keyword
https://read.qxmd.com/read/38534740/covid-19-associated-cardiovascular-disease-risks-prevention-and-management-heart-at-risk-due-to-covid-19
#21
REVIEW
Andrew Kemerley, Abhishek Gupta, Mahesh Thirunavukkarasu, Monica Maloney, Sean Burgwardt, Nilanjana Maulik
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the resulting COVID-19 pandemic have had devastating and lasting impact on the global population. Although the main target of the disease is the respiratory tract, clinical outcomes, and research have also shown significant effects of infection on other organ systems. Of interest in this review is the effect of the virus on the cardiovascular system. Complications, including hyperinflammatory syndrome, myocarditis, and cardiac failure, have been documented in the context of COVID-19 infection...
February 29, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534719/antimicrobial-treatment-challenges-in-the-management-of-infective-spondylodiscitis-associated-with-hemodialysis-a-comprehensive-review-of-literature-and-case-series-analysis
#22
JOURNAL ARTICLE
Ioana A Ratiu, Corina F Moisa, Laura Țiburcă, Edy Hagi-Islai, Anamaria Ratiu, Gabriel Cristian Bako, Cristian Adrian Ratiu, Liana Stefan
Infective spondylodiscitis (ISD), the infection of vertebral bodies and surrounding tissues, is a rare complication with major impact on the long-term survival of hemodialysis (HD) patients. Although the most frequent etiology is staphylococcal , identifying these pathogens in blood cultures and biopsy cultures is often difficult. This paper aims to present suitable antibiotic combinations for the treatment of these patients, which is usually challenging in the case of an unidentified pathogen. We presented the therapies applied for 13 HD patients and 19 patients without chronic kidney disease (CKD), diagnosed with ISD between 2013 and 2023 in Bihor County...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38533941/conservative-versus-surgical-therapy-in-patients-with-infective-endocarditis-and-surgical-indication-meta-analysis-of-reconstructed-time-to-event-data
#23
JOURNAL ARTICLE
Tulio Caldonazo, Stefan Hagel, Torsten Doenst, Hristo Kirov, Michel Pompeu Sá, Xander Jacquemyn, Panagiotis Tasoudis, Marcus Franz, Mahmoud Diab
BACKGROUND: Infective endocarditis represents a life-threatening disease with high mortality rates. A fraction of patients receives exclusively conservative antibiotic treatment due to their comorbidities and high operative risk, despite fulfilling criteria for surgical therapy. The aim of the present study is to compare outcomes in patients with infective endocarditis and indication for surgical therapy in those who underwent or did not undergo valve surgery. METHODS AND RESULTS: Three databases were systematically assessed...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38532129/proteomic-characteristics-of-the-treatment-trajectory-of-patients-with-covid-19
#24
JOURNAL ARTICLE
Xue Li, Guilan Ding, Shilin Li, Chun Liu, Xiangde Zheng, Jinliang Luo, Sichun He, Fanwei Zeng, Xuan Huang, Fanxin Zeng
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has prompted global concern due to its profound impact on public health and the economy. Effective treatment of COVID-19 patients in the acute phase or of those with long COVID is a major challenge. Using data-independent acquisition (DIA) technology, we performed proteomic profiling on plasma samples from 22 COVID-19 patients and six healthy controls at Dazhou Central Hospital. Random forest and least absolute shrinkage and selection operator algorithms were used for analysis at various COVID-19 treatment stages...
March 27, 2024: Archives of Virology
https://read.qxmd.com/read/38531830/homocysteine-modifies-the-association-of-coronary-stenosis-and-hiv-infection-in-an-inner-city-african-american-population
#25
JOURNAL ARTICLE
Thorsten M Leucker, Tarek Harb, Gary Gerstenblith, David D Celentano, Efthymios Ziogos, Glenn Treisman, Raul N Mandler, Jag Khalsa, Man Charurat, Shenghan Lai, Hong Lai
BACKGROUND AND AIMS: People with HIV (PWH) whose disease is controlled on anti-retroviral regimens remain at an increased risk for coronary artery disease (CAD). Traditional cardiovascular risk factors do not fully explain the residual risk in PWH suggesting contributions from nontraditional factors. Homocysteine (Hcy) may be one of these as prior work in adults without HIV demonstrate that Hcy may impair endothelial function by decreasing the availability of nitric oxide, promoting the development of atherosclerosis...
March 26, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38531396/practices-in-the-prescription-of-antiseizure-medications-is-it-time-to-change
#26
JOURNAL ARTICLE
Lécio Figueira Pinto, Lucas Scárdua Silva, Rafael Batista João, Vinícius Boldrini, Fernando Cendes, Clarissa Lin Yasuda
The treatment of epilepsy has advanced over the past 30 years through the development of new antiseizure medications (ASMs). Unfortunately, not all of them have been approved yet in Brazil, and many are still underused. When comparing new ASMs to older ones, they are generally not more effective in treating epilepsy. However, they offer better tolerability, with fewer interactions and long-term side effects, especially for patients with comorbidities or those requiring polytherapy. Enzyme induction caused by older ASMs is associated with increased cholesterol levels, drug interactions with decreased effects of statins and other cardiovascular medications, anticoagulants, chemotherapy, immunosuppressors, anti-infective agents (including HIV treatment), antidepressants, and contraceptives...
June 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38528394/association-of-hospital-treated-infectious-diseases-and-infection-burden-with-cardiovascular-diseases-and-life-expectancy
#27
JOURNAL ARTICLE
Jiazhen Zheng, Can Ni, S W Ricky Lee, Fu-Rong Li, Jinghan Huang, Rui Zhou, Yining Huang, Gregory Y H Lip, Xianbo Wu, Shaojun Tang
BACKGROUND: The association of a broad spectrum of infectious diseases with cardiovascular outcomes remains unclear. OBJECTIVES: We aim to provide the cardiovascular risk profiles associated with a wide range of infectious diseases and explore the extent to which infections reduce life expectancy. METHODS: We ascertained exposure to 900+ infectious diseases before cardiovascular disease (CVD) onset in 453,102 participants from the UK Biobank study...
March 25, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38526146/complete-remission-with-histamine-blocker-in-a-patient-with-intractable-hyperadrenergic-postural-orthostatic-tachycardia-syndrome-secondary-to-long-coronavirus-disease-syndrome
#28
JOURNAL ARTICLE
Felipe González-Alvarez, Bruno Estañol, Jesús Antonio González-Hermosillo, Francisco Javier Gómez-Pérez, Karla Maria Tamez-Torres, Eduardo Peña, Carlos Cantú, Erwin Chiquete, José Sifuentes-Osornio, Maria Del Carmen Alba-Lorenzo, Dulce Andrea Celestino-Montelongo, Guadalupe E Salazar-Calderón, Jose de Jesus Aceves Buendia
The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has emerged as a global public health concern and its sequels have barely started to outcrop. A good percentage of patients who suffered from COVID-19 are prone to develop long-COVID or post-COVID condition (PCC), a multisystemic, heterogeneous, chronic disorder. Patients with PCC may experience diverse manifestations, of which cardiovascular and neurological symptoms are among the most frequently reported...
March 11, 2024: Journal of Hypertension
https://read.qxmd.com/read/38525192/mendelian-randomization-supports-genetic-liability-to-hospitalization-for-covid-19-as-a-risk-factor-of-pre-eclampsia
#29
JOURNAL ARTICLE
Weizhen Wu, Junning Zhang, Yizhuo Qiao, Yuehan Ren, Xuezhi Rao, Zhijie Xu, Baoxing Liu
BACKGROUND: Pre-eclampsia and eclampsia are among the major threats to pregnant women and fetuses, but they can be mitigated by prevention and early screening. Existing observational research presents conflicting evidence regarding the causal effects of coronavirus disease 2019 (COVID-19) on pre-eclampsia risk. Through Mendelian randomization (MR), this study aims to investigate the causal effect of three COVID-19 severity phenotypes on the risk of pre-eclampsia and eclampsia to provide more rigorous evidence...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38524686/effect-of-aggressive-warming-versus-routine-thermal-management-on-the-incidence-of-perioperative-hypothermia-in-patients-undergoing-thyroid-surgery-a-prospective-randomized-double-blind-controlled-trial
#30
JOURNAL ARTICLE
Yue Zhang, Yafan Bai, Yi Zhang, Yingjie Du, Min Liu, Jiayu Zhu, Guyan Wang
PURPOSE: Despite the implementation of various insulation measures, the incidence of hypothermia during thyroid surgery remains high. This randomized controlled study aimed to evaluate the effects of aggressive thermal management combined with resistive heating mattresses to prevent perioperative hypothermia in patients undergoing thyroid surgery. PATIENTS AND METHODS: 142 consecutive patients scheduled for elective thyroid surgery were enrolled in the study. They were randomly and equally allocated to the aggressive warming or routine care groups (n = 71)...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38523985/clinical-features-and-treatment-of-patients-infected-with-sars-cov-2-omicron-variant-while-hospitalized-due-to-stroke-a-single-center-study-in-japan
#31
JOURNAL ARTICLE
Kazuki Miyazaki, Hiroshi Kanno, Sachiko Yamada, Yuuki Sagehashi, Shutaro Matsumoto, Satoru Takahashi, Yongson Kim, Keiko Namiki, Satoshi Fujii
BACKGROUND AND OBJECTIVE: In December 2019, COVID-19 spread rapidly across the globe. Throughout the pandemic, SARS-CoV-2 repeatedly mutated, transitioning from the alpha variant to the omicron variant. The severity and mortality of COVID-19 have been linked to age, sex, and the presence of underlying diseases (respiratory, cerebrovascular, cardiovascular, metabolic, and immune diseases, as well as cancer). The clinical features of patients infected with COVID-19 following a stroke, however, are fully unknown...
February 2024: Curēus
https://read.qxmd.com/read/38523928/clinical-course-and-outcomes-of-covid-19-patients-admitted-to-the-icu-of-a-tertiary-care-hospital-in-central-india-a-cross-sectional-study
#32
JOURNAL ARTICLE
Alka Modi Asati, Rakesh Patel, Kritika Singhal, Chakresh Jain, Sonali Tripathi
BACKGROUND: Coronavirus disease 2019 (COVID-19) rapidly spread globally, leading to a pandemic significantly impacting individuals, communities, and economies worldwide. Public health measures such as social distancing, mask-wearing, and hand hygiene have been implemented globally to mitigate the spread of the virus. Many people recovered from COVID-19, but some cases needed intensive care unit (ICU) care, among whom most required mechanical ventilation (MV). MATERIALS AND METHODS: This hospital-based cross-sectional study was done among 75 clinical or reverse transcriptase-polymerase chain reaction (RT-PCR) test-confirmed cases of COVID-19 infection admitted to the ICU of a tertiary care unit in India...
February 2024: Curēus
https://read.qxmd.com/read/38523466/changing-etiology-and-epidemiology-of-hepatocellular-carcinoma-asia-and-worldwide
#33
JOURNAL ARTICLE
Do Young Kim
Approximately 80% of hepatocellular carcinoma (HCC) cases arise in sub-Saharan Africa and Eastern Asia, following a similarly high prevalence of chronic hepatitis B virus (HBV) carriers in these regions. The etiology and epidemiology of HCC have recently changed worldwide. Although HBV infection is the main contributor to HCC development, a slow but continuous decline in HBV infection rates has been reported since 1990. Owing to the widespread use of direct-acting antivirals, the incidence of hepatitis C virus-related HCC has remarkably decreased in Japan and European countries...
March 25, 2024: Journal of liver cancer
https://read.qxmd.com/read/38523044/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-preoperative-phase-preoperative-management-of-the-patient-s-anemia
#34
JOURNAL ARTICLE
Bruno Deltreggia Benites, Flavia Leite, Selma Soriano, Roberto Luiz da Silva, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing anemia before surgery is extremely important as it is a clinical condition that can significantly increase surgical risk and affect patient outcomes. Anemia is characterized by a reduction in the number of red blood cells or hemoglobin levels leading to a lower oxygen-carrying capacity of the blood. Proper treatment requires a multifaceted approach to ensure patients are in the best possible condition for surgery and to minimize potential complications. The challenge is recognizing anemia early and implementing a timely intervention to correct it...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38523030/advancing-immunosuppression-in-liver-transplantation-a-narrative-review
#35
REVIEW
Samuele Iesari, Francesca Laura Nava, Ilaria Elena Zais, Laurent Coubeau, Mariano Ferraresso, Evaldo Favi, Jan Lerut
Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT...
March 16, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38522873/long-term-outcomes-of-mechanical-aortic-valve-replacement-in-children
#36
REVIEW
Michael Z L Zhu, Edward Buratto, Damien M Wu, Shuta Ishigami, Antonia Schulz, Christian P Brizard, Igor E Konstantinov
When the options of aortic valve repair or the Ross procedure are not feasible or have been exhausted, mechanical aortic valve replacement (AVR) may provide a reliable and structurally durable alternative, but with the limitations of long-term anticoagulation, thrombosis risk and lack of valve growth potential. In this article, we review the longitudinal outcomes of mechanical AVR in children in our institution and compare them to those recently reported by others. From 1978 to 2020, 62 patients underwent mechanical AVR at a median age of 12...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38522582/leadless-pacemakers-where-are-we
#37
REVIEW
Nicholas Beccarino, Moussa Saleh, Laurence M Epstein
Pacemakers have been the cornerstone of brady-arrhythmia management since the mid-20th century. Despite the widespread use and success of traditional transvenous pacemakers, they are associated with an estimated 15% complication rate at three years. Driven by the advantages over traditional transvenous pacemakers including a lack of transvenous leads, resistance to infection, and ease of implantation, the number of leadless pacemakers placed annually in the United States has dramatically increased since their initial approval...
March 22, 2024: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/38522483/microbiome-interactions-with-different-risk-factors-in-development-of-myocardial-infarction
#38
REVIEW
Manisha Bijla, Sunil Kumar Saini, Ajai Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites...
March 22, 2024: Experimental Gerontology
https://read.qxmd.com/read/38522319/recent-advances-in-the-therapeutic-potential-of-nobiletin-against-respiratory-diseases
#39
REVIEW
Yanqin Qin, Jingfan Yang, Haibo Li, Jiansheng Li
BACKGROUND: Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment. OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension...
March 1, 2024: Phytomedicine
https://read.qxmd.com/read/38521989/prediction-of-mortality-in-patients-with-secondary-pulmonary-embolism-based-on-primary-admission-indication-a-short-communication
#40
JOURNAL ARTICLE
Martin J Ryll, Toby N Weingarten, Juraj Sprung
We evaluated the prediction of mortality in patients admitted to the intensive care unit (ICU) who subsequently developed a pulmonary embolism (PE) (i.e., secondary PE) using three PE-specific scores, the Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and modified sPESI (ICU-sPESI) and compared them to the gold standard for the assessment of ICU all-cause mortality, the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV). All critical care admission indications were grouped into four major categories: post-operative, cardiovascular, infectious (sepsis), and other...
March 23, 2024: Biomol Biomed
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