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https://read.qxmd.com/read/30773550/-orthodontic%C3%AE-orthognathic-treatment-stability-in-skeletal-class-iii-malocclusion-patients
#1
X J Wang, Y M Zhang, Y H Zhou
OBJECTIVE: To investigate stability of skeletal hard tissues, dental hard tissues and soft tissues after orthodonticorthognathic treatment in a long term. This study reviewed longitudinal changes in orthodontic-orthognathic patients of skeletal class III malocculsion, using lateral cephalometric radiographs in 3-12 years after treatment in comparison to treatment finishing. METHODS: Twenty-two patients with skeletal Class III malocclusion following orthodontic-orthognathic surgery in Peking University School and Hospital of Stomatology from January 1, 2000 to January 1, 2009 were observed...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/30717118/understanding-implementation-challenges-to-genetic-testing-for-familial-hypercholesterolemia-in-the-united-states
#2
Rachele M Hendricks-Sturrup, Christine Y Lu
Cardiovascular disease (CVD) is the leading cause of death in the United States (US), with familial hypercholesterolemia (FH) being a major inherited and genetic risk factor for premature CVD and atherosclerosis. Genetic testing has helped patients and providers confirm the presence of known pathogenic and likely pathogenic variations in FH-associated genes. Key organizations, such as the Centers for Disease Control and Prevention (CDC), American Heart Association (AHA), FH Foundation, and National Lipid Association (NLA), have recognized the clinical utility of FH genetic testing...
February 1, 2019: Journal of Personalized Medicine
https://read.qxmd.com/read/30698882/novel-nanocapsule-of-%C3%AE-lipoic-acid-reveals-pigmentation-improvement-%C3%AE-lipoic-acid-stimulates-the-proliferation-and-differentiation-of-keratinocyte-in-murine-skin-by-topical-application
#3
REVIEW
Yoshiki Kubota, Mina Musashi, Teruaki Nagasawa, Nanako Shimura, Rie Igarashi, Yoko Yamaguchi
α-Lipoic acid is amphipathic with low molecular sulphur-containing fatty acid and has strong antioxidant effects. It has been used at the purposes of anti-ageing, treatment of diabetic neuropathy, and supplement as antioxidant. Though α-lipoic acid is normally administered in oral or injection, it has not been used in a topical use via skin because of its bad penetration. We developed the novel nanocapsule of α-lipoic acid, named α-lipoactive (nLA), to improve skin permeability. The nLA is constructed as micelles of α-lipoic acid mixed with the non-ionic surfactant, and its surface of the micelles was coated with inorganic metal salts...
February 2019: Experimental Dermatology
https://read.qxmd.com/read/30603620/influence-of-heritability-on-craniofacial-soft-tissue-characteristics-of-monozygotic-twins-dizygotic-twins-and-their-siblings-using-falconer-s-method-and-principal-components-analysis
#4
Jeongmin Song, Hwa Sung Chae, Jeong Won Shin, Joohon Sung, Yun-Mi Song, Seung-Hak Baek, Young Ho Kim
Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip...
January 2019: Korean Journal of Orthodontics
https://read.qxmd.com/read/30586775/systematic-review-for-the-2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol
#5
Peter W F Wilson, Tamar S Polonsky, Michael D Miedema, Amit Khera, Andrzej S Kosinski, Jeffrey T Kuvin
BACKGROUND: The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular disease (ASCVD) events. Since publication of these guidelines, multiple randomized controlled trials evaluating nonstatin lipid-modifying medications have been published. METHODS: We performed a systematic review to assess the magnitude of benefit and/or harm from additional lipid-modifying therapies compared with statins alone in individuals with known ASCVD or at high risk of ASCVD...
November 10, 2018: Circulation
https://read.qxmd.com/read/30586774/2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol
#6
Scott M Grundy, Neil J Stone, Alison L Bailey, Craig Beam, Kim K Birtcher, Roger S Blumenthal, Lynne T Braun, Sarah de Ferranti, Joseph Faiella-Tommasino, Daniel E Forman, Ronald Goldberg, Paul A Heidenreich, Mark A Hlatky, Daniel W Jones, Donald Lloyd-Jones, Nuria Lopez-Pajares, Chiadi E Ndumele, Carl E Orringer, Carmen A Peralta, Joseph J Saseen, Sidney C Smith, Laurence Sperling, Salim S Virani, Joseph Yeboah
No abstract text is available yet for this article.
November 10, 2018: Circulation
https://read.qxmd.com/read/30565953/2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol-executive-summary
#7
Scott M Grundy, Neil J Stone, Alison L Bailey, Craig Beam, Kim K Birtcher, Roger S Blumenthal, Lynne T Braun, Sarah de Ferranti, Joseph Faiella-Tommasino, Daniel E Forman, Ronald Goldberg, Paul A Heidenreich, Mark A Hlatky, Daniel W Jones, Donald Lloyd-Jones, Nuria Lopez-Pajares, Chiadi E Ndumele, Carl E Orringer, Carmen A Peralta, Joseph J Saseen, Sidney C Smith, Laurence Sperling, Salim S Virani, Joseph Yeboah
No abstract text is available yet for this article.
November 10, 2018: Circulation
https://read.qxmd.com/read/30529169/hydrophobic-drug-adsorption-loss-to-syringe-filters-from-a-perspective-of-drug-delivery
#8
Xiaoli Li, Xiaoxu Ding, Chengying Bian, Shaoqun Wu, Miao Chen, Weizhuo Wang, Jingjie Wang, Lingyun Cheng
Filtering with a syringe filter is a common operation in pharmaceutical analysis. Ophthalmic research often has a limited amount of sample and low amount of drug which is vulnerable to filtering membrane adsorption loss but not well recognized in the research community. Current study investigated drug adsorption by 11 types of syringe filters for 4 hydrophobic compounds commonly encountered in transscleral drug delivery. Among the 11 types of syringe filters surveyed, polytetrafluoroethylene - NBA, polytetrafluoroethylene - NLA, and polypropylene filters caused the least adsorptive drug loss for these four drugs studied...
December 4, 2018: Journal of Pharmacological and Toxicological Methods
https://read.qxmd.com/read/30509163/integrated-physiologic-genomic-and-transcriptomic-strategies-involving-the-adaptation-of-allotetraploid-rapeseed-to-nitrogen-limitation
#9
Zhen-Hua Zhang, Ting Zhou, Qiong Liao, Jun-Yue Yao, Gui-Hong Liang, Hai-Xing Song, Chun-Yun Guan, Ying-Peng Hua
BACKGROUND: Nitrogen (N) is a macronutrient that is essential for optimal plant growth and seed yield. Allotetraploid rapeseed (An An Cn Cn , 2n = 4x = 38) has a higher requirement for N fertilizers whereas exhibiting a lower N use efficiency (NUE) than cereal crops. N limitation adaptation (NLA) is pivotal for enhancing crop NUE and reducing N fertilizer use in yield production. Therefore, revealing the genetic and molecular mechanisms underlying NLA is urgent for the genetic improvement of NUE in rapeseed and other crop species with complex genomes...
December 4, 2018: BMC Plant Biology
https://read.qxmd.com/read/30423394/systematic-review-for-the-2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines
#10
Peter W F Wilson, Tamar S Polonsky, Michael D Miedema, Amit Khera, Andrzej S Kosinski, Jeffrey T Kuvin
BACKGROUND: The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular disease (ASCVD) events. Since publication of these guidelines, multiple randomized controlled trials evaluating nonstatin lipid-modifying medications have been published. METHODS: We performed a systematic review to assess the magnitude of benefit and/or harm from additional lipid-modifying therapies compared with statins alone in individuals with known ASCVD or at high risk of ASCVD...
November 3, 2018: Journal of the American College of Cardiology
https://read.qxmd.com/read/30423393/2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines
#11
Scott M Grundy, Neil J Stone, Alison L Bailey, Craig Beam, Kim K Birtcher, Roger S Blumenthal, Lynne T Braun, Sarah de Ferranti, Joseph Faiella-Tommasino, Daniel E Forman, Ronald Goldberg, Paul A Heidenreich, Mark A Hlatky, Daniel W Jones, Donald Lloyd-Jones, Nuria Lopez-Pajares, Chiadi E Ndumele, Carl E Orringer, Carmen A Peralta, Joseph J Saseen, Sidney C Smith, Laurence Sperling, Salim S Virani, Joseph Yeboah
No abstract text is available yet for this article.
November 8, 2018: Journal of the American College of Cardiology
https://read.qxmd.com/read/30423391/2018-aha-acc-aacvpr-aapa-abc-acpm-ada-ags-apha-aspc-nla-pcna-guideline-on-the-management-of-blood-cholesterol-executive-summary-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines
#12
Scott M Grundy, Neil J Stone, Alison L Bailey, Craig Beam, Kim K Birtcher, Roger S Blumenthal, Lynne T Braun, Lynne T Braun, Sarah de Ferranti, Joseph Faiella-Tommasino, Daniel E Forman, Ronald Goldberg, Paul A Heidenreich, Mark A Hlatky, Daniel W Jones, Donald Lloyd-Jones, Nuria Lopez-Pajares, Chiadi E Ndumele, Carl E Orringer, Carmen A Peralta, Joseph J Saseen, Sidney C Smith, Laurence Sperling, Salim S Virani, Joseph Yeboah
No abstract text is available yet for this article.
November 3, 2018: Journal of the American College of Cardiology
https://read.qxmd.com/read/30374089/arabidopsis-nitrogen-limitation-adaptation-regulates-ore1-homeostasis-during-senescence-induced-by-nitrogen-deficiency
#13
Bong Soo Park, Tao Yao, Jun Sung Seo, Eriko Chi Cheng Wong, Nobutaka Mitsuda, Chung-Hao Huang, Nam-Hai Chua
Nitrogen is an important macronutrient in plants and its deficiency induces rapid leaf senescence. Two genes, ORE1 and NITROGEN LIMITATION ADAPTATION (NLA), have been implicated in regulating the senescence process but their relationship is unclear1,2 . Here, we show that nla and pho2 (also known as ubc24) plants develop rapid leaf senescence under nitrogen-starvation condition, whereas ore1 and nla/ore1 and pho2 (ubc24)/ore1 plants stay green. These results suggest that ORE1 acts downstream of NLA and PHO2 (UBC24)...
November 2018: Nature Plants
https://read.qxmd.com/read/30109038/femtosecond-laser-assisted-synthesis-of-silver-nanoparticles-and-reduced-graphene-oxide-hybrid-for-optical-limiting
#14
Yang Yu, Lihe Yan, Mengmeng Yue, Huanhuan Xu
Reduced graphene oxide (rGO) functionalized with silver nanoparticles (Ag NPs) is prepared using a femtosecond laser ablation in liquids method. By ablating the mixed aqueous solutions of silver nitrate and graphene oxide (GO) using femtosecond laser pulses, Ag ions and GO are simultaneously reduced and well-dispersed Ag NPs supported on rGO are obtained. The effect of laser power, irritation time and Ag ion concentration on the optical property and morphology of the products are systematically studied. The nonlinear optical responses of the functionalized graphene are studied using a nanosecond Z-scan technique...
July 2018: Royal Society Open Science
https://read.qxmd.com/read/30053193/northern-lights-assay-a-versatile-method-for-comprehensive-detection-of-dna-damage
#15
Bjarki Gudmundsson, Hans G Thormar, Albert Sigurdsson, Wendy Dankers, Margret Steinarsdottir, Stefan Hermanowicz, Stefan Sigurdsson, David Olafsson, Anna M Halldorsdottir, Stephen Meyn, Jon J Jonsson
DNA damage assays have various limitations in types of lesions detected, sensitivity, specificity and samples that can be analyzed. The Northern Lights Assay (NLA) is based on 2D Strandness-Dependent Electrophoresis (2D-SDE), a technique that separates nucleic acids based on length, strandness, structure and conformation changes induced by damage. NLA is run on a microgel platform in 20-25 min. Each specimen is analyzed in pairs of non-digested DNA to detect single- and double-stranded breaks (DSBs) and Mbo I-digested DNA to detect other lesions...
November 16, 2018: Nucleic Acids Research
https://read.qxmd.com/read/30038869/phylogenomic-relationship-and-evolutionary-insights-of-sweet-potato-viruses-from-the-western-highlands-of-kenya
#16
James M Wainaina, Elijah Ateka, Timothy Makori, Monica A Kehoe, Laura M Boykin
Sweet potato is a major food security crop within sub-Saharan Africa where 90% of Africa production occurs. One of the major limitations of sweet potato production are viral infections. In this study, we used a combination of whole genome sequences from a field isolate obtained from Kenya and those available in GenBank. Sequences of four sweet potato viruses: Sweet potato feathery mottle virus ( SPFMV ), Sweet potato virus C ( SPVC ), Sweet potato chlorotic stunt viru s ( SPCSV ), Sweet potato chlorotic fleck virus ( SPCFV ) were obtained from the Kenyan sample...
2018: PeerJ
https://read.qxmd.com/read/29963332/the-lake-catchment-lakecat-dataset-characterizing-landscape-features-for-lake-basins-within-the-conterminous-usa
#17
Ryan A Hill, Marc H Weber, Rick M Debbout, Scott G Leibowitz, Anthony R Olsen
Natural and human-related landscape features influence the ecology and water quality of lakes. Summarizing these features in a hydrologically meaningful way is critical to understanding and managing lake ecosystems. Such summaries are often done by delineating watershed boundaries of individual lakes. However, many technical challenges are associated with delineating hundreds or thousands of lake watersheds at broad spatial extents. These challenges can limit the application of analyses and models to new, unsampled locations...
June 1, 2018: Freshwater Science (Print)
https://read.qxmd.com/read/29889638/a-multidisciplinary-minimally-invasive-approach-combining-lacrimoscopy-and-fluoroscopically-guided-stenting-for-management-of-nasolacrimal-apparatus-obstruction-in-dogs
#18
Ann R Strom, William T N Culp, Brian C Leonard, Jonathan D Dear, Erik R Wisner, Lynelle R Johnson, David J Maggs
OBJECTIVE To describe and evaluate outcomes of a multidisciplinary, minimally invasive approach combining lacrimoscopy and fluoroscopically guided stenting for management of nasolacrimal apparatus (NLA) obstruction in dogs. DESIGN Prospective, nonrandomized clinical trial. ANIMALS 16 client-owned dogs with confirmed NLA obstruction. PROCEDURES Dogs underwent CT contrast dacryocystorhinography, rhinoscopy, and lacrimoscopy. Whenever possible, the NLA was stented, typically with fluoroscopic guidance. RESULTS Median duration of clinical signs prior to treatment was 3...
June 15, 2018: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/29785576/prognostic-impact-of-the-components-of-progressive-disease-on-survival-after-first-line-tyrosine-kinase-inhibitor-therapy-for-metastatic-renal-cell-carcinoma
#19
Takashi Ikeda, Hiroki Ishihara, Toshio Takagi, Tsunenori Kondo, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe
BACKGROUND: According to the Response Evaluation Criteria in Solid Tumors (RECIST) classification, progressive disease (PD) is defined as target lesion growth (TLG), unequivocal non-target lesion growth (NTLG), or new lesion appearance (NLA). The prognostic impact of the components of PD in tyrosine kinase inhibitor (TKI) therapy for metastatic renal cell carcinoma (mRCC) remains unknown. OBJECTIVE: We retrospectively evaluated the prognostic impact of these PD components on survival in patients with mRCC after first-line TKI therapy...
June 2018: Targeted Oncology
https://read.qxmd.com/read/29773582/activation-of-large-conductance-calcium-activated-potassium-channels-by-nitric-oxide-mediates-apelin-induced-relaxation-of-isolated-rat-coronary-arteries
#20
Amreen Mughal, Chengwen Sun, Stephen T O'Rourke
Apelin increases coronary blood flow, cardiac contractility, and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs are being developed for treating heart failure and related disorders; however, the molecular mechanisms underlying apelin-induced coronary vasodilation are unknown. This study aimed to elucidate the signaling pathways by which apelin causes smooth muscle relaxation in coronary arteries. Receptors for apelin (APJ receptors) were expressed in coronary arteries, as determined by Western blot and polymerase chain reaction analyses...
August 2018: Journal of Pharmacology and Experimental Therapeutics
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