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https://read.qxmd.com/read/30778286/a-conditioning-sciatic-nerve-lesion-triggers-a-pro-regenerative-state-in-primary-sensory-neurons-also-of-dorsal-root-ganglia-non-associated-with-the-damaged-nerve
#1
Petr Dubový, Ilona Klusáková, Ivana Hradilová-Svíženská, Václav Brázda, Marcela Kohoutková, Marek Joukal
The primary sensory neurons of dorsal root ganglia (DRG) are a very useful model to study the neuronal regenerative program that is a prerequisite for successful axon regeneration after peripheral nerve injury. Seven days after a unilateral sciatic nerve injury by compression or transection, we detected a bilateral increase in growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with injured nerve, but also in remote cervical segments (C6-C8)...
2019: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/30777205/development-of-an-anthropomorphic-spine-phantom-suitable-for-fusion-of-mr-neurography-with-interventional-flat-panel-ct
#2
Adrian Kobe, Matthias Zadory, Qeumars M Hamie, Johannes M Froehlich, Markus Klarhöfer, Thilo Elsässer, Thomas Pfammatter, Roman Guggenberger
PURPOSE: To design a spine phantom suitable for fusion of MR neurography (MRN) with interventional flat panel computed tomography (FPCT) images from tissue-equivalent agarose gels and artificial nerves in MRI, including material with equal attenuation to bone in computed tomography (CT). METHODS: T1-/T2-relaxation times of target tissue were determined in vivo (n = 5) using MR mapping-techniques. Serial dilution of castor oil lipogels was performed ex vivo in order to define correct composition for tissue-equivalent relaxation times...
March 2019: European Journal of Radiology
https://read.qxmd.com/read/30774420/adhesive-arachnoiditis-following-lumbar-epidural-steroid-injections-a-report-of-two-cases-and-review-of-the-literature
#3
Elon Eisenberg, Rephael Goldman, Dorit Schlag-Eisenberg, Anat Grinfeld
Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search failed to detect even one published manuscript, clearly documenting LESI induced arachnoiditis. This article presents two patients who received a transforaminal L5-S1 and two L3-L4 interlaminar LESIs...
2019: Journal of Pain Research
https://read.qxmd.com/read/30772832/spinal-epidural-lipomatosis-following-bilateral-spinal-decompression-surgery
#4
Davyd Greenish, Karen Watura, Ian Harding
A 73-year-old man underwent bilateral spinal decompression of L4/5 for severe spinal canal stenosis, requiring minimal analgesia and providing immediate relief. Two days post-operatively, he presented with new onset bilateral leg pain and difficulty mobilising. MRI demonstrated spinal epidural lipomatosis (SEL), which was not present pre-operatively, at L5/S1. Further surgery was performed with decompression of L5/S1 through removal of epidural fat. At both 3 weeks and 5 months follow-up clinics, the patient was asymptomatic...
February 15, 2019: BMJ Case Reports
https://read.qxmd.com/read/30770419/ct-angiography-depicted-lumbar-spinal-artery-anatomic-course-defining-a-safer-zone-for-lumbar-sympathetic-and-splanchnic-blocks
#5
Richard Zhu, Kathryn Dean, Neel Mehta, Ajay Gupta, Jesse Gruber, Amitabh Gulati
INTRODUCTION: Determining safer techniques for lumbar injections is an important goal in pain medicine. This study aims to characterize the location of the T10-L5 spinal arteries using CT angiogram scans to define a safer approach for sympathetic and splanchnic blocks that minimizes intra-arterial injection. METHODS: CT angiograms of 68 patients were included this study. The path of the spinal arteries from the aorta origin along the vertebral body to the neural foramina was traced on axial CT images...
February 15, 2019: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/30767783/minimally-invasive-spinopelvic-crab-shaped-fixation-for-unstable-pelvic-ring-fractures-technical-note-and-16-case-series
#6
Akinori Okuda, Naoki Maegawa, Hiroaki Matsumori, Tomohiko Kura, Yasushi Mizutani, Hideki Shigematsu, Eiichiro Iwata, Masato Tanaka, Keisuke Masuda, Yusuke Yamamoto, Yusuke Tada, Yohei Kogeichi, Keisuke Takano, Hideki Asai, Yasuyuki Kawai, Yasuyuki Urisono, Kenji Kawamura, Hidetada Fukushima, Yasuhito Tanaka
BACKGROUND: Unstable sacral fractures are high-energy injuries and comprise polytrauma. Internal fixation to enable withstanding vertical loads is required to get up early from the bed after an unstable sacral fracture. We developed a new minimally invasive surgical (MIS) procedure for unstable pelvic ring fractures and reported it in Japanese in 2010. We presented our minimally invasive surgical technique of crab-shaped fixation for the treatment of unstable pelvic ring fractures and report on its short-term outcomes...
February 15, 2019: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/30764596/role-of-iliac-crest-tangent-in-correct-numbering-of-lumbosacral-transitional-vertebrae
#7
Nesrin Gündüz, Gülçin Durukan, Mehmet Bilgin Eser, Ahmet Aslan, Adnan Kabaalioğlu
Background/aim: The iliac crest tangent (ICT) has recently emerged as a reliable landmark to correctly number the lumbosacral transitional vertebrae (LSTV). We retrospectively evaluated the reproducibility and accuracy of the ICT as a landmark in subjects without disc degeneration. Materials and methods: Fifty-eight patients with LSTV [19 female, 41 (26–52) years] and 55 controls without LSTV [23 female, 40 (26–55) years] who had undergone spinal computed tomography were included...
February 11, 2019: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/30763748/anatomical-study-of-the-superior-cluneal-nerve-and-its-related-groove-on-the-iliac-crest
#8
Joe Iwanaga, Emily Simonds, Maia Schumacher, Emre Yilmaz, Juan Altafulla, R Shane Tubbs
Superior cluneal nerve entrapment neuropathy is one cause of low back pain often referred to as "pseudosciatica." Studies have found that the superior cluneal nerve can arise variably from the T11 to L5. The osteofibrous tunnels formed by a groove on the iliac crest might compress the superior cluneal nerve. Therefore, the purpose of this study was to investigate the origin of the superior cluneal nerve and its course through such bony grooves. Twenty sides from ten fresh frozen Caucasian cadavers were used in this study...
February 11, 2019: World Neurosurgery
https://read.qxmd.com/read/30762024/mechanism-of-persistent-hyperalgesia-in-neuropathic-pain-caused-by-chronic-constriction-injury
#9
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in peripheral pain transmission. To explore the role of TMEM16A in the persistent hyperalgesia that results from chronic constriction injury-induced neuropathic pain, a rat model of the condition was established by ligating the left sciatic nerve. A TMEM16A selective antagonist (10 μg T16Ainh-A01) was intrathecally injected at L5-6...
June 2019: Neural Regeneration Research
https://read.qxmd.com/read/30758862/exome-wide-association-of-deltamethrin-resistance-in-aedes-aegypti-from-mexico
#10
Karla Saavedra-Rodriguez, Corey L Campbell, Audrey Lenhart, Patricia Penilla, Saul Lozano-Fuentes, William C Black
Aedes aegypti is the major vector of a number of arboviruses that cause disease in humans. Without vaccines or pharmaceuticals, pyrethroid insecticides remain the major tool for public health protection. Pyrethroid resistance is now widespread. Replacement substitutions in the voltage-gated sodium channel (vgsc) that reduce the stability of pyrethroid binding account for most of the resistance but metabolic mechanisms also inactivate pyrethroids. High-throughput sequencing and the Ae. aegypti L5 annotated physical map has allowed interrogation of the exome for genes and single nucleotide polymorphisms (SNPs) associated with pyrethroid resistance...
February 13, 2019: Insect Molecular Biology
https://read.qxmd.com/read/30744956/spinal-osteosarcoma-in-the-paediatric-age-group-case-series-and-literature-review
#11
R M Egea-Gámez, V Ponz-Lueza, A Cendrero-Torrado, C Martínez-González, J A Certucha-Barragán, R González-Díaz
INTRODUCTION AND OBJECTIVE: Osteosarcoma is the most frequent malignant spinal tumour in the paediatric age group. Diagnosis and early treatment of this pathology is essential for a good prognosis. The aim of this study was to present the results of treatment of paediatric patients with lumbar osteosarcoma and conduct a literature review. MATERIAL AND METHODS: All the patients with lumbar osteosarcoma who were operated between 2012 and 2014 in the same centre were included...
February 7, 2019: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/30744307/the-prevalence-of-asymptomatic-cervical-and-lumbar-facet-arthropathy-a-computed-tomography-study
#12
Jung Hwan Kim, Alok Sharan, Woojin Cho, Mohammed Emam, Michael Hagen, Soo Yeon Kim
Study Design: Case control study. Purpose: To determine the prevalence and degree of asymptomatic cervical and lumbar facet joint arthritis. We retrospectively reviewed 500 computed tomography (CT) scans of cervical facet joints obtained from 50 subjects. Moreover, 500 lumbar facet joints obtained from an additional 50 subjects were reviewed. Overview of Literature: Numerous reports in the literature indicate that joint arthritis is a major source of axial neck and low back pain...
February 13, 2019: Asian Spine Journal
https://read.qxmd.com/read/30742965/fructose-induced-insulin-resistance-as-a-model-of-neuropathic-pain-in-rats
#13
Guadalupe García, Erika J Gutiérrez-Lara, David Centurión, Vinicio Granados-Soto, Janet Murbartián
Peripheral neuropathy is one of the main complications of diabetes. The pathogenesis of this affectation is not completely understood. Several studies refer to hyperglycemia as the principal cause of diabetic neuropathy. Nonetheless, there are changes in the expression of insulin receptor during the progress of diabetic neuropathy, suggesting that this disorder begins before high glucose blood levels are established. In this study, we investigated fructose-induced insulin resistance as a model of neuropathic pain...
February 8, 2019: Neuroscience
https://read.qxmd.com/read/30740380/parvimonas-micra-spondylodiscitis-a-case-report-and-systematic-review-of-the-literature
#14
D C van Duijvenbode, J W P Kuiper, R M Holewijn, A Stadhouder
Introduction: Treatment and risk factors for Parvimonas micra spinal infections are scarcely researched. This study reports a case and presents a systematic review of the literature to provide evidence-based ground for diagnosis and treatment of P. micra spinal infections. Case Report: This is a case of a 78-year-old male with severe back and leg pain. Advanced imaging demonstrated the destruction of L2-L3 with an extensive fluid collection in the remaining intervertebral space, paravertebral myositis, and multiple abscesses...
September 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30740291/efficient-and-recyclable-rucl-3-%C3%A2-3h-2-o-catalyst-modified-with-ionic-diphosphine-for-the-alkoxycarbonylation-of-aryl-halides
#15
Qing Zhou, Lei Liu, Wen-Di Guo, Wen-Yu Liang, Yong Lu, Ye Liu
A series of ionic (mono-/di-)phosphines ( L2 , L4 , and L6 ) with structural similarity and their corresponding neutral counterparts ( L1 , L3 , and L5 ) were applied to modulate the catalytic performance of RuCl3  ⋅ 3H2 O. With the involvement of the ionic diphosphine ( L4 ), in which the two phosphino-fragments were linked by butylene group, RuCl3  ⋅ 3H2 O with advantages of low cost, robustness, and good availability was found to be an efficient and recyclable catalyst for the alkoxycarbonylation of aryl halides...
February 2019: ChemistryOpen
https://read.qxmd.com/read/30738393/optimal-tether-configurations-and-preload-tensioning-to-prevent-proximal-junctional-kyphosis-a-finite-element-analysis
#16
Thomas J Buell, Shay Bess, Ming Xu, Frank J Schwab, Virginie Lafage, Christopher P Ames, Christopher I Shaffrey, Justin S Smith
OBJECTIVEProximal junctional kyphosis (PJK) is, in part, due to altered segmental biomechanics at the junction of rigid instrumented spine and relatively hypermobile non-instrumented adjacent segments. Proper application of posteriorly anchored polyethylene tethers (i.e., optimal configuration and tension) may mitigate adjacent-segment stress and help prevent PJK. The purpose of this study was to investigate the impact of different tether configurations and tensioning (preloading) on junctional range-of-motion (ROM) and other biomechanical indices for PJK in long instrumented spine constructs...
February 8, 2019: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/30738362/neuromuscular-morphometric-characteristics-in-low-back-pain-with-unilateral-radiculopathy-caused-by-disc-herniation-an-ultrasound-imaging-evaluation
#17
Hadi Sarafraz, Mohammad Reza Hadian, Niloofar Ayoobi Yazdi, Golamreza Olyaei, Hossein Bagheri, Shohreh Jalaei, Omid Rasouli
BACKGROUND: Little is known about the neuromuscular morphometric characteristics in patients with sciatica. OBJECTIVE: To evaluate the possible changes of nerve and muscle structures in patients with low back pain with unilateral radiculopathy due to lumbar disc herniation by ultrasound imaging. DESIGN: A case-control observational study. METHODS: Forty individuals were divided into case (n = 20; low back pain with unilateral radiculopathy due to disc herniation), and healthy control groups (n = 20)...
February 1, 2019: Musculoskeletal Science & Practice
https://read.qxmd.com/read/30738222/biomechanical-testing-of-different-posterior-fusion-devices-on-lumbar-spinal-range-of-motion
#18
Frank Hartmann, Thomas Nusselt, Gerrit Maier, Pol Maria Rommens, Erol Gercek
BACKGROUND: Recent minimal-invasive posterior fusion devices are supposed to provide stability and obtain fusion in combination with interbody cages in the instrumented segment. The aim of the present study is to evaluate the primary stability of two minimal-invasive posterior prototypes compared to an established spinous process plate and standard pedicle screw instrumentation. METHODS: Seven fresh frozen human cadaver lumbar spines (L2-L5) were tested in a spinal testing device with a moment of 7...
February 1, 2019: Clinical Biomechanics
https://read.qxmd.com/read/30736806/tnf-%C3%AE-stat3-pathway-epigenetically-upregulates-nav1-6-expression-in-drg-and-contributes-to-neuropathic-pain-induced-by-l5-vrt
#19
Huan-Huan Ding, Su-Bo Zhang, You-You Lv, Chao Ma, Meng Liu, Kui-Bo Zhang, Xiang-Cai Ruan, Jia-You Wei, Wen-Jun Xin, Shao-Ling Wu
BACKGROUND: Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregulation were not reported yet. METHODS: The paw withdrawal threshold was measured in the rodents following lumbar 5 ventral root transection (L5-VRT). Then qPCR, western blotting, immunoprecipitation, immunohistochemistry, and chromatin immunoprecipitation assays were performed to explore the molecular mechanisms in vivo and in vitro...
February 8, 2019: Journal of Neuroinflammation
https://read.qxmd.com/read/30735128/parallel-pathways-for-sound-processing-and-functional-connectivity-among-layer-5-and-6-auditory-corticofugal-neurons
#20
Ross S Williamson, Daniel B Polley
Cortical layers (L) 5 and 6 are populated by intermingled cell-types with distinct inputs and downstream targets. Here, we made optogenetically guided recordings from L5 corticofugal (CF) and L6 corticothalamic (CT) neurons in the auditory cortex of awake mice to discern differences in sensory processing and underlying patterns of functional connectivity. Whereas L5 CF neurons showed broad stimulus selectivity with sluggish response latencies and extended temporal non-linearities, L6 CTs exhibited sparse selectivity and rapid temporal processing...
February 8, 2019: ELife
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