keyword
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#1
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38536625/risk-of-esophageal-adenocarcinoma-after-bariatric-surgery-a-meta-analysis-of-retrospective-studies
#2
JOURNAL ARTICLE
Chenglou Zhu, Wenhan Liu, Dongping Hu, Lingzhi Peng
PURPOSE: This study aims to systematically review and meta-analyze the evidence on the risk of esophageal adenocarcinoma (EAC) following metabolic and bariatric surgery (MBS). MATERIALS AND METHODS: A systematic literature search was conducted on the China National Knowledge Infrastructure (CNKI), Wanfang, EMBASE, MEDLINE, Web of Science, The Cochrane Library, and PubMed databases. Meta-analysis utilized odds ratios (ORs) and 95% confidence intervals (CIs) to analyze the correlation between MBS and the risk of EAC...
March 27, 2024: Obesity Surgery
https://read.qxmd.com/read/38536011/evaluation-of-diagnostic-value-of-doppler-ultrasound-in-the-diagnosis-of-malignant-breast-masses
#3
JOURNAL ARTICLE
Bahareh Mehdikhani, Milad Benam, Afrooz Moradkhani, Ayda Roostaee, Seyedeh Sabahat Bahman, Pooyan Barmayoon, Ghazaleh Dezyani, Zeinab Safarpour Lima
Breast cancer is the leading cause of cancer mortality in women, and it is on the rise in Iran. Therefore, an early-stage diagnosis of breast cancer is of critical importance. Because ultrasound is one of the available, inexpensive, and minimally invasive techniques for distinguishing malignant from benign masses, a comparison of conventional ultrasound, color Doppler, and spectral Doppler findings can be useful. The purpose of this study was to determine the diagnostic value of sonographic indices, specifically Doppler parameters, in identifying the nature of breast masses...
March 26, 2024: European Journal of Translational Myology
https://read.qxmd.com/read/38535920/assessing-benzene-and-tvoc-pollution-and-the-carcinogenic-and-noncarcinogenic-risks-to-workers-in-an-industrial-plant-in-southeastern-romania
#4
JOURNAL ARTICLE
Sebastian-Barbu Barbeş, Alina Bărbulescu, Lucica Barbeș
The article aims to analyze the pollution with Volatile Organic Compounds (VOC) emitted from the biggest refinery in Romania, using the daily and monthly series registered for two years in two sites on the industrial platform, and the carcinogenic and noncarcinogenic risks for workers at the industrial plant. Since the values of the basic statistics (minimum, maximum, and average) and outliers indicate that most recorded values exceed the maximum admissible limits established by law, the Peaks Over Threshold (POT) method was utilized to model the maximum values of the series and determine the return levels for benzene and total VOC (TVOC)...
February 28, 2024: Toxics
https://read.qxmd.com/read/38535552/human-papillomavirus-hpv-infection-and-risk-behavior-in-vaccinated-and-non-vaccinated-paraguayan-young-women
#5
JOURNAL ARTICLE
María Liz Bobadilla, Verónica Villagra, Héctor Castro, Marta von Horoch, Soraya Araya, Gerardo Deluca, Vanessa Salete de Paula
Cervical cancer is a global health concern and ranks fourth among the most prevalent cancers in women worldwide. Human papillomavirus (HPV) infection is a known precursor of cervical cancer and preventive measures include prophylactic vaccines. This study focused on sexually active Paraguayan women aged 18-25 years, exploring the intersection of HPV vaccination and sexual behavior. Among 254 participants, 40.9% received the Gardasil-4 vaccine, with no significant differences in sexual behavior between the vaccinated and unvaccinated sexually active groups...
February 27, 2024: Pathogens
https://read.qxmd.com/read/38535332/association-between-protein-intake-and-diabetes-complications-risk-following-incident-type-2-diabetes-the-epic-potsdam-study
#6
JOURNAL ARTICLE
Elif Inan-Eroglu, Olga Kuxhaus, Franziska Jannasch, Daniela V Nickel, Matthias B Schulze
Our knowledge about the connection between protein intake and diabetes-related complications comes largely from studies among those already diagnosed with type 2 diabetes (T2D). However, there is a lack of information on whether changing protein intake after diabetes diagnosis affects complications risk. We aimed to explore the association between protein intake (total, animal, and plant) and vascular complications in incident T2D patients considering pre-diagnosis intake and changes in intake after diagnosis...
March 19, 2024: Metabolites
https://read.qxmd.com/read/38535080/differences-in-histological-subtypes-of-invasive-lobular-breast-carcinoma-according-to-immunohistochemical-molecular-classification
#7
JOURNAL ARTICLE
Ivan Ilić, Jana Cvetković, Ratko Ilić, Ljubiša Cvetković, Aleksandar Milićević, Stefan Todorović, Pavle Ranđelović
UNLABELLED: The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. BACKGROUND AND OBJECTIVES: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534958/utilization-and-impact-of-a-radiation-nursing-clinic-to-address-acute-care-needs-for-patients-with-gynecologic-cancers
#8
JOURNAL ARTICLE
Aaron Dou, Genevieve Bouchard-Fortier, Kathy Han, Michael Milosevic, Jelena Lukovic, Stephanie L'heureux, Xuan Li, Mary C Doherty, Jennifer Croke
BACKGROUND: The risk factors for acute care utilization in gynecologic oncology patients are poorly understood. This study aimed to evaluate risk factors for the utilization of our centre's acute care radiation nursing clinic (RNC) by gynecologic oncology patients receiving radiotherapy (RT). METHODS: This was a retrospective cohort study of gynecological cancer patients treated with RT at an academic cancer centre between 1 August 2021 and 31 January 2022. Data on socio-demographics, clinical and treatment characteristics, and RNC visits were collected and summarized by descriptive statistics...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534952/real-world-evidence-of-the-impact-of-the-covid-19-pandemic-on-lung-cancer-survival-canadian-perspective
#9
JOURNAL ARTICLE
Jason Agulnik, Goulnar Kasymjanova, Carmela Pepe, Jennifer Friedmann, David Small, Lama Sakr, Hangjun Wang, Alan Spatz, Khalil Sultanem, Victor Cohen
Background: The effect of COVID-19 on treatment outcomes in the literature remains limited and is mostly reported either as predictive survival using prioritization and modeling techniques. We aimed to quantify the effect of COVID-19 on lung cancer survival using real-world data collected at the Jewish General Hospital, Montreal. Methods: This is a retrospective chart review study of patients diagnosed between March 2019 and March 2022. We compared three cohorts: pre-COVID-19, and 1st and 2nd year of the pandemic...
March 19, 2024: Current Oncology
https://read.qxmd.com/read/38534772/5-aza-upregulates-socs3-and-ptpn6-shp1-inhibiting-stat3-and-potentiating-the-effects-of-ag490-against-primary-effusion-lymphoma-cells
#10
JOURNAL ARTICLE
Michele Di Crosta, Andrea Arena, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone
Epigenetic modifications, including aberrant DNA methylation occurring at the promoters of oncogenes and oncosuppressor genes and histone modifications, can contribute to carcinogenesis. Aberrant methylation mediated by histone methylatransferases, alongside histones, can affect methylation of proteins involved in the regulation of pro-survival pathways such as JAK/STAT and contribute to their activation. In this study, we used DNA or histone demethylating agents, 5-Azacytidine (5-AZA) or DS-3201 (valemetostat), respectively, to treat primary effusion lymphoma (PEL) cells, alone or in combination with AG490, a Signal transducer and activator of transcription 3 (STAT3) inhibitor...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534756/inflammation-factors-and-genistein-supplementation-in-cancer-preliminary-research
#11
JOURNAL ARTICLE
Karolina Banyś, Małgorzata Jelińska, Małgorzata Wrzosek, Dorota Skrajnowska, Robert Wrzesień, Wojciech Bielecki, Barbara Bobrowska-Korczak
The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro forms on the intensity of the DMBA-induced tumor process in rats and to understand the mechanisms of this action. The effect of genistein supplementation on the content of selected eicosanoids (HETEs, HODE, and HEPE) in the serum of rats was evaluated. The levels and expression of genes encoding various pro-inflammatory cytokines (IL-1, IL-6) and MMP-9 in the blood of rats were also investigated. The biological material for the study was blood obtained from female rats of the Sprague Dawley strain (n = 32)...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534494/feature-extraction-based-on-local-histogram-with-unequal-bins-and-a-recurrent-neural-network-for-the-diagnosis-of-kidney-diseases-from-ct-images
#12
JOURNAL ARTICLE
Abdorreza Alavi Gharahbagh, Vahid Hajihashemi, José J M Machado, João Manuel R S Tavares
Kidney disease remains one of the most common ailments worldwide, with cancer being one of its most common forms. Early diagnosis can significantly increase the good prognosis for the patient. The development of an artificial intelligence-based system to assist in kidney cancer diagnosis is crucial because kidney illness is a global health concern, and there are limited nephrologists qualified to evaluate kidney cancer. Diagnosing and categorising different forms of renal failure presents the biggest treatment hurdle for kidney cancer...
February 25, 2024: Bioengineering
https://read.qxmd.com/read/38534460/-ptch1-gene-variants-mrna-expression-and-bioinformatics-insights-in-mexican-cutaneous-squamous-cell-carcinoma-patients
#13
JOURNAL ARTICLE
Marianela Zambrano-Román, Jorge R Padilla-Gutiérrez, Yeminia Valle, José Francisco Muñoz-Valle, Elizabeth Guevara-Gutiérrez, Patricia Aidé López-Olmos, Laura Cristina Sepúlveda-Loza, Luis Alberto Bautista-Herrera, Emmanuel Valdés-Alvarado
BACKGROUND: Skin cancer is one of the most frequent types of cancer, and cutaneous squamous cell carcinoma (cSCC) constitutes 20% of non-melanoma skin cancer (NMSC) cases. PTCH1 , a tumor suppressor gene involved in the Sonic hedgehog signaling pathway, plays a crucial role in neoplastic processes. METHODS: An analytical cross-sectional study, encompassing 211 cSCC patients and 290 individuals in a control group (CG), was performed. A subgroup of samples was considered for the relative expression analysis, and the results were obtained using quantitative real-time PCR (qPCR) with TaqMan® probes...
March 16, 2024: Biology
https://read.qxmd.com/read/38534348/implementing-whole-genome-sequencing-wgs-in-clinical-practice-advantages-challenges-and-future-perspectives
#14
REVIEW
Petar Brlek, Luka Bulić, Matea Bračić, Petar Projić, Vedrana Škaro, Nidhi Shah, Parth Shah, Dragan Primorac
The integration of whole genome sequencing (WGS) into all aspects of modern medicine represents the next step in the evolution of healthcare. Using this technology, scientists and physicians can observe the entire human genome comprehensively, generating a plethora of new sequencing data. Modern computational analysis entails advanced algorithms for variant detection, as well as complex models for classification. Data science and machine learning play a crucial role in the processing and interpretation of results, using enormous databases and statistics to discover new and support current genotype-phenotype correlations...
March 13, 2024: Cells
https://read.qxmd.com/read/38534000/microwave-coagulation-for-liver-metastases
#15
REVIEW
Dawid Storman, Mateusz J Swierz, Jerzy W Mitus, Michal Pedziwiatr, Ning Liang, Robert Wolff, Malgorzata M Bala
BACKGROUND: Liver metastases (i.e. secondary hepatic malignancies) are significantly more common than primary liver cancer. Long-term survival after radical surgical treatment is approximately 50%. For people in whom resection for cure is not feasible, other treatments must be considered. One treatment option is microwave coagulation utilising electromagnetic waves. It involves placing an electrode into a lesion under ultrasound or computed tomography guidance. OBJECTIVES: To evaluate the beneficial and harmful effects of microwave coagulation versus no intervention, other ablation methods, or systemic treatments in people with liver metastases regardless of the location of the primary tumour...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533530/are-measures-and-related-symptoms-of-cachexia-recorded-as-outcomes-in-gastrointestinal-cancer-chemotherapy-clinical-trials
#16
JOURNAL ARTICLE
Ross Valaire, Frances Garden, Valentina Razmovski-Naumovski
BACKGROUND: Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes and chemotherapy compliance. We examined to what extent registered gastrointestinal cancer chemotherapy clinical trials record measures and related symptoms of cachexia as outcomes, and whether these were associated with trial characteristics. METHODS: Four public trial registries (2012-2022) were accessed for Phase II and/or III randomized controlled pancreatic, gastric, and colorectal cancer chemotherapy trial protocols...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533523/factors-influencing-breast-cancer-awareness-in-rural-southwest-china-a-cross-sectional-study
#17
JOURNAL ARTICLE
Lingling Zhu, Qiang Zhou, Ziyue Huang, Yuan Yang, Ying Yang, Yao Du, Yuqian Zhao, Xiaoping Yu, Tingyuan Li, Wen Chen
BACKGROUND: This study aimed to explore the current knowledge level of breast cancer among rural women in Southwest China and analyze the influencing factors of breast cancer cognition. METHODS: From May to November 2022, 1468 rural women were invited to participate in this study. Demographic information and the Chinese version of the Breast Cancer Awareness Measure (C-BCAM) were collected through one-on-one investigations. The data were analyzed using descriptive statistics, chi-square tests, and multiple regression analysis in SPSS 26...
2024: International Journal of Women's Health
https://read.qxmd.com/read/38533372/evaluation-of-the-association-between-glutathione-s-transferase-polymorphisms-and-susceptibility-to-cutaneous-melanoma-a-systematic-review-and-meta-analysis
#18
REVIEW
Qi Wang, Zhen Cai, Yang Sheng, Zhiyuan Jiang, Wei Cui, Zaihong Chen, Xiaobo You
INTRODUCTION: Glutathione S-transferase (GST) enzymes play a crucial role in detoxification by catalysing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Polymorphisms in GST genes may influence the susceptibility to various cancers, including melanoma. AIM: We reported a systematic review and meta-analysis to evaluate the association between GST polymorphisms and susceptibility to cutaneous melanoma. MATERIAL AND METHODS: A comprehensive search of four databases, namely PubMed, Scopus, Cochrane Library, and Web of Science, was conducted to gather pertinent studies up until 24 August 2023...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38532840/detecting-mri-invisible-prostate-cancers-using-a-weakly-supervised-deep-learning-model
#19
JOURNAL ARTICLE
Yao Zheng, Jingliang Zhang, Dong Huang, Xiaoshuo Hao, Weijun Qin, Yang Liu
BACKGROUND: MRI is an important tool for accurate detection and targeted biopsy of prostate lesions. However, the imaging appearances of some prostate cancers are similar to those of the surrounding normal tissue on MRI, which are referred to as MRI-invisible prostate cancers (MIPCas). The detection of MIPCas remains challenging and requires extensive systematic biopsy for identification. In this study, we developed a weakly supervised UNet (WSUNet) to detect MIPCas. METHODS: The study included 777 patients (training set: 600; testing set: 177), all of them underwent comprehensive prostate biopsies using an MRI-ultrasound fusion system...
2024: International Journal of Biomedical Imaging
https://read.qxmd.com/read/38532588/-propensity-score-matching-analysis-of-the-short-term-efficacy-of-kamikawa-versus-double-tract-reconstruction-in-laparoscopic-proximal-gastric-cancer-surgery
#20
JOURNAL ARTICLE
H C Yang, J X He, Y Yang, Z Han, B Zhang, S Zhou, T Wu, Q Qiao, X L He, N Wang
Objective: To compare the short-term efficacy of Kamikawa anastomosis and double-tract reconstruction (DTR) after proximal gastrectomy. Methods: This was a propensity score matched, retrospective, cohort study. Inclusion criteria comprised age 20-70 years, diagnosis of gastric cancer by pathological examination of preoperative endoscopic biopsies, tumor diameter ≤4 cm, and location in the upper 1/3 of the stomach (including the gastroesophageal junction), and TNM stage IA, IB, or IIA. The study cohort comprised 73 patients who had undergone laparoscopic proximal gastric cancer radical surgery in the Department of Gastroenterology, Tangdu Hospital, Air Force Medical University between June 2020 and February 2023, 19 of whom were in the Kamikawa group and 54 in the DTR group...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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