keyword
https://read.qxmd.com/read/38535622/differential-effect-of-chronic-morphine-on-neuronal-degeneration-in-male-vs-female-mice
#1
JOURNAL ARTICLE
Chet Brazile, Ruping Fan, Beau Benoit, Thomas Arnold, Nadejda Korneeva
Opioid abuse in the United States has been increasing at an alarming rate over the past 20 years. Sex differences are documented for the rates of opioid-related overdoses, abuse patterns, and drug-induced physiological effects. In our previous study, we demonstrated that chronic oxycodone administration in young female rats is associated with neurodegeneration in the brain. Males and females are susceptible to neurodegenerative diseases via differing mechanisms. To investigate whether opioid exposure affects males and females differently, we treated young mice with chronic morphine...
March 6, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#2
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535038/tumor-like-lesions-in-primary-angiitis-of-the-central-nervous-system-the-role-of-magnetic-resonance-imaging-in-differential-diagnosis
#3
REVIEW
Marialuisa Zedde, Manuela Napoli, Claudio Moratti, Claudio Pavone, Lara Bonacini, Giovanna Di Cecco, Serena D'Aniello, Ilaria Grisendi, Federica Assenza, Grégoire Boulouis, Thanh N Nguyen, Franco Valzania, Rosario Pascarella
Primary Angiitis of the Central Nervous System (PACNS) is a rare disease and its diagnosis is a challenge for several reasons, including the lack of specificity of the main findings highlighted in the current diagnostic criteria. Among the neuroimaging pattern of PACNS, a tumefactive form (t-PACNS) is a rare subtype and its differential diagnosis mainly relies on neuroimaging. Tumor-like mass lesions in the brain are a heterogeneous category including tumors (in particular, primary brain tumors such as glial tumors and lymphoma), inflammatory (e...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534984/clinical-research-into-central-nervous-system-inflammatory-demyelinating-diseases-related-to-covid-19-vaccines
#4
JOURNAL ARTICLE
Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Linyi Chen, Siew-Na Lim, Ming-Feng Liao, Long-Sun Ro
Various vaccines have been developed in response to the SARS-CoV-2 pandemic, and the safety of vaccines has become an important issue. COVID-19 vaccine-related central nervous system inflammatory demyelinating diseases (CNS IDDs) have been reported recently. We present one case of AstraZeneca vaccine-related myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease and a literature review of another 78 patients published from January 2020 to October 2022. Patients were divided into three vaccine types (viral vector, mRNA, and inactivated vaccines) for further analyses...
March 20, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534751/testosterone-inhibits-secretion-of-the-pro-inflammatory-chemokine-cxcl1-from-astrocytes
#5
JOURNAL ARTICLE
Malgorzata Turniak-Kusy, Maciej Studzian, Piotr Szpakowski, Piotr Kuchta, Kaja Smietanka, Claudia Mattern, Lukasz Pulaski, Bartosz Bielecki
Astrocytes play an important role in the regulation of the inflammatory response in the CNS, e.g., in demyelinating diseases. Since the chemokine CXCL1 is known to be secreted by astrocytes and to have a pro-inflammatory effect on immune cells in the CNS, we verified the effect of testosterone on its secretion in vitro (in the astrocytic cell line DI TNC1). Testosterone reduced the increase in CXCL1 production caused by the pro-inflammatory agent lysophosphatidylcholine and restored the basal production level of CXCL1...
March 6, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533708/body-fluid-markers-for-multiple-sclerosis-and-differential-diagnosis-from-atypical-demyelinating-disorders
#6
REVIEW
Angelika Bauer, Harald Hegen, Markus Reindl
INTRODUCTION: Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of the central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated in the current MS diagnostic criteria, could assist early MS diagnosis. AREAS COVERED: This review examines existing knowledge on a broad spectrum of body fluid markers in people with a first CNS demyelinating event, explores their potential to predict conversion to MS, to assess MS disease activity, as well as their utility to differentiate MS from atypical demyelinating disorders such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease...
March 27, 2024: Expert Review of Molecular Diagnostics
https://read.qxmd.com/read/38533505/ozanimod-mediated-remission-in-experimental-autoimmune-encephalomyelitis-is-associated-with-enhanced-activity-of-cns-cd27-low-nk-cell-subset
#7
JOURNAL ARTICLE
Doua Kamyan, Maya Hassane, Alanood Alnaqbi, Abdul-Kader Souid, Zakeya Al Rasbi, Abeer Al Tahrawi, Mariam Al Shamsi
BACKGROUND: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532189/encephalitis-like-episodes-with-cortical-edema-and-enhancement-in-patients-with-neuronal-intranuclear-inclusion-disease
#8
JOURNAL ARTICLE
Yu Shen, Kaiyan Jiang, Hanlin Liang, Ying Xiong, Ziwei Song, Bo Wang, Min Zhu, Yusen Qiu, Dandan Tan, Chengsi Wu, Jianwen Deng, Zhaoxia Wang, Daojun Hong
OBJECTIVES: Neuronal intranuclear inclusion disease (NIID) exhibited significant clinical heterogeneities. However, the clinical features, radiographic changes, and prognosis of patients with encephalitis-like NIID have yet to be systematically elucidated. METHODS: Clinical data including medical history, physical examination, and laboratory examinations were collected and analyzed. Skin and sural nerve biopsies were conducted on the patient. Repeat-primed PCR (RP-PCR) and fluorescence amplicon length PCR (AL-PCR) were used to detect the expansion of CGG repeat...
March 26, 2024: Neurological Sciences
https://read.qxmd.com/read/38529872/-neuropathy-in-n-hexane-poisoning
#9
JOURNAL ARTICLE
E S Druzhinina, A A Kozyreva, R T Bembeeva, A S Kozlovsky, V E Sokolova, I V Isaev, A G Narbutov, N N Zavadenko, O A Tikhonova
N-Hexane is a solvent widely used in manufacturing as a cleaner, degreaser and component of rubber cement. Chronic exposure to n -hexane either through contact with unprotected skin or inhalation can lead to the development of clinical symptoms and electrophysiological changes similar to those of inflammatory demyelinating polyneuropathy which requires careful differential diagnosis. This article presents three cases of severe predominantly motor polyneuropathy with demyelinating features in 15- and 16-year-old adolescents...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529033/probable-secondary-hemophagocytic-lymphohistiocytosis-manifesting-as-central-nervous-system-lesions-after-covid-19-vaccination-a-case-report
#10
Ju Hye Kim, Ji Yeon Chung, Jeong Bin Bong
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare systemic inflammatory disease commonly characterized by histiocyte infiltration in multiple organs, such as the liver, spleen, lymph nodes, bone marrow, and central nervous system. The clinical features of HLH include fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and elevated blood ferritin levels. HLH is categorized as either primary or secondary. Coronavirus disease 2019 (COVID-19) vaccines may occasionally trigger secondary HLH, which is related to hyperinflammatory syndrome...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38528529/p2x7-receptor-antagonists-modulate-experimental-autoimmune-neuritis-via-regulation-of-nlrp3-inflammasome-activation-and-th17-and-th1-cell-differentiation
#11
JOURNAL ARTICLE
Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang, Xiuju Chen
BACKGROUND: Guillain-Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Purinergic P2X7 receptors (P2X7R) play a crucial role in central nervous system inflammation. However, little is known about their role in the immune-inflammatory response within the peripheral nervous system. METHODS: Initially, we assessed the expression of purinergic P2X7R in the peripheral blood of patients with GBS using flow cytometry and qRT-PCR...
March 25, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38527054/the-proton-sensing-receptors-tdag8-and-gpr4-are-differentially-expressed-in-human-and-mouse-oligodendrocytes-exploring-their-role-in-neuroinflammation-and-multiple-sclerosis
#12
JOURNAL ARTICLE
Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska
Acidosis is one of the hallmarks of demyelinating central nervous system (CNS) lesions in multiple sclerosis (MS). The response to acidic pH is primarily mediated by a family of G protein-coupled proton-sensing receptors: OGR1, GPR4 and TDAG8. These receptors are inactive at alkaline pH, reaching maximal activation at acidic pH. Genome-wide association studies have identified a locus within the TDAG8 gene associated with several autoimmune diseases, including MS. Accordingly, we here found that expression of TDAG8, as opposed to GPR4 or OGR1, is upregulated in MS plaques...
2024: PloS One
https://read.qxmd.com/read/38527011/natalizumab-promotes-anti-inflammatory-and-repair-effects-in-multiple-sclerosis
#13
JOURNAL ARTICLE
Ragnhild Reehorst Lereim, Petra Nytrova, Astrid Guldbrandsen, Eva Kubala Havrdova, Kjell-Morten Myhr, Harald Barsnes, Frode S Berven
BACKGROUND: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system leading to demyelination and axonal loss. Relapsing-remitting multiple sclerosis (RRMS) is commonly treated by anti-inflammatory drugs, where one of the most effective drugs to date is the monoclonal antibody natalizumab. METHODS: The cerebrospinal fluid (CSF) proteome was analyzed in 56 patients with RRMS before and after natalizumab treatment, using label-free mass spectrometry and a subset of the changed proteins were verified by parallel reaction monitoring in a new cohort of 20 patients, confirming the majority of observed changes...
2024: PloS One
https://read.qxmd.com/read/38526582/myelin-oligodendrocyte-glycoprotein-antibody-disease-optic-neuritis-a-structure-function-paradox
#14
JOURNAL ARTICLE
Ruby Ross, Rachel Kenney, Laura J Balcer, Steven L Galetta, Lauren Krupp, Kimberly A O'Neill, Scott N Grossman
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a demyelinating disorder that most commonly presents with optic neuritis (ON) and affects children more often than adults. We report 8 pediatric patients with MOG-associated ON and characterize focal optical coherence tomography (OCT) abnormalities over time that help distinguish this condition from the trajectories of other demyelinating disorders. These OCT findings are examined in the context of longitudinal visual function testing...
March 25, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/38526238/targeted-neuroinflammation-mitigation-using-inflammasome-inhibiting-nanoligomers-is-therapeutic-in-an-experimental-autoimmune-encephalomyelitis-mouse-model
#15
JOURNAL ARTICLE
Sadhana Sharma, Sydney Risen, Vincenzo S Gilberto, Sean Boland, Anushree Chatterjee, Julie A Moreno, Prashant Nagpal
Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal cord and brain and is characterized by severe neuroinflammation, demyelination, and subsequent neuronal damage, resulting in symptoms like loss of mobility. While untargeted and pan-immunosuppressive therapies have proven to be disease-modifying and manage (or prolong the time between) symptoms in many patients, a significant fraction are unable to achieve remission...
March 25, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38525561/structural-mri-measures-are-associated-with-fatigue-severity-and-persistence-in-a-large-real-world-cohort-of-people-with-multiple-sclerosis
#16
JOURNAL ARTICLE
Alexandra C Simpson, Chen Hu, Ellen M Mowry, Robert T Naismith, Kathryn C Fitzgerald, Bardia Nourbakhsh
BACKGROUND: Results of research on radiological hallmarks of multiple sclerosis (MS) fatigue have been conflicting. OBJECTIVE: To investigate the associations of lesion and brain compartment volumes with fatigue severity and persistence in people with multiple sclerosis (PwMS). METHODS: The Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network collects standardized data during routine care of PwMS from 10 healthcare institutions...
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38525548/autologous-hematopoietic-stem-cells-transplantation-in-mogad
#17
JOURNAL ARTICLE
Sara Mariotto, Sara Carta
No abstract text is available yet for this article.
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38524138/autoimmune-nodopathy-with-anti-contactin-1-antibody-characterized-by-cerebellar-dysarthria-a-case-report-and-literature-review
#18
REVIEW
Jiajie Chen, Lingchun Liu, Hongyan Zhu, Jinming Han, Rong Li, Xiarong Gong, Hao Fu, Jingjing Long, Haixia Li, Qiang Meng
BACKGROUND: Autoimmune nodopathy (AN) has emerged as a novel diagnostic category that is pathologically different from classic chronic inflammatory demyelinating polyneuropathy. Clinical manifestations of AN include sensory or motor neuropathies, sensory ataxia, tremor, and cranial nerve involvement. AN with a serum-positive contactin-1 (CNTN1) antibody usually results in peripheral nerve demyelination. In this study, we reported a rare case of AN with CNTN1 antibodies characterized by the presence of CNTN1 antibodies in both serum and cerebrospinal fluid, which is associated with cerebellar dysarthria...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523325/torben-fog-a-danish-pioneer-in-a-multi-faceted-spectrum-of-multiple-sclerosis-research
#19
JOURNAL ARTICLE
Per Soelberg Sørensen, Stephan Bramow, Melinda Magyari, Lene Werdelin, Nils Koch-Henriksen, Patrick Vermersch, Finn Sellebjerg
Torben Fog was committed to multiple sclerosis (MS) research for more than four decades, starting before the defence of his thesis in 1948 and lasting until his death in 1987. His research was multi-facetted, making him one of the great pioneers in the study of essential parts of the pathology, immunology and treatment of MS. He has contributed with meticulous studies of the MS plaques, documenting the perivenous distribution of plaques in the spinal cord. He constructed a scoring system for the disability in MS and used a computer programme to calculate a total neurological deficit...
March 24, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38523205/clinical-features-of-adult-patients-with-positive-nmdar-igg-coexisting-with-mog-igg
#20
JOURNAL ARTICLE
Yuwei Dai, Yu Yuan, Fangfang Bi, Li Feng, Jing Li, Kai Hu, Si Chen, Qing Huang, Juan Li, Lili Long, Bo Xiao, Yuanyuan Xie, Yanmin Song
INTRODUCTION: This study was designed to analyze clinical and radiographic features of adult patients coexisting with NMDAR-IgG and MOG-IgG. METHODS: Eleven adult patients coexisting with NMDAR-IgG and MOG-IgG were collected from Xiangya Hospital, Central South University, between June 2017 and December 2021. Fifty-five patients with anti-NMDAR encephalitis and 49 with MOG-AD were served as controls. RESULTS: Onset age was 27 (IQR 20-34) years old...
March 25, 2024: Neurological Sciences
keyword
keyword
170021
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.