keyword
https://read.qxmd.com/read/38541815/-candida-auris-infection-a-rapidly-emerging-threat-in-the-neonatal-intensive-care-units-a-systematic-review
#1
REVIEW
Rozeta Sokou, Alexia Eleftheria Palioura, Paschalia Kopanou Taliaka, Aikaterini Konstantinidi, Andreas G Tsantes, Daniele Piovani, Konstantina A Tsante, Eleni A Gounari, Zoi Iliodromiti, Theodora Boutsikou, Argirios E Tsantes, Stefanos Bonovas, Nicoletta Iacovidou
(1) Background: In recent years, a global epidemiological shift in candidemia has been observed, marked by the emergence of resistant non-albicans Candida species. Candida auris , in particular, has become a significant global concern, causing infections in both pediatric and adult populations within healthcare settings. Despite its widespread impact, there is a limited understanding of the clinical course and transmission dynamics of neonatal systemic Candida auris infections, hindering effective prevention and management...
March 10, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38186776/can-multidrug-resistant-candida-auris-infect-the-neonates-opinion-on-neonatal-candidemia
#2
JOURNAL ARTICLE
Sahjid S Mukhida, Preethy Edavaloth
No abstract text is available yet for this article.
November 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38167789/evaluation-of-the-mannan-antigen-assay-in-neonates-with-or-without-candida-albicans-colonization
#3
JOURNAL ARTICLE
Vasiliki Bourika, Tania Siahanidou, Kalliopi Theodoridou, Athanasios Tsakris, Georgia Vrioni, Athanasios Michos
Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA(Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% sensitivity) and in 30/30 non-colonized neonates (100% specificity)...
January 2, 2024: Medical Mycology
https://read.qxmd.com/read/37899817/candidal-infections-in-the-neonatal-intensive-care-unit-a-retrospective-observational-study
#4
JOURNAL ARTICLE
Gaffari Tunc, Arife Toksoz, Fatih Kilicbay
OBJECTIVES: The aims of this study were to evaluate the demographic characteristics, risk factors, mortality rates, and laboratory findings of infants with fungal sepsis in the Neonatal Intensive Care Unit (NICU). METHODS: This retrospective multicenter study included patients in NICU with Candida spp isolated in blood cultures between November 01, 2019, and September 01, 2022. The patients were evaluated in two groups as Group 1 infants with Candida albicans and Group 2 infants with Candida non-albicans positive blood cultures...
2023: Şişli Etfal Hastanesi tıp bülteni
https://read.qxmd.com/read/37742427/neonatal-fungemia-caused-by-lodderomyces-elongisporus-first-case-report-in-latin-america
#5
Carolina Maria da Silva, Moacir Batista Jucá, Analy Salles de Azevedo Melo, Soraia Lopes Lima, Pauliana Valéria Machado Galvão, Danielle Patrícia Cerqueira Macêdo, Rejane Pereira Neves
Premature hospitalized neonates have a greater risk for candidemia, however, fungemia due to rare opportunistic yeasts have been recently reported and is associated with high mortality rates. We herein report the first case in Latin America of Lodderomyces elongisporus fungemia in a premature neonate with a fatal outcome.
September 3, 2023: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/37610276/high-prevalence-of-candida-auris-colonization-during-protracted-neonatal-unit-outbreak-south-africa
#6
JOURNAL ARTICLE
Liliwe Shuping, Tsidiso G Maphanga, Serisha D Naicker, Ruth Mpembe, Nqobile Ngoma, Sithembiso Velaphi, Firdose Nakwa, Jeannette Wadula, Prenika Jaglal, Nelesh P Govender
One third of patients were colonized by Candida auris during a point-prevalence survey in a neonatal unit during an outbreak in South Africa. The sensitivity of a direct PCR for rapid colonization detection was 44% compared with culture. The infection incidence rate decreased by 85% after the survey and implementation of isolation/cohorting.
September 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37448944/emerging-threat-of-candida-resistance-among-neonates-at-a-teaching-institute-of-jharkhand
#7
JOURNAL ARTICLE
Binita Biswas, Ashok Kumar Sharma, Kumari Seema, Abhay Kumar, Manju Boipai, Manoj Kumar
PURPOSE: In the past few decades, candidemia has escalated to worrisome levels, leading to substantial morbidity and mortality in neonates. The rise in anti-fungal drug resistance demands prompt diagnosis and treatment. This study aimed to determine the speciation and susceptibility pattern of Candida species recovered from special care new-born units and identify risk factors for developing candidemia in neonates. METHOD: A total of 580 blood samples from clinically suspected septicemic neonates were collected and subjected to culture...
May 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/37375027/application-of-novel-short-tandem-repeat-typing-for-wickerhamomyces-anomalus-reveals-simultaneous-outbreaks-within-a-single-hospital
#8
JOURNAL ARTICLE
Bram Spruijtenburg, Shivaprakash M Rudramurthy, Eelco F J Meijer, Merlijn H I van Haren, Harsimran Kaur, Arunaloke Chakrabarti, Jacques F Meis, Theun de Groot
Wickerhamomyces anomalus, previously known as Candida pelliculosa, occasionally causes candidemia in humans, primarily infecting neonates, and infants. The mortality rate of these invasive infections is high, and isolates with a reduced susceptibility to fluconazole have been reported. W. anomalus outbreaks are regularly reported in healthcare facilities, especially in neonatal intensive care units (NICUs). In order to rapidly genotype isolates with a high-resolution, we developed and applied a short tandem repeat (STR) typing scheme for W...
June 8, 2023: Microorganisms
https://read.qxmd.com/read/37008577/epidemiology-and-associated-risk-factors-for-candidemia-in-a-canadian-tertiary-paediatric-hospital-an-11-year-review
#9
JOURNAL ARTICLE
Suefay Harumi Liu, Hana Mitchell, Ghada Nasser Al-Rawahi
BACKGROUND: Candidemia represents a significant cause of morbidity and mortality in children. We examined the epidemiology and associated risk factors of candidemia at a Canadian tertiary care paediatric hospital over an 11-year period. METHODS: A retrospective chart review was conducted on children with positive blood culture for Candida species between January 1, 2007 and December 31, 2018. Patient demographics, previously described candidemia risk factors, Candida species, follow-up investigations, interventions, and outcome data were included in the analysis...
March 2023: Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal officiel de l’Association pour la microbiologie médicale et l’infectiologie Canada
https://read.qxmd.com/read/36892755/candidemia-in-brazilian-neonatal-intensive-care-units-risk-factors-epidemiology-and-antifungal-resistance
#10
JOURNAL ARTICLE
Carolina Maria da Silva, Ana Maria Rabelo de Carvalho, Danielle Patrícia Cerqueira Macêdo, Moacir Batista Jucá, Rosemary de Jesus Machado Amorim, Rejane Pereira Neves
Candidemia is responsible for substantial morbidity and mortality in neonatal intensive care units and represents a challenge due to the complexity of hospitalized neonates, the deficiency in approved and precise diagnostic techniques, and the increasing number of species resistant to antifungal agents. Thus, the objective of this study was to detect candidemia among neonates evaluating the risk factors, epidemiology, and antifungal susceptibility. Blood samples were obtained from neonates with suspected septicemia, and the mycological diagnosis was based on yeast growth in culture...
March 9, 2023: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/36758890/candida-albicans-causes-brain-regional-invasion-and-necrosis-and-activation-of-microglia-during-lethal-neonatal-neurocandidiasis
#11
JOURNAL ARTICLE
Orlando Flores-Maldonado, Gloria M González, Juan F Enríquez-Bañuelos, Ángel Andrade, Rogelio Treviño-Rangel, Miguel A Becerril-García
Neurocandidiasis is a fungal infection that primarily affects neonates, which is associated with 70% case fatality rates, while pediatric patients who survive infection often have long-term neurological sequelae, making it a clinical requirement to understand the pathogenesis of neonatal neurocandidiasis. Currently, the brain regions to C. albicans invasion during the neonatal period are not characterized. In this study, 0-day-old mice were infected with C. albicans intravenously to determine dissemination and invasion into the brain at different times post-infection by fungal burden assay and histopathological analysis, additionally cellular death and microglial activation were evaluated by flow cytometry...
February 7, 2023: Microbes and Infection
https://read.qxmd.com/read/36676116/risk-factors-diagnosis-and-treatment-of-neonatal-fungal-liver-abscess-a-systematic-review-of-the-literature
#12
REVIEW
Paschalia Kopanou Taliaka, Andreas G Tsantes, Aikaterini Konstantinidi, Dimitra Houhoula, Konstantina A Tsante, Aristeidis G Vaiopoulos, Daniele Piovani, Georgios K Nikolopoulos, Stefanos Bonovas, Nicoletta Iacovidou, Argirios E Tsantes, Rozeta Sokou
(1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on neonatal liver abscesses due to invasive fungal infections. (2) Methods: An electronic search of the PubMed and Scopus databases was conducted, considering studies that evaluated fungal liver abscesses in the neonatal population...
January 6, 2023: Life
https://read.qxmd.com/read/36373395/an-overview-of-micafungin-as-a-treatment-option-for-invasive-candidiasis-in-pediatric-patients-younger-than-4-months-old
#13
JOURNAL ARTICLE
Matteo Bassetti, Daniele Roberto Giacobbe, Antonio Vena, Susanna Esposito
INTRODUCTION: Invasive candidiasis remains a leading cause of morbidity and mortality in various categories of patients at risk. AREAS COVERED: Structure and mechanism of action, pharmacokinetics and pharmacodynamics, clinical studies, safety, and regulatory status of micafungin are explored in the present review, focusing on pediatric patients younger than 4 months old. EXPERT OPINION: Although limited, the available data on the efficacy and safety of micafungin in pediatric patients younger than 4 months old supports its use for the treatment of invasive candidiasis in this particular population, in line with the most updated recommendations from the European Medicines Agency and the US Food and Drug Administration...
November 14, 2022: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/36340431/candidemia-changing-dynamics-from-a-tertiary-care-hospital-in-north-india
#14
JOURNAL ARTICLE
Garima Gautam, Deepti Rawat, Ravinder Kaur, Masoom Nathani
Background and Purpose: Routine identification of Candida species and knowledge of antibiotic susceptibility patterns can prevent diagnostic delays and help clinicians choose appropriate empirical therapies. This study aimed to identify and speciate Candida isolates from bloodstream infections and evaluate their epidemiological profile and antibiotic susceptibility pattern in a tertiary care hospital in North India. Materials and Methods: Blood samples were cultured in the Department of Microbiology of a tertiary care hospital from January 2019 to May 2021, and the samples which showed growth of Candida species (spp...
March 2022: Current Medical Mycology
https://read.qxmd.com/read/35850964/incidence-and-factors-associated-with-invasive-candidiasis-in-a-neonatal-intensive-care-unit-in-mexico
#15
JOURNAL ARTICLE
Juan C Lona-Reyes, Larissa M Gómez-Ruiz, Araceli Cordero-Zamora, Sandra I Cortés-González, Moisés Quiles-Corona, Rene O Pérez-Ramírez, Herlinda Pinto-Macedo
INTRODUCTION: Neonatal Candida spp. infections are serious events due to their morbidity and mortality, however, epidemiological information is insufficient in developing countries. The objective of this study was to describe the incidence and factors associated with invasive infection by Candida spp. in a Neonatal Intensive Care Unit in Mexico. METHODS: Case-control study nested in a cohort and matched for birth weight. We estimated the incidence of invasive neonatal infection by Candida spp...
August 2022: Anales de pediatría
https://read.qxmd.com/read/35628721/clinical-and-microbiological-characteristics-of-neonates-with-candidemia-and-impacts-of-therapeutic-strategies-on-the-outcomes
#16
JOURNAL ARTICLE
Yu-Ning Chen, Jen-Fu Hsu, Shih-Ming Chu, Mei-Yin Lai, Chih Lin, Hsuan-Rong Huang, Peng-Hong Yang, Ming-Chou Chiang, Ming-Horng Tsai
Neonatal candidemia is associated with significant morbidities and a high mortality rate. We aimed to investigate the clinical characteristics of Candida bloodstream infections in neonates and the impact of therapeutic strategies on the outcomes. We identified all the neonates with candidemia from a medical center in Taiwan over an 18-year period (2003−2021) and analyzed them. Clinical isolates were confirmed by DNA sequencing, and antifungal susceptibility testing was performed. The prognostic factors associated with clinical treatment failure (30-day, all-cause mortality and persistent candidemia > 72 h after antifungal agents) and in-hospital mortality were analyzed using logistic regression modeling...
April 29, 2022: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/34882043/micafungin-injection-for-the-treatment-of-invasive-candidiasis-in-pediatric-patients-under-4-months-of-age
#17
JOURNAL ARTICLE
Nahed Abdel-Haq, Stephanie M Smith, Basim I Asmar
INTRODUCTION: Neonates and young infants with invasive candidiasis are particularly at increased risk of dissemination including hematogenous Candida meningoencephalitis. The echinocandins including micafungin have emerged as a preferred agent in most cases of candidemia and invasive candidiasis but data in pediatric patients under 4 months of age are limited. AREAS COVERED: In this report, we review the micafungin use in infants younger than 4 months of age. Animal studies as well as clinical data that support its use in neonatal candidiasis are reviewed...
December 9, 2021: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/34876342/comparisons-of-the-clinical-and-mycological-characteristics-of-pediatric-candidemia
#18
JOURNAL ARTICLE
Wan-Chen Chen, Pao-Yu Chen, Shun-Chen Yang, Ting-Yu Yen, Chun-Yi Lu, Jong-Min Chen, Ping-Ing Lee, Luan-Ying Chang, Yee-Chun Chen, Li-Min Huang
BACKGROUND/PURPOSE: Invasive candidiasis is a severe infectious disease that could lead to mortality in critically ill children. METHODS: We collected data regarding demographics, underlying diseases, predisposing factors, outcomes for pediatric patients with candidemia at a medical centre in Taiwan from 2011 to 2017. RESULTS: Fifty-eight patients with 60 candidemia episodes were diagnosed. The 3 most common species were Candida albicans (42%), Candida parapsilosis (25%) and Candida tropicalis (23%)...
December 4, 2021: Journal of the Formosan Medical Association
https://read.qxmd.com/read/34774701/dissemination-of-candida-auris-to-deep-organs-in-neonatal-murine-invasive-candidiasis
#19
JOURNAL ARTICLE
Orlando Flores-Maldonado, Gloria M González, Angel Andrade, Alexandra Montoya, Rogelio Treviño-Rangel, Aarón Silva-Sánchez, Miguel A Becerril-García
Candida auris is an emerging multidrug resistant fungal pathogen, which represents a major challenge for newborns systemic infections worldwide. Management of C. auris infections is complicated due to its intrinsic antifungal resistance and the limited information available on its pathogenesis, particularly during neonatal period. In this study, we developed a murine model of C. auris neonatal invasive infection. C. auris dissemination was evaluated by fungal burden and histopathological analysis of lung, brain, liver, kidney, and spleen at different time intervals...
November 10, 2021: Microbial Pathogenesis
https://read.qxmd.com/read/34718724/whole-genome-sequencing-confirms-candida-albicans-and-candida-parapsilosis-microsatellite-sporadic-and-persistent-clones-causing-outbreaks-of-candidemia-in-neonates
#20
JOURNAL ARTICLE
Jesús Guinea, Sergio Mezquita, Ana Gómez, Belén Padilla, Elena Zamora, Manuel Sánchez-Luna, Carlos Sánchez-Carrillo, Patricia Muñoz, Pilar Escribano
Whole genome sequencing has been extensively used to describe infection outbreaks, although with limited application on Candida albicans and Candida parapsilosis.We retrospectively studied all patients admitted to the neonatal care unit diagnosed with candidemia caused by C. albicans (n = 46) or C. parapsilosis (n = 31) between 2007 and 2010 (Period 1) and 2011 and 2014 (Period 2). All isolates were genotyped by microsatellite markers. A cluster was defined as a group of ≥ 2 patients infected by strains with identical genotypes...
December 10, 2021: Medical Mycology
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