Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Scott E Guimond, Patricia Procter, Gavin J Miller, Marco Guerrini, David G Fernig, Edwin A Yates, Marcelo A Lima, Mark A Skidmore
The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), a key drug target in Alzheimer's Disease. In addition, heparin has been shown to exert favourable bioactivities through a number of pathophysiological pathways involved in the disease processes of Alzheimer's Disease including inflammation, oxidative stress, tau phosphorylation and amyloid peptide generation...
January 26, 2023: Carbohydrate Research