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https://read.qxmd.com/read/30770737/the-health-and-economic-effects-of-light-rail-lines-design-methods-and-protocol-for-a-natural-experiment
#1
Lawrence D Frank, Jennifer L Kuntz, James E Chapman, Eric H Fox, John F Dickerson, Richard T Meenan, Brian E Saelens, Deborah R Young, Janne Boone-Heinonen, Stephen P Fortmann
BACKGROUND: The health impacts of community design have been studied extensively over the past two decades. In particular, public transportation use is associated with more walking between transit stops and shops, work, home and other destinations. Change in transit access has been linked with physical activity and obesity but seldom to health outcomes and associated costs, especially within a causal framework. Health related fiscal impacts of transit investment should be a key consideration in major transit investment decisions...
February 15, 2019: BMC Public Health
https://read.qxmd.com/read/30734043/pioglitazone-therapy-in-patients-with-stroke-and-prediabetes-a-post-hoc-analysis-of-the-iris-randomized-clinical-trial
#2
J David Spence, Catherine M Viscoli, Silvio E Inzucchi, Jennifer Dearborn-Tomazos, Gary A Ford, Mark Gorman, Karen L Furie, Anne M Lovejoy, Lawrence H Young, Walter N Kernan
Importance: In the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial, pioglitazone, an insulin-sensitizing agent, reduced the risk for recurrent stroke or myocardial infarction (MI) among patients with insulin resistance. However, insulin resistance is not commonly measured in clinical practice. Objective: To analyze the effects of pioglitazone in patients with good adherence as well as intention-to-treat effects of pioglitazone in patients with prediabetes in the IRIS trial...
February 7, 2019: JAMA Neurology
https://read.qxmd.com/read/30703769/erythropoietin-prevents-anemia-and-transfusions-in-extremely-premature-lambs-supported-by-an-extrauterine-environment-for-neonatal-development-extend
#3
Ali Y Mejaddam, Matthew A Hornick, Patrick E McGovern, Heron D Baumgarten, Kendall M Lawrence, Avery C Rossidis, Grace Hwang, Kathleen Young, Osheiza Abdulmalik, Emily A Partridge, William H Peranteau, Marcus G Davey, Alan W Flake
BACKGROUND: We recently developed an EXTrauterine Environment for Neonatal Development (EXTEND) that provides physiologic support for premature lambs. Here, we assess the efficacy of exogenous erythropoietin (EPO) to prevent anemia and transfusions on EXTEND. MATERIALS AND METHODS: Lambs were cannulated at 0.7 gestation and supported on EXTEND for up to 4 weeks. The lambs were divided into three groups: (1) No EPO, (2) Low EPO (300 U kg-1 per day), and (3) High EPO (800 U kg-1 per day)...
January 31, 2019: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/30580725/scoring-system-to-optimize-pioglitazone-therapy-after-stroke-based-on-fracture-risk
#4
Catherine M Viscoli, David M Kent, Robin Conwit, Jennifer L Dearborn, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Amber Stuart, Lawrence H Young, Walter N Kernan
Background and Purpose- The insulin sensitizer, pioglitazone, reduces cardiovascular risk in patients after an ischemic stroke or transient ischemic attack but increases bone fracture risk. We conducted a secondary analysis of the IRIS trial (Insulin Resistance Intervention After Stroke) to assess the effect of pretreatment risk for fracture on the net benefits of pioglitazone therapy. Methods- IRIS was a randomized placebo-controlled trial of pioglitazone that enrolled patients with insulin resistance but without diabetes mellitus within 180 days of an ischemic stroke or transient ischemic attack...
December 10, 2018: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30573417/independent-and-combined-effects-of-improved-water-sanitation-and-hygiene-and-improved-complementary-feeding-on-stunting-and-anaemia-among-hiv-exposed-children-in-rural-zimbabwe-a-cluster-randomised-controlled-trial
#5
Andrew J Prendergast, Bernard Chasekwa, Ceri Evans, Kuda Mutasa, Mduduzi N N Mbuya, Rebecca J Stoltzfus, Laura E Smith, Florence D Majo, Naume V Tavengwa, Batsirai Mutasa, Goldberg T Mangwadu, Cynthia M Chasokela, Ancikaria Chigumira, Lawrence H Moulton, Robert Ntozini, Jean H Humphrey
BACKGROUND: Children exposed to HIV have a high prevalence of stunting and anaemia. We aimed to test the effect of improved infant and young child feeding (IYCF) and improved water, sanitation, and hygiene (WASH) on child linear growth and haemoglobin concentrations. METHODS: We did a cluster randomised 2 × 2 factorial trial in two districts in rural Zimbabwe. Women were eligible for inclusion if they permanently lived in the trial clusters (ie, the catchment area of between one and four village health workers employed by the Zimbabwean Ministry of Health and Child Care) and were confirmed pregnant...
December 17, 2018: Lancet Child & Adolescent Health
https://read.qxmd.com/read/30559446/author-correction-tree-rings-reveal-globally-coherent-signature-of-cosmogenic-radiocarbon-events-in-774-and-993-ce
#6
Ulf Büntgen, Lukas Wacker, J Diego Galván, Stephanie Arnold, Dominique Arseneault, Michael Baillie, Jürg Beer, Mauro Bernabei, Niels Bleicher, Gretel Boswijk, Achim Bräuning, Marco Carrer, Fredrik Charpentier Ljungqvist, Paolo Cherubini, Marcus Christl, Duncan A Christie, Peter W Clark, Edward R Cook, Rosanne D'Arrigo, Nicole Davi, Ólafur Eggertsson, Jan Esper, Anthony M Fowler, Ze'ev Gedalof, Fabio Gennaretti, Jussi Grießinger, Henri Grissino-Mayer, Håkan Grudd, Björn E Gunnarson, Rashit Hantemirov, Franz Herzig, Amy Hessl, Karl-Uwe Heussner, A J Timothy Jull, Vladimir Kukarskih, Alexander Kirdyanov, Tomáš Kolář, Paul J Krusic, Tomáš Kyncl, Antonio Lara, Carlos LeQuesne, Hans W Linderholm, Neil J Loader, Brian Luckman, Fusa Miyake, Vladimir S Myglan, Kurt Nicolussi, Clive Oppenheimer, Jonathan Palmer, Irina Panyushkina, Neil Pederson, Michal Rybníček, Fritz H Schweingruber, Andrea Seim, Michael Sigl, Olga Churakova Sidorova, James H Speer, Hans-Arno Synal, Willy Tegel, Kerstin Treydte, Ricardo Villalba, Greg Wiles, Rob Wilson, Lawrence J Winship, Jan Wunder, Bao Yang, Giles H F Young
The original version of this Article contained an error in the Data Availability section, which incorrectly read 'All data will be freely available via https://www.ams.ethz.ch/research.html .' The correct version states ' http://www.ams.ethz.ch/research/published-data.html ' in place of ' https://www.ams.ethz.ch/research.html '. This has been corrected in both the PDF and HTML versions of the Article.
December 17, 2018: Nature Communications
https://read.qxmd.com/read/30554749/independent-and-combined-effects-of-improved-water-sanitation-and-hygiene-and-improved-complementary-feeding-on-child-stunting-and-anaemia-in-rural-zimbabwe-a-cluster-randomised-trial
#7
Jean H Humphrey, Mduduzi N N Mbuya, Robert Ntozini, Lawrence H Moulton, Rebecca J Stoltzfus, Naume V Tavengwa, Kuda Mutasa, Florence Majo, Batsirai Mutasa, Goldberg Mangwadu, Cynthia M Chasokela, Ancikaria Chigumira, Bernard Chasekwa, Laura E Smith, James M Tielsch, Andrew D Jones, Amee R Manges, John A Maluccio, Andrew J Prendergast
BACKGROUND: Child stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF) on stunting and anaemia in in Zimbabwe. METHODS: We did a cluster-randomised, community-based, 2 × 2 factorial trial in two rural districts in Zimbabwe. Clusters were defined as the catchment area of between one and four village health workers employed by the Zimbabwe Ministry of Health and Child Care...
January 2019: Lancet Global Health
https://read.qxmd.com/read/30507360/metabolic-syndrome-identifies-normal-weight-insulin-resistant-stroke-patients-at-risk-for-recurrent-vascular-disease
#8
Jennifer L Dearborn, Catherine M Viscoli, Silvio E Inzucchi, Lawrence H Young, Walter N Kernan
BACKGROUND: The obesity paradox refers to the finding in observational studies that patients with obesity have a better prognosis after stroke than normal weight patients. AIM: To test the hypothesis that there might be important heterogeneity within the obese stroke population, such that those with metabolic syndrome would be at higher risk for stroke or myocardial infarction and all-cause mortality compared to patients without metabolic syndrome. METHODS: The Insulin Resistance Intervention after Stroke trial enrolled non-diabetic patients with a recent ischemic stroke or transient ischemic attack and insulin resistance...
December 3, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/30480203/open-access-is-there-a-predator-at-the-door
#9
EDITORIAL
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
January 2018: OTO open
https://read.qxmd.com/read/30451345/quantitative-imaging-biomarkers-alliance-qiba-recommendations-for-improved-precision-of-dwi-and-dce-mri-derived-biomarkers-in-multicenter-oncology-trials
#10
REVIEW
Amita Shukla-Dave, Nancy A Obuchowski, Thomas L Chenevert, Sachin Jambawalikar, Lawrence H Schwartz, Dariya Malyarenko, Wei Huang, Susan M Noworolski, Robert J Young, Mark S Shiroishi, Harrison Kim, Catherine Coolens, Hendrik Laue, Caroline Chung, Mark Rosen, Michael Boss, Edward F Jackson
Physiological properties of tumors can be measured both in vivo and noninvasively by diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging. Although these techniques have been used for more than two decades to study tumor diffusion, perfusion, and/or permeability, the methods and studies on how to reduce measurement error and bias in the derived imaging metrics is still lacking in the literature. This is of paramount importance because the objective is to translate these quantitative imaging biomarkers (QIBs) into clinical trials, and ultimately in clinical practice...
November 19, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/30316542/the-early-natural-history-of-albuminuria-in-young-adults-with-youth-onset-type-1-and-type-2-diabetes
#11
Anna R Kahkoska, Scott Isom, Jasmin Divers, Elizabeth J Mayer-Davis, Lawrence Dolan, Amy S Shah, Maryam Afkarian, David J Pettitt, Jean M Lawrence, Santica Marcovina, Sharon H Saydah, Dana Dabelea, David M Maahs, Amy K Mottl
AIMS: To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression. METHODS: Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later)...
October 4, 2018: Journal of Diabetes and its Complications
https://read.qxmd.com/read/30307614/sunscreen-applied-at-%C3%A2-2mg-cm-2-during-a-sunny-holiday-prevents-erythema-a-biomarker-of-uvr-induced-dna-damage-and-suppression-of-acquired-immunity
#12
J Narbutt, P A Philipsen, G I Harrison, K A Morgan, K P Lawrence, K A Baczynska, K Grys, M Rogowski-Tylman, I Olejniczak-Staruch, A Tewari, M Bell, C O'Connor, H C Wulf, A Lesiak, A R Young
BACKGROUND: Sun protection factor (SPF) is assessed with sunscreen applied at 2mg/cm2 . People typically apply ~0·8mg/cm2 and use sunscreen daily for holidays. Such use typically results in erythema that is a risk factor for skin cancer. OBJECTIVES: To determine if (i) typical sunscreen use resulted in erythema, epidermal DNA damage and photoimmunosuppression during a sunny holiday, (ii) optimal sunscreen use inhibited erythema and (iii) erythema is a biomarker for photoimmunosuppression in a laboratory study...
October 11, 2018: British Journal of Dermatology
https://read.qxmd.com/read/30297969/fine-mapping-type-2-diabetes-loci-to-single-variant-resolution-using-high-density-imputation-and-islet-specific-epigenome-maps
#13
Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R Robertson, Jason M Torres, N William Rayner, Anthony J Payne, Valgerdur Steinthorsdottir, Robert A Scott, Niels Grarup, James P Cook, Ellen M Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F Bielak, Jennifer E Below, Donald W Bowden, John Campbell Chambers, Young Jin Kim, Maggie C Y Ng, Lauren E Petty, Xueling Sim, Weihua Zhang, Amanda J Bennett, Jette Bork-Jensen, Chad M Brummett, Mickaël Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon L R Kardia, Florian Kronenberg, Kristi Läll, Ching-Ti Liu, Adam E Locke, Jian'an Luan, Ioanna Ntalla, Vibe Nylander, Sebastian Schönherr, Claudia Schurmann, Loïc Yengo, Erwin P Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C Florez, Ian Ford, Oscar H Franco, Timothy M Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T Hattersley, Christian Herder, M Arfan Ikram, Martin Ingelsson, Marit E Jørgensen, Torben Jørgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L Mohlke, Andrew D Morris, Girish Nadkarni, James S Pankow, Annette Peters, Naveed Sattar, Alena Stančáková, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R Witte, Josée Dupuis, Patricia A Peyser, Eleftheria Zeggini, Ruth J F Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S Collins, J Wouter Jukema, Colin N A Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Köttgen, Goncalo R Abecasis, James B Meigs, Jerome I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J Wareham, Kari Stefansson, Anna L Gloyn, Andrew P Morris, Michael Boehnke, Mark I McCarthy
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence)...
November 2018: Nature Genetics
https://read.qxmd.com/read/30224361/pillars-article-three-dimensional-structure-of-a-human-class-ii-histocompatibility-molecule-complexed-with-superantigen-nature-1994-368-711-718
#14
Theodore S Jardetzky, Jerry H Brown, Joan C Gorga, Lawrence J Stern, Robert G Urban, Young-In Chi, Cynthia Stauffacher, Jack L Strominger, Don C Wiley
No abstract text is available yet for this article.
October 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://read.qxmd.com/read/30190505/tree-rings-reveal-globally-coherent-signature-of-cosmogenic-radiocarbon-events-in-774-and-993-ce
#15
Ulf Büntgen, Lukas Wacker, J Diego Galván, Stephanie Arnold, Dominique Arseneault, Michael Baillie, Jürg Beer, Mauro Bernabei, Niels Bleicher, Gretel Boswijk, Achim Bräuning, Marco Carrer, Fredrik Charpentier Ljungqvist, Paolo Cherubini, Marcus Christl, Duncan A Christie, Peter W Clark, Edward R Cook, Rosanne D'Arrigo, Nicole Davi, Ólafur Eggertsson, Jan Esper, Anthony M Fowler, Ze'ev Gedalof, Fabio Gennaretti, Jussi Grießinger, Henri Grissino-Mayer, Håkan Grudd, Björn E Gunnarson, Rashit Hantemirov, Franz Herzig, Amy Hessl, Karl-Uwe Heussner, A J Timothy Jull, Vladimir Kukarskih, Alexander Kirdyanov, Tomáš Kolář, Paul J Krusic, Tomáš Kyncl, Antonio Lara, Carlos LeQuesne, Hans W Linderholm, Neil J Loader, Brian Luckman, Fusa Miyake, Vladimir S Myglan, Kurt Nicolussi, Clive Oppenheimer, Jonathan Palmer, Irina Panyushkina, Neil Pederson, Michal Rybníček, Fritz H Schweingruber, Andrea Seim, Michael Sigl, Olga Churakova Sidorova, James H Speer, Hans-Arno Synal, Willy Tegel, Kerstin Treydte, Ricardo Villalba, Greg Wiles, Rob Wilson, Lawrence J Winship, Jan Wunder, Bao Yang, Giles H F Young
Though tree-ring chronologies are annually resolved, their dating has never been independently validated at the global scale. Moreover, it is unknown if atmospheric radiocarbon enrichment events of cosmogenic origin leave spatiotemporally consistent fingerprints. Here we measure the 14 C content in 484 individual tree rings formed in the periods 770-780 and 990-1000 CE. Distinct 14 C excursions starting in the boreal summer of 774 and the boreal spring of 993 ensure the precise dating of 44 tree-ring records from five continents...
September 6, 2018: Nature Communications
https://read.qxmd.com/read/30184553/effect-of-combined-treatment-with-mlc601-neuroaidtm-and-rehabilitation-on-post-stroke-recovery-the-chimes-and-chimes-e-studies
#16
Nijasri C Suwanwela, Christopher L H Chen, Chun Fan Lee, Sherry H Young, San San Tay, Thirugnanam Umapathi, Annabelle Y Lao, Herminigildo H Gan, Alejandro C Baroque Ii, Jose C Navarro, Hui Meng Chang, Joel M Advincula, Sombat Muengtaweepongsa, Bernard P L Chan, Carlos L Chua, Nirmala Wijekoon, H Asita de Silva, John Harold B Hiyadan, Ka Sing Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Narayanaswamy Venketasubramanian
BACKGROUND AND PURPOSE: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. METHODS: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. CHIMES-E was a 24-month follow-up study of subjects included in CHIMES, a multi-centre, double-blind placebo-controlled trial which randomized subjects with acute ischemic stroke, to either MLC601 or placebo for 3 months in addition to standard stroke treatment and rehabilitation...
2018: Cerebrovascular Diseases
https://read.qxmd.com/read/30166634/characterization-of-upper-gastrointestinal-symptoms-gastric-motor-functions-and-associations-in-patients-with-diabetes-at-a-referral-center
#17
Victor Chedid, Justin Brandler, Priya Vijayvargiya, Seon-Young Park, Lawrence A Szarka, Michael Camilleri
OBJECTIVES: Our aim was to characterize upper gastrointestinal (UGI) symptoms and associations in individuals with diabetes mellitus (DM) who had undergone evaluation of gastric emptying (GE) and accommodation (GA) at a referral center. METHODS: From the Mayo Clinic Rochester electronic medical records of adults with diabetes types 1 and 2 (DM1 and DM2) evaluated between January 1997 and December 2015, we extracted demographics, UGI symptoms, current medications, treatments for diabetes, GE solids by scintigraphy, GA by single photon emission computed tomography (SPECT), and diabetes complications...
August 30, 2018: American Journal of Gastroenterology
https://read.qxmd.com/read/30147378/output-from-the-cihr-canadian-hiv-trials-network-international-postdoctoral-fellowship-for-capacity-building-in-hiv-clinical-trials
#18
Lawrence Mbuagbaw, Amy L Slogrove, Jacqueline Sas, John Lengwe Kunda, Frederick Morfaw, Jackson K Mukonzo, Wei Cao, Gisele Ngomba-Kadima, Moleen Zunza, Pierre Ongolo-Zogo, Philip N Nana, Anne Cockcroft, Neil Andersson, Nelson Sewankambo, Mark F Cotton, Taisheng Li, Taryn Young, Joel Singer, Jean-Pierre Routy, Colin Jd Ross, Kyaw Thin, Lehana Thabane, Aslam H Anis
As a response to the human immunodeficiency virus (HIV) epidemic and part of Canadian Institutes for Health Research's mandate to support international health research capacity building, the Canadian Institutes for Health Research Canadian HIV Trial Network (CTN) developed an international postdoctoral fellowship award under the CTN's Postdoctoral Fellowship Awards Program to support and train young HIV researchers in resource-limited settings. Since 2010, the fellowship has been awarded to eight fellows in Cameroon, China, Lesotho, South Africa, Uganda and Zambia...
2018: HIV/AIDS: Research and Palliative Care
https://read.qxmd.com/read/30133185/prevalence-of-radiographic-and-mri-features-of-patellofemoral-osteoarthritis-in-young-and-middle-aged-adults-with-persistent-patellofemoral-pain
#19
Natalie J Collins, Edwin H G Oei, Janneke L de Kanter, Bill Vicenzino, Kay M Crossley
OBJECTIVE: In adults with persistent patellofemoral pain (PFP), (i) describe the prevalence of radiographic features of patellofemoral osteoarthritis (PFOA); (ii) describe the prevalence of magnetic resonance imaging (MRI) PFOA and compare to age- and sex-matched controls; and (iii) explore radiographic and MRI prevalence across age, sex and body mass index (BMI) groups. METHODS: This cross-sectional study included 84 individuals with PFP ≥3 months duration, and 26 age- and sex-matched controls...
August 21, 2018: Arthritis Care & Research
https://read.qxmd.com/read/30118251/first-dark-matter-constraints-from-a-supercdms-single-charge-sensitive-detector
#20
R Agnese, T Aralis, T Aramaki, I J Arnquist, E Azadbakht, W Baker, S Banik, D Barker, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, R Calkins, C Cartaro, D G Cerdeño, Y-Y Chang, J Cooley, B Cornell, P Cushman, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, C Fink, M Fritts, G Gerbier, R Germond, M Ghaith, S R Golwala, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, R E Lawrence, J V Leyva, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, W A Page, R Partridge, M Pepin, A Phipps, F Ponce, S Poudel, M Pyle, H Qiu, W Rau, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, R K Romani, T Saab, B Sadoulet, J Sander, A Scarff, R W Schnee, S Scorza, K Senapati, B Serfass, J So, D Speller, C Stanford, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, S L Watkins, J S Wilson, M J Wilson, J Winchell, D H Wright, S Yellin, B A Young, X Zhang, X Zhao
We present the first limits on inelastic electron-scattering dark matter and dark photon absorption using a prototype SuperCDMS detector having a charge resolution of 0.1 electron-hole pairs (CDMS HVeV, a 0.93 g CDMS high-voltage device). These electron-recoil limits significantly improve experimental constraints on dark matter particles with masses as low as 1  MeV/c^{2}. We demonstrate a sensitivity to dark photons competitive with other leading approaches but using substantially less exposure (0.49 g d)...
August 3, 2018: Physical Review Letters
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