Keisuke Kajita, Mitsuhiro Nishida, Yasuo Kurimoto, Satoshi Yokota, Sunao Sugita, Toshika Semba, Satoshi Shirae, Naoko Hayashi, Atsuta Ozaki, Yoko Miura, Akiko Maeda, Yoshinori Mitamura, Masayo Takahashi, Michiko Mandai
Clinical studies using suspensions or sheets of human pluripotent cell-derived retinal pigment epithelial cells (hiPSC-RPE) have been conducted globally for diseases such as age-related macular degeneration. Despite being minimally invasive, cell suspension transplantation faces challenges in targeted cell delivery and frequent cell leakage. Conversely, although the RPE sheet ensures targeted delivery with correct cell polarity, it requires invasive surgery, and graft preparation is time-consuming. We previously reported hiPSC-RPE strips as a form of quick cell aggregate that allows for reliable cell delivery to the target area with minimal invasiveness...
May 2, 2024: Scientific Reports