keyword
Keywords Kidney epithelial to mesenchym...

Kidney epithelial to mesenchymal transition

https://read.qxmd.com/read/38372186/continuous-genetic-monitoring-of-transient-mesenchymal-gene-activities-in-distal-tubule-and-collecting-duct-epithelial-cells-during-renal-fibrosis
#21
JOURNAL ARTICLE
Zihang Xu, Shaotong Zhang, Tingting Han, Letong Cai, Simin Zhong, Xiaojie Yang, Shaohua Zhang, Yan Li, Kuo Liu, Bin Zhou, Xueying Tian
Epithelial cells (ECs) have been proposed to contribute to myofibroblasts or fibroblasts through epithelial-mesenchymal transition (EMT) during renal fibrosis. However, since EMT may occur dynamically, transiently, and reversibly during kidney fibrosis, conventional lineage tracing based on Cre-loxP recombination in renal ECs could hardly capture the transient EMT activity, yielding inconsistent results. Moreover, previous EMT research has primarily focused on renal proximal tubule ECs, with few reports of distal tubules and collecting ducts...
February 19, 2024: Journal of Cellular Biochemistry
https://read.qxmd.com/read/38368837/2-dodecyl-6-methoxycyclohexa-2-5-diene-1-4-dione-isolated-from-averrhoa-carambola-l-root-inhibits-high-glucose-induced-emt-in-hk-2-cells-through-targeting-the-regulation-of-mir-21-5p-smad7-signaling-pathway
#22
JOURNAL ARTICLE
Jingyi Li, Qiuling Pang, Xiaoman Huang, Huixian Jiang, Ganling Tang, Hui Yan, Yanxiang Guo, Xiaoyi Yan, Lang Li, Hongliang Zhang
OBJECTIVE: 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione (DMDD) isolated from Averrhoa carambola L. root, has been proven therapeutic effects on diabetic kidney disease (DKD). This research aims to assess DMDD's effects on DKD and to investigate its underlying mechanisms, to establish DMDD as a novel pharmaceutical agent for DKD treatment. METHODS: The human renal tubular epithelial (HK-2) cells were induced by high glucose (HG) to mimic DKD and followed by DMDD treatment...
February 16, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38367917/acox1-deficiency-induced-lipid-metabolic-disorder-facilitates-chronic-interstitial-fibrosis-development-in-renal-allografts
#23
JOURNAL ARTICLE
Yang-He Zhang, Bin Liu, Qingfei Meng, Dan Zhang, Hongxia Yang, Guangtao Li, Yuxiong Wang, Mingdi Liu, Nian Liu, Jinyu Yu, Si Liu, Honglan Zhou, Zhi-Xiang Xu, Yishu Wang
Chronic interstitial fibrosis presents a significant challenge to the long-term survival of transplanted kidneys. Our research has shown that reduced expression of acyl-coenzyme A oxidase 1 (ACOX1), which is the rate-limiting enzyme in the peroxisomal fatty acid β-oxidation pathway, contributes to the development of fibrosis in renal allografts. ACOX1 deficiency leads to lipid accumulation and excessive oxidation of polyunsaturated fatty acids (PUFAs), which mediate epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) reorganization respectively, thus causing fibrosis in renal allografts...
February 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38345033/kr%C3%A3-ppel-like-factor-4-modulates-the-mir-101-col10a1-axis-to-inhibit-renal-fibrosis-after-aki-by-regulating-epithelial-mesenchymal-transition
#24
JOURNAL ARTICLE
Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao
Acute kidney injury (AKI) can progress to renal fibrosis and chronic kidney disease (CKD), which reduces quality of life and increases the economic burden on patients. However, the molecular mechanisms underlying renal fibrosis following AKI remain unclear. This study tested the hypothesis that the Krüppel-like factor 4 (KLF4)/miR-101/Collagen alpha-1X (COL10A1) axis could inhibit epithelial-mesenchymal transition (EMT) and renal fibrosis after AKI in a mouse model of ischemia-reperfusion (I/R)-induced renal fibrosis and HK-2 cells by gene silencing, overexpression, immunofluorescence, immunohistochemistry, real-time quantitative PCR, Western blotting, dual-luciferase reporter assay, fluorescence in situ hybridization (FISH) and ELISA...
December 2024: Renal Failure
https://read.qxmd.com/read/38342062/forsythiaside-a-suppresses-renal-fibrosis-and-partial-epithelial-mesenchymal-transition-by-targeting-thbs1-through-the-pi3k-akt-signaling-pathway
#25
JOURNAL ARTICLE
Kuerban Tuoheti, Xiaojie Bai, Lijie Yang, Xiaolong Wang, Yuanfei Cao, Zuhaer Yisha, Linfa Guo, Shanzhi Zhan, Zhonghua Wu, Tongzu Liu
Renal fibrosis is a key feature of chronic kidney disease (CKD) progression, whereas no proven effective anti-fibrotic treatments. Forsythiaside A (FTA), derived from Forsythia suspense, has been found to possess nephroprotective properties. However, there is limited research on its anti-fibrotic effects, and its mechanism of action remains unknown. This study aimed to investigate the suppressive effects of FTA on renal fibrosis and explore the underlying mechanisms. In vitro, we established a HK2 cell model induced by transforming growth factor β1 (TGF-β1), and in vivo, we used a mice model induced by unilateral ureteral obstruction (UUO)...
February 10, 2024: International Immunopharmacology
https://read.qxmd.com/read/38340720/identification-of-a-core-transcriptional-program-driving-the-human-renal-mesenchymal-to-epithelial-transition
#26
JOURNAL ARTICLE
John-Poul Ng-Blichfeldt, Benjamin J Stewart, Menna R Clatworthy, Julie M Williams, Katja Röper
During kidney development, nephron epithelia arise de novo from fate-committed mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET). Downstream of fate specification, transcriptional mechanisms that drive establishment of epithelial morphology are poorly understood. We used human iPSC-derived renal organoids, which recapitulate nephrogenesis, to investigate mechanisms controlling renal MET. Multi-ome profiling via snRNA-seq and ATAC-seq of organoids identified dynamic changes in gene expression and chromatin accessibility driven by activators and repressors throughout MET...
February 2, 2024: Developmental Cell
https://read.qxmd.com/read/38340582/naa10-gene-expression-is-associated-with-mesenchymal-transition-dedifferentiation-and-progression-of-clear-cell-renal-cell-carcinoma
#27
JOURNAL ARTICLE
Nguyen Xuong Duong, Thao Nguyen, Minh-Khang Le, Norifumi Sawada, Satoru Kira, Tetsuo Kondo, Takeshi Inukai, Takahiko Mitsui
INTRODUCTION: We aimed to investigate the expression and prognostic role of NAA10 in clear cell renal cell carcinoma (ccRCC). MATERIAL AND METHODS: We performed a gene expression and survival analysis based on the human cancer genome atlas database of ccRCC patients (TCGA-KIRC). RESULTS: The patients in the TCGA-KIRC (n = 537) were divided into two subgroups: NAA10-low and NAA10-high expression groups. NAA10-high ccRCC exhibited higher T stages (p = 0...
February 7, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38318047/altenusin-a-fungal-metabolite-alleviates-tgf-%C3%AE-1-induced-emt-in-renal-proximal-tubular-cells-and-renal-fibrosis-in-unilateral-ureteral-obstruction
#28
JOURNAL ARTICLE
Natechanok Thipboonchoo, Somsak Fongsupa, Sanya Sureram, Suliporn Sa-Nguansak, Chatchai Kesornpun, Prasat Kittakoop, Sunhapas Soodvilai
Renal fibrosis is a pathological feature of chronic kidney disease (CKD), progressing toward end-stage kidney disease (ESKD). The aim of this study is to investigate the therapeutic potential of altenusin, a farnesoid X receptor (FXR) agonist derived from fungi, on renal fibrosis. The effect of altenusin was determined (i) in vitro using the transforming growth factor β1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) of human renal proximal tubular cells and (ii) in vivo using mouse unilateral ureteral obstruction (UUO)...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38316267/tmem16a-inhibits-renal-tubulointerstitial-fibrosis-via-wnt-%C3%AE-catenin-signaling-during-hypertension-nephropathy
#29
JOURNAL ARTICLE
Feng Wang, Yiqing Zhang, Min Gao, Xuelin Zeng
BACKGROUND AND OBJECTIVE: Hypertensive nephropathy is the second leading cause of end-stage renal disease, but its underlying pathogenesis remains unclear. Therefore, this study aimed to explore whether transmembrane protein 16 A (TMEM16A), the molecular basis of calcium-activated chloride channels (CaCC), is involved in the development and progression of hypertensive nephropathy. METHODS: In vivo and in vitro experiments were conducted using a hypertensive murine model and human kidney cells (HK-2 cells), respectively...
February 3, 2024: Cellular Signalling
https://read.qxmd.com/read/38308271/dysregulated-lipid-metabolism-is-associated-with-kidney-allograft-fibrosis
#30
JOURNAL ARTICLE
Linjie Peng, Chang Wang, Shuangjin Yu, Qihao Li, Guobin Wu, Weijie Lai, Jianliang Min, Guodong Chen
BACKGROUND: Interstitial fibrosis and tubular atrophy (IF/TA), a histologic feature of kidney allograft destruction, is linked to decreased allograft survival. The role of lipid metabolism is well-acknowledged in the area of chronic kidney diseases; however, its role in kidney allograft fibrosis is still unclarified. In this study, how lipid metabolism contributes to kidney allografts fibrosis was examined. METHODS: A comprehensive bioinformatic comparison between IF/TA and normal kidney allograft in the Gene Expression Omnibus (GEO) database was conducted...
February 3, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38297163/targeting-the-m-6-a-rna-methyltransferase-mettl3-attenuates-the-development-of-kidney-fibrosis
#31
JOURNAL ARTICLE
Hae Rim Jung, Jeonghwan Lee, Seung-Pyo Hong, Nayeon Shin, Ara Cho, Dong-Jin Shin, Jin Woo Choi, Jong-Il Kim, Jung Pyo Lee, Sung-Yup Cho
Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N6 -methyladenosine (m6 A) RNA methylation is associated with organ fibrosis. We investigated m6 A profile alterations and the inhibitory effect of RNA methylation in kidney fibrosis in vitro (TGF-β-treated HK-2 cells) and in vivo (unilateral ureteral obstruction [UUO] mouse model). METTL3-mediated signaling was inhibited using siRNA in vitro or the METTL3-specific inhibitor STM2457 in vivo and in vitro. In HK-2 cells, METTL3 protein levels increased in a dose- and time-dependent manner along with an increase in the cellular m6 A levels...
February 1, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38269100/hdac1-2-inhibitor-therapy-improves-multiple-organ-systems-in-aged-mice
#32
JOURNAL ARTICLE
Alessandra Tammaro, Eileen G Daniels, Iman M Hu, Kelly C 't Hart, Kim Reid, Rio P Juni, Loes M Butter, Goutham Vasam, Rashmi Kamble, Aldo Jongejan, Richard I Aviv, Joris J T H Roelofs, Eleonora Aronica, Reinier A Boon, Keir J Menzies, Riekelt H Houtkooper, Georges E Janssens
Aging increases the risk of age-related diseases, imposing substantial healthcare and personal costs. Targeting fundamental aging mechanisms pharmacologically can promote healthy aging and reduce this disease susceptibility. In this work, we employed transcriptome-based drug screening to identify compounds emulating transcriptional signatures of long-lived genetic interventions. We discovered compound 60 (Cmpd60), a selective histone deacetylase 1 and 2 (HDAC1/2) inhibitor, mimicking diverse longevity interventions...
January 19, 2024: IScience
https://read.qxmd.com/read/38213726/ldh-a-inhibitor-as-a-remedy-to-potentiate-the-anticancer-effect-of-docetaxel-in-prostate-cancer
#33
JOURNAL ARTICLE
Cagri Cakici, Benay Daylan, Ruveyde Safiye Unluer, Ebru Emekli-Alturfan, Sule Ayla, Hilal Eren Gozel, Pakize Yigit, Elif Yavuz Dokgoz, Turkan Yigitbasi
Increased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal transition (EMT) in the murine prostate cancer (PCa) model. The prostate cancer murine model was developed subcutaneously in 50 male B57CL/6 mice using the Tramp-C2 prostate cancer cell line. From the tumor tissue samples, apoptosis analysis was performed using TUNEL staining, and EMT was investigated using western blot and qPCR...
2024: Journal of Cancer
https://read.qxmd.com/read/38189094/cxc-chemokine-receptor-7-ameliorates-renal-fibrosis-by-inhibiting-%C3%AE-catenin-signaling-and-epithelial-to-mesenchymal-transition-in-tubular-epithelial-cells
#34
JOURNAL ARTICLE
Ping Meng, Chunli Liu, Jingchun Li, Ping Fang, Bo Yang, Wei Sun, Yunfang Zhang
Renal fibrosis is a common feature of various chronic kidney diseases. However, the underlying mechanism remains poorly understood. The CXC chemokine receptor (CXCR) family plays a role in renal fibrosis; however, the detailed mechanisms have not been elucidated. In this study, we investigated the potential role of CXCR7 in mediating renal fibrosis. CXCR7 expression is decreased in unilateral ischemia-reperfusion injury (UIRI) and unilateral ureteral obstruction mouse models. Furthermore, CXCR7 was specifically expressed primarily in the Lotus Tetragonolobus Lectin-expressing segment of tubules, was slightly expressed in the peanut agglutinin-expressing segment, and was barely expressed in the Dolichos biflorus agglutinin-expressing segment...
December 2024: Renal Failure
https://read.qxmd.com/read/38183745/oleoylethanolamide-attenuates-acute-to-chronic-kidney-injury-in-vivo-and-in-vitro-evidence-of-ppar-%C3%AE-involvement
#35
JOURNAL ARTICLE
Federica Comella, Adriano Lama, Claudio Pirozzi, Chiara Annunziata, Giuseppe Piegari, Federica Sodano, Stefania Melini, Orlando Paciello, Francisca Lago Paz, Rosaria Meli, Giuseppina Mattace Raso
Chronic kidney disease (CKD) development after acute kidney injury (AKI) involves multiple mechanisms, including inflammation, epithelial-mesenchymal transition (EMT), and extracellular matrix deposition, leading to progressive tubulointerstitial fibrosis. Recently, a central role for peroxisome-proliferator activated receptor (PPAR)-α has been addressed in preserving kidney function during AKI. Among endogenous lipid mediators, oleoylethanolamide (OEA), a PPAR-α agonist, has been studied for its metabolic and anti-inflammatory effects...
January 4, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38158021/downregulation-of-pdzk1-by-tgf-%C3%AE-1-promotes-renal-fibrosis-via-inducing-epithelial-mesenchymal-transition-of-renal-tubular-cells
#36
JOURNAL ARTICLE
Shuanghui Lu, Xiu Chen, Yujia Chen, Yingqiong Zhang, Jun Luo, Huidi Jiang, Luo Fang, Hui Zhou
Transforming growth factor-beta 1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of renal tubular cells promotes renal fibrosis and the progression of chronic kidney disease (CKD). PDZ domain-containing 1 (PDZK1) is highly expressed in renal tubular epithelial cells; however, its role in TGF-β1-induced EMT remains poorly understood. The present study showed that PDZK1 expression was extremely downregulated in fibrotic mouse kidneys and its negative correlation with TGF-β1 expression and the degree of renal fibrosis...
February 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38157643/natural-products-in-traditional-chinese-medicine-molecular-mechanisms-and-therapeutic-targets-of-renal-fibrosis-and-state-of-the-art-drug-delivery-systems
#37
REVIEW
Li Song, Wei Zhang, Shi-Yun Tang, Si-Min Luo, Pei-Yu Xiong, Jun-Yu Liu, Heng-Chang Hu, Ying-Qi Chen, Bo Jia, Qian-Hua Yan, Song-Qi Tang, Wei Huang
Renal fibrosis (RF) is the end stage of several chronic kidney diseases. Its series of changes include excessive accumulation of extracellular matrix, epithelial-mesenchymal transition (EMT) of renal tubular cells, fibroblast activation, immune cell infiltration, and renal cell apoptosis. RF can eventually lead to renal dysfunction or even renal failure. A large body of evidence suggests that natural products in traditional Chinese medicine (TCM) have great potential for treating RF. In this article, we first describe the recent advances in RF treatment by several natural products and clarify their mechanisms of action...
December 28, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38148068/decreased-smp30-expression-is-related-with-emt-in-the-kidneys-of-two-siberian-tigers-with-ckd
#38
JOURNAL ARTICLE
Yi-Rang Jung, Jae-Hyuk Yim, Young-Jin Lee, Sae-Bom Lee, Sung-Yong Heo, Seul-Gi Bae, Kyoo-Tae Kim, Young-Sam Kwon, Sang-Joon Park, Jin-Kyu Park, Tae-Hwan Kim
BACKGROUND/AIM: Chronic kidney disease (CKD) is one of the most common causes of mortality in wild non-domestic felidae. The molecular mechanism regulating renal fibrosis in nephropathy is not fully understood especially in the felidae. This study aimed to elucidate senescence marker protein 30 (SMP30) expression patterns and its relationship with epithelial-mesenchymal transition (EMT) by immunostaining in two necropsied Siberian tigers (Panthera tigris altaica) with CKD. MATERIALS AND METHODS: Two kidney samples from male Siberian tigers were fixed and tissue sections were stained for histopathological assay...
2024: In Vivo
https://read.qxmd.com/read/38130311/low-ogdhl-expression-affects-the-prognosis-and-immune-infiltration-of-kidney-renal-clear-cell-carcinoma
#39
JOURNAL ARTICLE
Zhouzhou Xie, Nanhui Chen
BACKGROUND: Oxoglutarate dehydrogenase-like ( OGDHL ) modulates glutamine metabolism to influence tumor progression. Therefore, we aimed to explore the potential role of OGDHL in the prognosis of kidney renal clear cell carcinoma (KIRC) and its effect on immune infiltration. METHODS: The Cancer Genome Atlas, Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, Human Protein Atlas, and The University of Alabama at Birmingham Cancer databases and the GSE53757 dataset were utilized to analyze expression difference and prognosis of OGDHL in tumor and normal tissue; diagnostic value was assessed using receiver operating characteristic curves...
November 30, 2023: Translational Cancer Research
https://read.qxmd.com/read/38092315/imperatorin-ameliorates-kidney-injury-in-diabetic-mice-by-regulating-the-tgf-%C3%AE-smad2-3-signaling-axis-epithelial-to-mesenchymal-transition-and-renal-inflammation
#40
JOURNAL ARTICLE
Sourav Kundu, Ankana Ghosh, Karan Singh Yadav, Madhav Nilakanth Mugale, Bidya Dhar Sahu
Diabetic nephropathy (DN) is a serious concern in patients with diabetes mellitus. Prolonged hyperglycemia induces oxidative damage, chronic inflammation, and build-up of extracellular matrix (ECM) components in the renal cells, leading to kidney structural and functional changes. Imperatorin (IMP) is a naturally occurring furanocoumarin derivative with proven antioxidative and anti-inflammatory properties. We investigated whether IMP could improve DN and employed high glucose (HG)-induced HK-2 cells and high-fat diet-fed streptozotocin (HFD/STZ)-generated DN experimental model in C57BL/6 J mice...
December 11, 2023: European Journal of Pharmacology
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