keyword
https://read.qxmd.com/read/38018922/-the-dance-between-brucella-and-hematopoietic-stem-cells
#1
JOURNAL ARTICLE
Vilma Arce-Gorvel, Lisiena Hysenaj, Bérengère de Laval, Michael H Sieweke, Sandrine Sarrazin, Jean-Pierre Gorvel
No abstract text is available yet for this article.
November 2023: Médecine Sciences: M/S
https://read.qxmd.com/read/37639127/isolation-ex-vivo-expansion-and-lentiviral-transduction-of-alveolar-macrophages
#2
JOURNAL ARTICLE
Clara Jana-Lui Busch, Sethuraman Subramanian, Javier Linares, Jérémy Favret, Ridzky Anis Advent Yuda, Michael H Sieweke
Alveolar macrophages (AM) are resident macrophages of the lung and play important roles in the maintenance of tissue homeostasis as well as host defense. Here, we describe how they can be harvested from murine lungs, expanded in vitro, and transduced with lentiviral vectors.
2024: Methods in Molecular Biology
https://read.qxmd.com/read/37635627/m-csf-directs-myeloid-and-nk-cell-differentiation-to-protect-from-cmv-after-hematopoietic-cell-transplantation
#3
JOURNAL ARTICLE
Prashanth K Kandalla, Julien Subburayalu, Clément Cocita, Bérengère de Laval, Elena Tomasello, Johanna Iacono, Jessica Nitsche, Maria M Canali, Wilfried Cathou, Gilles Bessou, Noushin Mossadegh-Keller, Caroline Huber, Guy Mouchiroud, Roland P Bourette, Marie-France Grasset, Martin Bornhäuser, Sandrine Sarrazin, Marc Dalod, Michael H Sieweke
Therapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesviridae including cytomegalovirus (CMV). We show in a murine model of HCT that macrophage colony-stimulating factor (M-CSF) promoted rapid antiviral activity and protection from viremia caused by murine CMV. M-CSF given at transplantation stimulated sequential myeloid and natural killer (NK) cell differentiation culminating in increased NK cell numbers, production of granzyme B and interferon-γ...
August 28, 2023: EMBO Molecular Medicine
https://read.qxmd.com/read/37067792/cd150-dependent-hematopoietic-stem-cell-sensing-of-brucella-instructs-myeloid-commitment
#4
JOURNAL ARTICLE
Lisiena Hysenaj, Bérengère de Laval, Vilma Arce-Gorvel, Mile Bosilkovski, Gabriela González-Espinoza, Guilhaume Debroas, Michael H Sieweke, Sandrine Sarrazin, Jean-Pierre Gorvel
So far, hematopoietic stem cells (HSC) are considered the source of mature immune cells, the latter being the only ones capable of mounting an immune response. Recent evidence shows HSC can also directly sense cytokines released upon infection/inflammation and pathogen-associated molecular pattern interaction while keeping a long-term memory of previously encountered signals. Direct sensing of danger signals by HSC induces early myeloid commitment, increases myeloid effector cell numbers, and contributes to an efficient immune response...
July 3, 2023: Journal of Experimental Medicine
https://read.qxmd.com/read/36907380/the-multifaceted-roles-of-macrophages-in-nafld-pathogenesis
#5
REVIEW
Joscha Vonderlin, Triantafyllos Chavakis, Michael Sieweke, Frank Tacke
Non-alcoholic fatty liver disease (NAFLD) is the liver manifestation of the metabolic syndrome. NAFLD constitutes a spectrum of pathologies ranging from simple hepatic steatosis (NAFL) to the more progressive form of steatohepatitis (NASH) and fibrosis, which can culminate in liver cirrhosis and hepatocellular carcinoma. Macrophages play multiple roles in the context of NAFLD pathogenesis by regulating inflammatory responses and metabolic homeostasis in the liver and may thereby represent an attractive therapeutic target...
March 10, 2023: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/36764598/trained-immunity-and-epigenetic-memory-in-long-term-self-renewing-hematopoietic-cells
#6
REVIEW
Alban Johansson, Dawn S Lin, Francois E Mercier, Masayuki Yamashita, Maziar Divangahi, Michael H Sieweke
Immunological memory is a feature typically ascribed to the adaptive arm of the immune system. However, recent studies have demonstrated that hematopoietic stem cells (HSCs) and innate immune cells such as monocytes and macrophages are also capable of gaining epigenetic signatures to enhance their response in the context of reinfection. This suggests the presence of long-term memory, a phenomenon referred to as trained immunity. Trained immunity in HSCs can occur via changes in the epigenetic landscape and enhanced chromatin accessibility in lineage-specific genes, as well as through metabolic alterations...
February 8, 2023: Experimental Hematology
https://read.qxmd.com/read/36708514/network-analysis-of-large-scale-immgen-and-tabula-muris-datasets-highlights-metabolic-diversity-of-tissue-mononuclear-phagocytes
#7
JOURNAL ARTICLE
Anastasiia Gainullina, Denis A Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V Desai, Barbara Maier, Sébastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sébastien Dussaud, Tyng-An Zhou, Veronique Angeli, J Magarian Blander, Kyunghee Choi, Marc Dalod, Ivan Dzhagalov, Emmanuel L Gautier, Claudia Jakubzick, Kory Lavine, Michail S Lionakis, Helena Paidassi, Michael H Sieweke, Florent Ginhoux, Martin Guilliams, Christophe Benoist, Miriam Merad, Gwendalyn J Randolph, Alexey Sergushichev, Maxim N Artyomov
The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network analysis applied to three large-scale transcriptional datasets: we introduce (1) an ImmGen MNP open-source dataset of 337 samples across 26 tissues; (2) a myeloid subset of ImmGen Phase I dataset (202 MNP samples); and (3) a myeloid mouse single-cell RNA sequencing (scRNA-seq) dataset (51,364 cells) assembled based on Tabula Muris Senis...
January 27, 2023: Cell Reports
https://read.qxmd.com/read/36608675/c-ebp%C3%AE-dependent-epigenetic-memory-induces-trained-immunity-in-hematopoietic-stem-cells
#8
Bérengère de Laval, Julien Maurizio, Prashanth K Kandalla, Gabriel Brisou, Louise Simonnet, Caroline Huber, Gregory Gimenez, Orit Matcovitch-Natan, Susanne Reinhardt, Eyal David, Alexander Mildner, Achim Leutz, Bertrand Nadel, Christophe Bordi, Ido Amit, Sandrine Sarrazin, Michael H Sieweke
No abstract text is available yet for this article.
January 5, 2023: Cell Stem Cell
https://read.qxmd.com/read/36325333/autofluorescence-identifies-highly-phagocytic-tissue-resident-macrophages-in-mouse-and-human-skin-and-cutaneous-squamous-cell-carcinoma
#9
JOURNAL ARTICLE
Pierre Bourdely, Luciana Petti, Sokchea Khou, Aida Meghraoui-Kheddar, Roxane Elaldi, Julie Cazareth, Noushine Mossadegh-Keller, Julien Boyer, Michael H Sieweke, Gilles Poissonnet, Anne Sudaka, Veronique M Braud, Fabienne Anjuère
Macrophages from human and mouse skin share phenotypic and functional features, but remain to be characterized in pathological skin conditions. Skin-resident macrophages are known to derive from embryonic precursors or from adult hematopoiesis. In this report, we investigated the origins, phenotypes and functions of macrophage subsets in mouse and human skin and in cutaneous squamous cell carcinoma (cSCC) using the spectral flow cytometry technology that enables cell autofluorescence to be considered as a full-fledged parameter...
2022: Frontiers in Immunology
https://read.qxmd.com/read/34108972/tlr7-signaling-drives-the-development-of-sj%C3%A3-gren-s-syndrome
#10
JOURNAL ARTICLE
Yawen Wang, Annie Roussel-Queval, Lionel Chasson, Noël Hanna Kazazian, Laetitia Marcadet, Andrianos Nezos, Michael H Sieweke, Clio Mavragani, Lena Alexopoulou
Sjögren's syndrome (SS) is a chronic systemic autoimmune disease that affects predominately salivary and lacrimal glands. SS can occur alone or in combination with another autoimmune disease like systemic lupus erythematosus (SLE). Here we report that TLR7 signaling drives the development of SS since TLR8-deficient (TLR8ko) mice that develop lupus due to increased TLR7 signaling by dendritic cells, also develop an age-dependent secondary pathology similar to associated SS. The SS phenotype in TLR8ko mice is manifested by sialadenitis, increased anti-SSA and anti-SSB autoantibody production, immune complex deposition and increased cytokine production in salivary glands, as well as lung inflammation...
2021: Frontiers in Immunology
https://read.qxmd.com/read/34017127/author-correction-trained-immunity-tolerance-priming-and-differentiation-distinct-immunological-processes
#11
Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo A B Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W M van der Meer, Musa Mhlanga, Simone J C F M Moorlag, Willem J M Mulder, Shruti Naik, Boris Novakovic, Luke O'Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea
No abstract text is available yet for this article.
July 2021: Nature Immunology
https://read.qxmd.com/read/33293712/trained-immunity-tolerance-priming-and-differentiation-distinct-immunological-processes
#12
JOURNAL ARTICLE
Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo A B Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W M van der Meer, Musa Mhlanga, Simone J C F M Moorlag, Willem J M Mulder, Shruti Naik, Boris Novakovic, Luke O'Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea
No abstract text is available yet for this article.
January 2021: Nature Immunology
https://read.qxmd.com/read/32386557/c-ebp%C3%AE-dependent-epigenetic-memory-induces-trained-immunity-in-hematopoietic-stem-cells
#13
Bérengère de Laval, Julien Maurizio, Prashanth K Kandalla, Gabriel Brisou, Louise Simonnet, Caroline Huber, Gregory Gimenez, Orit Matcovitch-Natan, Susanne Reinhardt, Eyal David, Alexander Mildner, Achim Leutz, Bertrand Nadel, Christophe Bordi, Ido Amit, Sandrine Sarrazin, Michael H Sieweke
No abstract text is available yet for this article.
May 7, 2020: Cell Stem Cell
https://read.qxmd.com/read/32169166/c-ebp%C3%AE-dependent-epigenetic-memory-induces-trained-immunity-in-hematopoietic-stem-cells
#14
JOURNAL ARTICLE
Bérengère de Laval, Julien Maurizio, Prashanth K Kandalla, Gabriel Brisou, Louise Simonnet, Caroline Huber, Gregory Gimenez, Orit Matcovitch-Natan, Susanne Reinhardt, Eyal David, Alexander Mildner, Achim Leutz, Bertrand Nadel, Christophe Bordi, Ido Amit, Sandrine Sarrazin, Michael H Sieweke
Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can directly respond to infection, but sustained effects on the immune response remain unclear. We show that acute immune stimulation with lipopolysaccharide (LPS) induced only transient changes in HSC abundance, composition, progeny, and gene expression, but persistent alterations in accessibility of specific myeloid lineage enhancers occurred, which increased responsiveness of associated immune genes to secondary stimulation...
March 10, 2020: Cell Stem Cell
https://read.qxmd.com/read/31951251/tissue-resident-macrophages-in-omentum-promote-metastatic-spread-of-ovarian-cancer
#15
JOURNAL ARTICLE
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny and function of TAM subsets in a mouse model of metastatic ovarian cancer that is representative for visceral peritoneal metastasis. We show that the omentum is a critical premetastatic niche for development of invasive disease in this model and define a unique subset of CD163+ Tim4+ resident omental macrophages responsible for metastatic spread of ovarian cancer cells...
April 6, 2020: Journal of Experimental Medicine
https://read.qxmd.com/read/31909091/isolation-and-long-term-cultivation-of-mouse-alveolar-macrophages
#16
JOURNAL ARTICLE
Clara Jana-Lui Busch, Jérémy Favret, Laufey Geirsdóttir, Kaaweh Molawi, Michael H Sieweke
Alveolar macrophages (AM) are tissue-resident macrophages that colonize the lung around birth and can self-maintain long-term in an adult organism without contribution of monocytes. AM are located in the pulmonary alveoli and can be harvested by washing the lungs using the method of bronchoalveolar lavage (BAL). Here, we compared different conditions of BAL to obtain high yields of murine AM for in vitro culture and expansion of AM. In addition, we describe specific culture conditions, under which AM proliferate long-term in liquid culture in the presence of granulocyte-macrophage colony-stimulating factor...
July 20, 2019: Bio-protocol
https://read.qxmd.com/read/31414712/bhlhe40-and-bhlhe41-transcription-factors-regulate-alveolar-macrophage-self-renewal-and-identity
#17
JOURNAL ARTICLE
René Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A-Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J Rossner, Michael H Sieweke, Melanie Greter, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky
Tissues in multicellular organisms are populated by resident macrophages, which perform both generic and tissue-specific functions. The latter are induced by signals from the microenvironment and rely on unique tissue-specific molecular programs requiring the combinatorial action of tissue-specific and broadly expressed transcriptional regulators. Here, we identify the transcription factors Bhlhe40 and Bhlhe41 as novel regulators of alveolar macrophages (AMs)-a population that provides the first line of immune defense and executes homeostatic functions in lung alveoli...
October 1, 2019: EMBO Journal
https://read.qxmd.com/read/30931348/characterization-of-mouse-adult-testicular-macrophage-populations-by-immunofluorescence-imaging-and-flow-cytometry
#18
JOURNAL ARTICLE
Noushin Mossadegh-Keller, Michael H Sieweke
Testicular macrophages (tMΦ) are the most abundant immune cells residing in the testis, an immune-privileged organ. TMΦ are known to exhibit different functions, such as protecting spermatozoa from auto-immune attack by producing immunosuppressive cytokines and trophic roles in supporting spermatogenesis and male sex hormone production. They also contribute to fetal testicular development. Recently, we characterized two distinct tMΦ populations based on their morphology, localization, cell surface markers, and gene expression profiling...
March 5, 2019: Bio-protocol
https://read.qxmd.com/read/30733606/publisher-correction-c-maf-controls-immune-responses-by-regulating-disease-specific-gene-networks-and-repressing-il-2-in-cd4-t-cells
#19
Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M Luscombe, Anne O'Garra
In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML and PDF version of the article.
March 2019: Nature Immunology
https://read.qxmd.com/read/30142346/dna-damage-signaling-instructs-polyploid-macrophage-fate-in-granulomas
#20
JOURNAL ARTICLE
Laura Herrtwich, Indrajit Nanda, Konstantinos Evangelou, Teodora Nikolova, Veronika Horn, Sagar, Daniel Erny, Jonathan Stefanowski, Leif Rogell, Claudius Klein, Kourosh Gharun, Marie Follo, Maximilian Seidl, Bernhard Kremer, Nikolas Münke, Julia Senges, Manfred Fliegauf, Tom Aschman, Dietmar Pfeifer, Sandrine Sarrazin, Michael H Sieweke, Dirk Wagner, Christine Dierks, Thomas Haaf, Thomas Ness, Mario M Zaiss, Reinhard E Voll, Sachin D Deshmukh, Marco Prinz, Torsten Goldmann, Christoph Hölscher, Anja E Hauser, Andres J Lopez-Contreras, Dominic Grün, Vassilis Gorgoulis, Andreas Diefenbach, Philipp Henneke, Antigoni Triantafyllopoulou
No abstract text is available yet for this article.
August 23, 2018: Cell
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