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Yanzheng Gao, Chao Lu, Di Shen, Juan Liu, Zhao Ma, Bing Yang, Wanting Ling, Michael Gatheru Waigi
Since its discovery in Escherichia coli, the emergence and rapid spread of the plasmid-mediated colistin resistance gene mcr-1 have become a public health concern. Livestock manure is a potentially important reservoir of mcr-1 because colistin has been widely used in livestock production. Efforts made to accurately quantify the prevalence of mcr-1 in livestock manure and the dynamic changes therein during thermophilic composting have been few and far between. In this study, mcr-1 in 51 collected samples from four kinds of livestock manures was detected and quantified...
February 15, 2019: Environment International
Min Nian, Qing-Qing Li, Michael Bloom, Zhengmin Min Qian, Kevin M Syberg, Michael G Vaughn, Si-Quan Wang, Qi Wei, Mohammed Zeeshan, Namratha Gurram, Chu Chu, Jia Wang, Yan-Peng Tian, Li-Wen Hu, Kang-Kang Liu, Bo-Yi Yang, Ru-Qing Liu, Dan Feng, Xiao-Wen Zeng, Guang-Hui Dong
Exposure to chemicals may affect liver enzyme to increase the risk of liver diseases. Perfluoroalkyl acids (PFAAs) are one kind of persistent organic pollutants with hepatotoxic effect in organism. However, data is scarce to characterize the hepatotoxic effects of specific structural PFAA isomers in general population. To address this data gap, we evaluated the association between serum PFAAs concentration and liver function biomarkers in the Isomers of C8 Health Project in China. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to measure 18 serum PFAAs, except for linear and branched isomers of PFOA/PFOS, nine perfluorinated carboxylic acids (PFCAs) and two perfluorinated sulfonic acids (PFSAs) were also included, in 1605 adult residents of Shenyang, China...
February 11, 2019: Environmental Research
Rui Jiang, Peng Hao, Guisheng Yu, Chuanan Liu, Chuandong Yu, Yan Huang, Yongkun Wang
Kaempferol is a kind of bioflavonoid exerts diverse pharmacological activities, including anti-apoptotic and anti-inflammatory activities. Kaempferol has been recognized as an effective agent for alleviating the clinical symptoms of osteoarthritis (OA). This study aimed to provide evidence that Kaempferol has potential in the management of OA. Lipopolysaccharide (LPS) stimulation induced a significant cell death and inflammatory injury in ATDC5 cells, as evidenced by the decreased cell viability, the induced apoptosis, the activated caspase-3, and the excessive production of IL-6, IL-8 and TNF-α...
February 15, 2019: International Immunopharmacology
Mansooreh Heravi, Leila Dargahi, Soha Parsafar, Amir Tayaranian Marvian, Farhang Aliakbari, Dina Morshedi
BACKGROUND: Alpha-synuclein (αSN) is an abundant presynaptic brain protein that its aggregated species believed to play pivotal roles in the development of neurodegenerative diseases, especially Parkinson's disease (PD). In this study, we compared the response of primary neuronal cells with a well-known cell line model, PC12, against the toxic aggregates of αSN. METHODS: Primary hippocampal neurons (PHNs) were isolated from 17 to 18 days old rat embryos. Fibrillization was induced in recombinant αSN and monitored by standard methods...
February 15, 2019: Neuroscience Letters
Sabrina Sarrocco, Fabio Valenti, Sara Manfredini, Pilar Esteban, Rodolfo Bernardi, Grazia Puntoni, Riccardo Baroncelli, Miriam Haidukowski, Antonio Moretti, Giovanni Vannacci
Trichoderma gamsii T6085 was used in combination with a Fusarium oxysporum isolate (7121) in order to evaluate, in a multitrophic approach, their competitive ability against F. graminearum, one of the main causal agents of Fusarium head blight (FHB) on wheat. The two antagonists and the pathogen were coinoculated on two different natural substrates, wheat and rice kernels. Both T6085 and 7121, alone and coinoculated, significantly reduced the substrate colonization and mycotoxin production by the pathogen. The two antagonists did not affect each other...
February 18, 2019: Phytopathology
Yanjing Yang, Xingxing Ge, Lihua Guo, Teng Zhu, Zhenzhen Tian, Hairong Zhang, Qing Du, Hongwei Peng, Wenli Ma, Zhe Liu
Previous studies on the neutral and cationic half-sandwich iridium(iii) and ruthenium(ii) complexes showed that the charge and the substitution pattern of the bidentate ligands, as well as the nature of the accompanying counteranion have a significant effect on their biological activities. In this contribution, a series of zwitterionic and cationic half-sandwich iridium(iii) and ruthenium(ii) complexes containing sulfonate groups have been prepared and characterized. The different locations of counteranions between these two kinds of complexes exert great influence on the cytotoxic activity towards cancer cells...
February 18, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Yerai Doval, Carlos Gómez-Rodríguez
Word segmentation is the task of inserting or deleting word boundary characters in order to separate character sequences that correspond to words in some language. In this article we propose an approach based on a beam search algorithm and a language model working at the byte/character level, the latter component implemented either as an n-gram model or a recurrent neural network. The resulting system analyzes the text input with no word boundaries one token at a time, which can be a character or a byte, and uses the information gathered by the language model to determine if a boundary must be placed in the current position or not...
February 2019: Journal of the Association for Information Science and Technology
Hui Liu, Caiqin Wang, Peixi Wang, Nan Liu, Qingfeng Du
Extremely stable and biocompatible 3D magnetically responsive photonic crystals (MRPCs) are successfully prepared in aqueous solution. Classic hydrothermal synthesis was applied for preparation of the Fe3 O4 @C core. Modified Stöber method was then employed for synthesis of the different size of Fe3 O4 @C@SiO2 . Unlike the traditional magnetic nanoparticles, the highly negative charged superparamagnetic nanospheres (SMNs), i.e., the double-shell structure Fe3 O4 @C@SiO2 are capable of rapidly self-assembling into 3D MRPCs with full visible and various colors that can be periodically and reversibly tuned under different kinds of external magnetic fields (EMFs) within 1 s...
2019: Frontiers in Chemistry
Chan Nie, Tao Wang, Huiting Yu, Xue Wang, Xueqin Zeng, Zairong Wei, Xiuquan Shi
Objective: Burn and traumatic injury are two kinds of injury by modality. They cause acute phase response and lead to a series of pathological and physiological changes. In this study, we explored whether there are differences in routine blood parameters and liver enzyme levels between burned and traumatically injured children. Methods: Patients under 18 years old with injuries were recruited. Their demographic and clinical data were recorded. Collected clinical data included routine blood parameters (white blood cell count (WBC), red blood cell count (RBC), platelets (PLT), hemoglobin (HB)), serological enzyme levels (alanine aminotransferase (ALT), aspartate transaminase (AST), glutamyltransferase (GGT), alkaline phosphatase (ALP), cholinesterase (CHE)), and total protein (TP) levels (albumin (ALB), globulin (GLB))...
2019: PeerJ
Gianluca Cassese, Alfonso Amendola, Francesco Maione, Mariano Cesare Giglio, Gianluca Pagano, Marco Milone, Giovanni Aprea, Gaetano Luglio, Giovanni Domenico De Palma
Prompt diagnosis and correct management of the so called "serrated lesions" (SLs) of the colon-rectum are generally considered of crucial importance in the past years, mainly due to their histological heterogeneity and peculiar clinical and molecular patterns; sometimes, they are missed at conventional endoscopy and are possibly implicated in the genesis of interval cancers. The aim of this review is to focus on the diagnostic challenges of serrated lesions, underlying the role of both conventional endoscopy and novel technologies...
2019: Gastroenterology Research and Practice
Houman Mirzaalian Dastjerdi, Dominique Töpfer, Stefan J Rupitsch, Andreas Maier
Purpose: The treatment of skin lesions of various kinds is a common task in clinical routine. Apart from wound care, the assessment of treatment efficacy plays an important role. In this paper, we present a new approach to measure the skin lesion surface in two and three dimensions. Methods: For the 2D approach, a single photo containing a flexible paper ruler is taken. After semi-automatic segmentation of the lesion, evaluation is based on local scale estimation using the ruler...
2019: International Journal of Biomedical Imaging
Kai Cai, Longfei Zhu, Keke Zhang, Ling Li, Zhongyu Zhao, Wei Zeng, Xinchun Lin
Bamboo are woody grass species containing important economic and ecological values. Lei bamboo ( Phyllostachys violascens ) is a kind of shoot-producing bamboo species with the highest economic yield per unit area. However, identifying different varieties of Lei bamboo based on morphological characteristics is difficult. Microsatellites play an important role in plant identification and genetic diversity analysis and are superior to other molecular markers. In this study, we identified 18,356 expressed sequence tag-simple sequence repeat (EST-SSR) loci in Lei bamboo transcriptome data...
2019: Frontiers in Plant Science
Hitesh Aggarwal, Maria D'souza, Puja Panwar, Neeru Jyotsna, Tauheed Alvi, Yachna Solanki, Tarakant Kumar, Rajnish Sharma
Ewing's sarcoma is a kind of undifferentiated reticulocytic sarcoma, which was first reported in 1921 by James Ewing. It is difficult to differentiate Ewing's sarcoma from osteomyelitis on computed tomography (CT) and X-ray and hence cytological confirmation is needed. Fluorodeoxy glucose being a nonspecific tracer cannot differentiate between malignant and inflammatory lesions. However, it is found that Ewing's sarcoma has increased LAT1 transporter expression at the cell surface. This property has been utilized to specifically target the tumor cells and differentiate them from inflammatory lesions...
January 2019: World Journal of Nuclear Medicine
Aimei Li, Feng Yang, Jiaying Xin, Xuebo Bai
Purpose: Local anesthetics are used clinically for the control of pain following operation (including gastrointestinal surgery) or for the management of other acute and chronic pain. This study aimed to develop a kind of lipid-polymer hybrid nanoparticles (LPNs), which were constructed using poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the hydrophilic lipid shell and poly-ε-caprolactone (PCL) as the hydrophobic polymeric core. Methods: Ropivacaine (RPV) was entrapped in the LPNs (RPV-LPNs) and the physicochemical and biochemical properties such as size, zeta potential, drug release, and cytotoxicity were studied...
2019: International Journal of Nanomedicine
Hui Han, Songtao Guo, Hao Jiang, Xi Wu
Objective: Intracranial aneurysm is a kind of severe intracranial disease mainly responsible for subarachnoid hemorrhage, and the rupture of intracranial aneurysm results in a mortality rate of 30%-40%. For the first time in the world, this study aimed to assess the feasibility and efficacy of enhanced recovery after surgery (ERAS) protocol in Chinese elderly patients with intracranial aneurysm. Methods: In this study, 300 elderly patients with intracranial aneurysm were recruited and divided into two groups as follows: ERAS group (n=150, ERAS protocol) and control group (n=150, conventional management)...
2019: Clinical Interventions in Aging
Karolina Barcauskaitė
Depending on the origin, the compost produced may contain not only nutrients but also pollutants, such as heavy metals and persistent organic pollutants. It is very important to determine them in soil-improving substances, because persistent organic pollutants show environmental toxic, cancerogenic, mutagenic effects and do not decompose for a long time. The aim of this study was to determine seven polychlorinated biphenyls concentrations in different kinds of composts produced in Lithuania and to evaluate the appliance of these composts in agricultural land...
February 17, 2019: Waste Management & Research
Jiska Cohen-Mansfield, Rotem Eisner
OBJECTIVES: We identify and describe the meanings of loneliness among older persons, the kinds of relationships they are seeking in order to alleviate it, and the barriers they face in developing these connections. METHOD: Study participants were 35 older persons between the ages of 66 and 92 years from Tel Aviv, Israel, who participated in an intervention which involved group activities and individual meetings. The transcriptions of the individual meetings in which participants described their loneliness and explored potential solutions formed the data for thematic analysis...
February 17, 2019: Aging & Mental Health
Shuwen Zhao, Ying Tao, Yunxiang Chen, Yijie Zhou, Rong Li, Lingling Xie, Aibin Huang, Ping Jin, Shidong Ji
Vanadium dioxide is one kind of desirable infrared modulators for sensors because of its remarkable temperature-responsive infrared modulation ability via autogeneic metal-insulator transition. However, the detriments of poor chemical stability and narrow scope of extensive-researched application (e.g. smart windows) restrict its mass production. Here, we propose a VO2@MgF2@PDA inorganic-organic hybrid coated architecture for great enhancing the optical durability more than 13 times in contrast to the pristine VO2, meanwhile the transmittance difference between room and high temperature changed within 20% (decreasing from 25% to 20...
February 18, 2019: ACS Applied Materials & Interfaces
Kai-Fan Zhang, Kang-Jie Bian, Chao Li, Jie Sheng, Yan Li, Xi-Sheng Wang
A nickel-catalyzed 1,4-carbofluoroalkylation of 1,3-enynes to access structurally diverse fluoroalkylated allenes has been established. This method has demonstrated high catalytic reactivity, mild conditions, broad substrates scope and excellent functional group tolerance. The key to success is the use of nickel catalyst to generate different kinds of fluoroalkyl radicals from readily available and structurally diverse fluoroalkyl halides to access 1,4-difunctionalization of 1,3-enynes via a radical relay. This strategy provides facile synthesis of structurally diverse multi-substituted allenes, and offers a solution for batch production of various fluorinated bioactive molecules for drug discovery via further transformations...
February 17, 2019: Angewandte Chemie
Helena Dahlberg
Starting from a phenomenological understanding of the body, this article discusses the understanding of body awareness in health and illness. I question the common way to understand our relationship to our bodies in terms of subjective and objective perspectives on it, and furthermore, how this opposition has been used in the phenomenological literature to outline an understanding of health and illness as states where the body stays unnoticed versus resurfaces to our attention as dysfunctional. Using examples from an ongoing interview study, I argue for an understanding of the dialectical interplay between body and world in our awareness, and how it can be understood as an approaching or distancing movement to body and world...
February 17, 2019: Nursing Philosophy: An International Journal for Healthcare Professionals
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