keyword
Keywords Kidney epithelial to mesenchym...

Kidney epithelial to mesenchymal transition

https://read.qxmd.com/read/38531801/lncrna-meg3-aggravates-renal-fibrosis-caused-by-unilateral-ureteral-obstruction-in-rats-by-activating-the-hedgehog-pathway
#1
JOURNAL ARTICLE
Pei Dong, Sheng Zhang, Da-Jun Hu, Rui Hou, Li Lei
BACKGROUND: The hedgehog signaling pathway exerts vital functions in regulating epithelial-to-mesenchymal transition (EMT) in renal interstitial fibrosis (RIF). It was reported that lncRNA-maternally expressed gene 3 (lncRNA Meg3) can regulate hepatic fibrosis by regulating the expression of smoothened (Smo) in the hedgehog signaling pathway. However, the specific role of lncRNA Meg3 in renal fibrosis resulting from unilateral ureteral obstruction (UUO) by regulating the hedgehog signaling pathway has not been reported...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38513598/dexmedetomidine-attenuates-lipopolysaccharide-induced-renal-cell-fibrotic-phenotypic-changes-by-inhibiting-necroinflammation-via-activating-%C3%AE-2-adrenoceptor-a-combined-randomised-animal-and-in-vitro-study
#2
JOURNAL ARTICLE
Qizhe Sun, Priyanka Kamath, Yibing Sun, Min Liang, Lingzhi Wu, Enqiang Chang, Qian Chen, Azeem Alam, Yi Liu, Hailin Zhao, Daqing Ma
BACKGROUND: Acute kidney injury (AKI) was reported to be one of the initiators of chronic kidney disease (CKD) development. Necroinflammation may contribute to the progression from AKI to CKD. Dexmedetomidine (Dex), a highly selective α2 -adrenoreceptor (AR) agonist, has cytoprotective and "anti-" inflammation effects. This study was designed to investigate the anti-fibrotic properties of Dex in sepsis models. METHODS: C57BL/6 mice were randomly treated with an i...
March 19, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38495834/integrative-analysis-and-risk-model-construction-for-super%C3%A2-enhancer%C3%A2-related-immune-genes-in-clear-cell-renal-cell-carcinoma
#3
JOURNAL ARTICLE
Zhenyu Bi, Jinghao Zhou, Yan Ma, Qingxin Guo, Boyang Ju, Haoran Zou, Zuhao Zhan, Feihong Yang, Han Du, Xiuguo Gan, Erlin Song
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sensitive to immunotherapy...
May 2024: Oncology Letters
https://read.qxmd.com/read/38489601/-microrna-141-3p-suppressed-the-progression-of-the-clear-cell-renal-cell-carcinoma-by-targeting-transforming-growth-factor-beta-2-gene-expression
#4
JOURNAL ARTICLE
Xinming Hu, Desheng Li, Jiangtao Zhan, Changmin Yang, Pengfei Wang, Xusong Meng, Sheng Xu, Xianping Che, Lei Xu
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of kidney epithelial cells, one of the most common tumors in the world. Transforming growth factor beta (TGFβ)1 is a crucial factor that induces epithelial-mesenchymal transition (EMT) in cancer cells. microRNA-141-3p (miR-141-3p) is a microRNA that is considered a tumor suppressor. However, the role and mechanism of miR-141-3p in TGFβ1-induced ccRCC cells are not fully understood. This study investigated the roles of miR-141-3p and its target gene in regulating EMT in ccRCC development...
March 15, 2024: DNA and Cell Biology
https://read.qxmd.com/read/38483736/expression-and-significance-of-sirt6-in-human-peritoneal-dialysis-effluents-and-peritoneal-mesothelial-cells
#5
JOURNAL ARTICLE
Shuai-Shuai Shi, Yi-Qiang Zhang, Lu-Qi Zhang, Yun-Feng Li, Xiao-Shuang Zhou, Rong-Shan Li
Sirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal dialysis (PD) remains unclear. We collected 110 PD patients with a duration of PD for more than 3 months and studied the influence of PD duration and history of peritonitis on SIRT6 levels in PD effluents (PDEs). We also analyzed the relationship between SIRT6 levels in PDEs and transforming growth factor beta 1 (TGF-β1), IL-6, PD duration, peritoneal function, PD ultrafiltration (UF), and glucose exposure...
March 14, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38482624/advances-in-the-treatment-of-kidney-disorders-using-mesenchymal-stem-cells
#6
JOURNAL ARTICLE
Shivam Rajput, Rishabha Malviya, Prerna Uniyal
Renal disease is a medical condition that poses a potential threat to the life of an individual and is related to substantial morbidity and mortality rates in clinical environments. The aetiology of this condition is influenced by multiple factors, and its incidence tends to increase with progressive aging. Although supportive therapy and kidney transplantation have potential advantages, they also have limitations in terms of mitigating the progression of KD. Despite significant advancements in the domain of supportive therapy, mortality rates in patients continue to increase...
March 13, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38480032/stratification-of-patients-with-renal-cell-carcinoma-by-the-abundance-of-sarcomatoid-features-reveals-differences-in-survival-and-the-underlying-pathobiology
#7
JOURNAL ARTICLE
Nicholas J Salgia, Wilhelm M Aubrecht, Lin Wang, Bebu Ram, Brianna J Wasik, Adil Khan, Kristopher Attwood, Jorge Daza, Mark D Long, Kevin H Eng, Bo Xu, Jason B Muhitch, Eric C Kauffman
Sarcomatoid renal cell carcinoma (sRCC) is histologically heterogeneous, with variable sarcomatoid amounts intermixed within epithelial carcinoma. However, the current classification for this aggressive disease is homogeneous and agnostic to the sarcomatoid proportion. We investigated whether sRCC subclassification has prognostic value and can reveal the biology underlying dedifferentiation and its clinical aggressiveness. On the basis of the intratumoral abundance of sarcomatoid features, cases were classified as sarcomatoid-high (≥10% sarcomatoid features) or sarcomatoid-low (<10% sarcomatoid features) in a cohort of 104 consecutive patients with sRCC undergoing nephrectomy at a single center...
March 12, 2024: European Urology Oncology
https://read.qxmd.com/read/38478501/melatonin-serves-as-a-novel-treatment-in-bladder-fibrosis-through-tgf-%C3%AE-1-smad-and-emt
#8
JOURNAL ARTICLE
Yang Zhang, Sun Gong, Weixin He, Jie Yuan, Di Dong, Jialong Zhang, Haomin Wang, Binghai Chen
BACKGROUND: Melatonin (MEL) is an indole amine molecule primarily produced in the pineal gland. Melatonin has been shown in numerous studies to have antifibrotic effects on the kidney, liver, and other organs. However, it is still unclear how melatonin works in bladder fibrosis. We explored how melatonin affects animals with bladder fibrosis and the underlying mechanisms. MATERIALS AND METHODS: MEL was used to treat human bladder smooth muscle cells (HBdSMCs) after they were stimulated with transforming growth factor-β1 (TGF-β1) in vitro...
2024: PloS One
https://read.qxmd.com/read/38456329/qi-dan-dihuang-decoction-ameliorates-renal-fibrosis-in-diabetic-rats-via-p38mapk-akt-mtor-signaling-pathway
#9
JOURNAL ARTICLE
Liuyan Kuang, Yanting You, Jieying Qi, Jieyu Chen, Xinghong Zhou, Shuai Ji, Jingru Cheng, Hiu Yee Kwan, Pingping Jiang, Xiaomin Sun, Mengting Su, Ming Wang, Wenxiao Chen, Ren Luo, Xiaoshan Zhao, Lin Zhou
CONTEXT: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. OBJECTIVE: This study reveals the mechanism by which QDD ameliorates DKD. MATERIALS AND METHODS: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics...
March 8, 2024: Environmental Toxicology
https://read.qxmd.com/read/38453525/-beclin-1-derived-peptide-mp1-attenuates-renal-fibrosis-by-inhibiting-the-wnt-%C3%AE-catenin-pathway
#10
JOURNAL ARTICLE
Jianfeng Zhang, Xiaocui Feng, Runling Yang, Jingya Bai, Feiyun Gao, Bangzhi Zhang
Renal fibrosis is distinguished by the abnormal deposition of extracellular matrix (ECM) and progressive loss of nephron function, with a lack of effective treatment options in clinical practice. In this study, we discovered that the Beclin-1-derived peptide MP1 significantly inhibits the abnormal expression of fibrosis and Epithelial-mesenchymal transition (EMT)-related markers, including α-Smooth muscle actin (α-SMA), Fibronectin (FN), Collagen I (Col I), Matrix metallopeptidase 2 (MMP2), Snail1, and Vimentin (Vim) both in vitro and in vivo...
March 7, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38452697/paris-polyphylla-ethanol-extract-and-polyphyllin-i-ameliorate-adenomyosis-by-inhibiting-epithelial-mesenchymal-transition
#11
JOURNAL ARTICLE
Ya-Xin Shi, Li Xu, Xin Wang, Ke-Ke Zhang, Cheng-Yuan Zhang, Hong-Yun Liu, Ping-Ping Ding, Wei Shi, Zhi-Yong Liu
BACKGROUND: The active ingredients of the Chinese medical herb Paris polyphylla, P. polyphylla ethanol extract (PPE) and polyphyllin I (PPI), potentially inhibit epithelial-mesenchymal transition (EMT) in tumors. However, the roles of these ingredients in inhibiting EMT in adenomyosis (AM) remain to be explored. PURPOSE: The primary goal of the study was to uncover the underlying molecular processes through which PPE and PPI suppress EMT in AM, alongside assessing the safety profiles of these substances...
February 22, 2024: Phytomedicine
https://read.qxmd.com/read/38449390/sirt7-mediated-transcription-of-fascin-in-hyperglycemic-glomerular-endothelial-cells-contributes-to-endmt-in-diabetic-nephropathy
#12
JOURNAL ARTICLE
Mengchen Wu, Yingxiang Hao, Xinwan Wu, Minmin Zhu, Xiangyuan Chen, Jie Qi, Zhuang Yu, Hongjiao Xu
Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide. It is reported that the endothelial-to-mesenchymal transition (EndMT) in glomerular endothelial cells plays an important role in DN. As a specific form of epithelial-to-mesenchymal transition, EndMT may involve common regulators of epithelial-to-mesenchymal transition. Fascin has been shown to mediate epithelial-to-mesenchymal transition. In addition, SirT7 has been confir med to contribute to inflammation in hyperglycemic endothelial cells via the modulation of gene transcription...
March 7, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38443979/integrative-analysis-of-chromatin-accessibility-and-transcriptome-landscapes-in-the-induction-of-peritoneal-fibrosis-by-high-glucose
#13
JOURNAL ARTICLE
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan'e Yao, Wei Wang, Guangbo Tang, Sen Zhou
BACKGROUND: Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis. METHODS: To elucidate the molecular mechanisms underlying this process, we conducted an integrated analysis of the transcriptome and chromatin accessibility profiles of human peritoneal mesothelial cells (HMrSV5) during high-glucose treatment. RESULTS: Our study identified 2775 differentially expressed genes (DEGs) related to high glucose-triggered pathological changes, including 1164 upregulated and 1611 downregulated genes...
March 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38430461/fto-mediated-m6a-mrna-demethylation-aggravates-renal-fibrosis-by-targeting-runx1-and-further-enhancing-pi3k-akt-pathway
#14
JOURNAL ARTICLE
Da-Xi Wang, Si-Yu Bao, Na-Na Song, Wei-Ze Chen, Xiao-Qiang Ding, Robert J Walker, Yi Fang
Chronic kidney disease (CKD) is a global health burden, with ineffective therapies leading to increasing morbidity and mortality. Renal interstitial fibrosis is a common pathway in advanced CKD, resulting in kidney function and structure deterioration. In this study, we investigate the role of FTO-mediated N6-methyladenosine (m6A) and its downstream targets in the pathogenesis of renal fibrosis. M6A modification, a prevalent mRNA internal modification, has been implicated in various organ fibrosis processes...
March 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38416339/cell-division-cycle-42-attenuates-high-glucose-treated-renal-tubular-epithelial-cell-apoptosis-fibrosis-and-inflammation-but-activates-the-pak1-akt-pathway
#15
JOURNAL ARTICLE
Shanshan Zheng, Na Zhao, Chuwen Feng, Jian Ma
BACKGROUND: Cell division cycle 42 (CDC42) modulates metabolism, inflammation, and fibrosis to engage in the pathology of diabetic complications. This study intended to further investigate the influence of CDC42 on viability, apoptosis, inflammation, epithelial-mesenchymal transition, and fibrosis in high glucose (HG)-treated renal tubular epithelial cells. METHODS: HK-2 cells were exposed to HG medium (30 mM) to establish the diabetic nephropathy (DN) cellular model, then the cells were transfected with scramble overexpression control (oeNC) or CDC42 overexpression (oeCDC42) vectors...
February 28, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38406569/ellagic-acid-ameliorates-renal-fibrogenesis-by-blocking-epithelial-to-mesenchymal-transition
#16
JOURNAL ARTICLE
Po-Yu Huang, Yi-Hsien Hsieh, Yi-Hsuan Ting, Chu-Che Lee, Jen-Pi Tsai
OBJECTIVES: Ellagic acid (EA), a kind of polyphenol found in numerous fruits and vegetables, has anti-inflammatory, anti-apoptotic, anti-oxidant, and anti-fibrotic effects against a variety of diseases, but its role in mediating renal fibrogenesis remains unknown. MATERIALS AND METHODS: We used an in vivo mouse unilateral ureteral obstruction (UUO) model and an in vitro model with HK-2 cell lines treated with EA and transforming growth factor β1 (TGF-β1)...
2024: Tzu chi medical journal
https://read.qxmd.com/read/38397744/therapeutic-potential-and-mechanisms-of-rosmarinic-acid-and-the-extracts-of-lamiaceae-plants-for-the-treatment-of-fibrosis-of-various-organs
#17
REVIEW
Yong Chool Boo
Fibrosis, which causes structural hardening and functional degeneration in various organs, is characterized by the excessive production and accumulation of connective tissue containing collagen, alpha-smooth muscle actin (α-SMA), etc. In traditional medicine, extracts of medicinal plants or herbal prescriptions have been used to treat various fibrotic diseases. The purpose of this narrative review is to discuss the antifibrotic effects of rosmarinic acid (RA) and plant extracts that contain RA, as observed in various experimental models...
January 24, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38394641/grp78-contributes-to-the-beneficial-effects-of-sglt2-inhibitor-on-proximal-tubular-cells-in-dkd
#18
JOURNAL ARTICLE
Atsuko Nakatsuka, Satoshi Yamaguchi, Jun Wada
Beneficial effects of SGLT2 inhibitors on kidney function are well-known; however, their molecular mechanisms are not fully understood. We focused on 78 kDa glucose-regulated protein (GRP78) and its interaction with SGLT2 and Integrin ß1 beyond the chaperone property of GRP78. In STZinduced diabetic mouse kidneys, GRP78, SGLT2, and Integrin ß1 increased in the plasma membrane fraction, while they were suppressed by canagliflozin. The altered subcellular localization of GRP78/Integrin ß1 in STZ mice promoted epithelial mesenchymal transition (EMT) and fibrosis, which were mitigated by canagliflozin...
February 23, 2024: Diabetes
https://read.qxmd.com/read/38390305/hif2%C3%AE-promotes-cancer-metastasis-through-tcf7l2-dependent-fatty-acid-synthesis-in-ccrcc
#19
JOURNAL ARTICLE
Jian Shi, Qingyang Lv, Daojia Miao, Zhiyong Xiong, Zhihao Wei, Songming Wu, Diaoyi Tan, Keshan Wang, Xiaoping Zhang
Recent studies have highlighted the notable involvement of the crosstalk between hypoxia-inducible factor 2 alpha (HIF2α) and Wnt signaling components in tumorigenesis. However, the cellular function and precise regulatory mechanisms of HIF2α and Wnt signaling interactions in clear cell renal cell carcinoma (ccRCC) remain elusive. To analyze the correlation between HIF2α and Wnt signaling, we utilized the Cancer Genome Atlas - Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) public database, HIF2α RNA sequencing data, and conducted luciferase reporter assays...
2024: Research: a science partner journal
https://read.qxmd.com/read/38382346/ps-mps-promotes-the-progression-of-inflammation-and-fibrosis-in-diabetic-nephropathy-through-nlrp3-caspase-1-and-tgf-%C3%AE-1-smad2-3-signaling-pathways
#20
JOURNAL ARTICLE
Lixiang Feng, Chen Chen, Xi Xiong, Xiong Wang, Xinxin Li, Qihui Kuang, Xiao Wei, Likun Gao, Xuan Niu, Qingwen Li, Jun Yang, Lili Li, Pengcheng Luo
BACKGROUND: Diabetic nephropathy (DN) is a prevalent chronic microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Understanding the progressive etiology of DN is critical for the development of effective health policies and interventions. Recent research indicated that polystyrene microplastics (PS-MPs) contaminate our diets and accumulate in various organs, including the liver, kidneys, and muscles. METHODS: In this study, ten-week-old db/db mice and db/m mice were fed...
February 20, 2024: Ecotoxicology and Environmental Safety
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