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https://read.qxmd.com/read/30785647/association-between-hereditary-predisposition-to-common-cancers-and-congenital-multimalformations
#1
Fabrice Kwiatkowski, Isabelle Perthus, Nancy Uhrhammer, Christine Francannet, Marie Arbre, Yannick Bidet, Yves-Jean Bignon
INTRODUCTION: in a previous article we reported that mutations favoring cancer at adulthood seemed to improve fertility and limit miscarriages. Because spontaneous abortion may result from anomalies in embryo, we questioned if an increased frequency of congenital malformation could be evidenced among cancer prone families. METHODS: oncogenetics database (≈193,000 members) of the comprehensive cancer center Jean Perrin was crossed with regional registry of congenital malformations (≈10,000)...
February 20, 2019: Congenital Anomalies
https://read.qxmd.com/read/30784072/first-report-of-the-rare-rhce-depleted-d-phenotype-in-sixteen-people-of-iranian-origin
#2
Ehsan Shahverdi, Mostafa Moghaddam, Hassan Abolghasemi
BACKGROUND AND OBJECTIVES: In transfusion medicine, it may be a challenge to acquire compatible blood for patients who have clinically important alloantibodies to high-prevalence antigens. The aim of this study was to study prevalence of rare D-- phenotype in samples from patients and their relatives referred to the Immunohematology reference laboratory of the Iranian Blood Transfusion Organization and the detection and identification of the phenotype and associated antibodies, particularly in an antenatal setting...
February 19, 2019: Vox Sanguinis
https://read.qxmd.com/read/30755555/maternal-death-audit-in-a-tertiary-hospital
#3
K Guha, F Ashraf
Maternal death audit in a tertiary hospital was conducted to improve the quality of maternal health care. In this descriptive type cross sectional study, maternal deaths were reviewed and factors responsible for maternal death were identified and noted in Rajshahi Medical College Hospital from July 2008 to June 2009. During the study period total 63 maternal deaths recorded among 7560 deliveries. Almost 43% deceased mother was less than 25 years of age. 39.7% mother died during their first pregnancy. Among the delivery group 46% cases delivered vaginally...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30740546/making-mothers-in-jail-carceral-reproduction-of-normative-motherhood
#4
Carolyn Sufrin
The over-reliance on incarceration in the USA is a racialized phenomenon which has affected millions of families - disproportionately people of colour - reconfiguring kinship around the criminal legal system. Mass incarceration, then, disrupts conventional modes of reproduction and threatens reproductive justice, separates families and funnels children into foster care, diverts funds from social services into prisons, restricts women's access to abortion and adequate pregnancy care, shackles women in childbirth, and incarcerates people during their prime reproductive years...
November 2018: Reproductive Biomedicine & Society Online
https://read.qxmd.com/read/30704413/genome-analysis-of-salmonella-enterica-subsp-diarizonae-isolates-from-invasive-human-infections-reveals-enrichment-of-virulence-related-functions-in-lineage-st1256
#5
Joaquín Giner-Lamia, Pablo Vinuesa, Laura Betancor, Claudia Silva, Julieta Bisio, Lorena Soleto, José A Chabalgoity, José Luis Puente, Francisco García-Del Portillo
BACKGROUND: Salmonella enterica subsp. diarizonae (IIIb) is frequently isolated from the environment, cold-blooded reptiles, sheep and humans; however only a few studies describe the isolation of this subspecies from invasive human infections. The factors contributing to this unusual behavior are currently unknown. RESULTS: We report here the genome features of two diarizonae strains, SBO13 and SBO27, isolated from endocervical tissue collected post-abortion and from cerebrospinal fluid of a newborn child, respectively, in the city of Santa Cruz, Bolivia...
January 31, 2019: BMC Genomics
https://read.qxmd.com/read/30703238/-analysis-of-cytogenetic-characteristics-and-fertility-of-carriers-of-complex-chromosomal-rearrangements-from-henan-region
#6
Peng Dai, Shanshan Gao, Yaqin Hou, Xiangdong Kong
OBJECTIVE: To explore cytogenetic characteristics and fertility of carriers of complex chromosome rearrangements (CCR) from Henan region. METHODS: G-banded karyotyping analysis was carried out on peripheral blood lymphocytes derived from 160 601 patients with reproductive abnormalities. Relevant literature was retrieved from domestic and overseas databases. Cytogenetic characteristics and clinical data of CCR carriers were analyzed. RESULTS: Twenty-seven CCR carriers were identified among the 160 601 patients...
February 10, 2019: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://read.qxmd.com/read/30695903/-risk-factors-and-sonographic-findings-associated-with-the-type-of-placenta-accreta-spectrum-disorders
#7
H J Zhang, R C Dou, L Lin, Q Y Wang, B E Huang, X L Zhao, D J Chen, Y L Ding, H J Ding, S H Cui, W S Zhang, H Xin, W R Gu, Y L Hu, G F Ding, H B Qi, L Fan, Y Y Ma, J L Lu, Y Yang, L Lin, X C Luo, X H Zhang, S R Fan, H X Yang
Objective: To evaluate the risk factors and sonographic findings of pregnancies complicated by placenta increta or placenta percreta. Methods: Totally, 2 219 cases were retrospectively analyzed from 20 tertiary hospitals in China from January 2011 to December 2015. The data were collected based on the original case records. All cases were divided into two groups, the placenta increta (PI) group (79.1%, 1 755/2 219) and the placenta percreta (PP) group (20.9%, 464/2 219) , according to the degree of placental implantation...
January 25, 2019: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/30691391/identification-of-lncrnas-involved-in-rice-ovule-development-and-female-gametophyte-abortion-by-genome-wide-screening-and-functional-analysis
#8
Helian Liu, Ruihua Wang, Bigang Mao, Bingran Zhao, Jianbo Wang
BACKGROUND: As important female reproductive tissues, the rice (Oryza sativa L.) ovule and female gametophyte is significant in terms of their fertility. Long noncoding RNAs (lncRNAs) play important and wide-ranging roles in the growth and development of plants and have become a major research focus in recent years. Therefore, we explored the characterization and expression change of lncRNAs during ovule development and female gametophytic abortion. RESULTS: In our study, whole-transcriptome strand-specific RNA sequencing (ssRNA-seq) was performed in the ovules of a high-frequency female-sterile rice line (fsv1) and a wild-type rice line (Gui99) at the megaspore mother cell meiosis stage (stage 1), functional megaspore mitosis stage (stage 2) and female gametophyte mature stage (stage 3)...
January 28, 2019: BMC Genomics
https://read.qxmd.com/read/30682068/the-pregnancy-outcomes-of-patients-with-rudimentary-uterine-horn-a-30-year-experience
#9
Xiaoyan Li, Ping Peng, Xinyan Liu, Weilin Chen, Juntao Liu, Jianqiu Yang, Xuming Bian
OBJECTIVES: To evaluate the presentation, assessment, treatment, and pregnancy outcomes of 22 women with a rudimentary uterine horn. METHODS: We reviewed the data regarding the outcomes of patients with a rudimentary horn pregnancy (RHP) who were managed at Peking Union Medical College Hospital over the last 30 years. Twenty-two pregnant patients with a rudimentary horn have been treated at our institute over the last 30 years. All patients with RHP were divided into two groups: Type A (n = 4), a rudimentary horn with a cavity that communicated with the uterus; and Type B (n = 7), a rudimentary horn with a cavity that did not communicate with the uterus...
2019: PloS One
https://read.qxmd.com/read/30674713/macrophage-ifn-i-signaling-promotes-autoreactive-t-cell-infiltration-into-islets-in-type-1-diabetes-model
#10
Brett S Marro, Sarah Legrain, Brian C Ware, Michael Ba Oldstone
Here, we report a pathogenic role for type I IFN (IFN-I) signaling in macrophages, and not β cells in the islets, for the development of type 1 diabetes (T1D). Following lymphocytic choriomeningitis (LCMV) infection in the Rip-LCMV-GP T1D model, macrophages accumulated near islets and in close contact to islet-infiltrating GP-specific (autoimmune) CD8+ T cells. Depletion of macrophages with clodronate liposomes or genetic ablation of Ifnar in macrophages aborted T1D, despite proliferation of GP-specific (autoimmune) CD8+ T cells...
January 24, 2019: JCI Insight
https://read.qxmd.com/read/30674421/treatment-efficiency-of-comprehensive-hysteroscopic-evaluation-and-lesion-resection-combined-with-progestin-therapy-in-young-women-with-endometrial-atypical-hyperplasia-and-endometrial-cancer
#11
Bingyi Yang, Yuhui Xu, Qin Zhu, Liying Xie, Weiwei Shan, Chengcheng Ning, Bingying Xie, Yue Shi, Xuezhen Luo, Hongwei Zhang, Xiaojun Chen
OBJECTIVE: This study aimed to evaluate the efficacy of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young patients with endometrial atypical hyperplasia (EAH) and early stage endometrial cancer (EEC) who wished to preserve their fertility. METHODS: Patients with EAH (n = 120) or well-differentiated EEC (n = 40, FIGO stage IA, without myometrial invasion) were retrospectively included. All patients received constant oral progestin combined with hysteroscopic evaluation every 3 months until achieving complete response (CR)...
January 21, 2019: Gynecologic Oncology
https://read.qxmd.com/read/30671941/transcranial-magnetic-and-direct-current-stimulation-tms-tdcs-for-the-treatment-of-headache-a-systematic-review
#12
REVIEW
Joan M Stilling, Oury Monchi, Farnaz Amoozegar, Chantel T Debert
BACKGROUND: Headache is among the most prevalent causes of disability worldwide. Non-pharmacologic interventions, including neuromodulation therapies, have been proposed in patients who are treatment resistant or intolerant to medications. OBJECTIVE: To perform a systematic review on the use of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for the treatment of specific headache disorders (ie, migraine, tension, cluster, posttraumatic)...
January 23, 2019: Headache
https://read.qxmd.com/read/30669544/a-pattern-based-approach-for-detecting-pneumatic-failures-on-temporary-immersion-bioreactors
#13
Octavio Loyola-González, Miguel Angel Medina-Pérez, Dayton Hernández-Tamayo, Raúl Monroy, Jesús Ariel Carrasco-Ochoa, Milton García-Borroto
Temporary Immersion Bioreactors (TIBs) are used for increasing plant quality and plant multiplication rates. These TIBs are actioned by mean of a pneumatic system. A failure in the pneumatic system could produce severe damages into the TIB. Consequently, the whole biological process would be aborted, increasing the production cost. Therefore, an important task is to detect failures on a temporary immersion bioreactor system. In this paper, we propose to approach this task using a contrast pattern based classifier...
January 20, 2019: Sensors
https://read.qxmd.com/read/30665889/contraceptive-use-among-migrant-second-generation-migrant-and-non-migrant-women-seeking-abortion-care-a-descriptive-cross-sectional-study-conducted-in-sweden
#14
Karin Emtell Iwarsson, Elin C Larsson, Kristina Gemzell-Danielsson, Birgitta Essén, Marie Klingberg-Allvin
INTRODUCTION: The objective of this study was to compare ever-in life contraception use, use of contraception at current conception, and planned use of contraception after an induced abortion, among three groups of women: migrants, second-generation migrants and non-migrant women, and to compare the types of contraception methods used and intended for future use among the three groups of women. METHODS: The cross-sectional study administered a questionnaire face-to-face to women aged 18 years and older who were seeking abortion care at one of six abortion clinics in Stockholm County from January to April 2015...
January 21, 2019: BMJ sexual & reproductive health
https://read.qxmd.com/read/30661832/partial-protection-induced-by-salmonella-based-brucella-vaccine-candidate-in-pregnant-guinea-pigs
#15
Jonathan Lalsiamthara, Amal Senevirathne, John Hwa Lee
Residual virulence is a major drawback in current Brucella vaccines. Live vaccines induce abortions in pregnant animals. Hence, a novel anti-Brucella vaccine was developed utilizing rough Salmonella delivering four Brucella antigens. Safety implications during pregnancy, humoral immune responses, and protective efficacy against wild type Brucella was investigated in guinea pig model. The vaccine did not induce abortions or severe complications in pregnant guinea pigs when administered 4 × 108  CFU via intraperitoneal route...
January 17, 2019: Vaccine
https://read.qxmd.com/read/30650561/molecular-characterisation-of-equine-herpesvirus-1-isolates-from-cases-of-abortion-respiratory-and-neurological-disease-in-ireland-between-1990-and-2017
#16
Marie Garvey, Rachel Lyons, Ralph D Hector, Cathal Walsh, Sean Arkins, Ann Cullinane
Multiple locus typing based on sequencing heterologous regions in 26 open reading frames (ORFs) of equine herpesvirus 1 (EHV-1) strains Ab4 and V592 was used to characterise 272 EHV-1 isolates from 238 outbreaks of abortion, respiratory or neurological disease over a 28-year period. The analysis grouped the 272 viruses into at least 10 of the 13 unique long region (UL ) clades previously recognised. Viruses from the same outbreak had identical multi-locus profiles. Sequencing of the ORF68 region of EHV-1 isolates from 222 outbreaks established a divergence into seven groups and network analysis demonstrated that Irish genotypes were not geographically restricted but clustered with viruses from all over the world...
January 15, 2019: Pathogens
https://read.qxmd.com/read/30638471/the-association-between-abortion-experience-and-postmenopausal-suicidal-ideation-and-mental-health-results-from-the-5th-korean-national-health-and-nutrition-examination-survey-knhanes-v
#17
Jeong Ha Wie, Su Kyung Nam, Hyun Sun Ko, Jong Chul Shin, In Yang Park, Young Lee
OBJECTIVE: The association between abortion and postmenopausal mental health has not been clearly established in Asian women. The objective of this study was to evaluate the effect of abortion experiences on suicidal ideation and mental health in Korean postmenopausal women. MATERIALS AND METHODS: This study included 5133 postmenopausal women registered in the Korean National Health and Nutrition Examination Survey between 2010 and 2012. Difference in suicidal ideation according to type and number of abortions was analyzed...
January 2019: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/30633142/consensus-guidelines-for-facilities-performing-outpatient-procedures-evidence-over-ideology
#18
Barbara S Levy, Debra L Ness, Steven E Weinberger
In policy and law, regulation of abortion is frequently treated differently from other health services. The safety of abortion is similar to that of other types of office- and clinic-based procedures, and facility requirements should be based on assuring high-quality, safe performance of all such procedures. False concerns for patient safety are being used as a justification for promoting regulations that specifically target abortion. The Project on Facility Guidelines for the Safe Performance of Primary Care and Gynecology Procedures in Offices and Clinics was undertaken by clinicians, consumers, and representatives from accrediting bodies to review the available evidence and guidelines that inform safe delivery of outpatient care...
February 2019: Obstetrics and Gynecology
https://read.qxmd.com/read/30630395/beyond-autonomy-and-care-experiences-of-ambivalent-abortion-seekers
#19
Marianne Kjelsvik, Ragnhild J Tveit Sekse, Asgjerd Litleré Moi, Elin M Aasen, Per Nortvedt, Eva Gjengedal
BACKGROUND: While being prepared for abortions, some women experience decisional ambivalence during their encounters with health personnel at the hospital. Women's experiences with these encounters have rarely been examined. OBJECTIVE: The objective of this study was to explore ambivalent abortion-seeking women's experiences of their encounters with health personnel. RESEARCH DESIGN: The data were collected in individual interviews and analysed with dialogical narrative analyses...
January 10, 2019: Nursing Ethics
https://read.qxmd.com/read/30630038/phenotypic-molecular-and-genomic-characterization-of-actinobaculum-suis-isolated-from-swine-in-brazil
#20
Cristina Román Amigo, Luisa Zanolli Moreno, Thais Sebastiana Porfida Ferreira, Vasco Túlio de Moura Gomes, André Pegoraro Poor, Carolina Helena de Oliveira, Beatriz Martins Parra, Ana Paula Santos Silva, Andrea Micke Moreno
Urinary tract infections (UTI) are considered one of the most important diseases of sows due to its close relationship with reproductive problems such as reduced litter size, increase in the rate of return to estrous, vulvar discharge, abortion, mastitis and anestrus. Actinobaculum suis is one of the main agents involved in porcine urinary tract infection and is responsible for the most severe and fatal cases in sows. In the present report, 23 A. suis strains isolated from a sow and boars in Brazil were identified by PCR and further characterized by broth microdilution, molecular typing by pulsed-field gel electrophoresis (PFGE), single-enzyme amplified fragment length polymorphism (SE-AFLP), and whole-genome sequencing...
January 7, 2019: Anaerobe
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