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https://read.qxmd.com/read/30772725/abating-n-in-nordic-agriculture-policy-measures-and-way-forward
#1
Sofie Hellsten, Tommy Dalgaard, Katri Rankinen, Kjetil Tørseth, Lars Bakken, Marianne Bechmann, Airi Kulmala, Filip Moldan, Stina Olofsson, Kristoffer Piil, Kajsa Pira, Eila Turtola
During the past twenty years, the Nordic countries (Denmark, Sweden, Finland and Norway) have introduced a range of measures to reduce losses of nitrogen (N) to air and to aquatic environment by leaching and runoff. However, the agricultural sector is still an important N source to the environment, and projections indicate relatively small emission reductions in the coming years. The four Nordic countries have different priorities and strategies regarding agricultural N flows and mitigation measures, and therefore they are facing different challenges and barriers...
February 14, 2019: Journal of Environmental Management
https://read.qxmd.com/read/30772659/major-seminal-plasma-proteome-of-rabbits-and-associations-with-sperm-quality
#2
M J B Bezerra, J M Arruda-Alencar, J A M Martins, A G A Viana, A M Viana Neto, J P A Rêgo, R V Oliveira, M Lobo, A C O Moreira, R A Moreira, A A Moura
The present study was conducted to describe the major seminal plasma proteome of rabbits and potential associations between seminal proteins and semen criteria. Semen samples were collected from 18 New Zealand adult rabbits, and seminal plasma proteins were analyzed by 2-D SDS-PAGE and tandem mass spectrometry. Sperm motility, vigor, concentration, morphology and membrane sperm viability were evaluated. Rabbits ejaculated 364 ± 70 million sperm/ml, with 81 ± 6.1% motile cells, 3.8 ± 0.2 vigor and 66...
February 7, 2019: Theriogenology
https://read.qxmd.com/read/30772649/synthesis-crystal-structure-and-biological-evaluation-of-new-phosphoramide-derivatives-as-urease-inhibitors-using-docking-qsar-and-kinetic-studies
#3
Khodayar Gholivand, Mahsa Pooyan, Fahimeh Mohammadpanah, Foroogh Pirastefar, Peter C Junk, Jun Wang, Ali Asghar Ebrahimi Valmoozi, Ahmad Mani-Varnosfaderani
In an attempt to achieve a new class of phosphoramide inhibitors with high potency and resistance to the hydrolysis process against urease enzyme, we synthesized a series of bisphosphoramide derivatives (01-43) and characterized them by various spectroscopic techniques. The crystal structures of compounds 22 and 26 were investigated using X-ray crystallography. The inhibitory activities of the compounds were evaluated against the jack bean urease and were compared to monophosphoramide derivatives and other known standard inhibitors...
February 8, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30772606/pyranocarbazole-derivatives-as-potent-anti-cancer-agents-triggering-tubulin-polymerization-stabilization-induced-activation-of-caspase-dependent-apoptosis-and-downregulation-of-akt-mtor-in-breast-cancer-cells
#4
Om P S Patel, Ashutosh Arun, Pankaj K Singh, Deepika Saini, Sharanbasappa Shrimant Karade, Manish K Chourasia, Rituraj Konwar, Prem P Yadav
A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya koenigii. Among all, compound 3bg displayed significant anti-cancer activity against MDA-MB-231, DU145 and PC3 cell lines with the IC50 values of 3.8, 7.6 and 5.8 μM, respectively. It was also observed that the halogenated-benzyl substitution at N-9 position, C-3 Methyl and C-7 methoxy group on carbazole motif are favoured for anti-cancer activity...
February 7, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30772577/managing-risks-and-future-options-from-new-lakes-in-the-deglaciating-andes-of-peru-the-example-of-the-vilcanota-urubamba-basin
#5
Fabian Drenkhan, Christian Huggel, Lucía Guardamino, Wilfried Haeberli
Rapidly growing lakes in deglaciating mountain regions represent both: emerging risks and options for human livelihoods. In the Andes of Peru, seasonal water scarcity and Glacial Lake Outburst Floods (GLOF) pose a serious threat for highly exposed and vulnerable people. In addition, water demand is growing due to increasing irrigated agriculture, population and hydropower production. In this context, we assess current and future water risks and management options for the Vilcanota-Urubamba basin, Southern Peru...
February 6, 2019: Science of the Total Environment
https://read.qxmd.com/read/30772495/the-study-of-interactions-between-genome-and-exposome-in-the-development-of-systemic-lupus-erythematosus
#6
REVIEW
Henrik Christian Bidstrup Leffers, Theis Lange, Christopher Collins, Constance Jensina Ulff-Møller, Søren Jacobsen
Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by a broad spectrum of clinical and serological manifestations. This may reflect a complex and multifactorial etiology involving several identified genetic and environmental factors, though not explaining the full risk of SLE. Established SLE risk genotypes are either very rare or with modest effect sizes and twin studies indicate that other factors besides genetics must be operative in SLE etiology. The exposome comprises the cumulative environmental influences on an individual and associated biological responses through the lifespan...
February 14, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30772480/therapeutics-strategies-against-cancer-stem-cell-in-breast-cancer
#7
Faezeh Ghasemi, Parisa Zia Sarabi, Seyyed Shamsadin Athari, Abdulreza Esmaielzadeha
Breast cancer is known as a most prevalent cancer and second deadly cancer, among women worldwide. Due to the high incidence rate of breast cancer and limitations of conventional therapy it seemed essential to look for new targets in cancer cells and directly target them such as target therapy on breast cancer stem cells. In this review we indicate some of therapeutic uses of cancer stem cells in breast cancer. Some strategies are targeting surface specific markers and activated signaling pathways in their microenvironment such as Notch, Hedgehog, Wnt/b-catenin, PI3K/Akt, NF-kB, BMP and TGF-β and their maintenance and drug resistance, using various miRNAs, enhancement of CSCs apoptosis, differentiation therapy, blocking epithelial to mesenchymal transition and using different natural compounds...
February 14, 2019: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/30772407/chitosan-intercalated-bentonite-as-natural-adsorbent-matrix-for-water-soluble-sappanwood-dye
#8
Ampa Jimtaisong, Thapanee Sarakonsri
Chitosan-bentonite clay composite was prepared for use as adsorbent matrix of water-soluble natural dyes. The addition of chitosan resulted in a relatively rough texture of the composite compared with bentonite. XRD analysis showed that a basal d001 -space value of the composite (15.545 Å) is higher than that of bentonite clay (14.525 Å) which indicates that chitosan was intercalated into the layer of clay. FT-IR and SEM measurement also suggested that new compound was formed. Water soluble dye extracted from sappanwood was adsorbed onto chitosan-bentonite clay composite at 81...
February 14, 2019: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30772401/desynchronizing-to-be-faster-perceptual-and-attentional-modulation-of-brain-rhythms-at-the-sub-millisecond-scale
#9
Yasuki Noguchi, Yi Xia, Ryusuke Kakigi
Neural oscillatory signals has been associated with many high-level functions (e.g. attention and working memory), because they reflect correlated behaviors of neural population that would facilitate the information transfer in the brain. On the other hand, a decreased power of oscillation (event-related desynchronization, ERD) has been associated with an irregular state in which many neurons behave in an uncorrelated manner. In contrast to this view, here we show that the human ERD is linked to the increased regularity of oscillatory signals...
February 14, 2019: NeuroImage
https://read.qxmd.com/read/30772400/hierarchical-complexity-of-the-adult-human-structural-connectome
#10
Keith Smith, Mark E Bastin, Simon R Cox, Maria C Valdés Hernández, Stewart Wiseman, Javier Escudero, Catherine Sudlow
The structural network of the human brain has a rich topology which many have sought to characterise using standard network science measures and concepts. However, this characterisation remains incomplete and the non-obvious features of this topology have largely confounded attempts towards comprehensive constructive modelling. This calls for new perspectives. Hierarchical complexity is an emerging paradigm of complex network topology based on the observation that complex systems are composed of hierarchies within which the roles of hierarchically equivalent nodes display highly variable connectivity patterns...
February 14, 2019: NeuroImage
https://read.qxmd.com/read/30772361/are-slings-still-the-gold-standard-for-female-stress-urinary-incontinence-con-artificial-urinary-sphincter-for-female-incontinence
#11
Emmanuel Chartier-Kastler, Christine Reus
As slings are the most frequent first-line treatment for management of female urinary incontinence, an artificial urinary sphincter may be indicated in cases of failure and sphincter deficiency. The level of evidence has to improve and prospective studies or new devices are awaited.
February 13, 2019: European Urology Focus
https://read.qxmd.com/read/30772345/brillouin-spectroscopy-of-normal-and-keratoconus-corneas
#12
Theo G Seiler, Peng Shao, Amira Eltony, Theo Seiler, Seok-Hyun Yun
PURPOSE: To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas. DESIGN: Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017. METHODS: Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy perpendicular to the corneal surface...
February 14, 2019: American Journal of Ophthalmology
https://read.qxmd.com/read/30772339/hyaluronan-bound-mature-sperm-count-hb-masc-is-a-more-informative-indicator-of-fertility-than-conventional-sperm-parameters-correlations-with-body-mass-index-bmi
#13
Miklos Szucs, Peter Osvath, Attila Jakab, Daniel Varga, Balazs Varga, Bela Juhasz
The relationship between overweight and male fertility is well studied, still the correlation of obesity and decreased sperm quality is a subject to debate. The widely used conventional spermatological examinations alone seem to be inadequate to assess fertilization potential. Hyaluronan Binding Assay (HBA® ) is one of the available validated tests that allows the functional examination of sperm. Data of 72 male patients (mean age 33.9 (24-43) years) from infertile couples were analysed. Body Mass Index (BMI) determination, conventional semen analysis and HBA were performed...
February 13, 2019: Reproductive Biology
https://read.qxmd.com/read/30772268/the-novel-hybrid-agonist-hynda-1-targets-the-d3r-nachr-heteromeric-complex-in-dopaminergic-neurons
#14
Carlo Matera, Federica Bono, Silvia Pelucchi, Ginetta Collo, Leonardo Bontempi, Cecilia Gotti, Michele Zoli, Marco De Amici, Cristina Missale, Chiara Fiorentini, Clelia Dallanoce
In this paper, we designed, synthesized and tested a small set of three new derivatives potentially targeting the D3R-nAChR heteromer, a receptor complex recently identified and characterized as the molecular entity that, in dopaminergic neurons, mediates the neurotrophic effects of nicotine. By means of a partially rigidified spacer of variable length, we incorporated in the new compounds (1a-c) the pharmacophoric substructure of a known β2-subunit-containing nAChR agonist (A-84543) and that of the D2/D3R agonist drug ropinirole...
February 14, 2019: Biochemical Pharmacology
https://read.qxmd.com/read/30772250/estimating-hiv-incidence-from-surveillance-data-indicates-a-second-wave-of-infections-in-brazil
#15
Tara D Mangal, Ana Roberta Pati Pascom, Juan F Vesga, Mariana Veloso Meireles, Adele Schwartz Benzaken, Timothy B Hallett
Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Individual-level surveillance data for 1,077,295 cases (HIV/AIDS diagnoses, ART dispensations, CD4 counts and HIV/AIDS-related deaths) were used to calibrate the model using Bayesian inference...
February 7, 2019: Epidemics
https://read.qxmd.com/read/30772199/superselective-methohexital-challenge-prior-to-intracranial-endovascular-embolization
#16
Orhan Bican, Charles Cho, Areli Suarez-Roman, Viet Nguyen, Leslie Lee, Scheherazade Le, Jeremy Heit, Robert Dodd, Jaime López
Pharmacologic provocative testing (PT) and intraoperative neurophysiologic monitoring (IONM) both mitigate and predict risks associated with endovascular embolization procedures. We present a series of patients undergoing endovascular intracranial embolization predominantly for AVMs both under general anesthesia and awake with the use of IONM. We reviewed our database to identify all patients undergoing endovascular procedures between January 1, 2014 and January 1, 2016. Awake patients were tested with SSEP, EEG and real time neurologic examination while TcMEPs were performed in all anesthetized patients...
February 13, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/30771981/a-novel-reversed-phase-and-weak-anion-exchange-mixed-mode-stationary-phase-based-on-horizontal-polar-copolymerized-approach-for-separation-of-small-organic-molecules-and-inorganic-anions
#17
Qingguo Song, Kailou Zhao, Hongjun Xia, Jiawei Liu, Quan Bai
A novel silica-based reversed-phase/weak anion-exchange mixed-mode chromatography (MMC) stationary phase referred to as OTAS was synthesized based on the horizontal polar-copolymerized approach using trichlorooctadecylsilane (ODS) and (3-glycidyloxypropyl)trimethoxysilane (GPS) as ligands, and then followed by the reaction of epoxy group with diethylamine to introduce the tertiary ammonium functional group. The new stationary phase was characterized by instrumental analysis, and evaluated by separating the mixture of alkylbenzene homologues in reversed-phase mode and acidic organic compounds in ion-exchange chromatography mode, respectively...
May 15, 2019: Talanta
https://read.qxmd.com/read/30771925/a-new-double-emission-fluorescent-probe-for-fast-detection-of-thiophenols-in-aqueous-solution-and-living-cells
#18
Wenjuan Lv, Yonglei Chen, Lei Bian, Xingguo Chen
A new fluorescent probe was designed and synthesized according to the photo-induced electron transfer theory (PET) and the results of density functional theory calculation. The synthesized probe had a larger Stokes shift (130 nm) and double emission peak in response to highly toxic thiophenols, which could be applied in rapid and high sensitive detection of thiophenol in aqueous solution. A 25-fold fluorescence intensity enhancement was achieved and the fluorescent intensity at 460 nm had a linear relationship to the thiophenol in concentration range of 0-2...
May 15, 2019: Talanta
https://read.qxmd.com/read/30771904/pd-1-efficiently-inhibits-t-cell-activation-even-in-the-presence-of-co-stimulation-through-cd27-and-gitr
#19
Reina Mizuno, Takumi Maruhashi, Daisuke Sugiura, Kenji Shimizu, Mizuki Watada, Il-Mi Okazaki, Taku Okazaki
Cancer immunotherapies targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 revolutionized cancer treatment and instigated various trials to develop new cancer immunotherapies with higher therapeutic efficacy. Agonistic Abs against tumor necrosis factor receptor super family (TNFRSF) molecules are highly expected due to their high potential to enhance survival, proliferation, and effector function of T cells. To date, agonistic antibodies (Abs) against CD27, GITR, OX40, and 4-1BB have been reported to increase the efficacy of anti-PD-1 therapy in animal models and clinical trials of these combinatorial therapies are underway...
February 13, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30771891/revealing-the-structure-of-the-associations-between-housing-system-facilities-management-and-welfare-of-commercial-laying-hens-using-additive-bayesian-networks
#20
Arianna Comin, Alexandra Jeremiasson, Gilles Kratzer, Linda Keeling
After the ban of battery cages in 1988, a welfare control programme for laying hens was developed in Sweden. Its goal was to monitor and ensure that animal welfare was not negatively affected by the new housing systems. The present observational study provides an overview of the current welfare status of commercial layer flocks in Sweden and explores the complexity of welfare aspects by investigating and interpreting the inter-relationships between housing system, production type (i.e. organic or conventional), facilities, management and animal welfare indicators...
March 1, 2019: Preventive Veterinary Medicine
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