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Frans G Van Heerden, Marthinus J Hartman, Vanessa McClure, Robert M Kirberger
A 12-year-old spayed Newfoundland bitch was presented with chronic non-productive vomiting, regurgitation and coughing of six weeks' duration. On clinical examination, the dog was depressed with no other significant findings. Haematology and biochemistry investigations detected no abnormalities. Thoracic and abdominal radiographs revealed a megaoesophagus and an abnormally positioned pylorus. A thoracic and abdominal computed tomography scan confirmed the abnormal position of the stomach, together with moderate aspiration pneumonia...
November 6, 2018: Journal of the South African Veterinary Association
Houda Meyiz, Mounia Elyousfi
Achalasia, also known as cardiospasm or megaoesophagus is a rare disorder of unknown origin. It is a primary motor disorder of the esophagus characterized by the absence of the esophageal peristalsis and by an incomplete or an absent relaxation of the lower oesophageal sphincter. Common symptoms include dysphagia, regurgitations and retrosternal pain. At an advanced level, fibroscopy can show a dilation of the lower esophagus and a shrinkage that can be easily passed through with a lifting at the level of the cardia...
2018: Pan African Medical Journal
F Cinti, D Della Santa, S Borgonovo, R Bussadori, D Troiano, G Pisani
Three entire, domestic, shorthair male cats (age range: 3 months to 5 years) were referred because of regurgitation. Megaoesophagus attributable to aberrant right subclavian artery, originating from the aorta at the level of the fourth intercostal space, was diagnosed in all cats using thoracic radiography and CT angiography. One cat had concurrent patent ductus arteriosus with a normal aortic arch. Three-dimensional volume-rendered CT images were used to assess the malformations and to plan surgery for the treatment of the vascular anomalies...
May 7, 2018: Journal of Small Animal Practice
Veronique Saey, Jonathan Tang, Richard Ducatelle, Siska Croubels, Siegrid De Baere, Stijn Schauvliege, Gunther van Loon, Koen Chiers
BACKGROUND: Friesian horses are known for their high inbreeding rate resulting in several genetic diseases such as hydrocephaly and dwarfism. This last decade, several studies focused on two other presumed hereditary traits in Friesian horses: megaoesophagus and aortic rupture. The pathogenesis of these diseases remains obscure but an important role of collagen has been hypothesized. The purpose of this study was to examine possible breed-related differences in collagen catabolism. Urinary specimens from Friesian (n = 17, median age 10 years old) and Warmblood horses (n = 17, median age 10 years old) were assessed for mature collagen cross-links, i...
April 25, 2018: BMC Veterinary Research
Jeremy Mortier, Estelle Elissalt, Sophie Palierne, Marie Odile Semin, Maxence Delverdier, Armelle Diquélou
Case summary A 7-year-old neutered male Persian cat was presented for acute vomiting and inappetence. Physical examination revealed severe abdominal distension. Radiographs demonstrated pneumoperitoneum, megaoesophagus and generalised gaseous distension of the digestive tract. Exploratory coeliotomy was performed, revealing markedly distended and thickened small and large intestines with no observable peristalsis. No intestinal perforation was present. Bacteriological and cytological analysis of abdominal fluid revealed a septic peritonitis involving Pasteurella multocida ...
January 2016: JFMS Open Reports
F Quintavalla, A Menozzi, C Pozzoli, E Poli, P Donati, D K Wyler, P Serventi, S Bertini
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). The dogs were given sildenafil oral suspension 1 mg/kg every 12 hours for 14 days or placebo in a masked fashion. Clinical signs (frequency of regurgitation and weight gain) and oesophagrams (relative oesophageal diameter, ROD) were evaluated in order to assess the efficacy of drug treatment, by examiners who were unaware of the study protocol...
April 22, 2017: Veterinary Record
I Biasato, G Lanteri, F Guarda, M T Capucchio, F Marino, G Briguglio, F Macrì
A 2-months-old male German shepherd puppy was referred for regurgitation and delayed growth. Radiographic and endoscopic investigations revealed a precardiac megaoesophagus and oesophageal constriction at the level of the heart base. At post-mortem examination, a specific form of persistent right aortic arch characterized by an aberrant left subclavian artery in combination with a ligamentum arteriosum originating at the aberrant left subclavian artery (PRAA-SA-LA) was detected. A complete-type persistent left cranial vena cava (PLCVC) was also observed...
April 2017: Anatomia, Histologia, Embryologia
Emma J Molena, Ashwin Krishnamoorthy, Coimbatore Praveen
Achalasia is an idiopathic motility disorder of the oesophagus of increasing incidence. It is characterized by aperistalsis of the lower oesophagus and failure of relaxation of the lower oesophageal sphincter. Patients classically present with chronic symptoms of dysphagia, chest pain, weight loss and regurgitation, and they commonly suffer pulmonary complications such as recurrent microaspiration of static, retained food contents of the upper oesophagus. However, it has also been described, uncommonly, to present with megaoesophagus and secondary tracheal compression...
2016: Journal of Surgical Case Reports
D Nguyen, F Dip, E Lo Menzo, S Szomstein, R Rosenthal
When achalasia is unrecognised during the preoperative phase in patients who have undergone bariatric procedures, a late Heller oesophagomyotomy may be used as the treatment modality to prevent the development of megaoesophagus. We present the case of a 66-year-old man with achalasia 3 years after a Roux-en-Y gastric bypass procedure.
January 2016: Annals of the Royal College of Surgeons of England
L A Murphy, R K Nakamura, J M Miller
Three dogs presented for evaluation of acute onset tachypnoea and dyspnoea following episodes of vomiting and/or regurgitation. Thoracic radiographs were suggestive of a gastro-oesophageal intussusception in all three dogs; one dog also showed evidence of aspiration pneumonia. All three dogs underwent surgical correction with a bilateral incisional gastropexy. All dogs recovered from anaesthesia uneventfully and were discharged from the hospital 3 days after presentation. Persistent megaoesophagus was evident in all three dogs, and they are being chronically managed with a strict feeding regime and pro-motility agents...
October 2015: Journal of Small Animal Practice
Nigel Tapiwa Mabvuure, Shi Ying Hey, Matthew Forshaw
INTRODUCTION: Respiratory distress and arrest from tracheal compression secondary to megaoesophagus are rare complications of achalasia. We present the case of a man with end-stage achalasia who required oesophagectomy to prevent recurrent life-threatening tracheal compression and respiratory arrest. A literature review is also presented. PRESENTATION OF CASE: A 40-year old man presented with post-prandial stridor which resolved spontaneously, later being diagnosed with achalasia...
2014: International Journal of Surgery Case Reports
Francesca Bresciani, Laura Zagnoli, Federico Fracassi, Ezio Bianchi, Carlo Cantile, Francesca Abramo, Marco Pietra
BACKGROUND: Canine dermatomyositis is a hereditary disease described in collies and Shetland sheep dogs and their cross-breeds. A similar disease, called dermatomyositis-like disease, has been described occasionally in other breeds but never in the Rottweiler. HYPOTHESIS/OBJECTIVES: We report on the clinicopathological findings associated with dermatomyositis-like disease in a Rottweiler. ANIMAL: A 7-month-old female Rottweiler was referred for dermatological abnormalities, regurgitation and weakness...
June 2014: Veterinary Dermatology
Patrícia Rocha Martins, Rodolfo Duarte Nascimento, André de Souza Lisboa, Patrícia Massara Martinelli, Débora d'Ávila Reis
Tryptase and chymase are mast cell (MC)-specific proteases, which influence in the activation of inflammatory cells. In this study, we quantified tryptase- or chymase-expressing MCs in the oesophaguses of Chagas patients, and searched for a correlation between those data with area of nerve fibres that expressed either PGP9.5 (pan-marker) or vasoactive intestinal polypeptide (VIP), which is a neuromediator that has anti-inflammatory activity. Samples from the oesophaguses of 14 individuals Trypanosoma cruzi-infected and from six uninfected individuals were analysed by immunohistochemistry...
April 2014: Human Immunology
Nívia Carolina Nogueira-Paiva, Kátia da Silva Fonseca, Paula Melo de Abreu Vieira, Lívia Figueiredo Diniz, Ivo Santana Caldas, Sandra Aparecida Lima de Moura, Vanja Maria Veloso, Paulo Marcos da Matta Guedes, Washington Luiz Tafuri, Maria Terezinha Bahia, Cláudia Martins Carneiro
Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase...
February 2014: Memórias do Instituto Oswaldo Cruz
José Rodrigues Coura, José Borges-Pereira
The pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue regeneration to prevent fibrosis, (iii) reverse existing fibrosis, (iv) prevent cardiomyopathy, megaoesophagus and megacolon and (v) reduce or eliminate cardiac block and arrhythmia. All cases of the indeterminate chronic form of Chagas disease without contraindications due to other concomitant diseases or pregnancy should be treated and not only cases involving children or recently infected cases...
September 2011: Memórias do Instituto Oswaldo Cruz
Susanne Thümmler, Angela Huebner, Elisabeth Baechler-Sadoul
Triple A syndrome is a rare disease of autosomal recessive inheritance. It was first described in 1978. The typical triad includes adrenocorticotrophic-hormone-resistant glucocorticoid insufficiency, reduced or absent tearing (alacrima) and achalasia. But clinical symptoms can be extremely heterogeneous and of variable clinically expression. This report describes a 7-year-old boy with a 1 year history of fatigue and muscle weakness. Physical examination showed skin and mucosal hyperpigmentation, and hormonal analysis revealed isolated glucocorticoid function...
2009: BMJ Case Reports
Yahya Al-Habbal
Mrs FW, 83 years of age, presented to the emergency department with repeated episodes of attacks of vomiting over several months, coughing, weight loss and worsening shortness of breath. On examination she was not distressed, but mildly dehydrated. Chest examination revealed decreased air entry in both sides of the chest. Heart sounds were muffled. Other examination was within normal limits.
May 2011: Australian Family Physician
Aluízio Prata, João Carlos Pinto Dias, José Rodrigues Coura
Originating from the ancient enzootic cycle of Trypanosoma cruzi, human Chagas disease (HCD) emerged focally in different points of America, in the Pre Christian period. Being slowly expanded as a consequence of internal migrations, HCD was settled in those locals where some vector species reached domiciliation and where different kinds of reservoirs entered in domestic environment , with major expression in the post Columbus era, particularly between the final of XIX Century and the middle of XX Century, when the maximum prevalence rates were attained...
2011: Revista da Sociedade Brasileira de Medicina Tropical
F Fracassi, A Tamborini
No abstract text is available yet for this article.
March 26, 2011: Veterinary Record
Rosa Novellas, Kerry E Simpson, Danièlle A Gunn-Moore, Gawain J C Hammond
Dysautonomia is caused by degeneration of the autonomic ganglia. Failure of the autonomic system affecting the gastrointestinal and urinary tracts can cause oesophageal distension and/or dysfunction, gastric and bowel distension and hypomotility, and urinary bladder distension. The aim of this retrospective study was to describe diagnostic imaging findings in cats with dysautonomia. Common findings were megaoesophagus and/or oesophageal dysfunction, gastric distension and signs of intestinal ileus. Associated aspiration pneumonia and megacolon appeared less commonly...
August 2010: Journal of Feline Medicine and Surgery
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