keyword
https://read.qxmd.com/read/37784031/diagnosis-and-treatment-of-chronic-lyme-primum-non-nocere
#21
JOURNAL ARTICLE
Prat Sébastien, Dalbin Jacques, Plotton Catherine, Gocko Xavier
BACKGROUND: Approximately 10% of patients experience prolonged symptoms after Lyme disease. PTLDS (post treatment Lyme disease syndrome) is a controversial topic. It has been described as a source of overdiagnosis and off-label treatment. This review aims to describe the diagnostic errors and adverse events associated with the diagnosis and treatment of PTLDS. METHODS: systematic review of the literature in the Medline and Cochrane Library databases, according to PRISMA criteria, including randomized clinical trials (RCT), observational studies, and case reports addressing diagnostic errors and adverse events published between January 2010 and November 2020 in English or French...
October 2, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37779775/cutaneous-leukocytoclastic-vasculitis-induced-by-apixaban-and-or-rivaroxaban-with-seronegative-anti-neutrophil-cytoplasmic-antibody-anca-titers-a-case-report-and-literature-review
#22
Mohamad El-Sabbagh, Sarah Rifai, Zainalabedeen M Sabah, Adam M Tarakji, Ahmad O Rifai, Sally Dahan, Kristin M Denig
A 45-year-old man presented with a diffuse petechial rash and a non-blanching palpable purpura, mainly on his lower extremities, some of which had coalesced, blistered, and ulcerated. The patient had a history of hypercoagulability and was chronically on anticoagulant medication. The rash appeared a week after starting apixaban 5 mg twice daily by mouth. Prior to that, he was receiving rivaroxaban. The rash was biopsied, which demonstrated cutaneous leukocytoclastic vasculitis (LCV). Serum anti-neutrophil cytoplasmic antibody (ANCA) titers were negative...
August 2023: Curēus
https://read.qxmd.com/read/37764145/comparison-of-the-efficacy-of-longer-versus-shorter-pulsed-high-dose-dapsone-combination-therapy-in-the-treatment-of-chronic-lyme-disease-post-treatment-lyme-disease-syndrome-with-bartonellosis-and-associated-coinfections
#23
JOURNAL ARTICLE
Richard I Horowitz, John Fallon, Phyllis R Freeman
Twenty-five patients with relapsing and remitting Borreliosis, Babesiosis, and bartonellosis despite extended anti-infective therapy were prescribed double-dose dapsone combination therapy (DDDCT), followed by one or several courses of High Dose Dapsone Combination Therapy (HDDCT). A retrospective chart review of these 25 patients undergoing DDDCT therapy and HDDCT demonstrated that 100% improved their tick-borne symptoms, and patients completing 6-7 day pulses of HDDCT had superior levels of improvement versus 4-day pulses if Bartonella was present...
September 12, 2023: Microorganisms
https://read.qxmd.com/read/37760644/neuropsychiatric-lyme-disease-and-vagus-nerve-stimulation
#24
REVIEW
Nicholas Biniaz-Harris, Mara Kuvaldina, Brian A Fallon
Lyme disease, the most common tick-borne disease in the United States, is caused by infection with the spirochete Borrelia burgdorferi . While most patients with acute Lyme disease recover completely if treated with antibiotics shortly after the onset of infection, approximately 10-30% experience post-treatment symptoms and 5-10% have residual symptoms with functional impairment (post-treatment Lyme disease syndrome or PTLDS). These patients typically experience pain, cognitive problems, and/or fatigue. This narrative review provides a broad overview of Lyme disease, focusing on neuropsychiatric manifestations and persistent symptoms...
August 22, 2023: Antibiotics
https://read.qxmd.com/read/37750203/autocrine-positive-feedback-of-tumor-necrosis-factor-from-activated-microglia-proposed-to-be-of-widespread-relevance-in-chronic-neurological-disease
#25
REVIEW
Ian A Clark, Bryce Vissel
Over a decade's experience of post-stroke rehabilitation by administering the specific anti-TNF biological, etanercept, by the novel perispinal route, is consistent with a wide range of chronically diminished neurological function having been caused by persistent excessive cerebral levels of TNF. We propose that this TNF persistence, and cerebral disease chronicity, largely arises from a positive autocrine feedback loop of this cytokine, allowing the persistence of microglial activation caused by the excess TNF that these cells produce...
October 2023: Pharmacology Research & Perspectives
https://read.qxmd.com/read/37727539/lyme-disease-an-overview
#26
REVIEW
Vikram K Mahajan
Lyme disease, a tick-borne multisystem disease, is caused by spirochete Borrelia burgdorferi (sensu lato) . It is a common illness in temperate countries, especially the United States, but the incidence is increasing across continents due to increasing reforestation, travel and adventure tourism, increased intrusion in the vector habitat, and changing habitat of the vector. Transmission primarily occurs via bite of an infected tick ( Ixodes spp.). The appearance of an erythema migrans rash following a tick bite is diagnostic of early Lyme disease even without laboratory evidence...
2023: Indian Dermatology Online Journal
https://read.qxmd.com/read/37711861/posttreatment-lyme-disease-syndrome-and-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-systematic-review-and-comparison-of-pathogenesis
#27
REVIEW
Natalie A Bai, Christie S Richardson
Lyme disease is the most common vector-borne illness in the United States and has been causing significant morbidity since its discovery in 1977. It is well-documented that about 10% of patients properly treated with antibiotics never fully recover, but instead go on to develop a chronic illness dubbed, posttreatment Lyme disease syndrome (PTLDS) characterized by severe fatigue, cognitive slowing, chronic pain, and sleep difficulties. This review includes 18 studies that detail the symptoms of patients with PTLDS and uses qualitative analysis to compare them to myalgic encephalitis/chronic fatigue syndrome (ME/CFS), a strikingly similar syndrome...
September 2023: Chronic Diseases and Translational Medicine
https://read.qxmd.com/read/37653608/developing-a-blood-cell-based-diagnostic-test-for-myalgic-encephalomyelitis-chronic-fatigue-syndrome-using-peripheral-blood-mononuclear-cells
#28
JOURNAL ARTICLE
Jiabao Xu, Tiffany Lodge, Caroline Kingdon, James W L Strong, John Maclennan, Eliana Lacerda, Slawomir Kujawski, Pawel Zalewski, Wei E Huang, Karl J Morten
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by debilitating fatigue that profoundly impacts patients' lives. Diagnosis of ME/CFS remains challenging, with most patients relying on self-report, questionnaires, and subjective measures to receive a diagnosis, and many never receiving a clear diagnosis at all. In this study, a single-cell Raman platform and artificial intelligence are utilized to analyze blood cells from 98 human subjects, including 61 ME/CFS patients of varying disease severity and 37 healthy and disease controls...
August 31, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37641764/neurosarcoidosis-presenting-with-confusion-and-speech-alteration
#29
Sara Heard, Flavia Miller Machado, Jai Juganya Ponnusamy
Neurosarcoidosis (NS) is a rare manifestation of sarcoidosis, a multisystem inflammatory granulomatous disease. We describe a unique case of NS with confusion and speech alteration as presenting symptoms. A 65-year-old male with a history of Ramsay Hunt syndrome and Lyme infection presented to the emergency room after an acute episode of disorientation, garbled speech, and left facial droop, along with months of worsening generalized fatigue, gait ataxia, left-sided periorbital headaches, bilateral peripheral neuropathy, and bladder disturbance...
July 2023: Curēus
https://read.qxmd.com/read/37528399/lyme-borreliosis-diagnosis-state-of-the-art-of-improvements-and-innovations
#30
REVIEW
Mickaël Guérin, Marc Shawky, Ahed Zedan, Stéphane Octave, Bérangère Avalle, Irene Maffucci, Séverine Padiolleau-Lefèvre
With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks of the genus Ixodes and caused by bacteria Borrelia burgdorferi sensu lato, LB occurs with various symptoms, such as erythema migrans, which is characteristic, whereas others involve blurred clinical features such as fatigue, headaches, arthralgia, and myalgia. The diagnosis of Lyme borreliosis, based on a standard two-tiered serology, is the subject of many debates and controversies, since it relies on an indirect approach which suffers from a low sensitivity depending on the stage of the disease...
August 1, 2023: BMC Microbiology
https://read.qxmd.com/read/37512931/the-use-of-natural-bioactive-nutraceuticals-in-the-management-of-tick-borne-illnesses
#31
REVIEW
Samuel M Shor, Sunjya K Schweig
The primary objective of this paper is to provide an evidence-based update of the literature on the use of bioactive phytochemicals, nutraceuticals, and micronutrients (dietary supplements that provide health benefits beyond their nutritional value) in the management of persistent cases of Borrelia burgdorferi infection (Lyme disease) and two other tick-borne pathogens, Babesia and Bartonella species. Recent studies have advanced our understanding of the pathophysiology and mechanisms of persistent infections...
July 5, 2023: Microorganisms
https://read.qxmd.com/read/37471146/autoimmunity-to-synovial-extracellular-matrix-proteins-in-patients-with-post-infectious-lyme-arthritis
#32
JOURNAL ARTICLE
Korawit Kanjana, Klemen Strle, Robert B Lochhead, Annalisa Pianta, Laura M Mateyka, Qi Wang, Sheila L Arvikar, David E Kling, Cameron A DeAngelo, Lucy Curham, Alan G Barbour, Catherine E Costello, James J Moon, Allen C Steere
BACKGROUND: Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked up-regulation of HLA-DR molecules, including in post-infectious Lyme arthritis (LA). However, the identity of HLA-DR-presented peptides and therefore, the reasons for these associations have frequently remained elusive. METHODS: Using immunopeptidomics to detect HLA-DR-presented peptides from synovial tissue, we identified T cell epitopes from 3 extracellular matrix (ECM) proteins in patients with post-infectious LA, identified potential Borreliella burgdorferi (Bb)-mimic epitopes, and characterized T and B cell responses to these peptides or proteins...
July 20, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37351009/does-biological-sex-matter-in-lyme-disease-the-need-for-sex-disaggregated-data-in-persistent-illness
#33
JOURNAL ARTICLE
Lorraine Johnson, Mira Shapiro, Sylvia Janicki, Jennifer Mankoff, Raphael B Stricker
BACKGROUND: Biological sex should be included as an important variable in clinical research studies to identify outcome differences between men and women. Very few Lyme disease studies were designed to consider sex-based differences or gender bias as an important component of the research design. METHODS: To assess sex-based differences in Lyme disease patients who were clinically diagnosed and reported remaining ill for six or more months after receiving antibiotic treatment, we analyzed self-reported clinical data from 2170 patients in the MyLymeData patient registry...
2023: International Journal of General Medicine
https://read.qxmd.com/read/37182295/contesting-misrecognition-online-experiences-of-epistemic-in-justice-by-vloggers-with-contested-illnesses
#34
JOURNAL ARTICLE
I P Irene Groenevelt, M L Marjolein de Boer
Contested illnesses, such as fibromyalgia, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and chronic Lyme disease (CLD), are surrounded by polemic debates regarding their etiology, symptomology, treatment, and even their existence. People who suffer from these contested illnesses arguably also suffer from "epistemic injustice." This concept, coined by the philosopher Miranda Fricker, captures how people's knowledge may be discredited because of identity prejudices. In our paper, this concept is used to understand how seven Dutch women with contested illnesses experience the emancipatory potential of their vlogging practices...
May 7, 2023: Social Science & Medicine
https://read.qxmd.com/read/37172117/bilateral-knee-lyme-arthritis-in-children-a-report-of-3-cases
#35
JOURNAL ARTICLE
Thomas A Gagliardi, Avinesh Agarwalla, Philip K Johnson, Jennifer Leong, Damon A DelBello
CASES: Three patients presented with bilateral knee pain, effusion, decreased range of motion, and difficulty ambulating. Synovial analysis demonstrated leukocytosis in bilateral knees with positive serum enzyme-linked immunosorbent assay. All cases were managed with antibiotics and anti-inflammatories. One patient developed chronic Lyme arthritis and underwent arthroscopic synovectomy. CONCLUSION: Bilateral knee arthritis is a possible presentation of Lyme disease in children...
April 1, 2023: JBJS Case Connector
https://read.qxmd.com/read/37101730/a-comprehensive-review-of-herbal-supplements-used-for-persistent-symptoms-attributed-to-lyme-disease
#36
REVIEW
Allison Thompson, Lauren M Hynicka, Kalpana D Shere-Wolfe
CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years. Patients who attribute chronic symptoms to Lyme disease commonly use herbal supplements. The complexity, variability in dose and formulation, and lack of data for these herbal compounds make it difficult to assess their efficacy and safety. OBJECTIVE: This review examines the evidence for the antimicrobial activity, safety, and drug-drug interactions of 18 herbal supplements that patients commonly use for treatment of persistent symptoms attributed to Lyme disease...
March 2023: Integrative Medicine
https://read.qxmd.com/read/37067290/borrelia-burgdorferi-engages-mammalian-type-i-ifn-responses-via-the-cgas-sting-pathway
#37
JOURNAL ARTICLE
Lauren C Farris, Sylvia Torres-Odio, L Garry Adams, A Phillip West, Jenny A Hyde
Borrelia burgdorferi, the etiologic agent of Lyme disease, is a spirochete that modulates numerous host pathways to cause a chronic, multisystem inflammatory disease in humans. B. burgdorferi infection can lead to Lyme carditis, neurologic complications, and arthritis because of the ability of specific borrelial strains to disseminate, invade, and drive inflammation. B. burgdorferi elicits type I IFN (IFN-I) responses in mammalian cells and tissues that are associated with the development of severe arthritis or other Lyme-related complications...
April 17, 2023: Journal of Immunology
https://read.qxmd.com/read/37009275/case-report-subacute-transverse-myelitis-with-gait-preservation-secondary-to-lyme-disease-and-a-review-of-the-literature
#38
Charlotte Colot, Catherine Adler, Céline Mignon, Alessandro De Leucio, Patrice Jissendi, Jean Fonteyne, Alec Aeby
Subacute presentation with gait preservation is rare in the initial presentation of transverse myelitis (TM) in children. Lyme TM is poorly described in the literature. Here, we present the case of a 10-year-old boy who presented with neck pain with irradiation in the upper limbs for 13 days, accompanied by a right latero-torticollis. Magnetic resonance imaging (MRI) of the spine showed a hypersignal in the centromedullary T2 weighted image (WI) between C1 and C7, which was suggestive of cervical TM. A lumbar puncture revealed pleocytosis and proteinorachia...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/36958992/systematic-comparisons-between-lyme-disease-and-post-treatment-lyme-disease-syndrome-in-the-u-s-with-administrative-claims-data
#39
JOURNAL ARTICLE
Ming Kei Chung, Mariaelena Caboni, Philip Strandwitz, Anthony D'Onofrio, Kim Lewis, Chirag J Patel
BACKGROUND: Post-treatment Lyme disease syndrome (PTLDS) is used to describe Lyme disease patients who have the infection cleared by antibiotic but then experienced persisting symptoms of pain, fatigue, or cognitive impairment. Currently, little is known about the cause or epidemiology of PTLDS. METHODS: We conducted a data-driven study with a large nationwide administrative dataset, which consists of more than 98 billion billing and 1.4 billion prescription records between 2008 and 2016, to identify unique aspects of PTLDS that could have diagnostic and etiologic values...
April 2023: EBioMedicine
https://read.qxmd.com/read/36830172/disulfiram-mitigating-unintended-effects
#40
REVIEW
Martha M Grout, Kenneth B Mitchell
Lyme disease caused by infection with a multitude of vector-borne organisms can sometimes be successfully treated in its very early stages. However, if diagnosis is delayed, this infection can become disseminated and, like another spirochetal infection syphilis, can affect multiple organ systems in the body, causing a wide variety of life-altering symptoms. Conventional antibiotic therapy may not be effective in eradicating the symptoms of the disease we know as Lyme disease. The recent literature has suggested that disulfiram (DSM) may be a potent drug in the armamentarium of physicians who treat chronic Lyme disease...
January 28, 2023: Antibiotics
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