Takahiro Hamada, Daisuke Tsuruta, Shunpei Fukuda, Norito Ishii, Kwesi Teye, Sanae Numata, Teruki Dainichi, Tadashi Karashima, Chika Ohata, Minao Furumura, Takashi Hashimoto
Inherited keratinizing disorders are caused by mutations in the genes encoding cornified cell envelope proteins, enzymes and their inhibitors, adhesion molecules, cytoskeletal proteins and others in the epidermis. These molecules are known to regulate differentiation, proliferation and cell adhesions. Intriguingly, some keratinizing disorders show blistering skin lesions, while some inherited blistering disorders show abnormal keratinization. Therefore, hereditary keratinizing and blistering diseases are closely related and show overlapping genetic backgrounds...
February 2013: Experimental Dermatology