keyword
https://read.qxmd.com/read/38536752/causal-functional-maps-of-brain-rhythms-in-working-memory
#1
JOURNAL ARTICLE
Miles Wischnewski, Taylor A Berger, Alexander Opitz, Ivan Alekseichuk
Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in healthy humans with the advance of transcranial alternating current stimulation (tACS)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38534560/comparison-of-immediate-neuromodulatory-effects-between-focal-vibratory-and-electrical-sensory-stimulations-after-stroke
#2
JOURNAL ARTICLE
Legeng Lin, Wanyi Qing, Yanhuan Huang, Fuqiang Ye, Wei Rong, Waiming Li, Jiao Jiao, Xiaoling Hu
Focal vibratory stimulation (FVS) and neuromuscular electrical stimulation (NMES) are promising technologies for sensory rehabilitation after stroke. However, the differences between these techniques in immediate neuromodulatory effects on the poststroke cortex are not yet fully understood. In this research, cortical responses in persons with chronic stroke ( n = 15) and unimpaired controls ( n = 15) were measured by whole-brain electroencephalography (EEG) when FVS and NMES at different intensities were applied transcutaneously to the forearm muscles...
March 17, 2024: Bioengineering
https://read.qxmd.com/read/38534532/electric-field-characteristics-of-rotating-permanent-magnet-stimulation
#3
JOURNAL ARTICLE
Pei L Robins, Sergey N Makaroff, Michael Dib, Sarah H Lisanby, Zhi-De Deng
Neurostimulation devices that use rotating permanent magnets are being explored for their potential therapeutic benefits in patients with psychiatric and neurological disorders. This study aims to characterize the electric field (E-field) for ten configurations of rotating magnets using finite element analysis and phantom measurements. Various configurations were modeled, including single or multiple magnets, and bipolar or multipolar magnets, rotated at 10, 13.3, and 350 revolutions per second (rps). E-field strengths were also measured using a hollow sphere (r=9...
March 6, 2024: Bioengineering
https://read.qxmd.com/read/38532608/topological-quantum-switching-enabled-neuroelectronic-synaptic-modulators-for-brain-computer-interface
#4
JOURNAL ARTICLE
Dani S Assi, Hongli Huang, Vaithinathan Karthikeyan, Vaskuri C S Theja, Maria Merlyne de Souza, Vellaisamy A L Roy
Aging and genetic-related disorders in the human brain lead to impairment of daily cognitive functions. Due to their neural synaptic complexity and the current limits of knowledge, reversing these disorders remains a substantial challenge for Brain-Computer Interfaces (BCI). In this work, we provide a solution to potentially override aging and neurological disorder-related cognitive function loss in the human brain through the application of our quantum synaptic device. To illustrate this point, we design and develop a quantum topological insulator (QTI) Bi2 Se2 Te-based synaptic neuroelectronic device, where the electric field-induced tunable topological surface edge states and quantum switching properties make them a premier option for establishing artificial synaptic neuromodulation approaches...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38531115/high-spatial-resolution-transcranial-focused-ultrasound-neuromodulation-using-frequency-modulated-pattern-interference-radiation-force
#5
JOURNAL ARTICLE
Young Hun Kim, Ki Chang Kang, Jeong Nyeon Kim, Kwan Kyu Park, Kamyar Firouzi, Butrus T Khuri-Yakub
Stimulating the brain in a precise location is crucial in ultrasound neuromodulation. However, improving the resolution proves a challenge owing to the characteristics of transcranial focused ultrasound. In this paper, we present a new neuromodulation system that overcomes the existing limitations based on an acoustic radiation force with a frequency-modulated waveform and standing waves. By using the frequency-modulated pattern interference radiation force (FM-PIRF), the axial spatial resolution can be reduced to a single wavelength level and the target location can be controlled in axial direction electronically...
March 16, 2024: Ultrasonics
https://read.qxmd.com/read/38531027/continuous-stellate-ganglion-block-for-ventricular-arrhythmias-case-series-systematic-review-and-differences-from-thoracic-epidural-anaesthesia
#6
JOURNAL ARTICLE
Veronica Dusi, Filippo Angelini, Enrico Baldi, Antonio Toscano, Carol Gravinese, Simone Frea, Sara Compagnoni, Arianna Morena, Andrea Saglietto, Eleonora Balzani, Matteo Giunta, Andrea Costamagna, Mauro Rinaldi, Anna Chiara Trompeo, Roberto Rordorf, Matteo Anselmino, Simone Savastano, Gaetano Maria De Ferrari
BACKGROUND: Percutaneous stellate ganglion block (PSGB) through single bolus injection and thoracic epidural anaesthesia (TEA) have been proposed for the acute management of refractory ventricular arrhythmias (VAs). However, data on continuous PSGB (C-PSGB) are scant. AIMS: To report our dual-center experience with C-PSGB and to perform a systematic review on C-PSGB and TEA. METHODS: Consecutive patients receiving C-PSGB at 2 centers were enrolled...
March 26, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38530712/feasibility-study-for-a-high-frequency-flexible-ultrasonic-cuff-for-high-precision-vagus-nerve-ultrasound-neuromodulation
#7
JOURNAL ARTICLE
Cornelis Van Damme, Gandhika K Wardhana, Andrada Iulia Velea, Vasiliki Giagka, Tiago L Costa
In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to reduce side effects, as well as to increase the effectiveness of the delivered therapy, sub-fascicle stimulation specificity is required. In the electrical domain, increasing spatial selectivity can only be achieved using invasive and potentially damaging approaches like compressive forces or nerve penetration...
March 26, 2024: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://read.qxmd.com/read/38520459/prospective-six-month-analysis-of-multiarea-burst-spinal-cord-stimulation-correlating-intraoperative-neuromonitoring-with-postoperative-programming-and-clinical-outcomes
#8
JOURNAL ARTICLE
Steven M Falowski, Ameya C Nanivadekar
INTRODUCTION: DeRidder burst spinal cord stimulation (SCS) has shown superior relief from overall pain to traditional tonic neurostimulation therapies and a reduction in back and leg pain. However, nearly 80% of patients have two or more noncontiguous pain areas. This affects the ability to effectively program stimulation and deliver long-term efficacy of the therapy. Multiple DeRidder burst region programming is an option to treat multisite pain by interleaving stimulation at multiple areas along the spinal cord...
March 22, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38518369/galvanic-vs-pulsatile-effects-on-decision-making-networks-reshaping-the-neural-activation-landscape
#9
JOURNAL ARTICLE
Paul W Adkisson, Cynthia R Steinhardt, Gene Yevgeny Fridman
OBJECTIVE: Primarily due to safety concerns, biphasic pulsatile stimulation is the present standard for electrical excitation of neural tissue with a diverse set of applications. While pulses have been shown to be effective to achieve functional outcomes, they have well-known deficits. Due to recent technical advances, galvanic stimulation, delivery of current for extended periods of time (>1s), has re-emerged as an alternative to pulsatile stimulation. APPROACH: In this paper, we use a winner-take-all decision-making cortical network model to investigate differences between pulsatile and galvanic stimulation in the context of a perceptual decision-making task...
March 22, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38508626/evidence-informed-and-consensus-based-statements-about-safety-of-physical-agent-modalities-practice-in-physiotherapy-and-rehabilitation-medicine-safe-pamp-a-national-delphi-of-healthcare-scientific-societies
#10
JOURNAL ARTICLE
Silvia Gianola, Silvia Bargeri, Leonardo Pellicciari, Simone Gambazza, Giacomo Rossettini, Anna Fulvio, Vincenzo Genovese, Matteo Benedini, Emanuele Proverbio, Simone Cecchetto, Greta Castellini, Andrea Turolla
OBJECTIVE: A shared consensus on the safety about physical agent modalities (PAMs) practice in physiotherapy and rehabilitation is lacking. We aimed to develop evidence-informed and consensus-based statements about the safety of PAMs. STUDY DESIGN AND SETTING: A RAND-modified Delphi Rounds' survey was used to reach a consensus. We established a steering committee of the Italian Association of Physiotherapy (Associazione Italiana di Fisioterapia) to identify areas and questions for developing statements about the safety of the most commonly used PAMs in physiotherapy and rehabilitation...
March 19, 2024: BMJ Open
https://read.qxmd.com/read/38508591/first-evidence-of-a-biomarker-based-dose-response-relationship-in-chronic-pain-using-physiological-closed-loop-spinal-cord-stimulation
#11
JOURNAL ARTICLE
Leah Muller, Jason Pope, Paul Verrills, Erika Petersen, Jan Willem Kallewaard, Ian Gould, Dean M Karantonis
BACKGROUND AND OBJECTIVES: In spinal cord stimulation (SCS) therapy, electricity is the medication delivered to the spinal cord for pain relief. In contrast to conventional medication where dose is determined by desired therapeutic plasma concentration, there is lack of equivalent means of determining dose delivery in SCS. In open-loop (OL) SCS, due to the dynamic nature of the epidural space, the activating electric field delivered is inconsistent at the level of the dorsal columns. Recent Food and Drug Administration guidance suggests accurate and consistent therapy delivered using physiologic closed-loop control (PCLC) devices can minimize underdosage or overdosage and enhance medical care...
March 19, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38506767/effects-of-transcranial-direct-current-stimulation-on-clinical-outcomes-calcitonin-gene-related-peptide-and-pituitary-adenylate-cyclase-activating-polypeptide-38-levels-in-menstrual-migraine
#12
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Serkan Aksu, Haşim Gezegen, Zerrin Karaaslan, Hande Yüceer, Tuba Cerrahoğlu Şirin, Cem İsmail Küçükali, Adnan Kurt, Sacit Karamürsel, Vuslat Yılmaz, Betül Baykan
OBJECTIVES: Transcranial direct current stimulation (tDCS) has been suggested as an alternative treatment option for migraine. The present study aimed to evaluate the efficacy of tDCS on clinical outcomes in addition to calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide 38 (PACAP-38) levels in individuals with menstrual-related migraine (MRM) for the first time. MATERIALS AND METHODS: In this parallel study, 58 female patients between the ages of 18 and 45 years, including 36 with MRM and 22 with nonmenstrual migraines (nMM), were recruited...
March 19, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38506766/effects-of-transcranial-ultrasound-stimulation-on-blood-oxygen-metabolism-and-brain-rhythms-in-nitroglycerin-induced-migraine-mice
#13
JOURNAL ARTICLE
Nannan Bian, Yi Yuan, Xiaoli Li
OBJECTIVES: In this study, we aimed to investigate the regulatory mechanism of transcranial ultrasound stimulation (TUS) on nitroglycerin-induced migraine in mice. MATERIALS AND METHODS: The experiment was divided into four groups, namely, the normal saline control group (n = 9), ultrasound stimulation control group (n = 6), nitroglycerin-induced migraine group (n = 9), and ultrasound stimulation group (n = 9). The behavior, blood oxygen metabolism, and brain rhythm distribution of the four groups were analyzed...
March 18, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38506681/pulsed-radiofrequency-therapy-at-different-voltages-on-dorsal-root-ganglia-using-multifunctional-catheter-to-treat-low-back-pain-a-comparative-retrospective-study
#14
JOURNAL ARTICLE
Dolores Rufolo, Carmelo Attilio Costa, Giulia Bravo, Paola Nosella
BACKGROUND: Applying pulsed radiofrequency (PRF) to the dorsal root ganglion (DRG) is an electrical neuromodulation technique, a valid complementary therapeutic treatment for failed back surgery syndrome (FBBS). Peridurolysis, when applied to vertebral canal adhesions, can be performed with dedicated catheters, providing patients with the benefits of mechanical, electrical, and pharmacological techniques. OBJECTIVES: The aim of this study was to evaluate PRF's effects on the DRG as part of FBSS treatment at different follow-up times, comparing 2 groups of patients exposed to distinct levels of voltage (100 V vs...
March 2024: Pain Physician
https://read.qxmd.com/read/38505983/noninvasive-intervention-by-transcranial-ultrasound-stimulation-modulation-of-neural-circuits-and-its-clinical-perspectives
#15
JOURNAL ARTICLE
Takahiro Osada, Seiki Konishi
Low-intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method is recognized for its potential to comprehensively perturb various brain regions, enabling the modulation of neural circuits, in a manner not achievable through conventional magnetic or electrical brain stimulation techniques. The underlying mechanisms of neuromodulation are based on a phenomenon where mechanical waves of ultrasound kinetically interact with neurons, specifically affecting neuronal membranes and mechanosensitive channels...
March 20, 2024: Psychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38502956/computational-modeling-of-dorsal-root-ganglion-stimulation-using-an-injectrode
#16
JOURNAL ARTICLE
Sauradeep Bhowmick, Robert D Graham, Nishant Verma, James K Trevathan, Manfred Franke, Stephan Nieuwoudt, Lee E Fisher, Andrew J Shoffstall, Douglas J Weber, Kip A Ludwig, Scott F Lempka
Minimally invasive neuromodulation therapies like the Injectrode, which is composed of a tightly wound polymer-coated platinum/iridium microcoil, offer a low-risk approach for administering electrical stimulation to the dorsal root ganglion (DRG). This flexible electrode is aimed to conform to the DRG. The stimulation occurs through a transcutaneous electrical stimulation (TES) patch, which subsequently transmits the stimulation to the Injectrode via a subcutaneous metal collector. However, effectiveness of stimulation relies on the specific geometrical configurations of the Injectrode-collector-patch system...
March 19, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38499664/responsive-deep-brain-stimulation-for-the-treatment-of-tourette-syndrome
#17
JOURNAL ARTICLE
Michael S Okun, Jackson Cagle, Julieth Gomez, Dawn Bowers, Joshua Wong, Kelly D Foote, Aysegul Gunduz
To report the results of 'responsive' deep brain stimulation (DBS) for Tourette syndrome (TS) in a National Institutes of Health funded experimental cohort. The use of 'brain derived physiology' as a method to trigger DBS devices to deliver trains of electrical stimulation is a proposed approach to address the paroxysmal motor and vocal tic symptoms which appear as part of TS. Ten subjects underwent bilateral staged DBS surgery and each was implanted with bilateral centromedian thalamic (CM) region DBS leads and bilateral M1 region cortical strips...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38496621/thalamic-stimulation-induced-changes-in-effective-connectivity
#18
Nicholas M Gregg, Gabriela Ojeda Valencia, Harvey Huang, Brian N Lundstrom, Jamie J Van Gompel, Kai J Miller, Gregory A Worrell, Dora Hermes
Deep brain stimulation (DBS) is a viable treatment for a variety of neurological conditions, however, the mechanisms through which DBS modulates large-scale brain networks are unresolved. Clinical effects of DBS are observed over multiple timescales. In some conditions, such as Parkinson's disease and essential tremor, clinical improvement is observed within seconds. In many other conditions, such as epilepsy, central pain, dystonia, neuropsychiatric conditions or Tourette syndrome, the DBS related effects are believed to require neuroplasticity or reorganization and often take hours to months to observe...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38495402/short-term-effects-of-transcutaneous-auricular-vagus-nerve-stimulation-on-t-wave-alternans-in-people-with-focal-epilepsy-an-exploratory-pilot-study
#19
JOURNAL ARTICLE
Jan Pukropski, Jan Baumann, Arthur Jordan, Marcel Bausch, Randi von Wrede, Rainer Surges
High levels of T-wave alternans (TWA) are linked to an increased risk of sudden cardiac death. People with epilepsy display elevated TWA levels that are decreased by chronic vagus nerve stimulation via implanted devices after 2-4 weeks or later. Our objective was to explore short-term effects of transcutaneous auricular vagus nerve stimulation (tVNS) on TWA. Five patients (3 female) with focal epilepsy undergoing video-EEG monitoring were included. TWA levels were determined using a one-channel modified lead I ECG via an open-source TWA-algorithm on two consecutive days, 1 h before, during and after tVNS via the left auricle...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38488536/exploring-the-synergy-of-the-eye-brain-connection-neuromodulation-approaches-for-neurodegenerative-disorders-through-transcorneal-electrical-stimulation
#20
JOURNAL ARTICLE
Antara Verma, Stephen K Agadagba, Leanne Lai-Hang Chan
No abstract text is available yet for this article.
October 1, 2024: Neural Regeneration Research
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