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Satoru Takahashi

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https://read.qxmd.com/read/30773130/calcium-channel-blockers-possibly-delay-the-elimination-of-plasma-methotrexate-in-patients-receiving-high-dose-methotrexate-therapy
#1
Ryo Inose, Katsuyuki Takahashi, Satoru Nanno, Masayuki Hino, Katsuya Nagayama
Delayed elimination of plasma methotrexate (MTX), which leads to elevated toxicity, is often observed in patients receiving high-dose methotrexate (HD-MTX) therapy, despite of the preventive measures. In this study, we investigated the factors that delay elimination of plasma MTX in patients on HD-MTX therapy. Fifteen patients who received HD-MTX therapy (21 cycles) were classified into two groups: delayed elimination of plasma MTX (38.1%, 8/21) and normal elimination of plasma MTX (61.9%, 13/21). Patient characteristics, plasma MTX concentrations, laboratory values, and adverse reactions were compared between the two groups using Fisher's exact test...
February 2019: Journal of Chemotherapy
https://read.qxmd.com/read/30759267/pulmonary-and-pleural-toxicity-of-potassium-octatitanate-fibers-rutile-titanium-dioxide-nanoparticles-and-mwcnt-7-in-male-fischer-344-rats
#2
Mohamed Abdelgied, Ahmed M El-Gazzar, David B Alexander, William T Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Hiroyuki Tsuda, Satoru Takahashi
Potassium octatitanate (K2 O·8TiO2 , POT) fibers are used as an alternative to asbestos. Their shape and biopersistence suggest that they are possibly carcinogenic. However, inhalation studies have shown that respired POT fibers have little carcinogenic potential. We conducted a short-term study in which we administered POT fibers, and anatase and rutile titanium dioxide nanoparticles (a-nTiO2 , r-nTiO2 ) to rats using intra-tracheal intra-pulmonary spraying (TIPS). We found that similarly to other materials, POT fibers were more toxic than non-fibrous nanoparticles of the same chemical composition, indicating that the titanium dioxide composition of POT fibers does not appear to account for their lack of carcinogenicity...
February 13, 2019: Archives of Toxicology
https://read.qxmd.com/read/30737815/bezafibrate-improves-globe-and-uk-pbc-scores-and-long-term-outcomes-in-patients-with-primary-biliary-cholangitis
#3
Akira Honda, Atsushi Tanaka, Tetsuji Kaneko, Atsumasa Komori, Masanori Abe, Mie Inao, Tadashi Namisaki, Naoaki Hashimoto, Kazuhito Kawata, Atsushi Takahashi, Masashi Ninomiya, Jong-Hon Kang, Mie Arakawa, Satoshi Yamagiwa, Satoru Joshita, Takeji Umemura, Ken Sato, Akira Kaneko, Kentaro Kikuchi, Jun Itakura, Takako Nomura, Keisuke Kakisaka, Hideki Fujii, Norifumi Kawada, Yasuhiro Takikawa, Tsutomu Masaki, Hiromasa Ohira, Satoshi Mochida, Hitoshi Yoshiji, Satoshi Iimuro, Yasushi Matsuzaki, Hajime Takikawa
In Japan, bezafibrate (BF) is a second-line agent for primary biliary cholangitis (PBC) that is refractory to ursodeoxycholic acid (UDCA) treatment. From a retrospective cohort (n=873) from the Japan PBC Study Group, we enrolled 118 patients who had received UDCA monotherapy for ≥1 year followed by combination therapy with UDCA+BF for ≥1 year. GLOBE and UK-PBC scores after UDCA monotherapy (that is, immediately before UDCA+BF combination therapy) were compared with those after 1 year of UDCA+BF combination therapy...
February 8, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30733536/characterisation-of-n-glycans-in-the-epithelial-like-tissue-of-the-rat-cochlea
#4
Yoriko Nonomura, Seishiro Sawamura, Ken Hanzawa, Takashi Nishikaze, Sadanori Sekiya, Taiga Higuchi, Fumiaki Nin, Satoru Uetsuka, Hidenori Inohara, Shujiro Okuda, Eiji Miyoshi, Arata Horii, Sugata Takahashi, Shunji Natsuka, Hiroshi Hibino
Membrane proteins (such as ion channels, transporters, and receptors) and secreted proteins are essential for cellular activities. N-linked glycosylation is involved in stability and function of these proteins and occurs at Asn residues. In several organs, profiles of N-glycans have been determined by comprehensive analyses. Nevertheless, the cochlea of the mammalian inner ear, a tiny organ mediating hearing, has yet to be examined. Here, we focused on the stria vascularis, an epithelial-like tissue in the cochlea, and characterised N-glycans by liquid chromatography with mass spectrometry...
February 7, 2019: Scientific Reports
https://read.qxmd.com/read/30713281/inhibitory-effect-of-grapefruit-seed-extract-gse-on-avian-pathogens
#5
Miyuki Komura, Mayuko Suzuki, Natthanan Sangsriratanakul, Mariko Ito, Satoru Takahashi, Md Shahin Alam, Mizuki Ono, Chisato Daio, Dany Shoham, Kazuaki Takehara
The inhibitory activities of grapefruit seed extract (GSE) on avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), Salmonella Infantis (SI) and Escherichia coli (EC) were evaluated. Original GSE contained 0.24% benzalkonium chloride (BZC), however, 0.0025% BZC solution could not inactivate bacteria. The activity of diluted GSE (×100, ×500 and ×1,000 with redistilled water) against selected viruses and bacteria was evaluated in this study. The GSE solutions were incubated with the pathogens over a period of time after which the remaining viruses were titrated and the bacterial colonies were counted...
February 4, 2019: Journal of Veterinary Medical Science
https://read.qxmd.com/read/30705423/publisher-correction-defective-epstein-barr-virus-in-chronic-active-infection-and-haematological-malignancy
#6
Yusuke Okuno, Takayuki Murata, Yoshitaka Sato, Hideki Muramatsu, Yoshinori Ito, Takahiro Watanabe, Tatsuya Okuno, Norihiro Murakami, Kenichi Yoshida, Akihisa Sawada, Masami Inoue, Keisei Kawa, Masao Seto, Koichi Ohshima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yohei Narita, Masahiro Yoshida, Fumi Goshima, Jun-Ichi Kawada, Tetsuya Nishida, Hitoshi Kiyoi, Seiichi Kato, Shigeo Nakamura, Satoko Morishima, Tetsushi Yoshikawa, Shigeyoshi Fujiwara, Norio Shimizu, Yasushi Isobe, Masaaki Noguchi, Atsushi Kikuta, Keiji Iwatsuki, Yoshiyuki Takahashi, Seiji Kojima, Seishi Ogawa, Hiroshi Kimura
In the version of this Letter originally published, in the sentence beginning "The major driver role of DDX3X mutations...", the citation "Fig. 2a-f" should have been "Fig. 2". In addition, in the sentence beginning "Another finding of interest was the presence of identical driver mutations...", the citation "Fig. 3a,b and Fig. 4" should have been "Fig. 3". This has now been amended in all versions of the Letter.
January 30, 2019: Nature Microbiology
https://read.qxmd.com/read/30703739/a-phase-i-ii-trial-of-olaparib-tablet-in-combination-with-eribulin-in-japanese-patients-with-advanced-or-metastatic-triple-negative-breast-cancer-previously-treated-with-anthracyclines-and-taxanes
#7
Kan Yonemori, Akihiko Shimomura, Hiroyuki Yasojima, Norikazu Masuda, Kenjiro Aogi, Masato Takahashi, Yoichi Naito, Satoru Shimizu, Rikiya Nakamura, Jun Hashimoto, Harukaze Yamamoto, Akihiro Hirakawa, Hirofumi Michimae, Akinobu Hamada, Teruhiko Yoshida, Tamie Sukigara, Kenji Tamura, Yasuhiro Fujiwara
BACKGROUND: We conducted a multicenter phase I/II trial of olaparib plus eribulin in Japanese patients with advanced or metastatic triple-negative breast cancer (TNBC) to determine the recommended phase II dose (RP2D) (phase I) and to examine the efficacy and safety (phase II) (UMIN00009498) of the combined therapy. PATIENTS AND METHODS: In phase I, olaparib tablet was orally administered twice daily from level 1:25 mg BID to level 7:300 mg BID, with 1.4 mg/m2 of eribulin on days 1 and 8...
January 28, 2019: European Journal of Cancer
https://read.qxmd.com/read/30700132/critical-role-of-srebp-sterol-regulatory-element-binding-protein-1c-large-vldl-very-low-density-lipoprotein-pathway-in-environment-induced-hypertriglyceridemia-of-apo-av-deficiency
#8
Mikio Takanashi, Takeshi Kimura, Chengcheng Li, Masaki Tanaka, Ako Matsuhashi, Hiroki Yoshida, Akari Noda, Pengfei Xu, Satoru Takase, Sachiko Okazaki, Yoko Iizuka, Hidetoshi Kumagai, Yuichi Ikeda, Takanari Gotoda, Manabu Takahashi, Hiroaki Yagyu, Shun Ishibashi, Toshimasa Yamauchi, Takashi Kadowaki, Guosheng Liang, Hiroaki Okazaki
Objective- APOA5 variants are strongly associated with hypertriglyceridemia, as well as increased risks of cardiovascular disease and acute pancreatitis. Hypertriglyceridemia in apo AV dysfunction often aggravates by environmental factors such as high-carbohydrate diets or aging. To date, the molecular mechanisms by which these environmental factors induce hypertriglyceridemia are poorly defined, leaving the high-risk hypertriglyceridemia condition undertreated. Previously, we reported that LXR (liver X receptor)-SREBP (sterol regulatory element-binding protein)-1c pathway regulates large-VLDL (very low-density lipoprotein) production induced by LXR agonist...
January 31, 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/30691296/investigation-of-approval-trends-and-benefits-of-new-fixed-dose-combination-drugs-in-japan
#9
Chikara Kikuchi, Mifuyu Ohno, Takafumi Izumo, Satoru Takahashi, Masayuki Aoki, Hitoshi Shimomura, Yohei Kawano, Shuji Shimada, Takao Aoyama
BACKGROUND: New fixed-dose combination drugs (FDCs) had been developed in limited numbers in Japan. Since regulatory requirements were relaxed in 2005, 73 new FDCs have been approved by PMDA since 2006. In this study, we investigate trends in new FDCs and their benefits through a questionnaire survey provided to patients and pharmacists. METHODS: The new FDCs were analyzed by therapeutic categories, first approval country and drug lag (DL). Questionnaire surveys were conducted on hypertension, bronchial asthma, and glaucoma in approximately 300 patients and 700 pharmacists in 66 hospitals to investigate the benefits of new FDCs...
January 28, 2019: Therapeutic Innovation & Regulatory Science
https://read.qxmd.com/read/30664667/defective-epstein-barr-virus-in-chronic-active-infection-and-haematological-malignancy
#10
Yusuke Okuno, Takayuki Murata, Yoshitaka Sato, Hideki Muramatsu, Yoshinori Ito, Takahiro Watanabe, Tatsuya Okuno, Norihiro Murakami, Kenichi Yoshida, Akihisa Sawada, Masami Inoue, Keisei Kawa, Masao Seto, Koichi Ohshima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yohei Narita, Masahiro Yoshida, Fumi Goshima, Jun-Ichi Kawada, Tetsuya Nishida, Hitoshi Kiyoi, Seiichi Kato, Shigeo Nakamura, Satoko Morishima, Tetsushi Yoshikawa, Shigeyoshi Fujiwara, Norio Shimizu, Yasushi Isobe, Masaaki Noguchi, Atsushi Kikuta, Keiji Iwatsuki, Yoshiyuki Takahashi, Seiji Kojima, Seishi Ogawa, Hiroshi Kimura
Epstein-Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer1,2 . Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification1,2 . CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms3 . Here, we show that CAEBV originates from an EBV-infected lymphoid progenitor that acquires DDX3X and other mutations, causing clonal evolution comprising multiple cell lineages...
January 21, 2019: Nature Microbiology
https://read.qxmd.com/read/30649406/selection-criteria-for-3d-conformal-radiotherapy-versus-volumetric-modulated-arc-therapy-in-high-grade-glioma-based-on-normal-tissue-complication-probability-of-brain
#11
Satoshi Tanabe, Haruna Takahashi, Hirotake Saito, Atsushi Ohta, Toshimichi Nakano, Ryuta Sasamoto, Miki Shioi, Satoru Utsunomiya, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama
There are no quantitative selection criteria for identifying high-grade glioma (HGG) patients who are suited for volumetric-modulated arc therapy (VMAT). This study aimed to develop selection criteria that can be used for the selection of the optimal treatment modality in HGG. We analyzed 20 patients with HGG treated by 3D conformal radiotherapy (3DCRT). First, VMAT plans were created for each patient retrospectively. For each plan, the normal tissue complication probability (NTCP) for normal brain was calculated...
January 11, 2019: Journal of Radiation Research
https://read.qxmd.com/read/30649323/integrative-genomic-analysis-of-oct1-reveals-coordinated-regulation-of-androgen-receptor-in-advanced-prostate-cancer
#12
Ken-Ichi Takayama, Yutaka Suzuki, Shinichiro Yamamoto, Daisuke Obinata, Satoru Takahashi, Satoshi Inoue
The ligand-dependent transcription factor androgen receptor (AR) plays a critical role in prostate cancer progression. We have previously reported that OCT1, an AR collaborative factor, facilitated the AR genomic bindings to regulate diverse programs of gene expression in AR-dependent prostate cancer cells. Repression of OCT1 binding can serve as a potential treatment strategy for advanced prostate cancer. However, the precise mechanism underlying the functions of OCT1 in advanced prostate cancer, especially the lethal castration-resistant prostate cancer (CRPC) is still unclear...
January 11, 2019: Endocrinology
https://read.qxmd.com/read/30643196/poglut1-the-putative-effector-gene-driven-by-rs2293370-in-primary-biliary-cholangitis-susceptibility-locus-chromosome-3q13-33
#13
Yuki Hitomi, Kazuko Ueno, Yosuke Kawai, Nao Nishida, Kaname Kojima, Minae Kawashima, Yoshihiro Aiba, Hitomi Nakamura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Kazuhiro Sugi, Toshiki Nikami, Tsutomu Yamashita, Shinji Katsushima, Toshiki Komeda, Keisuke Ario, Atsushi Naganuma, Masaaki Shimada, Noboru Hirashima, Kaname Yoshizawa, Fujio Makita, Kiyoshi Furuta, Masahiro Kikuchi, Noriaki Naeshiro, Hironao Takahashi, Yutaka Mano, Haruhiro Yamashita, Kouki Matsushita, Seiji Tsunematsu, Iwao Yabuuchi, Hideo Nishimura, Yusuke Shimada, Kazuhiko Yamauchi, Tatsuji Komatsu, Rie Sugimoto, Hironori Sakai, Eiji Mita, Masaharu Koda, Yoko Nakamura, Hiroshi Kamitsukasa, Takeaki Sato, Makoto Nakamuta, Naohiko Masaki, Hajime Takikawa, Atsushi Tanaka, Hiromasa Ohira, Mikio Zeniya, Masanori Abe, Shuichi Kaneko, Masao Honda, Kuniaki Arai, Teruko Arinaga-Hino, Etsuko Hashimoto, Makiko Taniai, Takeji Umemura, Satoru Joshita, Kazuhiko Nakao, Tatsuki Ichikawa, Hidetaka Shibata, Akinobu Takaki, Satoshi Yamagiwa, Masataka Seike, Shotaro Sakisaka, Yasuaki Takeyama, Masaru Harada, Michio Senju, Osamu Yokosuka, Tatsuo Kanda, Yoshiyuki Ueno, Hirotoshi Ebinuma, Takashi Himoto, Kazumoto Murata, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Atsumasa Komori, Kiyoshi Migita, Masahiro Ito, Hiroshi Yatsuhashi, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate the genetic architecture of PBC, a GWAS was performed on an additional independent sample set, then a genome-wide meta-analysis with our previous GWAS was performed based on a whole-genome single nucleotide polymorphism (SNP) imputation analysis of a total of 4,045 Japanese individuals (2,060 cases and 1,985 healthy controls)...
January 14, 2019: Scientific Reports
https://read.qxmd.com/read/30635375/manipulation-of-nephron-patterning-signals-enables-selective-induction-of-podocytes-from-human-pluripotent-stem-cells
#14
Yasuhiro Yoshimura, Atsuhiro Taguchi, Shunsuke Tanigawa, Junji Yatsuda, Tomomi Kamba, Satoru Takahashi, Hidetake Kurihara, Masashi Mukoyama, Ryuichi Nishinakamura
BACKGROUND: Previous research has elucidated the signals required to induce nephron progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of kidney organoids. However, selectively controlling differentiation of NPCs to podocytes has been a challenge. METHODS: We investigated the effects of various growth factors in cultured mouse embryonic NPCs during three distinct steps of nephron patterning: from NPC to pretubular aggregate, from the latter to epithelial renal vesicle (RV), and from RV to podocyte...
February 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30633424/znf671-dna-methylation-as-a-molecular-predictor-for-the-early-recurrence-of-serous-ovarian-cancer
#15
Shoko Mase, Keiko Shinjo, Haruhito Totani, Keisuke Katsushima, Atsushi Arakawa, Satoru Takahashi, Hung-Cheng Lai, Ru-Inn Lin, Michael W Y Chan, Mayumi Sugiura-Ogasawara, Yutaka Kondo
Serous ovarian cancer is the most frequent type of epithelial ovarian cancer. Despite the use of surgery and platinum-based chemotherapy, many patients suffer from recurrence within 6 months, termed platinum-resistance. Currently, the lack of relevant molecular biomarkers for the prediction of the early recurrence of serous ovarian cancers is linked to the poor prognosis. To identify an effective biomarker for early recurrence, we analyzed the genome-wide DNA methylation status characteristic of early recurrence after treatment...
January 11, 2019: Cancer Science
https://read.qxmd.com/read/30632632/inhibition-of-angiogenesis-and-tumor-growth-by-a-novel-1-4-naphthoquinone-derivative
#16
Hiroko Murota, Tomohiro Shinya, Arisa Nishiuchi, Mariko Sakanaka, Ken-Ichi Toda, Tokutaro Ogata, Noboru Hayama, Tetsutaro Kimachi, Satoru Takahashi
Hit, Lead & Candidate Discovery Antiangiogenesis therapy is a promising way for treatment of solid cancers, and many angiogenesis inhibitors that target vascular endothelial growth factor (VEGF) or its receptors have been developed. We explored novel antiangiogenic compounds other than anti-VEGF drugs by screening our synthetic compound library and found that 6-thiophen-3-yl-2-methoxy-1,4-naphthoquinone (6-TMNQ) had potential as a novel angiogenesis inhibitor. This paper describes the effects of 6-TMNQ on angiogenesis and tumor growth in vitro and in vivo...
January 11, 2019: Drug Development Research
https://read.qxmd.com/read/30601868/generating-vegfr3-reporter-transgenic-mouse-expressing-membrane-tagged-venus-for-visualization-of-vegfr3-expression-in-vascular-and-lymphatic-endothelial-cells
#17
Chisato Watanabe, Jun Matsushita, Takuya Azami, Setsuko Tsukiyama-Fujii, Tomoyuki Tsukiyama, Seiya Mizuno, Satoru Takahashi, Masatsugu Ema
Vascular endothelial growth factor receptor 3 (Vegfr3) has been widely used as a marker for lymphatic and vascular endothelial cells during mouse embryonic development and in adult mouse, making it valuable for studying angiogenesis and lymphangiogenesis under normal and pathological conditions. Here, we report the generation of a novel transgenic (Tg) mouse that expresses a membrane-localized fluorescent reporter protein, Gap43-Venus, under the control of the Vegfr3 regulatory sequence. Vegfr3-Gap43-Venus BAC Tg recapitulated endogenous Vegfr3 expression in vascular and lymphatic endothelial cells during embryonic development and tumor development...
2019: PloS One
https://read.qxmd.com/read/30591323/different-determinants-of-vascular-and-nonvascular-deaths-in-patients-with-atrial-fibrillation-a-sakura-af-registry-substudy
#18
Keiichiro Kuronuma, Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada, Kazumiki Nomoto, Ken Arima, Fumiyuki Takahashi, Tomobumi Kotani, Yukitoshi Ikeya, Seiji Fukushima, Satoru Itou, Kunio Kondo, Masaaki Chiku, Yasumi Ohno, Motoyuki Onikura, Atsushi Hirayama
BACKGROUND: The incidence and causes of death among patients in Japan treated for atrial fibrillation (AF), a major determinant of strokes and death, with direct oral anticoagulants (DOACs) are unclear. This study's aim was two-fold: to compare the incidence and causes of death between DOAC and warfarin users in Japan and to identify the factors associated with vascular and nonvascular death in the Japanese AF population. METHODS: The study was based on the SAKURA AF registry, in which clinical events were tracked in 3267 enrollees from 63 institutions for 2-4 years...
March 2019: Journal of Cardiology
https://read.qxmd.com/read/30588709/a-phase-1-study-of-alpelisib-byl719-an-%C3%AE-specific-pi3k-inhibitor-in-japanese-patients-with-advanced-solid-tumors
#19
Yuichi Ando, Satoru Iwasa, Shunji Takahashi, Hideo Saka, Tomoyuki Kakizume, Kazuto Natsume, Naoko Suenaga, Cornelia Quadt, Yasuhide Yamada
This Phase 1 study aimed to determine tolerability and preliminary efficacy of single-agent alpelisib (BYL719) in Japanese patients with advanced solid malignancies. The primary objective of the study was to estimate the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of oral alpelisib in patients with advanced solid tumors who had progressed despite standard therapy. The expansion part included patients with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation/amplification; safety, preliminary efficacy, pharmacokinetic (PK)/pharmacodynamic profile, and food effect on the PK profile of alpelisib at the MTD/RP2D were determined...
December 26, 2018: Cancer Science
https://read.qxmd.com/read/30587117/important-cardiac-transcription-factor-genes-are-accompanied-by-bidirectional-long-non-coding-rnas
#20
Yutaro Hori, Yoko Tanimoto, Satoru Takahashi, Tetsushi Furukawa, Kazuko Koshiba-Takeuchi, Jun K Takeuchi
BACKGROUND: Heart development is a relatively fragile process in which many transcription factor genes show dose-sensitive characteristics such as haploinsufficiency and lower penetrance. Despite efforts to unravel the genetic mechanism for overcoming the fragility under normal conditions, our understanding still remains in its infancy. Recent studies on the regulatory mechanisms governing gene expression in mammals have revealed that long non-coding RNAs (lncRNAs) are important modulators at the transcriptional and translational levels...
December 27, 2018: BMC Genomics
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