keyword
https://read.qxmd.com/read/38534417/ccl28-a-promising-biomarker-for-assessing-salivary-gland-functionality-and-maintaining-healthy-oral-environments
#1
JOURNAL ARTICLE
Yuichiro Kaibori, Saho Tamoto, Sayoko Okuda, Kazuhiko Matsuo, Takashi Nakayama, Daisuke Nagakubo
The oral cavity serves as the primary path through which substances from the outside world enter our body. Therefore, it functions as a critical component of host defense. Saliva is essential for maintaining a stable oral environment by catching harmful agents, including pathogens, allergens, and chemicals, in the air or food. CCL28, highly expressed in mucosal tissues, such as the colon and salivary glands, is a chemokine that attracts CCR10/CCR3 expressing cells. However, the role of CCL28 in salivary gland formation remains unclear...
February 27, 2024: Biology
https://read.qxmd.com/read/38528314/protective-mechanism-of-polysaccharide-orp-1-isolated-from-oudemansiella-raphanipes-against-age-related-cognitive-decline-through-the-microbiota-gut-brain-axis
#2
JOURNAL ARTICLE
Yu-Ru Ren, Wen-Ting Cui, Kai-Li Jiang, Kai-Qi He, Yong-Ming Lu, Yan Chen, Wen-Juan Pan
Age-related cognitive decline is primarily attributed to the progressive weakening of synaptic function and loss of synapses, while age-related gut microbial dysbiosis is known to impair synaptic plasticity and cognitive behavior by metabolic alterations. To improve the health of the elderly, the protective mechanisms of Oudemansiella raphanipes polysaccharide (ORP-1) against age-related cognitive decline are investigated. The results demonstrate that ORP-1 and its gut microbiota-derived metabolites SCFAs restore a healthy gut microbial population to handle age-related gut microbiota dysbiosis mainly by increasing the abundance of beneficial bacteria Dubosiella, Clostridiales, and Prevotellaceae and reducing the abundance of harmful bacteria Desulfovibrio, strengthen intestinal barrier integrity by abolishing age-related alterations of tight junction (TJ) and mucin 2 (MUC2) proteins expression, diminish age-dependent increase in circulating inflammatory factors, ameliorate cognitive decline by reversing memory- and synaptic plasticity-related proteins levels, and restrain hyperactivation of microglia-mediated synapse engulfment and neuroinflammation...
March 25, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38504429/mucin-and-salt-combination-simulate-typical-fern-like-pattern-of-buffalo-saliva-smear-at-estrus
#3
JOURNAL ARTICLE
Varun Kumar, Mansi Joshi, Ashutosh Vats, Lal Krishan Kumar, Surya Kant Verma, Neeraj, Rubina Kumari Baithalu, Vedamurthy Gowdar Veerappa, Dheer Singh, Suneel Kumar Onteru
Estrus detection in buffaloes primarily relies on behavioral and physiological signs. Especially during summer, these signs are less prominent to recognize. Thus, estrus detection is a pronounced challenge within the realm of buffalo husbandry, particularly in the summer. Therefore, a simple and accurate estrus detection method is required for buffalo farmers. The observation of fern-like salivary crystallization patterns is one such simple method to detect estrus in buffaloes, bactrian camels, beagle bitches, and cows...
March 19, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38500992/diosmin-alleviates-ulcerative-colitis-in-mice-by-increasing-akkermansia-muciniphila-abundance-improving-intestinal-barrier-function-and-modulating-the-nf-%C3%AE%C2%BAb-and-nrf2-pathways
#4
JOURNAL ARTICLE
Maha Badr Salem, Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Olfat Ali Hammam, Safia Samir
Ulcerative colitis is a common type of inflammatory bowel disease that affects millions of individuals around the world. Traditional UC treatment has focused on suppressing immune responses rather than treating the underlying causes of UC, which include oxidative stress, inflammation, and microbiota dysbiosis. Diosmin (DIO), a naturally occurring flavonoid, possesses antioxidant and anti-inflammatory properties. This study aimed to assess the efficacy of DIO in treating dextran-sulfate sodium (DSS)-induced colitis, and to investigate some of its underlying mechanisms, with an emphasis on Akkermansia muciniphila abundance, inflammatory markers, and intestinal barrier function...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38500386/pofut1-and-plagl2-are-characteristic-markers-of-mucinous-colorectal-cancer-associated-with-muc2-expression
#5
JOURNAL ARTICLE
Masayoshi Monno, Masayo Ogiri, Ryo Seishima, Yoshiyuki Suzuki, Kaoru Hattori, Shimpei Matsui, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Colorectal mucinous adenocarcinoma (MAC) is one of the most lethal histological types of colorectal cancer, and its mechanism of development is not well understood. In this study, we aimed to clarify the molecular characteristics of MAC via in silico analysis using The Cancer Genome Atlas database. The expression of genes on chromosome 20q (Chr20q) was negatively associated with the expression of MUC2, which is a key molecule that can be used to distinguish between MAC and nonmucinous adenocarcinoma (NMAC)...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38492821/mutational-profile-evaluates-metastatic-capacity-of-chinese-colorectal-cancer-patients-revealed-by-whole-exome-sequencing
#6
JOURNAL ARTICLE
Yian Yang, Jiawei Chen, Honghua Peng, Zhigang Xiao, Wei Xu, Mingchuan Zheng, Zheng Li, Peiguo Cao
Colorectal cancer (CRC) is the third most common cancer and the prevalence rate of CRC is increasing in the China. In this study, whole-exome sequencing (WES) was performed on primary tissues of 47 CRC Chinese patients including 22 metastatic and 25 non-metastatic patients. By comparison with data from western colorectal cancer patients in the Cancer Genome Atlas (TCGA), we identified a number of genes that are more likely to be mutated in Chinese colorectal cancer patients, such as MUC12, MUC12, MUC2, MUC4, HYDIN and KMT2C...
March 14, 2024: Genomics
https://read.qxmd.com/read/38485903/shifts-in-microbiota-and-gene-expression-of-nutrient-transporters-mucin-and-interleukins-in-the-gut-of-fast-growing-and-slow-growing-chickens-infected-by-salmonella-enteritidis
#7
JOURNAL ARTICLE
Maylane Rayane Brito Dos Santos, Alexandre Lemos de Barros Moreira Filho, Oliveiro Caetano Freitas Neto, Maria de Fátima de Souza Andrade, Núbia Michelle Vieira da Silva, Gustavo Felipe Correia Sales, Celso José Bruno de Oliveira, Patrícia Emília Naves Givisiez
Slow-growing breeds are more resistant to Salmonella infection compared to fast-growing broilers. However, it is unclear whether that is associated with innate resistance or rather rely on differences in Salmonella-induced gut responses. We investigated the microbial composition and gene expression of nutrient transporters, mucin, and interleukin in the gut of a fast-growing (Cobb500) and a slow-growing naked neck (NN) chicken breeds challenged with Salmonella Enteritidis. Hatchlings were inoculated at two days of age using sterile broth (sham) or Salmonella Enteritidis (SE) and distributed according to a completely randomized design into four treatments: Cobb-sham; Cobb-SE; NN-sham; and NN-SE...
March 15, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38479098/comparison-of-necrotic-enteritis-effects-on-growth-performance-and-intestinal-health-in-two-different-meat-type-chicken-strains-athens-canadian-random-bred-and-cobb-500
#8
JOURNAL ARTICLE
Doyun Goo, Hanseo Ko, Milan Kumar Sharma, Venkata Sesha Reddy Choppa, Deependra Paneru, Hanyi Shi, Woo Kyun Kim
Chickens have undergone genetic improvements in the past few decades to maximize growth efficiency. However, necrotic enteritis (NE), an enteric disease primarily caused by C. perfringens, remains a significant problem in poultry production. A study investigated the differences in intestinal health between the nonselected meat-type chicken Athens Canadian Random Bred (ACRB) and the modern meat-type Cobb 500 broilers (Cobb) when challenged with experimental NE. The study utilized a 2 × 3 factorial arrangement, consisting of two main effects of chicken strain and NE challenge model (nonchallenged control, NC; NE challenge with 2,500/12,500 Eimeria maxima oocysts + 1 × 109 C...
February 28, 2024: Poultry Science
https://read.qxmd.com/read/38478391/assessment-of-muc5ac-and-muc2-immunoexpression-in-glandular-odontogenic-cysts-dentigerous-cysts-and-mucoepidermoid-carcinomas
#9
JOURNAL ARTICLE
Kiran Jot, Vivek Nayyar, Varun Surya, Aanchal Kakkar, Shraddhanjali Satapathy, Ajoy Roychoudhury, Deepika Mishra
Glandular odontogenic cysts (GOCs) and dentigerous cysts may show mucous metaplasia. Central mucoepidermoid carcinoma is very rare and mostly associated with dental cysts. It is hypothesized that odontogenic cysts showing mucus differentiation in their lining, have a propensity to transform into MEC. The present study is the first attempt to explore the relationship between odontogenic cysts [GOCs and dentigerous cysts with mucus metaplasia (DCMM)] and MEC by evaluating immunoexpression of MUC5AC and MUC2. Immunoexpression of MUC5AC and MUC2 was evaluated semiquantitatively in GOCs (20 cases), DCMMs (20 cases), and MECs (20 cases)...
March 14, 2024: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/38475799/antidepressant-fluoxetine-alleviates-colitis-by-reshaping-intestinal-microenvironment
#10
JOURNAL ARTICLE
Shuo Teng, Yi Yang, Wanru Zhang, Xiangji Li, Wenkun Li, Zilu Cui, Li Min, Jing Wu
BACKGROUND: The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear. METHODS: We systematically assessed how antidepressants (fluoxetine, fluvoxamine and venlafaxine) affected IBD and chose fluoxetine, the most effective one, for mechanism studies. We treated the C56BL/6 mice of the IBD model with fluoxetine and their controls...
March 12, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38474847/effect-of-lifelong-exposure-to-dietary-plant-and-marine-sources-of-n-3-polyunsaturated-fatty-acids-on-morphologic-and-gene-expression-biomarkers-of-intestinal-health-in-early-life
#11
JOURNAL ARTICLE
Julianna E Acosta, Jessie L Burns, Lyn M Hillyer, Kelsey Van, Elaina B K Brendel, Camille Law, David W L Ma, Jennifer M Monk
Altered intestinal health is also associated with the incidence and severity of many chronic inflammatory conditions, which could be attenuated via dietary n -3 PUFA interventions. However, little is known about the effect of lifelong exposure to n -3 PUFA from plant and marine sources (beginning in utero via the maternal diet) on early life biomarkers of intestinal health. Harems of C57Bl/6 mice were randomly assigned to one of three isocaloric AIN-93G modified diets differing in their fat sources consisting of the following: (i) 10% safflower oil (SO, enriched in n -6 PUFA), (ii) 3% flaxseed oil + 7% safflower oil (FX, plant-based n -3 PUFA-enriched diet), or (iii) 3% menhaden fish oil + 7% safflower oil (MO, marine-based n -3 PUFA-enriched diet)...
March 1, 2024: Nutrients
https://read.qxmd.com/read/38473881/validating-enteroid-derived-monolayers-from-murine-gut-organoids-for-toxicological-testing-of-inorganic-particles-proof-of-concept-with-food-grade-titanium-dioxide
#12
JOURNAL ARTICLE
Yann Malaisé, Eva Casale, Aurélie Pettes-Duler, Christel Cartier, Eric Gaultier, Natalia Martins Breyner, Eric Houdeau, Lauris Evariste, Bruno Lamas
Human exposure to foodborne inorganic nanoparticles (NPs) is a growing concern. However, identifying potential hazards linked to NP ingestion often requires long-term exposure in animals. Owing these constraints, intestinal organoids are a promising alternative to in vivo experiments; as such, an in vitro approach should enable a rapid and reliable assessment of the effects of ingested chemicals on the gut. However, this remains to be validated for inorganic substances. In our study, a transcriptomic analysis and immunofluorescence staining were performed to compare the effects of food-grade TiO2 ( fg -TiO2 ) on enteroid-derived monolayers (EDMs) from murine intestinal organoids to the known impacts of TiO2 on intestinal epithelium...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473746/protective-effects-of-inulin-on-stress-recurrent-inflammatory-bowel-disease
#13
JOURNAL ARTICLE
Yao Du, Kanta Kusama, Koki Hama, Xinyue Chen, Yu Tahara, Susumu Kajiwara, Shigenobu Shibata, Kanami Orihara
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the digestive tract and is closely associated with the homeostasis of the gut microbiota. Inulin, as a natural prebiotic, displays anti-inflammatory activity and maintains equilibrium of the intestinal microbiota. In this study, our research aimed to explore the potential of inulin in enhancing intestinal immunity and reducing inflammation in stress-recurrent IBD. In this study, a co-culture intestinal epithelium model and a stress-recurrent IBD mouse model was used to examine the protective effects of inulin...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38451208/post-cross-linked-ros-responsive-poly-%C3%AE-amino-ester-plasmid-polyplex-nps-for-gene-therapy-of-ebv-associated-nasopharyngeal-carcinoma
#14
JOURNAL ARTICLE
Caiyan Yuan, Shuangyan Chang, Chong Zhang, Dirong Dong, Jiahui Ding, Ali Reza Mahdavian, Zheng Hu, Lili Sun, Songwei Tan
Nasopharyngeal carcinoma (NPC) is one of the most common tumors in South China and Southeast Asia and is thought to be associated with Epstein-Barr virus (EBV) infection. Downregulation of latent membrane protein 1 (LMP1) encoded by EBV can reduce the expression of NF-κB and PI3K, induce apoptosis, and inhibit the growth of EBV-related NPC. For targeted cleavage of the Lmp1 oncogene via the CRISPR/Cas9 gene editing system, a post cross-linked ROS-responsive poly(β-amino ester) (PBAE) polymeric vector was developed for the delivery of CRISPR/Cas9 plasmids both in vitro and in vivo ...
March 7, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38433057/-gastric-hamartomatous-inverted-polyps-a-clinicopathological-analysis-of-five-cases
#15
JOURNAL ARTICLE
Z H Du, M Hong, Z F Zhang, J Zhao, X F Lin, H F Yang
Objective: To investigate the endoscopic and histopathological features, diagnosis and differential diagnosis of gastric hamartomatous inverted polyp (GHIP). Methods: Five cases of GHIP were collected at the University Town Hospital of Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China, from May 2021 to May 2023. The endoscopic, pathological and immunohistochemical features of the 5 GHIP cases were analyzed. The relevant literature was reviewed. Results: There were 3 males and 2 females, aged from 49 to 60 years, with a mean age of 56 years...
March 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38423356/reg%C3%AE-mitigates-radiation-induced-enteritis-by-preserving-mucin-secretion-and-sustaining-microbiome-homeostasis
#16
JOURNAL ARTICLE
Xiangzhan Zhu, Ya Li, Xue Tian, Yiming Jing, Zimeng Wang, Lingling Yue, Jianhui Li, Ling Wu, Xinkui Zhou, Zhidan Yu, Yaodong Zhang, Fangxia Guan, Minglei Yang, Bianhong Zhang
Radiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice lacking REGγ, as opposed to wild-type mice...
February 27, 2024: American Journal of Pathology
https://read.qxmd.com/read/38423222/mucin-phenotype-and-genetic-alterations-in-non-v600e-braf-mutated-colorectal-cancer
#17
JOURNAL ARTICLE
Hikaru Ozeki, Yoshifumi Shimada, Mae Nakano, Shuhei Kondo, Riuko Ohashi, Yamato Miwa, Daisuke Yamai, Akio Matsumoto, Kaoru Abe, Yosuke Tajima, Hiroshi Ichikawa, Jun Sakata, Yasumasa Takii, Mika Sugai, Takahiro Nagai, Yiwei Ling, Shujiro Okuda, Toshifumi Wakai
Colorectal cancer (CRC) is a heterogeneous disease that develops through stepwise accumulation of genetic alterations and progresses via several distinct pathways. However, the tumorigenesis of CRCs with BRAF non-V600E mutations remains unclear. Here, we aimed to elucidate the tumorigenesis of CRCs with BRAF non-V600E mutations, focusing on differences in mucin phenotype and genetic alterations between CRCs with non-V600E and V600E mutations. We investigated 201 patients with CRC and performed panel testing of 415 genes to identify BRAF mutations...
March 2024: Human Pathology
https://read.qxmd.com/read/38417315/fecal-transplantation-of-young-mouse-donors-effectively-improves-enterotoxicity-in-elderly-recipients-exposed-to-triphenyltin
#18
JOURNAL ARTICLE
Xiuxiu Chen, Donghui Zhu, Renshan Ge, Zhijun Bao
Triphenyltin (TPT) is a widely used biocide known for its high toxicity to various organisms, including humans, and its potential contribution to environmental pollution. The aging process leads to progressive deterioration of physiological functions in the elderly, making them more susceptible to the toxic effects of environmental pollutants. This study aimed to investigate the mitigating effect of fecal transplantation in young mice on the toxicological impairment caused by TPT exposure. For the study, 18-month-old mice were divided into four groups with six replicates each...
February 27, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38414417/the-protective-effect-of-l-theanine-on-the-intestinal-barrier-in-heat-stressed-organisms
#19
JOURNAL ARTICLE
Bin Wang, Sha Liu, Ling Lin, Wei Xu, Zhihua Gong, Wenjun Xiao
Heat stress caused by heatwaves, extreme temperatures, and other weather can damage the intestinal barrier of organisms. L-Theanine (LTA) attenuates heat stress-induced oxidative stress, inflammatory responses, and impaired immune function, but its protective effect on the intestinal barrier of heat-stressed organisms is unclear. In this study, low (100 mg kg-1 d-1 ), medium (200 mg kg-1 d-1 ), and high (400 mg kg-1 d-1 ) dosages of LTA were used in the gavage of C57BL/6J male mice that were experimented on for 50 d...
February 28, 2024: Food & Function
https://read.qxmd.com/read/38414039/equine-enteroid-derived-monolayers-recapitulate-key-features-of-parasitic-intestinal-nematode-infection
#20
JOURNAL ARTICLE
Stina Hellman, Frida Martin, Eva Tydén, Mikael E Sellin, Albin Norman, Bernt Hjertner, Pia Svedberg, Caroline Fossum
Stem cell-derived organoid cultures have emerged as attractive experimental models for infection biology research regarding various types of gastro-intestinal pathogens and host species. However, the large size of infectious nematode larvae and the closed structure of 3-dimensional organoids often hinder studies of the natural route of infection. To enable easy administration to the apical surface of the epithelium, organoids from the equine small intestine, i.e. enteroids, were used in the present study to establish epithelial monolayer cultures...
February 27, 2024: Veterinary Research
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