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Vancomycin AND Nephrotoxicity

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https://read.qxmd.com/read/30946754/the-association-of-vancomycin-trough-levels-with-outcomes-among-patients-with-methicillin-resistant-staphylococcus-aureus-mrsa-infections-retrospective-cohort-study
#1
Dafna Yahav, Maria Abbas, Laila Nassar, Alia Ghrayeb, Daniel Kurnik, Daniel Shepshelovich, Leonard Leibovici, Mical Paul
INTRODUCTION: Current guidelines recommend maintaining vancomycin trough concentrations between 15-20 mg/L for serious methicillin resistant staphylococcus aureus (MRSA) infections. This recommendation is based on limited evidence. METHODS: A retrospective study including patients with vancomycin susceptible MRSA infections (MIC< = 2 mg/L), treated with vancomycin. We compared outcomes among patients attaining high (> = 15mg/L) vs low (<15mg/L) trough vancomycin levels...
2019: PloS One
https://read.qxmd.com/read/30935799/comparative-study-of-antibiotic-elution-profiles-from-alternative-formulations-of-polymethylmethacrylate-bone-cement
#2
Daniel G Meeker, Kasa B Cooper, Regis L Renard, Simon C Mears, Mark S Smeltzer, C Lowry Barnes
BACKGROUND: Polymethylmethacrylate (PMMA) bone cement is commonly used in orthopedic surgery for implant fixation and local antibiotic delivery following surgical debridement. The incidence of nephrotoxicity necessitates the balance of antiinfective properties with the potential for toxicity. Thus, understanding antibiotic elution characteristics of different PMMA formulations is essential. We sought to address this by assessing elution of vancomycin, daptomycin, and tobramycin from Palacos LV (Palacos), Stryker Surgical Simplex P (Simplex), BIOMET Cobalt HV (Cobalt), and Zimmer Biomet Bone Cement R (Zimmer) radiopaque bone cements...
March 12, 2019: Journal of Arthroplasty
https://read.qxmd.com/read/30924910/polymyxin-b-for-gram-negative-multidrug-resistant-bacteria-in-a-hispanic-population
#3
Rafael De León-Borrás, Carlos Sánchez-Sergentón, Angel Mayor-Becerra, Angel F Laureano-Cuadrado
OBJECTIVE: This study intends to determine the prevalence of multidrug resistant (MDR) infections by A. baumannii, K. pneumoniae and P. aeruginosa in a tertiary care teaching hospital intensive care unit (ICU) in San Juan, PR, estimate the mortality rate and compare the morbidity and mortality differences among those treated with and without polymyxin B. METHODS: We selected adults patients admitted to the ICU who had positive cultures from January 2012 to June 2013...
March 2019: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/30923406/evaluation-of-vancomycin-dosing-in-patients-with-cirrhosis-beginning-de-liver-ations-about-a-new-nomogram
#4
Randolph E Regal, Steven P Ren, Gregory Paige, Cesar Alaniz
Background: Reduced hepatic production of creatinine precursors in patients with decompensated cirrhosis leads to falsely low serum creatinine values. Therefore, when performing empiric dosing of vancomycin, an overestimation of creatinine clearance may result in significantly supratherapeutic vancomycin levels and increased risks of nephrotoxicity. Objective: The objective of the study is to evaluate vancomycin dosing requirements in patients with cirrhosis stratified by Child-Pugh Score, with subsequent comparison with doses that are recommended in the previously published and validated Kullar nomogram...
April 2019: Hospital Pharmacy
https://read.qxmd.com/read/30919233/clinical-and-pharmacokinetic-outcomes-of-peak-trough-based-versus-trough-based-vancomycin-therapeutic-drug-monitoring-approaches-a-pragmatic-randomized-controlled-trial
#5
Fatima Khalifa Al-Sulaiti, Ahmed Mohamed Nader, Mohamed Omar Saad, Adila Shaukat, Rakesh Parakadavathu, Ahmed Elzubair, Daoud Al-Badriyeh, Hazem Elewa, Ahmed Awaisu
BACKGROUND: Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration-time curve to minimum inhibitory concentration cure breakpoints (AUC24 /MIC). Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date. OBJECTIVES: We aimed to compare clinical and pharmacokinetic outcomes between peak-trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC24 /MIC and cure rates...
March 27, 2019: European Journal of Drug Metabolism and Pharmacokinetics
https://read.qxmd.com/read/30892160/vancomycin-therapeutic-regime-adjustment-in-newborn-and-infant-with-bacterial-infection-case-series
#6
Nadielle Silva Bidu, Bruno José Dumêt Fernandes, Eduardo Jorge Cavalvante Dias, Jucelino Nery Conceição Filho, Regina Eunice de Andrade Bastos, Ana Leonor Pardo Campos Godoy, Francine Johansson Azeredo, Joice Neves Reis Pedreira, Ricardo David Couto
BACKGROUND: Vancomycin is used mostly to overcome infections caused by methicillin-resistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to outside range serum concentrations. OBJECTIVE: This case series evaluates the pharmacokinetics adjustment from a vancomycin therapeutic regimen prescribed to neonates and infants with bacterial infection at a neonatal public hospital intensive-care-unit, with the primary purpose to verify cases of nephrotoxicity...
March 19, 2019: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/30888462/correction-to-risk-factors-for-vancomycin-nephrotoxicity-and-time-course-of-renal-function-during-vancomycin-treatment
#7
Toshinori Hirai, Kazuhiko Hanada, Ayako Kanno, Megumi Akashi, Toshimasa Itoh
After online publication, we found a typographical error in Table 2. We consider correcting "VCM trough concentration > 20 g/mL" to "VCM trough concentration > 20 μg/mL".
March 19, 2019: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/30867724/evaluation-of-efficacy-and-nephrotoxicity-during-vancomycin-therapy-a-retrospective-study-in-china
#8
Liping Wang, Qing Yuan, Min Tan, Shuanshuan Xie, Jufang Wu, Xiaolian Song, Changhui Wang
The aim of the present study was to investigate the predictive value of vancomycin serum concentrations regarding its efficacy and nephrotoxicity in a Chinese population and to determine a relatively safe optimal target concentration during vancomycin therapy. A total of 65 patients that received vancomycin between March 2013 and March 2018 at Shanghai 10th People's Hospital (Shanghai, China) were enrolled and their vancomycin trough and peak concentrations were monitored. Factor analysis was performed in order to exclude interaction between variables...
March 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30863989/a-murine-ex-vivo-3d-kidney-proximal-tubule-model-predicts-clinical-drug-induced-nephrotoxicity
#9
Dorina Diekjürgen, David W Grainger
Drug attrition and clinical product withdrawals due to nephrotoxicity remain major challenges for pharmaceutical drug development pipelines. Currently, no reliable high-throughput in vitro screening models are available that provide reliable, predictive toxicology data for clinical nephrotoxicity. Drug screens to predict toxicity and pharmacology assessments are compromised by standard two-dimensional (2D) cell monoculture models. Here we extend a previously reported murine three-dimensional (3D) kidney-derived intact proximal tubule model to provide ex vivo drug toxicity data that reliably compare to clinical experiences and improve nephrotoxicity predictions over current 2D cell assays...
March 12, 2019: Archives of Toxicology
https://read.qxmd.com/read/30862206/potential-renoprotective-effects-of-silymarin-against-vancomycin-induced-nephrotoxicity-in-rats
#10
Sevda Guzel, Zuhal Uckun Sahinogullari, Necmiye Canacankatan, Serife Efsun Antmen, Deniz Kibar, Banu Coskun Yilmaz
Silymarin (SLY), a flavonoid complex isolated from the seeds of Silybum marianum (Asteraceae), has antioxidant, anti-apoptotic, anti-inflammatory, and anti-lipid peroxidative effects. Vancomycin (VA), used for treating serious infections, has been associated with nephrotoxicity, which limits its use. Therefore, this study aimed to investigate the potential renoprotective effects of SLY on VA-induced nephrotoxicity using renal, apoptotic (caspase-3, caspase-8, and caspase-9 enzyme activities), and oxidative stress [nitric oxide (NO) and malondialdehyde (MDA)] markers; serum blood urea nitrogen (BUN) and creatinine levels; and histopathological examination...
March 12, 2019: Drug and Chemical Toxicology
https://read.qxmd.com/read/30855726/early-and-late-adverse-renal-effects-after-potentially-nephrotoxic-treatment-for-childhood-cancer
#11
REVIEW
Esmee Cm Kooijmans, Arend Bökenkamp, Nic S Tjahjadi, Jesse M Tettero, Eline van Dulmen-den Broeder, Helena Jh van der Pal, Margreet A Veening
BACKGROUND: Improvements in diagnostics and treatment for paediatric malignancies resulted in a major increase in survival. However, childhood cancer survivors (CCS) are at risk of developing adverse effects caused by multimodal treatment for their malignancy. Nephrotoxicity is a known side effect of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate (GFR) impairment, proteinuria, tubulopathy, and hypertension...
March 11, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30820395/ceftaroline-fosamil-as-an-alternative-for-a-severe-methicillin-resistant-staphylococcus-aureus-infection-a-case-report
#12
Talha N Jilani, Syed O Masood
Bacteremia secondary to methicillin-resistant Staphylococcus aureus (MRSA) is a dreaded medical condition that is not only associated with a significant medical cost but also carries high morbidity and mortality. The poor clinical outcomes seen in MRSA patients and the nephrotoxic effects of high-doses of vancomycin are challenging its current status as the first-line treatment for MRSA. Fortunately, vancomycin-intermediate-staphylococcus aureus (VISA) and vancomycin-resistant-staphylococcus aureus (VRSA) are not common in the United States...
December 25, 2018: Curēus
https://read.qxmd.com/read/30808269/vancomycin-associated-acute-kidney-injury-in-critically-ill-adolescent-and-young-adult-patients
#13
William B Hays, Emma Tillman
BACKGROUND: Risk factors for the development of vancomycin-associated acute kidney injury (AKI) have been evaluated in both pediatric and adult populations; however, no previous studies exist evaluating this in the critically ill adolescent and young adult patients. OBJECTIVE: Identify the incidence of AKI and examine risk factors for the development of AKI in critically ill adolescents and young adults on vancomycin. METHODS: This retrospective review evaluated the incidence of AKI in patients 15 to 25 years of age who received vancomycin, while admitted to an intensive care unit...
February 26, 2019: Journal of Pharmacy Practice
https://read.qxmd.com/read/30776089/the-effectiveness-of-a-vancomycin-dosing-guideline-in-the-neonatal-intensive-care-unit-for-achieving-goal-therapeutic-trough-concentrations
#14
Ashley M Reilly, Michelle X Ding, Joseph E Rower, Tyree H Kiser
Concern for bacterial resistance and treatment failure with vancomycin trough concentrations < 10 μg/mL have led guidelines to increase goal concentrations. There is a paucity of data evaluating vancomycin dosage necessary to achieve goals in the neonatal intensive care unit (NICU). We aimed to evaluate the implementation of a new vancomycin dosing guideline in improving trough target attainment. This retrospective study evaluated neonates in the NICU treated with vancomycin between January 2009 and December 2015...
February 18, 2019: Journal of Clinical Pharmacology
https://read.qxmd.com/read/30770940/risk-factors-for-vancomycin-nephrotoxicity-and-time-course-of-renal-function-during-vancomycin-treatment
#15
Toshinori Hirai, Kazuhiko Hanada, Ayako Kanno, Megumi Akashi, Toshimasa Itoh
PURPOSE: Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. METHODS: We conducted a retrospective analysis of patients receiving intravenous VCM treatment between June 2015 and August 2017 at Tokyo Women's Medical University, Medical Center East...
February 15, 2019: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/30763561/postoperative-acute-kidney-injury-in-young-adults-with-congenital-heart-disease
#16
Dana Y Fuhrman, Lan G Nguyen, Joan Sanchez-de-Toledo, Priyanka Priyanka, John A Kellum
BACKGROUND: There is an increasing number of young adults living with congenital heart disease (CHD). The goal of this study was to ascertain the frequency of acute kidney injury (AKI) as well as the risk factors and outcomes associated with AKI in young adults with CHD after a surgical procedure. METHODS: This was a single center retrospective cohort study including all patients 18-40 years of age with a diagnosis of CHD admitted to a quaternary care children's hospital cardiac intensive care unit postoperatively from 2004-2015...
February 11, 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30741619/the-incidence-risk-factors-and-clinical-outcomes-of-acute-kidney-injury-staged-using-the-rifle-classification-associated-with-intravenous-acyclovir-administration
#17
Eun Ju Lee, Ha Nee Jang, Hyun Seop Cho, Eunjin Bae, Tae Won Lee, Se-Ho Chang, Dong Jun Park
Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV acyclovir administration. We retrospectively reviewed the medical records of 287 patients who were medicated IV acyclovir from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented medical histories and underwent medical review...
November 2018: Renal Failure
https://read.qxmd.com/read/30739996/age-dependent-changes-in-vancomycin-induced-nephrotoxicity-in-mice
#18
Masaki Takigawa, Hirofumi Masutomi, Yoshitomo Shimazaki, Tomio Arai, Jaewon Lee, Toshihiro Ishii, Yoshiko Mori, Akihito Ishigami
Vancomycin hydrochloride (VCM) is a glycopeptide antibiotic that is commonly used to eradicate methicillin-resistant gram-positive cocci, despite its nephrotoxic side effects. Elderly people are particularly susceptible to developing VCM-induced nephrotoxicity. However, the precise mechanism by which VCM induces nephrotoxicity in elderly people is not completely understood. Therefore, we investigated VCM-induced nephrotoxicity in mice of different ages. VCM was injected intraperitoneally into mice at 1, 3, 6, 12, and 24 months of age at a dosage of 400 mg/kg body weight for 3 and 14 days...
January 2019: Journal of Toxicologic Pathology
https://read.qxmd.com/read/30739349/conversion-from-vancomycin-trough-concentration-guided-dosing-to-area-under-the-curve-guided-dosing-using-two-sample-measurements-in-adults-implementation-at-an-academic-medical-center
#19
Lina Meng, Tiffany Wong, Sharon Huang, Emily Mui, Vinhkhoa Nguyen, Gabriela Espinosa, Janjri Desai, Marisa Holubar, Stan Deresinski
STUDY OBJECTIVE: The optimal pharmacodynamic parameter for prediction of efficacy of vancomycin is the area under the concentration-time curve (AUC), and current published data indicate that dosing based on vancomycin trough concentrations is an inaccurate substitute. In this study, our objective was to compare the achievement of therapeutic target attainment after switching from a trough-based to an AUC-based dosing strategy as a part of our institution's vancomycin-per-pharmacy protocol...
February 10, 2019: Pharmacotherapy
https://read.qxmd.com/read/30737860/paediatric-acute-kidney-injury-induced-by-vancomycin-monotherapy-versus-combined-vancomycin-and-meropenem
#20
Tao Zhang, Hua Cheng, Yuan Li, Yu-Zhu Dong, Ying Zhang, Xiao-Liang Cheng, An-Min Wang, Ya-Lin Dong
WHAT IS KNOWN AND OBJECTIVE: Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase the nephrotoxicity of VAN is unclear. This study aimed to determine whether meropenem is a suitable drug to combine with VAN based on whether meropenem enhances the nephrotoxicity of VAN...
February 8, 2019: Journal of Clinical Pharmacy and Therapeutics
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