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National lipid Association

Prashantha Hebbar, Jehad Ahmed Abubaker, Mohamed Abu-Farha, Jaakko Tuomilehto, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an increased risk for metabolic disorders. Unlike the European population, the Arab population lacks well-established genetic risk determinants for metabolic disorders, and the transferability of established risk loci to this population has not been satisfactorily demonstrated. The most recent findings have identified over 240 genetic risk loci (with ~400 independent association signals) for type 2 diabetes, but thus far only 25 risk loci ( ADAMTS9 , ALX4, BCL11A, CDKAL1, CDKN2A/B , COL8A1, DUSP9, FTO, GCK, GNPDA2, HMG20A, HNF1A, HNF1B, HNF4A, IGF2BP2, JAZF1, KCNJ11, KCNQ1, MC4R, PPAR γ , SLC30A8, TCF7L2, TFAP2B, TP53INP1 , and WFS1 ) have been replicated in Arab populations...
2019: Frontiers in Endocrinology
Min Lu, Beirong Wu, Rong Qiao, Haoxiang Gu, Ying Din, Xiaoyan Dong
Objective: Studies have reported inconsistent results of the associations between lipids and insulin resistance (IR) and asthma. The purpose of this study was to examine the associations between abnormal serum lipid levels and homeostatic model assessment-insulin resistance (HOMA-IR) and the presence of current asthma in children and adolescents. Methods: The United States National Health and Nutrition Examination Survey database from 1999 to 2012 was randomly searched for children (aged 3-11 years) and adolescents (aged 12-19 years) with and without asthma and with complete demographic and clinical data of interest...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
Tuyen N M Hua, Min-Kyu Kim, Vu T A Vo, Jong-Whan Choi, Jang Hyun Choi, Hyun-Won Kim, Seung-Kuy Cha, Kyu-Sang Park, Yangsik Jeong
BACKGROUND: c-Src is a driver oncogene well-known for tumorigenic signaling, but little for metabolic function. Previous reports about c-Src regulation of glucose metabolism prompted us to investigate its function in other nutrient modulation, particularly in lipid metabolism. METHODS: Oil-red O staining, cell growth assay, and tumor volume measurement were performed to determine lipid amount and growth inhibitory effect of treatments in lung cancer cells and xenograft model...
February 9, 2019: EBioMedicine
Li Cai, Bingjie Ma, Lizi Lin, Yajun Chen, Wenhan Yang, Jun Ma, Jin Jing
With the increasing number of the one-child family, it is important to investigate whether the only-child status is associated with dyslipidemia. Among a national sample of 65,347 Chinese children aged 6-17 years, 16,100 lipid profiles were available. Children's height, weight, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured. In comparison to children with siblings, only children (OC) were more likely to be boys and live in urban areas...
February 5, 2019: Scientific Reports
Chun-Ming Chang, Tina H T Chiu, Chia-Chen Chang, Ming-Nan Lin, Chin-Lon Lin
Vegetarian diets may lower symptomatic gallstone disease via cholesterol lowering. This study aimed to examine the risk of symptomatic gallstone disease (GSD) in Taiwanese vegetarians vs. nonvegetarians in a prospective cohort and to explore if this association is related to cholesterol concentration. We prospectively followed 4839 participants, and in the 29,295 person-years of follow-up, 104 new incident GSD cases were confirmed. Diet was assessed through a validated food frequency questionnaire. Symptomatic GSD was ascertained through linkage to the Taiwan National Health Insurance Research Database...
February 4, 2019: Nutrients
Rachele M Hendricks-Sturrup, Christine Y Lu
Cardiovascular disease (CVD) is the leading cause of death in the United States (US), with familial hypercholesterolemia (FH) being a major inherited and genetic risk factor for premature CVD and atherosclerosis. Genetic testing has helped patients and providers confirm the presence of known pathogenic and likely pathogenic variations in FH-associated genes. Key organizations, such as the Centers for Disease Control and Prevention (CDC), American Heart Association (AHA), FH Foundation, and National Lipid Association (NLA), have recognized the clinical utility of FH genetic testing...
February 1, 2019: Journal of Personalized Medicine
Humberto Parada, Xuezheng Sun, Chiu-Kit Tse, Lawrence S Engel, Andrew F Olshan, Melissa A Troester
OBJECTIVES: To examine plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. METHODS: Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/DDT and lipid measurements from blood samples obtained on average 4...
February 1, 2019: Environment International
Xiangyan Ruan, Meng Li, Alfred O Mueck
BACKGROUND: Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with numerous severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. METHODS: We summarized the literature focused on the symptoms and negative long-term consequences of untreated PCOS and the existing options for the treatment. We reviewed the Pubmed and China National Knowledge Infrastructure databases and the relevant literature for the recent 20 years...
January 29, 2019: Current Pharmaceutical Design
Mohamed Hassan Elnaem, Mohamad Haniki Nik Mohamed, Hasniza Zaman Huri, Azarisman Shah Mohd Shah
Background: Cardiovascular diseases (CVDs) are the main complication leading to morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). There is a large amount of evidence to support the use of lipid-lowering therapy (LLT) for the prevention of CVD. This study aimed to assess the effectiveness and prescription quality of LLT among T2DM patients and to identify its associated factors. Methods: A multicenter cross-sectional study included 816 T2DM patients from four different primary care centers in Pahang, Malaysia...
2019: Therapeutics and Clinical Risk Management
Jen-Kuang Lee, Chi-Sheng Hung, Ching-Chang Huang, Ying-Hsien Chen, Pao-Yu Chuang, Jiun-Yu Yu, Yi-Lwun Ho
BACKGROUND: Telehealth programs are generally diverse in approaching patients, from traditional telephone calling and texting message and to the latest fourth-generation synchronous program. The predefined outcomes are also different, including hypertension control, lipid lowering, cardiovascular outcomes, and mortality. In previous studies, the telehealth program showed both positive and negative results, providing mixed and confusing clinical outcomes. A comprehensive and integrated approach is needed to determine which patients benefit from the program in order to improve clinical outcomes...
January 31, 2019: Journal of Medical Internet Research
Amrendra Mandal, Bikash Bhattarai, Paritosh Kafle, Mazin Khalid, Saikiran K Jonnadula, Jenny Lamicchane, Rajan Kanth, Vijay Gayam
Background Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver condition. Approximately 70% of type 2 diabetes mellitus (T2DM) patients have a fatty liver; the progression to non-alcoholic steatohepatitis (NASH) dramatically increases the risks of cirrhosis and hepatocellular carcinoma. The aim of our study was to assess the profile of liver enzymes in subjects with T2DM and NAFLD. Method This was a cross-sectional clinic-based study in patients with T2DM. An ultrasonography of the abdomen was done in all patients in order to examine the presence of a fatty liver...
November 23, 2018: Curēus
Kimberly E Kelly, Michael R Jiroutek, Kimberly Lewis, Brenda Zagar
PURPOSE: The American College of Cardiology (ACC) and the American Heart Association (AHA) introduced new lipid guidelines in late 2013 that were a vast departure from older guidelines. Concerns were raised regarding the likely increase in the number of adults who would be eligible for lipid-lowering therapy, namely moderate to high intensity statins. We sought to determine whether, in the first year after the ACC/AHA guideline release, more patients were prescribed statins, prescribed moderate- to high-intensity statins, and eligible for statins compared with the previous year...
January 25, 2019: Clinical Therapeutics
Junjia Zhu, Kevin Nelson, Jennifer Toth, Joshua E Muscat
BACKGROUND: Atherosclerosis and COPD are systemic inflammatory diseases that share common risk factors including cigarette smoking. A high level of nicotine dependence is emerging as a recently identified risk factor for pulmonary impairment, chronic obstructive pulmonary disease and tobacco-related cancers. We hypothesized that nicotine dependence is associated with the risk of atherosclerosis in long-term cigarette smokers. METHODS: A nested case-control study was conducted within the National Lung Cancer Screening Trial- American College of Radiology Imaging Network...
January 22, 2019: BMC Public Health
Patricia C Heyn, Alex Tagawa, Zhaoxing Pan, Sruthi Thomas, James J Carollo
AIM: To investigate the prevalence of metabolic syndrome and cardiovascular disease (CVD) risk factors and the association between common metabolic markers and Gross Motor Function Classification System (GMFCS) levels in ambulatory adults with cerebral palsy (CP). METHOD: Metabolic markers and GMFCS levels were evaluated in a cross-sectional study of 70 ambulatory adults with CP (34 males, 36 females; mean age 24y 5mo [SD 5y 4mo], range 18y 6mo-48y 8mo) to determine the prevalence of metabolic syndrome and CVD risk factors, and were compared to age-matched, population norms from the National Health and Nutrition Examination Survey (NHANES) registry...
January 20, 2019: Developmental Medicine and Child Neurology
David E Kaplan, Marina Serper, Rajni Mehta, Rena Fox, Binu John, Ayse Aytaman, Michelle Baytarian, Kristel Hunt, Jeffrey Albrecht, Basile Njei, Tamar H Taddei
BACKGROUND & AIMS: Concerns related to hepatotoxicity frequently lead to discontinuation or non-initiation of HMG-coA reductase therapy in patients with cirrhosis despite data supporting statin use. We aimed to investigate the independent effects of hyperlipidemia and statin exposure on mortality, hepatic decompensation, and hepatocellular carcinoma development in a large national cohort of patients with cirrhosis. METHODS: We performed a retrospective cohort study of patients with newly diagnosed cirrhosis from January 1, 2008 through June 30, 2016 in the Veterans Health administration...
January 17, 2019: Gastroenterology
Lindsey M Locks, Simeon Nanama, Yaw Addo, Bope Albert, Fanny Sandalinas, Ambroise Nanema, Ralph D Whitehead, Aashima Garg, Roland Kupka, Maria Elena Jefferds, Katie Tripp
Integrating small-quantity lipid-based nutrient supplements (SQ-LNS) into infant and young child feeding (IYCF) programs can increase consumption of essential nutrients among children in vulnerable populations; however, few studies have assessed the impact of integrated IYCF-SQ-LNS programs on IYCF practices. A two-year, enhanced IYCF intervention targeting pregnant women and infants (0-12 months) was implemented in a health zone in the Democratic Republic of Congo (DRC). The enhanced IYCF intervention included community- and facility-based counselling for mothers on handwashing, SQ-LNS and IYCF practices, plus monthly SQ-LNS distributions for children 6-12 months; a control zone received the national IYCF program (facility-based IYCF counselling with no SQ-LNS distributions)...
January 18, 2019: Maternal & Child Nutrition
K-Y Bian, H-F Jin, W Sun, Y-J Sun
OBJECTIVE: To investigate the effect of tauroursodeoxycholic acid (TUDCA) on neurological impairment induced by acute cerebral infarction (ACI) and its relevant mechanism of action. PATIENTS AND METHODS: A total of 60 male Sprague-Dawley (SD) rats were randomly divided into Sham group (n = 20), ACI group (n = 20), and TUDCA group (n = 20). The rat model of ACI in middle cerebral artery was established. TUDCA was intravenously injected into rats in the TUDCA group, while an equal amount of sodium bicarbonate solution was intravenously injected into the other two groups...
January 2019: European Review for Medical and Pharmacological Sciences
Shuo Yang, Rui-Xing Yin, Liu Miao, Qing-Hui Zhang, Yong-Gang Zhou, Jie Wu
BACKGROUD: Maonan nationality is a relatively isolated minority in China. Little is known about the endothelial lipase gene (LIPG) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. The present study was undertaken to detect the association of several LIPG SNPs and environmental factors with serum lipid levels in the Chinese Maonan and Han populations. METHODS: A total of 773 subjects of Maonan nationality and 710 participants of Han nationality were randomly selected from our previous stratified randomized samples...
January 18, 2019: Journal of Gene Medicine
Roni M Joentausta, Antti Rannikko, Teemu J Murtola
BACKGROUND: Improved prostate cancer (PCa) survival by statin use has been reported among PCa patients managed with radiation or androgen deprivation therapy (ADT), while results are controversial for men managed surgically. We evaluate the association between cholesterol-lowering medication with initiation of ADT and disease-specific death among PCa cases who underwent radical prostatectomy in Finland between 1995 and 2013. METHODS: The study cohort included 14 424 men with PCa who underwent radical prostatectomy in Finland between 1995 and 2013...
January 16, 2019: Prostate
Qinchang Chen, Lingling Li, Qingui Chen, Xixia Lin, Yonghui Li, Kai Huang, Chen Yao
BACKGROUND: Peripheral artery disease (PAD) is often asymptomatic but increases the risk of developing cardiovascular events. Due to the uncertainties regarding the quality of related guidelines and a lack of clear-cut evidence, we performed a systematic review and critical appraisal of these guidelines to evaluate their consistency of the recommendations in asymptomatic PAD population. METHODS: Guidelines in English between January 1st, 2000 to December 31th, 2017 were screened in databases including Medline via PubMed, EMBASE, the G-I-N International Guideline Library, the National Guidelines Clearinghouse, the Canadian Medication Association Infobase and the National Library for Health...
January 15, 2019: BMC Cardiovascular Disorders
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