Caitlin M Tilsed, Barzan A Sadiq, Tyler E Papp, Phurin Areesawangkit, Kenji Kimura, Estela Noguera-Ortega, John Scholler, Nicholas Cerda, Haig Aghajanian, Adrian Bot, Barbara Mui, Ying Tam, Drew Weissman, Carl H June, Steven M Albelda, Hamideh Parhiz
The use of lipid nanoparticles (LNP) to encapsulate and deliver mRNA has become an important therapeutic advance. In addition to vaccines, LNP-mRNA can be used in many other applications. For example, targeting the LNP with anti-CD5 antibodies (CD5/tLNP) can allow for efficient delivery of mRNA payloads to T cells to express protein. As the percentage of protein expressing T cells induced by an intravenous injection of CD5/tLNP is relatively low (4-20%), our goal was to find ways to increase mRNA-induced translation efficiency...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America