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https://read.qxmd.com/read/30760335/association-of-recurrent-venous-thromboembolism-and-circulating-micrornas
#1
Xiao Wang, Kristina Sundquist, Peter J Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A Memon, Jan Sundquist, Bengt Zöller
BACKGROUND: Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to examine whether circulating miRNAs are associated with the risk of VTE recurrence. RESULTS: A nested case-control study design was used where plasma samples were obtained from 78 patients with unprovoked VTE from the Malmö Thrombophilia Study (MATS)...
February 13, 2019: Clinical Epigenetics
https://read.qxmd.com/read/30755150/anticoagulation-risk-assessment-for-patients-with-non-valvular-atrial-fibrillation-and-venous-thromboembolism-a-clinical-review
#2
Vincent A Pallazola, Rishi K Kapoor, Karan Kapoor, John W McEvoy, Roger S Blumenthal, Ty J Gluckman
Non-valvular atrial fibrillation and venous thromboembolism anticoagulation risk assessment tools have been increasingly utilized to guide implementation and duration of anticoagulant therapy. Anticoagulation significantly reduces stroke and recurrent venous thromboembolism risk, but comes at the cost of increased risk of major and clinically relevant non-major bleeding. The decision for anticoagulation in high-risk patients is complicated by the fact that many risk factors associated with increased thromboembolic risk are simultaneously associated with increased bleeding risk...
February 12, 2019: Vascular Medicine
https://read.qxmd.com/read/30710735/impact-of-the-chinese-herbal-medicines-on-dual-antiplatelet-therapy-with-clopidogrel-and-aspirin-pharmacokinetics-and-pharmacodynamics-outcomes-and-related-mechanisms-in-rats
#3
Min Xiao, Chenyu Qian, Xi Luo, Mengbi Yang, Yufeng Zhang, Cheyuen Wu, Chungtong Mok, Puiwai Lee, Zhong Zuo
ETHNOPHARMACOLOGICAL RELEVANCE: Dual antiplatelet therapy (DAPT) with aspirin (ASA) and clopidogrel (CLP) has been consistently shown clinical effectiveness in patients with coronary artery disease. According to the literature, four traditional Chinese medicine (TCM) herbs effective for prevention cardiovascular diseases, namely Radix Salvia Miltiorrhiza (Red sage root, Danshen), Radix Pueraria Lobata (Kudzu root, Gegen), Radix Angelica Sinensis (Angelica root, Danggui), and Rhizoma Ligusticum chuanxiong (Szehuan lovage rhizome, Chuanxiong), are of high potential to be co-administered during DAPT...
January 30, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30705386/in-vivo-response-of-acellular-porcine-pericardial-for-tissue-engineered-transcatheter-aortic-valves
#4
Reza Khorramirouz, Jason L Go, Christopher Noble, David Morse, Amir Lerman, Melissa D Young
Current heart valve prostheses have limitations that include durability, inability to grow in pediatric patients, and lifelong anticoagulation. Transcatheter aortic valve replacements are minimally invasive procedures, and therefore have emerged as an alternative to traditional valve prostheses. In this experiment, the regenerative capacity of potential tissue engineered transcatheter valve scaffolds (1) acellular porcine pericardium and (2) mesenchymal stem cell-seeded acellular porcine pericardium were compared to native porcine aortic valve cusps in a rat subcutaneous model for up to 8 weeks...
January 31, 2019: Scientific Reports
https://read.qxmd.com/read/30694079/d-dimer-preanalytical-analytical-postanalytical-variables-and-clinical-applications
#5
Julien Favresse, Giuseppe Lippi, Pierre-Marie Roy, Bernard Chatelain, Hugues Jacqmin, Hugo Ten Cate, François Mullier
D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the optimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE...
December 2018: Critical Reviews in Clinical Laboratory Sciences
https://read.qxmd.com/read/30690570/incidental-significant-arrhythmia-in-scleroderma-associates-with-cardiac-magnetic-resonance-measure-of-fibrosis-and-hs-tni-and-nt-probnp
#6
Lesley-Anne Bissell, Raluca B Dumitru, Bara Erhayiem, Giuseppina Abignano, Graham Fent, Ananth Kidambi, Helena Donica, Agata Burska, Francesco Del Galdo, John Biglands, David L Buckley, John P Greenwood, Sven Plein, Lee Graham, Maya H Buch
Objectives: To screen for significant arrhythmias with an implantable loop recorder (ILR) in patients with SSc and no known cardiovascular disease, and identify associated disease phenotype, blood and cardiovascular magnetic resonance (CMR) biomarkers. Methods: Twenty patients with SSc with no history of primary SSc heart disease, traditional cardiovascular disease, diabetes or maximum one traditional cardiovascular risk factor underwent clinical assessment, contrast-enhanced CMR and ILR insertion...
January 28, 2019: Rheumatology
https://read.qxmd.com/read/30675362/successful-treatment-for-disseminated-intravascular-coagulation-dic-corresponding-to-phenotype-changes-in-a-heat-stroke-patient
#7
Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Yuki Nakabayashi, Naoki Moriyama, Suguru Annen, Muneaki Ohshita, Satoshi Kikuchi, Norio Sato, Mayuki Aibiki
Background: Heat stroke induces coagulofibrinolytic activation, which leads to life-threatening disseminated intravascular coagulation (DIC). However, treatment strategies for DIC in heat stroke have not yet been established, and also, the time course changes in coagulofibrinolytic markers have not been thoroughly evaluated. We report a severe heat stroke case with DIC who was eventually saved by anti-DIC treatments in accordance with changes in coagulofibrinolytic markers. Case presentation: A 45-year-old man was found unconscious outside, and his body temperature was elevated to 41...
2019: Journal of Intensive Care
https://read.qxmd.com/read/30651032/cardiac-biomarkers-and-left-ventricular-hypertrophy-in-relation-to-outcomes-in-patients-with-atrial-fibrillation-experiences-from-the-re-ly-trial
#8
Ziad Hijazi, Paolo Verdecchia, Jonas Oldgren, Ulrika Andersson, Gianpaolo Reboldi, Giuseppe Di Pasquale, Giovanni Mazzotta, Fabio Angeli, John W Eikelboom, Michael D Ezekowitz, Stuart J Connolly, Salim Yusuf, Lars Wallentin
Background Cardiac biomarkers and left ventricular hypertrophy ( LVH ) are related to the risk of stroke and death in patients with atrial fibrillation. We investigated the interrelationship between LVH and cardiac biomarkers and their independent associations with outcomes. Methods and Results Plasma samples were obtained at baseline in 5275 patients with atrial fibrillation in the RE - LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial. NT -proBNP (N-terminal pro-B-type natriuretic peptide), cardiac troponin I and T, and growth differentiation factor-15 were determined using high-sensitivity (hs) assays...
January 22, 2019: Journal of the American Heart Association
https://read.qxmd.com/read/30620768/measurement-of-micronutrient-deficiency-associated-biomarkers-in-dried-blood-spots-using-a-multiplexed-immunoarray
#9
Eleanor Brindle, Lorraine Lillis, Rebecca Barney, Pooja Bansil, Christopher Lyman, David S Boyle
Simplifying blood collection is often critical when collecting specimens in remote and/or austere settings. The use of dried blood spots (DBS) offers a practical collection method suitable for a wide variety of analytes. A small volume of whole blood can be obtained rapidly through a minimally invasive heel- or finger-stick using a disposable safety lancet. Once dried, the samples require no further processing, are stable for months or longer, pose minimal risk of disease transmission, and are easy to ship...
2019: PloS One
https://read.qxmd.com/read/30604046/direct-oral-anticoagulants-and-vitamin-k-antagonists-are-linked-to-differential-profiles-of-cardiac-function-and-lipid-metabolism
#10
Lisa Eggebrecht, Jürgen H Prochaska, Sven-Oliver Tröbs, Sören Schwuchow-Thonke, Sebastian Göbel, Simon Diestelmeier, Andreas Schulz, Natalie Arnold, Marina Panova-Noeva, Thomas Koeck, Steffen Rapp, Tommaso Gori, Karl J Lackner, Hugo Ten Cate, Thomas Münzel, Philipp Sebastian Wild
BACKGROUND: Experimental data indicate that direct acting oral anticoagulants (DOAC) and vitamin K antagonists (VKA) may exert differential effects on cardiovascular disease. METHODS: Data from the prospective, observational, single-center MyoVasc Study were used to examine associations of DOAC as compared to VKA with subclinical markers of cardiovascular disease, cardiac function, and humoral biomarkers in heart failure (HF). RESULTS: Multivariable analysis adjusted for age, sex, traditional cardiovascular risk factors, comorbidities, and medications with correction for multiple testing demonstrated that DOAC therapy was among all investigated parameters an independent significant predictor of better diastolic function (E/E': β - 0...
January 2, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30602199/apolipoprotein-c-iii-strongly-correlates-with-activated-factor-vii-anti-thrombin-complex-an-additional-link-between-plasma-lipids-and-coagulation
#11
Nicola Martinelli, Marcello Baroni, Annalisa Castagna, Barbara Lunghi, Filippo Stefanoni, Federica Tosi, Jacopo Croce, Silvia Udali, Barry Woodhams, Domenico Girelli, Francesco Bernardi, Oliviero Olivieri
Activated factor VII-anti-thrombin (FVIIa-AT) complex is a potential biomarker of pro-thrombotic diathesis reflecting FVIIa-tissue factor (TF) interaction and has been associated with mortality in patients with coronary artery disease (CAD). Previous data indicated plasma lipids as predictors of FVIIa-AT variability, and plasma lipoproteins as potential stimulators of the coagulation cascade. Our aim was to evaluate the relationships between FVIIa-AT plasma concentration and a broad apolipoprotein profile (including ApoA-I, ApoB, ApoC-III and ApoE)...
January 2, 2019: Thrombosis and Haemostasis
https://read.qxmd.com/read/30595328/determinants-of-in-hospital-clinical-outcome-in-patients-with-sub-massive-pulmonary-embolism
#12
Bishav Mohan, Rohit Tandon, Raahat Bansal, Maninder Singh, Bhupinder Singh, Abhishek Goyal, Shibba Takkar Chhabra, Naved Aslam, Gurpreet S Wander
INTRODUCTION: There is limited data regarding in hospital determinants of clinical deterioration and outcome in sub massive pulmonary embolism (PE). We aimed to evaluate these determinants by comparing biomarkers, CT pulmonary angiogram echocardiography, electrocardiography variables. METHODS: 57 patients of sub massive PE diagnosed on CT pulmonary angiogram were included. All patients received UFH on admission and were divided into two groups based on their clinical course...
December 2018: Indian Heart Journal
https://read.qxmd.com/read/30586727/performance-of-the-abc-scores-for-assessing-the-risk-of-stroke-or-systemic-embolism-and-bleeding-in-patients-with-atrial-fibrillation-in-engage-af-timi-48
#13
David Douglas Berg, Christian T Ruff, Petr Jarolim, Robert P Giugliano, Francesco Nordio, Hans J Lanz, Michele F Mercuri, Elliott M Antman, Eugene Braunwald, David A Morrow
BACKGROUND: The ABC-stroke and ABC-bleeding risk scores incorporate clinical variables and cardiovascular biomarkers to estimate risk of stroke or systemic embolic events (S/SEE) and bleeding, respectively, in patients with atrial fibrillation (AF). These scores have been proposed for routine clinical use but their performance in external cohorts remains uncertain. METHODS: ENGAGE AF-TIMI 48 was a multinational, randomized trial of the oral factor Xa inhibitor edoxaban in patients with AF and CHADS2 score ≥2...
November 11, 2018: Circulation
https://read.qxmd.com/read/30582882/derangement-of-the-endothelial-glycocalyx-in-sepsis
#14
REVIEW
Toshiaki Iba, Jerrold H Levy
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel-like layer composed of a membrane-binding domain that contains proteoglycans, glycosaminoglycan side-chains, and plasma proteins such as albumin and antithrombin. The endothelial glycocalyx plays a critical role in maintaining vascular homeostasis. However, this component is highly vulnerable to damage and is also difficult to examine. Recent advances in analytical techniques have enabled biochemical, visual, and computational investigation of this vascular component...
December 24, 2018: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/30526522/takotsubo-syndrome-with-pulmonary-embolism-a-case-report-and-literature-review
#15
Qi Jin, Qin Luo, Zhihui Zhao, Qing Zhao, Xue Yu, Lu Yan, Liu Gao, Zhihong Liu
BACKGROUND: Takotsubo syndrome (TTS) is an acute cardiac condition with reversible heart failure which is often triggered by psychological and physical stressful events. Although pulmonary embolism (PE) was reported as a trigger for TTS, the concurrence of TTS and PE has been rarely reported, let alone that triggered by PE. Here we describe a case of a postmenopausal female presenting with symptoms similar to myocardial ischemia, which may be caused by PE, and review the available literature that may help clinicians with their practice to similar situations since no published guidelines are available...
December 10, 2018: BMC Cardiovascular Disorders
https://read.qxmd.com/read/30487982/obesity-paradox-on-outcome-in-atrial-fibrillation-maintained-even-considering-the-prognostic-influence-of-biomarkers-insights-from-the-aristotle-trial
#16
Roopinder K Sandhu, Justin A Ezekowitz, Ziad Hijazi, Johan Westerbergh, Julia Aulin, John H Alexander, Christopher B Granger, Sigrun Halvorsen, Michael S Hanna, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
Objective: We investigated the association between obesity and biomarkers indicating cardiac or renal dysfunction or inflammation and their interaction with obesity and outcomes. Methods: A total of 14 753 patients in the Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial provided plasma samples at randomisation to apixaban or warfarin. Median follow-up was 1.9 years. Body Mass Index (BMI) was measured at baseline and categorised as normal, 18...
2018: Open Heart
https://read.qxmd.com/read/30464183/impact-of-preanalytical-conditions-on-plasma-concentration-and-size-distribution-of-extracellular-vesicles-using-nanoparticle-tracking-analysis
#17
Simin Jamaly, Cathrine Ramberg, Randi Olsen, Nadezhda Latysheva, Paul Webster, Timofey Sovershaev, Sigrid K Brækkan, John-Bjarne Hansen
Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy volunteers to investigate the impact of plasma preparation and anticoagulants, and from 40 individuals from a population-based study to investigate the impact of postprandial lipidemia...
November 21, 2018: Scientific Reports
https://read.qxmd.com/read/30446716/inherited-genetic-predispositions-in-f13a1-and-f13b-genes-predict-abdominal-adhesion-formation-identification-of-gender-prognostic-indicators
#18
Donato Gemmati, Savino Occhionorelli, Veronica Tisato, Marco Vigliano, Giovanna Longo, Arianna Gonelli, Maria G Sibilla, Maria L Serino, Paolo Zamboni
Abdominal adhesions (AA) account for the most common complication of peritoneal surgery with bowel obstruction being the severest problem in the absence of effective predicting biomarkers. Anti-AA-barriers or adhesiolysis did not completely prevent bowel obstruction, although there is evidence they might reduce related complications requiring reoperation. In addition, gender-related predispositions have not been adequately investigated. We explored the role of coagulation Factor XIII (F13A1 and F13B subunit-genes) in patients following laparotomy, mostly median/lower median incision line...
November 16, 2018: Scientific Reports
https://read.qxmd.com/read/30442679/cerebral-cavernous-malformations-form-an-anticoagulant-vascular-domain
#19
Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimäki, Sean Polster, Laleh Saadat, Ignacio A Romero, Charles T Esmon, Frederic Lagarrigue, Issam A Awad, Laurent O Mosnier, Mark H Ginsberg
Cerebral cavernous malformations (CCM) are common brain vascular dysplasias prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis of recurrent bleeding in CCM is incompletely understood. Here we show that central nervous system (CNS) hemorrhage in CCM is associated with locally elevated expression of the anticoagulant endothelial receptors thrombomodulin (TM) and endothelial protein C receptor (EPCR). TM levels are increased in human CCM lesions and in the plasma of patients with CCMs...
November 15, 2018: Blood
https://read.qxmd.com/read/30441448/a-deep-deterministic-policy-gradient-approach-to-medication-dosing-and-surveillance-in-the-icu
#20
Rongmei Lin, Matthew D Stanley, Mohammad M Ghassemi, Shamim Nemati
Medication dosing in a critical care environment is a complex task that involves close monitoring of relevant physiologic and laboratory biomarkers and corresponding sequential adjustment of the prescribed dose. Misdosing of medications with narrow therapeutic windows (such as intravenous [IV] heparin) can result in preventable adverse events, decrease quality of care and increase cost. Therefore, a robust recommendation system can help clinicians by providing individualized dosing suggestions or corrections to existing protocols...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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