mitochondrial dynamics, and mitochondrial stress (unfolded protein response), discuss novel imaging technology, fluorescent lifetime imaging microscopy to visualize mitochondria and their function in oocytes and early embryos, provide a critical and objective review of the data suggesting and refuting the possible use of mitochondrial DNA as well as other emerging technologies as a biomarker for embryo viability and finally to review the use of mitochondria as a rejuvenation tool in human in vitro fertilization...
February 2019: Fertility and Sterility
Muhammad Asad Salim, Sailesh Ranjitkar, Robbie Hart, Tika Khan, Sajid Ali, Chandni Kiran, Asma Parveen, Zahra Batool, Shanila Bano, Jianchu Xu
BACKGROUND: The ethnic groups in Gilgit-Baltistan have been utilizing local resources in their centuries-old traditional healing system. Most tribes within these ethnic groups still rely on traditional healing systems. We aim to understand the current status, uses, and abundance of medicinal plants, associated traditional knowledge, and trade. MATERIALS AND METHODS: The study incorporated over 300 local community members (70% men and 30% women) in focused group discussions, semi-structured interviews, and homework assignments for 8th to 12th grade students to document traditional knowledge (TK) in six districts in Northeast Pakistan...
January 28, 2019: Journal of Ethnobiology and Ethnomedicine
Elbert E Vaca, Jonathan T Bricker, Irene Helenowski, Eugene D Park, Mohammed S Alghoul
Background: The goal of upper eyelid procedures is to restore or create the ideal proportions between the pretarsal space and the upper lid fold. Objectives: The aim of this study was to define the topographic features of the attractive upper lid. Methods: Caucasian female frontal facial photographs were obtained from public media and periorbital areas were cropped. Two-hundred and ninety-four single eye photographs were rated by 6 evaluators using a 4-point Likert scale...
January 23, 2019: Aesthetic Surgery Journal
Lisa Ramaut, Patrick Tonnard, Alexis Verpaele, Koenraad Verstraete, Phillip Blondeel
BACKGROUND: In scientific literature, numerous theories on the mechanism of facial aging can be found. The debate about facial sagging versus deflation is still ongoing. In this study, the metric changes in perioral soft tissue were demonstrated. These data can contribute to a better understanding of physical changes in the aging perioral area. METHODS: Upper lip measurements were performed on cranial magnetic resonance images of 200 Caucasian subjects (100 men and 100 women)...
February 2019: Plastic and Reconstructive Surgery
Laura Lukjanenko, Sonia Karaz, Pascal Stuelsatz, Uxia Gurriaran-Rodriguez, Joris Michaud, Gabriele Dammone, Federico Sizzano, Omid Mashinchian, Sara Ancel, Eugenia Migliavacca, Sophie Liot, Guillaume Jacot, Sylviane Metairon, Frederic Raymond, Patrick Descombes, Alessio Palini, Benedicte Chazaud, Michael A Rudnicki, C Florian Bentzinger, Jerome N Feige
Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate that aging impairs the function of mouse fibro-adipogenic progenitors (FAPs) and thereby indirectly affects the myogenic potential of MuSCs. Using transcriptomic profiling, we identify WNT1 Inducible Signaling Pathway Protein 1 (WISP1) as a FAP-derived matricellular signal that is lost during aging...
January 15, 2019: Cell Stem Cell
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