Alessandra Tammaro, Eileen G Daniels, Iman M Hu, Kelly C 't Hart, Kim Reid, Rio P Juni, Loes M Butter, Goutham Vasam, Rashmi Kamble, Aldo Jongejan, Richard I Aviv, Joris J T H Roelofs, Eleonora Aronica, Reinier A Boon, Keir J Menzies, Riekelt H Houtkooper, Georges E Janssens
Aging increases the risk of age-related diseases, imposing substantial healthcare and personal costs. Targeting fundamental aging mechanisms pharmacologically can promote healthy aging and reduce this disease susceptibility. In this work, we employed transcriptome-based drug screening to identify compounds emulating transcriptional signatures of long-lived genetic interventions. We discovered compound 60 (Cmpd60), a selective histone deacetylase 1 and 2 (HDAC1/2) inhibitor, mimicking diverse longevity interventions...
January 19, 2024: IScience