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Colon* And Cancer

Rachel S Lee, Luxi Zhang, Adeline Berger, Mitchell G Lawrence, Jiangning Song, Birunthi Niranjan, Rebecca G Davies, Natalie L Lister, Shahneen K Sandhu, Mark A Rubin, Gail P Risbridger, Renea A Taylor, David S Rickman, Lisa G Horvath, Roger J Daly
Approximately 50% of prostate cancers harbor the TMPRSS2:ERG fusion, resulting in elevated expression of the ERG transcription factor. Despite the identification of this subclass of prostate cancers, no personalized therapeutic strategies have achieved clinical implementation. Kinases are attractive therapeutic targets as signaling networks are commonly perturbed in cancers. The impact of elevated ERG expression on kinase signaling networks in prostate cancer has not been investigated. Resolution of this issue may identify novel therapeutic approaches for ERG-positive prostate cancers...
March 19, 2019: Neoplasia: An International Journal for Oncology Research
Zhiyuan Li, Xiaohui Sun, Xiaoming Liu, Ziyuan Sun, Jingwei Li
BACKGROUND: Ruyiping is an effective traditional Chinese herbal medicine formula for preventing postoperative recurrence and metastasis of breast cancer. However, the exact function and underlying mechanism of Ruyiping in breast cancer remain unclear. MATERIALS AND METHODS: After breast cancer cell lines MDA-MB-231 and MDA-MB-468 were treated with Ruyiping, the CCK8, colony formation, wound-healing, and transwell invasion assays were used to examine cell proliferation, migration, and invasion, respectively...
March 22, 2019: Cancer Biotherapy & Radiopharmaceuticals
Fabian Eichelmann, Matthias B Schulze, Clemens Wittenbecher, Juliane Menzel, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner Boeing, Krasimira Aleksandrova
Importance: Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. Objective: To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. Design, Setting, and Participants: Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years...
March 1, 2019: JAMA Network Open
Qiuli Li, Weichao Chen, Ming Song, Wenkuan Chen, Zhongyuan Yang, Ankui Yang
Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with suboptimal survival outcomes. In this study, we aimed to find an independent prognostic factor of head and neck squamous cell carcinoma and investigate its effect on tumor cell proliferation, apoptosis, migration progress and cell cycle phase. Weighted gene co-expression network analysis (WGCNA) is an analysis method for mining module information in chip data through soft threshold. In this article, it was used to divide differential genes into different modules and determined the ten hub genes...
March 22, 2019: Cancer Biology & Therapy
Byung-Gon Na, Sung-Sik Han, Yeong-Ah Cho, Gyung-Ah Wie, Ji-Yeon Kim, Jong-Mog Lee, Seung Duk Lee, Seong Hoon Kim, Sang-Jae Park
BACKGROUND: We aimed to assess the nutritional status of cancer patients according to site or treatment type. METHODS: We prospectively evaluated the nutritional status of 1,588 patients based on cancer site and treatment type using the Patient-Generated Subjective Global Assessment tool. We also investigated length of stay (LOS), complication rates after surgery and quality of life (QoL). RESULTS: The patients with esophageal, pancreaticobiliary, and lung cancer had higher malnutrition rates than those with stomach, liver, and colon cancer (52...
March 22, 2019: Nutrition and Cancer
Mahmood Nazari, Seyed Latif Mousavi Gargari, Abbas Sahebghadam Lotfi, Mohammad Javad Rasaee, Ramezan Ali Taheri
Thymidine Kinase 1 (TK1) is traditionally a serum biomarker which is elevated in the early stages of malignancies. The diagnostic and prognostic role of TK1 for screening and monitoring the human malignancies has recently been investigated. Anti-human Thymidine Kinase 1 (TK1) aptamers were selected through 12 iterative rounds of SELEX from a DNA library. Aptamers pool of round 12, was amplified and PCR product was cloned on TA vector. Out of 85 colonies obtained, fifty two were identified as positive clones...
March 22, 2019: Biochemistry
Nirupa Thomas, Rekha Krishnapillai, P Ramakrishnan Bindhu, Priya Thomas
Background and Aim: Oral cancer is a major health problem in South East Asia. The immunohistochemical (IHC) overexpression of COX-2 in squamous cell carcinoma is well documented. This IHC study was undertaken to understand the COX-2 expression in different grades of oral squamous cell carcinoma (OSCC) and to compare the COX-2 expression in OSCC and normal mucosa. Material and Methods: A total of 30 cases of OSCC and 10 cases of normal mucosa and positive control colon cancer were studied for IHC expression of COX-2...
January 2019: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Jamal Naderi, Fariba Samani, Alireza Amooheidari, Shaghayegh Haghjooy Javanmard, Gelareh Vahabzadeh, Golnaz Vaseghi
Purpose: Breast and cervical cancers are the two most common cancers among women worldwide. Morphine is a potent analgesic for cancer pain, and radiation therapy is a conventional treatment for cancer. Unfortunately, the combined adjuvant cellular effects of morphine and ionizing radiation in cancer cells are largely unknown. Materials and Methods: In this study, we examined the effects of morphine and single radiation dose of 2 Gy on viability and survival fraction of human breast cancer cell line MDA-MB 231 and human cervical cancer cell line HeLa, by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assays...
March 2019: Journal of Cancer Research and Therapeutics
Sun Hee Jang, Yuzhu Jiang, Sun Shin, Seung Hyun Jung, Chan Kwon Jung, Yeun Jun Chung
PURPOSE: Papillary renal cell carcinoma ( PRCC ) gene, which located in 1q23.1, is recurrently amplified in non-small cell lung cancer (NSCLC). However, it is unknown whether PRCC is overexpressed in primary NSCLCs and whether PRCC overexpression contributes to lung tumorigenesis. In this study, we aimed to identify the profiles of PRCC expression in Korean NSCLC patients and to elucidate the role of PRCC overexpression on lung tumorigenesis. MATERIALS AND METHODS: We performed immunohistochemistry analysis with a tissue array containing 161 primary NSCLCs...
April 2019: Yonsei Medical Journal
Xiaohuan Tang, Xiaofang Qiao, Chao Chen, Yuanda Liu, Jiaming Zhu, Jingjing Liu
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse and metastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remain unclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention in the past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recent studies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association...
April 2019: Yonsei Medical Journal
Ludovica Taglieri, Francesco Saccoliti, Alice Nicolai, Giovanna Peruzzi, Valentina Noemi Madia, Valeria Tudino, Antonella Messore, Roberto Di Santo, Marco Artico, Samanta Taurone, Maurizio Salvati, Roberta Costi, Susanna Scarpa
Recently, some synthetic nitrogen-based heterocyclic molecules, such as PJ34, have shown pronounced antitumor activity. Therefore, we designed and synthesized new derivatives characterized by a nitrogen-containing scaffold and evaluated their antiproliferative properties in tumor cells. We herein report the effects of three newly synthesized compounds on cell lines from three different human cancers: triple-negative breast cancer, colon carcinoma and glioblastoma. We found that two of these compounds did not affect proliferation, while the third significantly inhibited replication of the three cell lines...
March 21, 2019: Investigational New Drugs
K Leigh Greathouse, James Robert White, R Noah Padgett, Brittany G Perrotta, Gregory D Jenkins, Nicholas Chia, Jun Chen
Objective: Obesity is a risk factor for colorectal cancer (CRC), accounting for more than 14% of CRC incidence. Microbial dysbiosis and chronic inflammation are common characteristics in both obesity and CRC. Human and murine studies, together, demonstrate the significant impact of the microbiome in governing energy metabolism and CRC development; yet, little is understood about the contribution of the microbiome to development of obesity-associated CRC as compared to individuals who are not obese...
2019: BMJ Open Gastroenterology
Haiou Qu, Weifeng Jiang, Yongxu Wang, Peng Chen
STOML2 (Stomatin-like protein 2) is up-regulated and acts as an oncogenic protein in multiple cancers. However, the role and regulatory mechanism of STOML2 in head and neck squamous cell carcinoma remain unclear. Here, we found that STOML2 is overexpressed and indicates poor outcomes in HNSCC. In addition, the expression of STOML2 correlates positively with T stage, lymph node metastasis and recurrence. Reduced STOML2 dramatically inhibits cell proliferation, colony formation and motility of HNSCC cells in vitro ...
2019: American Journal of Translational Research
Chenggang Yang, Yanbo Zhang, Wenfeng Du, Honggang Cheng, Chaobin Li
In this study, we investigated the role of eukaryotic translation initiation factor 3 subunit G (EIF3G) in colorectal cancer. Immunohistochemical analysis showed higher EIF3G expression in stage IV human colorectal cancer tissues than in adjacent normal tissues (P<0.01). EIF3G short hairpin RNA (shRNA) knockdown in HCT116 colon cancer cells reduced proliferation and increased apoptosis as compared to control. EIF3G knockdown also increased autophagy and reduced mTOR signaling, as evidenced by low phospho-AKT, phospho-S6K and phospho-4EBP1 levels...
2019: American Journal of Translational Research
Maciej Matyja, Artur Pasternak, Mirosław Szura, Michał Wysocki, Michał Pędziwiatr, Kazimierz Rembiasz
Introduction: Colonoscopy has been widely regarded as the gold standard in colorectal cancer (CRC) screening. Within recent years different endoscopic imaging techniques have been introduced to improve the quality of colonoscopy. The adenoma detection rate (ADR) is the single most important quality indicator for colonoscopy. The aim of this study was to evaluate the quality of CRC screening expressed by ADR in two different eras of endoscopic technology advancement. Material and methods: We conducted a dual-center study that enrolled 24 055 patients, who underwent colonoscopy as part of a national screening program...
March 2019: Archives of Medical Science: AMS
Yong Cao, Fei Dai, Yanmei Li, Lu Jia, Yunpeng Luan, Youjie Zhao
The roots of Codonopis bulleynana Forest ex diels ( cb Fed), locally known as Tsoong, have been used as a tonic food. Tsoong has wide range of pharmacological effects, including anticancer effects. In the present study, the anticancer activity of Tsoong and its potential molecular mechanisms were investigated. Using high throughput sequencing the apoptotic pathway was ranked as one of the most important pathways and the differential expressions of apoptosis-related genes such as Casp3, Casp6 and Apaf1 were identified...
March 2019: Saudi Journal of Biological Sciences
Chunxia Liu, Xiaojian Yao, Ming Li, Yaming Xi, Li Zhao
USP39 is one member of the cysteine proteases of the USP family, which represents the largest group of DeUbiquitinases with more than 50 members in humans. The roles of USP39 in human cancer have been widely investigated. However, the roles of USP39 in human leukemia and the underlying mechanism remain unknown. Here we reported the function of USP39 in human leukemia. We observed that the expression of USP39 was up-regulated in human leukemia cells and the high expression of USP39 was correlated with poor survival of the patients with leukemia...
March 21, 2019: Bioscience Reports
S P Breininger, F C Malcomson, S Afshar, D M Turnbull, L Greaves, J C Mathers
Colorectal cancer (CRC) is the third most common cancer globally. CRC risk is increased by obesity, and by its lifestyle determinants notably physical inactivity and poor nutrition. Obesity results in increased inflammation and oxidative stress which cause genomic damage and contribute to mitochondrial dysregulation and CRC risk. The mitochondrial dysfunction associated with obesity includes abnormal mitochondrial size, morphology and reduced autophagy, mitochondrial biogenesis and expression of key mitochondrial regulators...
March 22, 2019: Proceedings of the Nutrition Society
Weining Wu, Tianfu Yu, Youzhi Wu, Wei Tian, Junxia Zhang, Yingyi Wang
BACKGROUND: Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as molecular sponge for competing with microRNAs (miRNAs) to regulate downstream molecules in tumor progression. We previously reported that miR155 host gene (miR155HG), an lncRNA, and its derivative miR-155 promote epithelial-to-mesenchymal transition in glioma. However, the other biological functions and mechanisms of miR155HG sponging miRNAs have been unknown...
March 21, 2019: Journal of Experimental & Clinical Cancer Research: CR
Karin M Knudson, Kristin C Hicks, Sarah Alter, Jeffrey Schlom, Sofia R Gameiro
BACKGROUND: Immunotherapy targeting PD-1/PD-L1 fails to induce clinical responses in most patients with solid cancers. N-803, formerly ALT-803, is an IL-15 superagonist mutant and dimeric IL-15RαSushi-Fc fusion protein complex that enhances CD8+ T and NK cell expansion and function and exhibits anti-tumor efficacy in preclinical models. Previous in vitro studies have shown that IL-15 increases PD-L1 expression, a negative regulator of CD8+ T and NK cell function. Most reported preclinical studies administered N-803 intraperitoneally not subcutaneously, the current clinical route of administration...
March 21, 2019: Journal for Immunotherapy of Cancer
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