keyword
https://read.qxmd.com/read/38543231/functional-chitosan-and-its-derivative-related-drug-delivery-systems-for-nano-therapy-recent-advances
#21
REVIEW
Zixu Wang, Fangying Yu, Fuqiang Hu
In the struggle against diseases, the development of nano-therapy has certainly been a tremendous progression owing to the various superiority, and chitosan is no doubt a kind of prominent biopolymer material with versatility for applications in disease treatments. For the rational construction of chitosan-related nano-biodevices, it is necessary to pay full attention to the material itself, where it is the material properties that guide the design criteria. Additionally, the well-matched preparation methods between material carriers and therapeutic agents draw much attention to the final construction since they seem to be more realistic...
February 28, 2024: Pharmaceutics
https://read.qxmd.com/read/38543161/small-angle-x-ray-scattering-saxs-used-for-the-identification-of-nicomorphine-polymorphic-changes-at-the-early-stage-to-avoid-varied-stability-and-possible-side-effects
#22
JOURNAL ARTICLE
Nermina Malanovic, Giovanni Birarda, Simone Eder, Heidrun Gruber-Woelfler, Franz Reiter, Krunoslav Juraic, Aden Hodzic
In this paper, we present the identification of polymorphisms at an early stage, identified by applying non-standard methods such as SAXS. We provide an analytical approach to polymorphism in the quality/purity of an active pharmaceutical ingredient (API), supplied to a generic company by two different suppliers (i.e., manufacturers). Changes in thermodynamic polymorphism firstly become visible in traces in the larger crystal lattices, which are visible on the SAXS spectrum only using the logarithmic scale, as shown in the result figures...
March 15, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543005/facile-solid-state-chemical-synthesis-of-comoo-4-nanorods-for-high-performance-supercapacitors
#23
JOURNAL ARTICLE
Rui Yu, Xiaoyan Lu, Zhenjiang Lu, Yali Cao
The development of electrode materials with excellent performance serves as the key for researchers to enhance the energy density of supercapacitors. Cobalt molybdate (CoMoO4 ) nanomaterials have been regarded as one of the most prospective electrode materials for supercapacitors due to their high theoretical capacitance and excellent electrical conductivity. In this paper, three kinds of CoMoO4 nanorods were prepared directly via simple and environmentally friendly solid-phase chemical reactions with solid inorganic salts as raw materials...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542990/evaluation-on-the-potential-for-hepatotoxic-components-from-herba-epimedii-to-induce-apoptosis-in-hepg2-cells-and-the-analysis-of-the-influence-of-metabolism-in-liver-microsomes
#24
JOURNAL ARTICLE
Lin Zhang, Cai Zhang, Xiyi Peng, Zhaojuan Guo, Song Yang, Dongjun Fu
The potential hepatotoxicity of Herba Epimedii is a focal point in traditional Chinese medicine security applications. As determined in our previous study, the flavonoid constituents of Herba Epimedii, sagittatoside A, icariside I, baohuoside I and icaritin, are related to the hepatotoxicity of this herb. However, the hepatotoxic mechanism of these components needs to be clarified further, and whether these components can maintain their injury action following liver metabolism needs to be confirmed. Herein, the effects of sagittatoside A, icariside I, baohuoside I and icaritin on the apoptosis of HepG2 cells and the expression of key proteins, including Bax, Bcl-2, Caspase-3 and Caspase-9, were evaluated...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542983/study-of-the-structure-and-bioactivity-of-polysaccharides-from-different-parts-of-stemona-tuberosa-lour
#25
JOURNAL ARTICLE
Xiang Qiu, Yanghui Ou, Shengjia Lu, Yibin Liang, Yali Zhang, Mengjie Li, Gang Li, Hongwei Ma, Yanting Wu, Zhaoyu He, Zhensheng Zhang, Hongliang Yao, Wen-Hua Chen
The polysaccharides from Stemona tuberosa Lour, a kind of plant used in Chinese herbal medicine, have various pharmacological activities, such as anti-inflammatory and antioxidant properties. However, the effects of the extraction methods and the activity of polysaccharides from different parts are still unknown. Therefore, this study aimed to evaluate the effects of different extraction methods on the yields, chemical compositions, and bioactivity of polysaccharides extracted from different parts of Stemona tuberosa Lour...
March 18, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542676/prevalence-of-food-insecurity-and-associations-with-academic-performance-food-consumption-and-social-support-among-university-students-during-the-covid-19-pandemic-finescop-project-in-iceland
#26
JOURNAL ARTICLE
Brittany M Repella, James G Rice, Marta Arroyo-Izaga, Liv E Torheim, Bryndis E Birgisdottir, Greta Jakobsdottir
(1) Background: Food insecurity (FI) among university students has received less attention in Europe than in other regions before and during the COVID-19 pandemic. (2) Methods: A cross-sectional study was conducted between January and March 2022 using an online questionnaire ( n = 924). The questionnaire addressed food security status; demographic, socioeconomic, and educational variables; academic performance; food consumption; and social support networks. The validated Food Insecurity Experience Scale was used to measure food security...
March 7, 2024: Nutrients
https://read.qxmd.com/read/38542629/a-novel-3d-printed-and-miniaturized-periodic-counter-current-chromatography-system-for-continuous-purification-of-monoclonal-antibodies
#27
JOURNAL ARTICLE
Carlotta Kortmann, Taieb Habib, Christopher Heuer, Dörte Solle, Janina Bahnemann
Continuous chromatography has emerged as one of the most attractive methods for protein purification. Establishing such systems involves installing several chromatographic units in series to enable continuous separation processes and reduce the cost of the production of expensive proteins and biopharmaceuticals (such as monoclonal antibodies). However, most of the established systems are bulky and plagued by high dead volume, which requires further optimization for improved separation procedures. In this article, we present a miniaturized periodic counter-current chromatography (PCCC) system, which is characterized by substantially reduced dead volume when compared to traditional chromatography setups...
March 13, 2024: Micromachines
https://read.qxmd.com/read/38542587/design-of-2-45-ghz-high-efficiency-rectifying-circuit-for-wireless-rf-energy-collection-system
#28
JOURNAL ARTICLE
Yanhu Huang, Jiajun Liang, Zhao Wu, Qian Chen
A 2.45 GHz high-efficiency rectifying circuit for a wireless radiofrequency (RF) energy collection system is proposed. The RF energy collection system is composed of a transmitting antenna, a receiving antenna, a rectifying circuit and a load. The designed receiving antenna is a kind of dual-polarised cross-dipole antenna; its bandwidth is 2.3-2.5 GHz and gain is 7.97 dBi. The proposed rectifying circuit adopts the technology of an output matching network, which can suppress the high-harmonic components. When the input power at 2...
February 29, 2024: Micromachines
https://read.qxmd.com/read/38542222/impact-of-tnf-and-il-33-cytokines-on-mast-cells-in-neuroinflammation
#29
REVIEW
Pio Conti, Gianpaolo Ronconi, Dorina Lauritano, Filiberto Mastrangelo, Alessandro Caraffa, Carla E Gallenga, Ilias Frydas, Spyridon K Kritas, Francesco Carinci, Federico Gaudelli, Ciro Annicchiarico, Cristian D'Ovidio
Mast cells (MCs) are derived from hematopoietic progenitors, mature in vascularized tissues, and participate in innate and acquired immunity. Neuroinflammation is a highly debated topic in the biomedical literature; however, the impact of tumor necrosis factor (TNF) and IL-33 on MCs in the brain has not been widely addressed. MCs can be activated by IgE binding to FcεRI, as well as by different antigens. After activation, MCs mediate various immunological and inflammatory responses through TNF and IL-33...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542075/assessment-of-common-factors-associated-with-droplet-digital-pcr-ddpcr-quantification-of-paratrichodorus-allius-in-soil
#30
JOURNAL ARTICLE
Bisho Ram Lawaju, Guiping Yan
This research investigated the factors associated with the quantitative detection of Paratrichodorus allius in soil using droplet digital PCR (ddPCR). Small-sized nematodes exhibited significantly lower DNA quantities compared to their medium and large counterparts. Soil pre-treatments (room temperature drying and 37 °C oven-drying) demonstrated no substantial impact on ddPCR detection, and soil storage (0-3 months at 4 °C) exhibited negligible alterations in DNA quantities. A commercial DNA purification kit improved the resulting quality of ddPCR, albeit at the cost of a notable reduction in DNA quantity...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541835/right-ventricular-dysfunction-before-and-after-cardiac-surgery-prognostic-implications
#31
REVIEW
Anna Merlo, Camilla Cirelli, Enrico Vizzardi, Laura Fiorendi, Federica Roncali, Marco Marino, Maurizio Merlo, Michele Senni, Edoardo Sciatti
Right ventricular dysfunction is a prognostic factor for morbidity and mortality across a broad spectrum of cardiovascular diseases. While the role of the right ventricle in surgical patients has emerged, the prognostic impact of right ventricular dysfunction remains unclear in a large cardiac surgery population. We reviewed the existing literature about the role of right ventricular dysfunction in adults undergoing different kinds of cardiac surgery either present before or developed after surgery itself. Pre- and post-operative right ventricular dysfunction has demonstrated substantial prognostic implications...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541689/back-to-the-future-of-metabolism-advances-in-the-discovery-and-characterization-of-unknown-biocatalytic-functions-and-pathways
#32
REVIEW
Roland Wohlgemuth
The architecture, organization, and functioning of biocatalytic reaction networks, which are coded in the cell-specific genome and which work together in the small space of biological cells, are a fascinating feature of life evolved over more than 3 billion years. Knowledge about the diversity of biocatalytic functions and metabolic pathways sustaining life on our planet is highly important, especially as the currently occurring loss of biodiversity is considered a planetary boundary that is at high risk, and knowledge about the life of current biological organisms should be gained before they become extinct...
March 10, 2024: Life
https://read.qxmd.com/read/38541602/methylated-biochemical-fulvic-acid-derived-hydrogels-with-improved-swelling-behavior-and-water-retention-capacity
#33
JOURNAL ARTICLE
Chunhui Shi, Xifeng Lv, Jingfan Peng, Jikui Zhu, Fengqin Tang, Libing Hu
Although humic acids (HAs) have been used to prepare absorbent hydrogels, their applications in many areas, such as agriculture, wastewater treatment and hygienic products, are not satisfactory due to their low solubility in organic solvents. In this work, biochemical fulvic acid (BFA), as a kind of HA, was initially methylated for preparation of the methylated BFA (M-BFA), which contributed to enhancing the solubility in organic solvents. Then, M-BFA reacted with N,N'-methylene diacrylamide (MBA) in the N,N-Dimethylacrylamide (DMAA) solution, and the expected hydrogel (M-BFA/DMAA) was successfully obtained...
March 21, 2024: Materials
https://read.qxmd.com/read/38541597/vaporization-phase-transition-in-cryogenic-liquid-oxygen-sealing-film-on-spiral-groove-faces
#34
JOURNAL ARTICLE
Junjie Chen, Chunhong Ma, Shaoxian Bai, Jing Yang
The property of vaporization phase transition in liquid oxygen face seals is a key factor affecting the stability of mechanical face seals in many fields, especially under cryogenic conditions. Here, a numerical model based on the saturated vapor pressure is established to investigate the vaporization phase transition property of liquid oxygen sealing film. The novelty of this model is to take the influence of heat transfer and face distortions into consideration at the same time. The pressure and temperature distributions as well as face distortions are calculated, and then the property of vaporization phase transition and sealing performance are analyzed...
March 21, 2024: Materials
https://read.qxmd.com/read/38541485/effect-of-al-ni-ratio-on-the-microstructure-and-properties-of-nickel-aluminum-bronze-alloys
#35
JOURNAL ARTICLE
Yinxun Tan, Haofeng Xie, Xue Feng, Shuhui Huang, Wenjing Zhang, Lijun Peng, Wanyu Wang, Yizhi Zhao
To study the effect of aluminum and nickel elements on the microstructures and properties of the nickel-aluminum bronze (NAB) alloy, four kinds of alloys with different compositions, ZCuAl7-7-4-2, ZCuAl8-6-4-2, ZCuAl9-5-4-2, and ZCuAl10-4-4-2, are prepared by vacuum-melting technology. The effects of different Al/Ni ratios on the microstructures of NAB are investigated using a metalloscope, scanning electron microscopy, transmission electron microscopy, and XPS analysis. The mechanical property is evaluated with microhardness testing and tensile mechanical testing...
March 14, 2024: Materials
https://read.qxmd.com/read/38541479/microstructure-and-properties-of-ticp-fe-hierarchical-composites-prepared-by-a-new-pressure-infiltration-method
#36
JOURNAL ARTICLE
Shengnian Zhao, Dehong Lu, Fengbin Wang, Jiaxing Zhong, Yehua Jiang
TiCp/steel composites are conventionally produced via powder metallurgy. In this paper, a liquid pressure infiltration method was developed to prepare a kind of spherical hierarchical architectured composite, in which spherical TiCp-rich hard phase regions were uniformly dispersed in TiCp-free soft phase region. The microstructure and mechanical properties of the architectured composites were carefully studied and compared with the common composite, as well as the effect of TiCp fraction on the properties. The results show that architecturual design can effectively improve both the toughness and strength of the composites...
March 13, 2024: Materials
https://read.qxmd.com/read/38541388/characteristics-of-2d-ultrasonic-vibration-incremental-forming-of-a-1060-aluminum-alloy-sheet
#37
JOURNAL ARTICLE
Yuan Lv, Yifan Wang, Yan Wang, Xixiang Pan, Cong Yi, Meng'en Dong
Currently, 1060 aluminum alloy is widely applied in the electronics industry, construction, the aerospace field, traffic engineering, decorations, and the consumer goods market for its good chemical, physical, and mechanical properties. In general, excellent processing property is necessary and important for the manufacturing of complicated panels. In this paper, a special 2D ultrasonic vibration incremental forming method is designed to improve its plasticity and mechanical properties. Three kind of processing methods, including traditional single-point incremental forming, longitudinal ultrasonic vibration incremental forming, and 2D ultrasonic vibration incremental forming, are used for the flexible manufacturing of cones and cylindrical cups of 1060 aluminum alloy sheet...
March 7, 2024: Materials
https://read.qxmd.com/read/38541375/a-bi-objective-home-health-care-routing-and-scheduling-problem-under-uncertainty
#38
JOURNAL ARTICLE
Jiao Zhao, Tao Wang, Thibaud Monteiro
Home health care companies provide health care services to patients in their homes. Due to increasing demand, the provision of home health care services requires effective management of operational costs while satisfying both patients and caregivers. In practice, uncertain service times might lead to considerable delays that adversely affect service quality. To this end, this paper proposes a new bi-objective optimization problem to model the routing and scheduling problems under uncertainty in home health care, considering the qualification and workload of caregivers...
March 21, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541218/associations-between-atopic-dermatitis-and-behavior-difficulties-in-children
#39
JOURNAL ARTICLE
Inga Kisieliene, Beatrice Aukstuolyte, Antanas Mainelis, Odilija Rudzevicienė, Matilda Bylaite-Bucinskiene, Andreas Wolenberg
Background and Objectives : There has been increasing evidence that atopic dermatitis (AD) is associated with behavioral difficulties (BDs). There is currently a lack of evidence of how the severity of the disease determines BDs and what additional factors may contribute to their manifestation. The aim is to determine what kind of BDs occur in children with AD compared to healthy children and to find out what additional factors may contribute to the development of BDs in AD patients. Materials and Methods: This is a cross-sectional, prospective study with the application of a risk assessment instrument for behavior difficulties (Child Behavior Checklist, CBCL 6/18) in pediatric patients with AD and healthy controls (6-17 years) between 1 January 2020 and 31 December 2022...
March 17, 2024: Medicina
https://read.qxmd.com/read/38540961/a-method-of-reducing-salt-content-in-fermented-soy-sauce-improves-its-flavor-and-quality
#40
JOURNAL ARTICLE
Shuang Zheng, Zhenbin Zhang, Xiuli Zhao, Wanning Li, Lihua Hou
Most commercially available soy sauce is fermented by high-salt liquid-state (HS) fermentation, which has an excessive salt content and a long fermentation period. In this study, a new salt-reduced fermentation (SR) soy sauce technology involving multiple strains of bacteria was developed to reduce consumers' salt intake. The SR soy sauce was found to have an amino acid nitrogen content of 8.40 g/L and over 80 kinds of flavor substances, which were significantly higher than those of low-salt solid-state fermented soy sauce and approximately equal to HS soy sauce...
March 21, 2024: Foods (Basel, Switzerland)
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