keyword
https://read.qxmd.com/read/38510303/linguistic-markers-for-major-depressive-disorder-a-cross-sectional-study-using-an-automated-procedure
#21
JOURNAL ARTICLE
Raluca Nicoleta Trifu, Bogdan Nemeș, Dana Cristina Herta, Carolina Bodea-Hategan, Dorina Anca Talaș, Horia Coman
INTRODUCTION: The identification of language markers, referring to both form and content, for common mental health disorders such as major depressive disorder (MDD), can facilitate the development of innovative tools for early recognition and prevention. However, studies in this direction are only at the beginning and are difficult to implement due to linguistic variability and the influence of cultural contexts. AIM: This study aims to identify language markers specific to MDD through an automated analysis process based on RO-2015 LIWC (Linguistic Inquiry and Word Count)...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38509062/expression-of-als-pfn1-impairs-vesicular-degradation-in-ipsc-derived-microglia
#22
JOURNAL ARTICLE
Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J Keagle, Justin A McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A Nickerson, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, Daryl A Bosco
Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like cells derived from human induced pluripotent stem cells (iPSCs), termed iMGs, harboring mutations in profilin-1 (PFN1) that are causative for amyotrophic lateral sclerosis (ALS). ALS-PFN1 iMGs exhibited evidence of lipid dysmetabolism, autophagy dysregulation and deficient phagocytosis, a canonical microglia function...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38508584/building-citizen-science-intelligence-for-outbreak-preparedness-and-response-a-mixed-method-study-in-nine-countries-to-assess-knowledge-readiness-and-feasibility
#23
JOURNAL ARTICLE
Yi-Roe Tan, Manh Duc Nguyen, Caroline Antonia Mubaira, Dan Kajungu, Dinesh Kumar, Felipe C Canlas, Firli Yogiteten Sunaryoko, Gyanu Raja Maharjan, Harjyot Khosa, Ingo Hauter, Joan Thiga, Md Mazharul Anowar, Patrick Okwen, Tariro Kutadza, Walter Chikanya, Marc Choisy, Peiling Yap
INTRODUCTION: Citizen science (CS) is an emerging approach in public health to harness the collective intelligence of individuals to augment traditional scientific efforts. However, citizens' viewpoint, especially the hard-to-reach population, is lacking in current outbreak-related literature. We aim to understand the awareness, readiness and feasibility of outbreak-related CS, including digitally enabled CS, in low-income and middle-income countries. METHODS: This mixed-method study was conducted in nine countries between October 2022 and June 2023...
March 19, 2024: BMJ Global Health
https://read.qxmd.com/read/38504123/human-cytomegalovirus-cmv-dysregulates-neurodevelopmental-pathways-in-cerebral-organoids
#24
JOURNAL ARTICLE
Ece Egilmezer, Stuart T Hamilton, Charles S P Foster, Manfred Marschall, William D Rawlinson
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury. This study investigated potential CMV pathogenetic mechanisms of fetal neural malformation using in vitro human cerebral organoids. Cerebral organoids were permissive to CMV replication, and infection dysregulated cellular pluripotency and differentiation pathways. Aberrant expression of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK), sonic hedgehog (SHH), pluripotency, neurodegeneration, axon guidance, hippo signalling and dopaminergic synapse pathways were observed in CMV-infected organoids using immunofluorescence and RNA-sequencing...
March 19, 2024: Communications Biology
https://read.qxmd.com/read/38503738/long-term-effects-of-omicron-ba-2-breakthrough-infection-on-immunity-metabolism-balance-a-6-month-prospective-study
#25
JOURNAL ARTICLE
Yanhua Li, Shijie Qin, Lei Dong, Shitong Qiao, Xiao Wang, Dongshan Yu, Pengyue Gao, Yali Hou, Shouzhen Quan, Ying Li, Fengyan Fan, Xin Zhao, Yueyun Ma, George Fu Gao
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long-term effects of COVID-19 and immune recovery after Omicron BTIs is crucial for understanding the disease and managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents for six-month with routine blood tests, proteomic analysis and single-cell RNA sequencing (scRNA-seq). We found that major organs exhibited ephemeral dysfunction and recovered to normal in approximately six-month after BA...
March 19, 2024: Nature Communications
https://read.qxmd.com/read/38499606/multiple-pathways-light-modulation-in-pleurosigma-strigosum-bi-raphid-diatom
#26
JOURNAL ARTICLE
Edoardo De Tommasi, Ilaria Rea, Maria Antonietta Ferrara, Luca De Stefano, Mario De Stefano, Adil Y Al-Handal, Marija Stamenković, Angela Wulff
Ordered, quasi-ordered, and even disordered nanostructures can be identified as constituent components of several protists, plants and animals, making possible an efficient manipulation of light for intra- and inter- species communication, camouflage, or for the enhancement of primary production. Diatoms are ubiquitous unicellular microalgae inhabiting all the aquatic environments on Earth. They developed, through tens of millions of years of evolution, ultrastructured silica cell walls, the frustules, able to handle optical radiation through multiple diffractive, refractive, and wave-guiding processes, possibly at the basis of their high photosynthetic efficiency...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38499548/nuclei-specific-hypothalamus-networks-predict-a-dimensional-marker-of-stress-in-humans
#27
JOURNAL ARTICLE
Daria E A Jensen, Klaus P Ebmeier, Sana Suri, Matthew F S Rushworth, Miriam C Klein-Flügge
The hypothalamus is part of the hypothalamic-pituitary-adrenal axis which activates stress responses through release of cortisol. It is a small but heterogeneous structure comprising multiple nuclei. In vivo human neuroimaging has rarely succeeded in recording signals from individual hypothalamus nuclei. Here we use human resting-state fMRI (n = 498) with high spatial resolution to examine relationships between the functional connectivity of specific hypothalamic nuclei and a dimensional marker of prolonged stress...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38499535/htra1-disaggregates-%C3%AE-synuclein-amyloid-fibrils-and-converts-them-into-non-toxic-and-seeding-incompetent-species
#28
JOURNAL ARTICLE
Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel
Parkinson's disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer's disease, and inactivating mutations to mitochondrial HTRA2 are implicated in PD. Here, we report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The protease domain of HTRA1 is necessary and sufficient for inhibiting aggregation, yet this activity is proteolytically-independent...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38499518/population-wide-cerebellar-growth-models-of-children-and-adolescents
#29
JOURNAL ARTICLE
Carolin Gaiser, Rick van der Vliet, Augustijn A A de Boer, Opher Donchin, Pierre Berthet, Gabriel A Devenyi, M Mallar Chakravarty, Jörn Diedrichsen, Andre F Marquand, Maarten A Frens, Ryan L Muetzel
In the past, the cerebellum has been best known for its crucial role in motor function. However, increasingly more findings highlight the importance of cerebellar contributions in cognitive functions and neurodevelopment. Using a total of 7240 neuroimaging scans from 4862 individuals, we describe and provide detailed, openly available models of cerebellar development in childhood and adolescence (age range: 6-17 years), an important time period for brain development and onset of neuropsychiatric disorders. Next to a traditionally used anatomical parcellation of the cerebellum, we generated growth models based on a recently proposed functional parcellation...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38495193/unlocking-stroke-prediction-harnessing-projection-based-statistical-feature-extraction-with-ml-algorithms
#30
JOURNAL ARTICLE
Saad Sahriar, Sanjida Akther, Jannatul Mauya, Ruhul Amin, Md Shahajada Mia, Sabba Ruhi, Md Shamim Reza
Non-communicable diseases, such as cardiovascular disease, cancer, chronic respiratory diseases, and diabetes, are responsible for approximately 71% of all deaths worldwide. Stroke, a cerebrovascular disorder, is one of the leading contributors to this burden among the top three causes of death. Early recognition of symptoms can encourage a balanced lifestyle and provide essential information for stroke prediction. To identify a stroke patient and risk factors, machine learning (ML) is a key tool for physicians...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38493236/predictors-of-health-related-quality-of-life-for-children-with-neurodevelopmental-conditions
#31
JOURNAL ARTICLE
Maryam Mahjoob, Robyn Cardy, Melanie Penner, Evdokia Anagnostou, Brendan F Andrade, Jennifer Crosbie, Elizabeth Kelley, Muhammad Ayub, Muhammad Ayub, Jessica Brian, Alana Iaboni, Russell Schachar, Stelios Georgiades, Rob Nicolson, Jessica Jones, Azadeh Kushki
Neurodevelopmental conditions can be associated with decreased health-related quality of life; however, the predictors of these outcomes remain largely unknown. We characterized the predictors of health-related quality of life (HRQoL) in a sample of neurodiverse children and youth. We used a cross-sectional subsample from the Province of Ontario Neurodevelopmental Disorders Network (POND) consisting of those children and young people in the POND dataset with complete study data (total n = 615; 31% female; age: 11...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493191/hermitian-and-non-hermitian-topology-from-photon-mediated-interactions
#32
JOURNAL ARTICLE
Federico Roccati, Miguel Bello, Zongping Gong, Masahito Ueda, Francesco Ciccarello, Aurélia Chenu, Angelo Carollo
As light can mediate interactions between atoms in a photonic environment, engineering it for endowing the photon-mediated Hamiltonian with desired features, like robustness against disorder, is crucial in quantum research. We provide general theorems on the topology of photon-mediated interactions in terms of both Hermitian and non-Hermitian topological invariants, unveiling the phenomena of topological preservation and reversal, and revealing a system-bath topological correspondence. Depending on the Hermiticity of the environment and the parity of the spatial dimension, the atomic and photonic topological invariants turn out to be equal or opposite...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38493176/broadened-quantum-critical-ground-state-in-a-disordered-superconducting-thin-film
#33
JOURNAL ARTICLE
Koichiro Ienaga, Yutaka Tamoto, Masahiro Yoda, Yuki Yoshimura, Takahiro Ishigami, Satoshi Okuma
A superconductor-insulator transition (SIT) in two dimensions is a prototypical quantum phase transition (QPT) with a clear quantum critical point (QCP) at zero temperature (T = 0). The SIT is induced by a field B and observed in disordered thin films. In some of weakly disordered or crystalline thin films, however, an anomalous metallic (AM) ground state emerges over a wide B range between the superconducting and insulating phases. It remains a fundamental open question how the QPT picture of the SIT is modified when the AM state appears...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38491121/identification-of-membrane-curvature-sensing-motifs-essential-for-vps37a-phagophore-recruitment-and-autophagosome-closure
#34
JOURNAL ARTICLE
Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C Bewley, Kouta Hamamoto, Xiaoming Liu, John M Flanagan, Hong-Gang Wang, Yoshinori Takahashi, Fang Tian
VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the mechanism by which VPS37A is targeted to the phagophore remains obscure. Here, we demonstrate that the VPS37A N-terminal domain exhibits selective interactions with highly curved membranes, mediated by two membrane-interacting motifs within the disordered regions surrounding its Ubiquitin E2 variant-like (UEVL) domain. Site-directed mutations of residues in these motifs disrupt ESCRT-I localization to the phagophore and result in defective phagophore closure and compromised autophagic flux in vivo, highlighting their essential role during autophagy...
March 15, 2024: Communications Biology
https://read.qxmd.com/read/38490989/bubble-water-catalyst-triphase-interface-microenvironment-accelerates-photocatalytic-oer-via-optimizing-semi-hydrophobic-oh-radical
#35
JOURNAL ARTICLE
Guanhua Ren, Min Zhou, Peijun Hu, Jian-Fu Chen, Haifeng Wang
Photocatalytic water splitting (PWS) as the holy grail reaction for solar-to-chemical energy conversion is challenged by sluggish oxygen evolution reaction (OER) at water/catalyst interface. Experimental evidence interestingly shows that temperature can significantly accelerate OER, but the atomic-level mechanism remains elusive in both experiment and theory. In contrast to the traditional Arrhenius-type temperature dependence, we quantitatively prove for the first time that the temperature-induced interface microenvironment variation, particularly the formation of bubble-water/TiO2 (110) triphase interface, has a drastic influence on optimizing the OER kinetics...
March 15, 2024: Nature Communications
https://read.qxmd.com/read/38488215/flexible-and-stretchable-implantable-devices-for-peripheral-neuromuscular-electrophysiology
#36
REVIEW
Hanfei Li, Hang Zhao, Kaikai Song, Fei Han, Zhiyuan Liu, Qiong Tian
The peripheral nervous and muscular system, a cornerstone of human physiology, plays a pivotal role in ensuring the seamless functioning of the human body. This intricate network, comprising nerves and muscles extending throughout the body, is essential for motor control, sensory feedback, and the regulation of autonomic bodily functions. The qualified implantable peripheral interface can accurately monitor the biopotential of the target tissue and conduct treatment with stimulation, enhancing the human-machine interaction and new achievements in disease cure...
March 15, 2024: Nanoscale
https://read.qxmd.com/read/38486448/addressing-the-intersections-of-chronic-pain-and-oud-integrative-management-of-chronic-pain-and-oud-for-whole-recovery-impowr-research-network
#37
JOURNAL ARTICLE
Zu-In Su
The appearance of both chronic pain (CP) and opioid use disorder (OUD)/opioid misuse is common, can bidirectionally affect treatment outcomes, and can be challenging to treat. The successful treatment of these conditions can be further complicated by co-occurring hazardous alcohol use, general anxiety disorder, and/or major depressive disorder, and calls for the need to attend to the whole health of the patient. Health systems providing care for these individuals are often fragmented, and suffer from limited resources, expertise, and communication...
March 14, 2024: Subst Use Addctn J
https://read.qxmd.com/read/38486093/glutamine-suppresses-senescence-and-promotes-autophagy-through-glycolysis-inhibition-mediated-ampk%C3%AE-lactylation-in-intervertebral-disc-degeneration
#38
JOURNAL ARTICLE
Yangyang Zhang, Zhengqi Huang, Weitao Han, Jiajun Wu, Shuangxing Li, Tianyu Qin, Chao Zhang, Ming Shi, Shun Han, Bo Gao, Song Jin, Yin Xiao, Kang Xu, Wei Ye
Regulating metabolic disorders has become a promising focus in treating intervertebral disc degeneration (IDD). A few drugs regulating metabolism, such as atorvastatin, metformin, and melatonin, show positive effects in treating IDD. Glutamine participates in multiple metabolic processes, including glutaminolysis and glycolysis; however, its impact on IDD is unclear. The current study reveals that glutamine levels are decreased in severely degenerated human nucleus pulposus (NP) tissues and aging Sprague-Dawley (SD) rat nucleus pulposus tissues, while lactate accumulation and lactylation are increased...
March 14, 2024: Communications Biology
https://read.qxmd.com/read/38485980/quantum-spin-liquid-signatures-in-monolayer-1t-nbse-2
#39
JOURNAL ARTICLE
Quanzhen Zhang, Wen-Yu He, Yu Zhang, Yaoyao Chen, Liangguang Jia, Yanhui Hou, Hongyan Ji, Huixia Yang, Teng Zhang, Liwei Liu, Hong-Jun Gao, Thomas A Jung, Yeliang Wang
Quantum spin liquids (QSLs) are in a quantum disordered state that is highly entangled and has fractional excitations. As a highly sought-after state of matter, QSLs were predicted to host spinon excitations and to arise in frustrated spin systems with large quantum fluctuations. Here we report on the experimental observation and theoretical modeling of QSL signatures in monolayer 1T-NbSe2 , which is a newly emerging two-dimensional material that exhibits both charge-density-wave (CDW) and correlated insulating behaviors...
March 15, 2024: Nature Communications
https://read.qxmd.com/read/38480803/exploring-the-anatomical-configurations-of-the-cerebral-arteries-in-a-cohort-of-south-african-patients
#40
JOURNAL ARTICLE
Gugulethu Sibiya, Bukola R Omotoso, Rohen Harrichandparsad, Lelika Lazarus
The cerebral arteries, specifically the anterior cerebral artery (ACA) and posterior cerebral artery (PCA), work together with the smaller calibre arteries to provide effective communication between the anterior and posterior circuits of the brain via the circle of Willis (CoW). Morphologic variations of the cerebral arteries and the CoW may alter blood flow to the brain, resulting in intracranial vascular disorders associated with stroke, and aneurysms. This study aimed to document the morphology of the cerebral arteries and the CoW in the South African population...
March 13, 2024: Scientific Reports
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