Amy E Flowers, Tania L Gonzalez, Nikhil V Joshi, Laura E Eisman, Ekaterina L Clark, Rae A Buttle, Erica Sauro, Rosemarie DiPentino, Yayu Lin, Di Wu, Yizhou Wang, Chintda Santiskulvong, Jie Tang, Bora Lee, Tianyanxin Sun, Jessica L Chan, Erica T Wang, Caroline Jefferies, Kate Lawrenson, Yazhen Zhu, Yalda Afshar, Hsian-Rong Tseng, John Williams, Margareta D Pisarska
Maternal and fetal pregnancy outcomes related to placental function vary based on fetal sex, which may be due to sexually dimorphic epigenetic regulation of RNA expression. We identified sexually dimorphic miRNA expression throughout gestation in human placentae. Next-generation sequencing identified miRNA expression profiles in first and third trimester uncomplicated pregnancies using tissue obtained at chorionic villous sampling (n = 113) and parturition (n = 47). Sequencing analysis identified 986 expressed mature miRNAs from female and male placentae at first and third trimester (baseMean>10)...
March 19, 2022: Biology of Reproduction