D Ryan King, Mustafa Demirtas, Mikhail Tarasov, Heather L Struckman, Xiaolei Meng, Drew Nassal, Nicolae Moise, Alec Miller, Dennison Min, Andrew M Soltisz, Midhun N K Anne, Patrícia A Alves Dias, Jacy L Wagnon, Seth H Weinberg, Thomas J Hund, Rengasayee Veeraraghavan, Przemysław B Radwański
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is a fatal complication experienced by otherwise healthy epilepsy patients. Dravet syndrome (DS) is an inherited epileptic disorder resulting from loss of function of the voltage-gated sodium channel, NaV 1.1, and is associated with particularly high SUDEP risk. Evidence is mounting that NaV s abundant in the brain also occur in the heart, suggesting that the very molecular mechanisms underlying epilepsy could also precipitate cardiac arrhythmias and sudden death...
February 15, 2024: JACC. Clinical Electrophysiology