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https://read.qxmd.com/read/30781660/the-emerging-role-of-robotic-surgery-among-minimally-invasive-surgical-approaches-in-the-treatment-of-hypopharyngeal-carcinoma-systematic-review-and-meta-analysis
#1
REVIEW
Armando De Virgilio, Oreste Iocca, Luca Malvezzi, Pasquale Di Maio, Raul Pellini, Fabio Ferreli, Giovanni Cugini, Giovanni Colombo, Giuseppe Spriano
The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer...
February 18, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30781617/an-explorative-study-of-qualities-in-interactive-processes-with-children-and-their-parents-in-music-therapy-during-and-after-pediatric-hematopoietic-stem-cell-transplantation
#2
Lena Uggla, Katarina Mårtenson Blom, Lars Ole Bonde, Britt Gustafsson, Björn Wrangsjö
Background: Hematopoietic stem cell transplantation (HSCT) is an established treatment for severe disorders of the pediatric hematopoietic system. However, there is a need for supportive interventions due to physiological and psychological strain. Music therapy is used in health care to help patients through difficult experiences and enable well-being. Our previous randomized studies showed significantly reduced heart rates four to eight hours after intervention as well as increased health-related quality of life...
February 18, 2019: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/30781521/exploring-lncrna-mediated-regulatory-networks-in-endometrial-cancer-cells-and-the-tumor-microenvironment-advances-and-challenges
#3
REVIEW
Peixin Dong, Ying Xiong, Junming Yue, Sharon J B Hanley, Noriko Kobayashi, Yukiharu Todo, Hidemichi Watari
Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways...
February 16, 2019: Cancers
https://read.qxmd.com/read/30781399/protective-effect-of-antrodia-cinnamomea-extract-against-irradiation-induced-acute-hepatitis
#4
Tsu-Hsiang Kuo, Yueh-Hsiung Kuo, Chun-Yu Cho, Chih-Jung Yao, Gi-Ming Lai, Shuang-En Chuang
Radiotherapy for treatment of hepatocellular carcinoma causes severe side effects, including acute hepatitis and chronic fibrosis. Complementary and alternative medicine (CAM) has emerged as an important part of integrative medicine in the management of diseases. Antrodia cinnamomea (AC), a valuable medicinal fungus originally found only in Taiwan, has been shown to possess anti-oxidation, vaso-relaxtation, anti-inflammation, anti-hepatitis, and anti-cancer effects. In this paper we evaluate the protective effects of ethanol extract of Antrodia cinnamomea (ACE) against radiotoxicity both in normal liver cell line CL48 and in tumor-bearing mice...
February 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30780193/utility-of-weight-bearing-radiographs-compared-to-computed-tomography-scan-for-the-diagnosis-of-subtle-lisfranc-injuries-in-the-emergency-setting
#5
Hannah Kennelly, Kassey Klaassen, Daniel Heitman, Rhys Youngberg, Simon R Platt
OBJECTIVE: The goal of the present study was to compare the diagnostic yield of weight-bearing radiographs with non-weight-bearing computed tomography (CT) scan for subtle Lisfranc (LF) injuries in the ED. METHODS: Retrospective analysis of patients presenting with a suspected LF injury over a 2 year period from 2016 to 2017 who had both weight-bearing bilateral foot radiographs and CT scan. Information extracted included patient demographics, radiographic findings of metatarsal fractures, fleck sign and measurements of diastasis between the medial cuneiform and second metatarsal expressed as a ratio of the uninjured side, clinical findings and treatment modality...
February 19, 2019: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/30779954/prediction-of-bloodstream-infection-caused-by-esbl-producing-enterobacterales-in-patients-with-suspected-community-onset-sepsis
#6
Inga Fröding, John Karlsson Valik, Ludvig Bolinder, Pontus Nauclér, Christian G Giske
BACKGROUND: In severe infections, time to appropriate therapy is decisive for survival. Patients with bloodstream infection with extended-spectrum β-lactamase-producing Enterobacterales (EPE BSI) often receive inadequate empiric treatment. OBJECTIVES: We aimed to identify risk factors, evaluate a previously suggested risk score, and suggest a new score for facilitating empiric treatment choice. METHODS: We assessed predictors for EPE BSI through a retrospective case-control design, and evaluated diagnostic performance of the two scores...
February 16, 2019: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/30779826/contrast-enhanced-ultrasound-performance-in-predicting-blunt-splenic-injuries-requiring-only-observation-and-monitoring
#7
Corrado Tagliati, Giulio Argalia, Gian Marco Giuseppetti
AIMS: To assess contrast enhanced ultrasound (CEUS) performance in the prediction of non-operatively managed blunt spleen injuries requiring only observation and monitoring during follow-up and to evaluate if CEUS accuracy was higher than conventional ultrasound (US) in this field. MATERIAL AND METHODS: In 112 hemodynamic stable blunt spleen trauma patients, CEUS was performed for follow-up after computed tomography evaluation in the emergency department. CEUS and US performance were assessed considering as true negative cases patients that had not underwent interventional or surgical treatment during follow-up and were assessed as negative for splenic complications respectively by CEUS or US examinations...
February 17, 2019: Medical Ultrasonography
https://read.qxmd.com/read/30779730/a-numerical-approach-for-a-discrete-markov-model-for-progressing-drug-resistance-of-cancer
#8
Masayuki Maeda, Hideaki Yamashita
The presence of treatment-resistant cells is an important factor that limits the efficacy of cancer therapy, and the prospect of resistance is considered the major cause of the treatment strategy. Several recent studies have employed mathematical models to elucidate the dynamics of generating resistant cancer cells and attempted to predict the probability of emerging resistant cells. The purpose of this paper is to present numerical approach to compute the number of resistant cells and the emerging probability of resistance...
February 19, 2019: PLoS Computational Biology
https://read.qxmd.com/read/30779651/management-of-cardiovascular-disease-in-women-with-breast-cancer
#9
Rachel Barish, Filipa Lynce, Keith Unger, Ana Barac
Cardio-oncology is a rapidly developing field which seeks to improve patient outcomes through enhanced clinical and research collaboration across the disciplines of oncology and cardiology. Breast cancer (BC) is the most common cancer diagnosis among women in the United States and, as decades of research have resulted in decreased mortality rates, there has been an increasing focus on reducing short- and long-term treatment toxicity and improving morbidity among survivors. Preexisting or emergent cardiovascular disease in a patient with BC requires a multidisciplinary, team-based approach to balance the need for curative cancer treatment while preventing increased cardiovascular disease morbidity and mortality...
February 19, 2019: Circulation
https://read.qxmd.com/read/30779610/application-of-the-incident-command-system-to-the-hospital-biocontainment-unit-setting
#10
Lauren M Sauer, Mark Romig, Jennifer Andonian, Jade Borromeo Flinn, Noreen Hynes, Robert Maloney, Lisa L Maragakis, Brian Garibaldi
High-consequence pathogens create a unique problem. To provide effective treatment for infected patients while providing safety for the community, a series of 10 high-level isolation units have been created across the country; they are known as Regional Ebola and Special Pathogen Treatment Centers (RESPTCs). The activation of a high-level isolation unit is a highly resource-intensive activity, with effects that ripple across the healthcare system. The incident command system (ICS), a standard tool for command, control, and coordination in domestic emergencies, is a command structure that may be useful in a biocontainment event...
January 2019: Health Security
https://read.qxmd.com/read/30779603/merit-based-claim-adjudication-for-cancer-treatment-toxicities-policy-trends-that-lower-downstream-costs
#11
Ricky McCullough
BACKGROUND: -Due largely to the lack of effective therapeutic options, between 1973-2013, chemoradiation toxic mucositis (CRTM) has remained an uncapped expenditure for 40 years, with incremental costs of $17,000-$40,000 per patient per episode. Costs in patient morbidity and mortality have continued as well. A recent therapeutic option associated with complete prevention and/or rapid sustained elimination (high potency polymerized cross-linked sucralfate, HPPCLS) delivers value by eliminating downstream costs CRTM experienced in the first 12 months...
February 19, 2019: Journal of Insurance Medicine
https://read.qxmd.com/read/30779485/-treatment-dilemmas-in-fulminant-intracranial-hypertension
#12
Eyal Aloni, Majd Arow, Moris Harstein, Zina Almer, Galina Sholohov
Fulminant intracranial hypertension is a rare, acute presentation of idiopathic intracranial hypertension with rapid and devastating visual loss that can lead to blindness. As vision deteriorates quickly and often irreversibly, prevention of further visual loss requires emergent treatment to decrease intracranial pressure. The case presented is that of an 18 years old male with new symptoms of headaches and visual obscurations that had rapid progressive visual loss with findings of severe bilateral swollen discs...
February 2019: Harefuah
https://read.qxmd.com/read/30779461/the-clinical-value-of-hematological-markers-in-rheumatoid-arthritis-patients-treated-with-tocilizumab
#13
Li Zhou, Dong-Mei Xiao, Wen Qin, Bin-Hua Xie, Ting-Hui Wang, Hua Huang, Bao-Jing Zhao, Xi Han, Qing-Qing Sun, Xiu-Di Wu, Han Cen
BACKGROUND: Emerging evidence indicates that some hematological markers have critical value in evaluating treatment response. This study was performed to determine the clinical value of hemoglobin (Hb), platelet (Plt), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ). METHODS: Fifty-two RA patients receiving TCZ were recruited and followed for 6 months. The values of abovementioned hematological markers were collected...
February 19, 2019: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/30779441/predicting-postoperative-liver-dysfunction-based-on-blood-derived-microrna-signatures
#14
Patrick Starlinger, Hubert Hackl, David Pereyra, Susanna Skalicky, Elisabeth Geiger, Michaela Finsterbusch, Dietmar Tamandl, Christine Brostjan, Thomas Grünberger, Matthias Hackl, Alice Assinger
There is an urgent need for an easily assessable preoperative test to predict postoperative liver function recovery and thereby determine the optimal time point of liver resection, specifically as current markers are often expensive, time consuming and invasive. Emerging evidence suggests that microRNA (miRNA) signatures represent potent diagnostic, prognostic and treatment response biomarkers for several diseases. Using next-generation sequencing as an unbiased systematic approach 554 miRNAs were detected in preoperative plasma of 21 patients suffering from postoperative liver dysfunction (LD) after liver resection and 27 matched controls...
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779313/financial-impact-of-an-outbreak-of-clinically-diagnosed-blackleg-a-case-study-from-lao-pdr
#15
Sonevilay Nampanya, Syseng Khounsy, Navneet K Dhand, Russell D Bush, Peter A Windsor
Blackleg (BL) is an acute to peracute highly fatal infectious disease of mainly large ruminants characterised by lesions of myonecrosis caused by Clostridium chauvoei, usually presenting as a sudden onset of sporadic mortalities. In Southeast Asia, 'BL' is considered a cause of occasional outbreaks of a subacute febrile illness, although there are few published reports available. Investigation of a major outbreak of clinically diagnosed BL occurring in large ruminants (cattle and buffalo) in three neighbouring villages in central Laos in mid-2017, was conducted to determine the financial impacts of BL on smallholder livelihoods...
February 19, 2019: Veterinary Medicine and Science
https://read.qxmd.com/read/30779140/metformin-ameliorates-experimental-diabetic-periodontitis-independently-of-mammalian-target-of-rapamycin-mtor-inhibition-by-reducing-nima-related-kinase-7-nek7-expression
#16
Xinyi Zhou, Peng Zhang, Qian Wang, Ning Ji, Sisi Xia, Yi Ding, Qi Wang
BACKGROUND: Metformin, a classical treatment for diabetes mellitus, has shown sound anti-inflammatory effects. Emerging studies have focused on the mechanism underlying inflammation-related diabetic complications, such as diabetic periodontitis. Herein, we investigated the anti-inflammatory effects of metformin on the NIMA-related kinase 7(Nek7)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway both in vivo and in vitro in experimental diabetic periodontitis. METHODS: All procedures were conducted in Porphyromonas gingivalis (P...
February 19, 2019: Journal of Periodontology
https://read.qxmd.com/read/30779047/ultrasensitive-detection-of-circulating-tumor-dna-in-lymphoma-via-targeted-hybridization-capture-and-deep-sequencing-of-barcoded-libraries
#17
Miguel Alcaide, Christopher Rushton, Ryan D Morin
Liquid biopsies are rapidly emerging as powerful tools for the early detection of cancer, noninvasive genomic profiling of localized or metastatic tumors, prompt detection of treatment resistance-associated mutations, and monitoring of therapeutic response and minimal residual disease in patients during clinical follow-up. Growing evidence strongly supports the utility of circulating tumor DNA (ctDNA) as a biomarker for the stratification and clinical management of lymphoma patients. However, ctDNA is diluted by variable amounts of cell-free DNA (cfDNA) shed by nonneoplastic cells causing a background signal of wild-type DNA that limits the sensitivity of methods that rely on DNA sequencing...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779041/studying-cancer-heterogeneity-by-single-cell-rna-sequencing
#18
Johannes W Bagnoli, Lucas E Wange, Aleksandar Janjic, Wolfgang Enard
A major hurdle for the treatment of cancer is the incomplete understanding of its evolution through the course of its emergence, dispersal, and relapse. Genetic and epigenetic changes in combination with external cues and selective forces are the driving factors behind tumor heterogeneity. Understanding this variability within and across patients may partly explain the unpredictable outcomes of cancer treatments. Measuring the variation of gene expression levels within cells of the same tumor is a crucial part of this endeavor...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30778843/management-of-esophageal-achalasia-after-roux-en-y-gastric-bypass-narrative-review-of-the-literature
#19
Alberto Aiolfi, Stefania Tornese, Gianluca Bonitta, Emanuele Rausa, Giancarlo Micheletto, Davide Bona
INTRODUCTION: The development of achalasia after Roux-en-Y gastric bypass (RYGB) is rare. Heller myotomy (HM) is the gold standard treatment while peroral endoscopic myotomy (POEM) is an emerging technique with promising results. The aim of this narrative review was to summarize the current knowledge on the treatment of esophageal achalasia after RYGB. METHODS: PubMed, EMBASE, and Web of Science databases were consulted. All articles that described the management of achalasia after RYGB were included in this narrative review...
February 18, 2019: Obesity Surgery
https://read.qxmd.com/read/30778690/spontaneous-pulmonary-hematoma-with-diffuse-pulmonary-ossification-requiring-emergency-treatment-a-case-report
#20
Takumi Sonokawa, Takuma Matsui, Kyoshiro Takegahara, Tatsuya Inoue, Takeru Kashiwada, Yasuhiro Terasaki, Jitsuo Usuda
BACKGROUND: Pulmonary hematoma is most often caused by thoracic trauma. However, rare cases of pulmonary hematoma without any obvious cause are sometimes reported, when the condition is referred to as spontaneous or idiopathic pulmonary hematoma. Herein, we report a very rare case-to the best of our knowledge, this is the first case of pulmonary hematoma associated with diffuse pulmonary ossification requiring emergency treatment reported in the English literature. CASE PRESENTATION: Our patient was a 44-year-old man with a history of IgA nephropathy and had no history of trauma or anticoagulant use...
February 18, 2019: Surgical Case Reports
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