Huimin Li, Lei Wang, Xin Ye, Changlin Yao, Shuhong Song, Yaqian Qu, Jinke Jiang, Hongshuai Wang, Peizhuo Han, Yang Liu, Xutang Tao
Cocrystal screening and single-crystal growth remain the primary obstacles in the development of pharmaceutical cocrystals. Here, we present a new approach for cocrystal screening, microspacing in-air sublimation (MAS), to obtain new cocrystals and grow high-quality single crystals of cocrystals within tens of minutes. The method possesses the advantages of strong designable ability of devices, user-friendly control, and compatibility with materials, especially for the thermolabile molecules. A novel drug-drug cocrystal of favipiravir (FPV) with salicylamide (SAA) was first discovered by this method, which shows improved physiochemical properties...
April 17, 2024: Journal of the American Chemical Society