keyword
https://read.qxmd.com/read/38547269/biodegradable-ferroelectric-molecular-crystal-with-large-piezoelectric-response
#1
JOURNAL ARTICLE
Han-Yue Zhang, Yuan-Yuan Tang, Zhu-Xiao Gu, Peng Wang, Xiao-Gang Chen, Hui-Peng Lv, Peng-Fei Li, Qing Jiang, Ning Gu, Shenqiang Ren, Ren-Gen Xiong
Transient implantable piezoelectric materials are desirable for biosensing, drug delivery, tissue regeneration, and antimicrobial and tumor therapy. For use in the human body, they must show flexibility, biocompatibility, and biodegradability. These requirements are challenging for conventional inorganic piezoelectric oxides and piezoelectric polymers. We discovered high piezoelectricity in a molecular crystal HOCH2 (CF2 )3 CH2 OH [2,2,3,3,4,4-hexafluoropentane-1,5-diol (HFPD)] with a large piezoelectric coefficient d 33 of ~138 picocoulombs per newton and piezoelectric voltage constant g 33 of ~2450 × 10-3  volt-meters per newton under no poling conditions, which also exhibits good biocompatibility toward biological cells and desirable biodegradation and biosafety in physiological environments...
March 29, 2024: Science
https://read.qxmd.com/read/38546663/physical-activity-using-a-wearable-device-as-an-alternative-to-performance-status-in-patients-with-advanced-lung-cancer
#2
JOURNAL ARTICLE
Kentaro Ito, Yuta Suzuki, Tadashi Sakaguchi, Kentaro Fujiwara, Yoichi Nishii, Hiroki Yasui, Osamu Taguchi, Osamu Hataji
IMPORTANCE: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among observers. OBJECTIVE: To investigate the association between measured physical activity and ECOG PS, as well as the potential prognostic value of physical activity measurements in patients with advanced lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This single-institution, prospective observational study enrolled 119 patients with advanced lung cancer scheduled to receive systemic therapy as outpatients at Matsusaka Municipal Hospital in Mie, Japan...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546408/cardiac-implantable-electronic-devices-and-bloodstream-infections-management-and-outcomes
#3
JOURNAL ARTICLE
Tardu Özkartal, Andrea Demarchi, Giulio Conte, Damiano Pongan, Catherine Klersy, Maria Luce Caputo, Marco Bergonti, Enos Bernasconi, Valeria Gaia, Christopher B Granger, Angelo Auricchio
BACKGROUND AND AIMS: Bloodstream infection (BSI) of any cause may lead to device infection in cardiac implantable electronic device (CIED) patients. Aiming for a better understanding of the diagnostic approach, treatment, and outcome, patients with an implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy and defibrillator (CRT-D) hospitalized with BSI were investigated. METHODS: This is a single-centre, retrospective, cohort analysis including consecutive ICD/CRT-D patients implanted between 2012 and 2021...
March 28, 2024: European Heart Journal
https://read.qxmd.com/read/38546238/intraluminal-suture-placement-for-management-of-hypotony-after-glaucoma-drainage-device-surgery
#4
JOURNAL ARTICLE
Minjia Tang, Anupama R Anchala, Angelo P Tanna
PRCIS: Intraluminal 3-0 Supramid stent placement can be an effective long-term solution for hypotony after glaucoma drainage device surgery. This procedure may obviate the need for conjunctival dissection. In some cases, additional procedures are required. PURPOSE: To describe the utility of implantation of a multifilament polyamide suture (Supramid) in the tube lumen to reverse hypotony after glaucoma drainage device (GDD) surgery. PATIENTS: Patients who underwent tube revision with intraluminal placement of a 3-0 Supramid stent, with or without external ligature, to manage hypotony following GDD surgery between January 2010-October 2020...
March 28, 2024: Journal of Glaucoma
https://read.qxmd.com/read/38546008/mask-interfaces-and-devices-for-home-noninvasive-ventilation-in-children
#5
JOURNAL ARTICLE
Sonia Khirani, Vivian Ducrot
Home noninvasive ventilation (NIV), including continuous (CPAP) and bilevel (BPAP) positive airway pressure, is increasingly used in children worldwide. In this narrative review, we present a comprehensive summary of the equipment available for home NIV in pediatrics, excluding neonates. NIV may be challenging in young children, as the majority of the equipment has been developed for adults. Regarding the interfaces, only a few masks have been specifically developed for young children in recent years, while older children may benefit from a large variety of interfaces...
March 28, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38545682/retrieval-of-a-left-appendage-device-from-the-left-ventricle-using-a-large-bore-steerable-catheter
#6
Abou-Bakr Abbadi, Mariama Akodad, Jérôme Horvilleur, Antoinette Neylon
Left atrium appendage closure is a safe and effective therapy for patients with atrial fibrillation and high thromboembolic and hemorrhagic risks. Prosthesis embolization is a potential major complication with an incidence of 0.07%. We report a case of migration of an Amplatzer Amulet (Abbott) device that was successfully retrieved in an innovative way (4).
March 28, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38545423/evaluation-of-the-external-soft-tissue-changes-following-the-correction-of-class-ii-skeletal-malocclusion-in-the-adolescence-period-using-removable-and-fixed-functional-appliances-a-systematic-review-and-meta-analysis
#7
REVIEW
Dima M Almrayati, Mohammad Y Hajeer, Alaa Oudah A Almusawi, Samer T Jaber, Mohammad O Baba, Mowaffak A Ajaj
In this systematic review, we aimed to assess the current evidence regarding the effectiveness of functional treatment with both removable and fixed appliances to normalize the external soft tissue for skeletal class II adolescent individuals. We performed a broad electronic search to retrieve relevant studies from nine databases to identify randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that investigated soft tissue changes following functional treatment and evaluated the changes using 2D lateral cephalometric radiographs and 3D-optical surface laser scanning...
March 2024: Curēus
https://read.qxmd.com/read/38545346/contemporary-approach-to-cardiogenic-shock-care-a-state-of-the-art-review
#8
REVIEW
Aditya Mehta, Ilan Vavilin, Andrew H Nguyen, Wayne B Batchelor, Vanessa Blumer, Lindsey Cilia, Aditya Dewanjee, Mehul Desai, Shashank S Desai, Michael C Flanagan, Iyad N Isseh, Jamie L W Kennedy, Katherine M Klein, Hala Moukhachen, Mitchell A Psotka, Anika Raja, Carolyn M Rosner, Palak Shah, Daniel G Tang, Alexander G Truesdell, Behnam N Tehrani, Shashank S Sinha
Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selective utilization of temporary mechanical circulatory support devices has been associated with improved outcomes...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545328/association-between-frailty-and-in-hospital-outcomes-in-patients-undergoing-leadless-pacemaker-implantation-a-nationwide-analysis
#9
JOURNAL ARTICLE
Carlos Diaz-Arocutipa, Pablo M Calderon-Ramirez, Frank Mayta-Tovalino, Javier Torres-Valencia
BACKGROUND: Leadless pacing has recently emerged as a promising therapy. The impact of frailty on the prognosis of these patients is currently unknown. OBJECTIVE: The purpose of this study was to assess the association between frailty and clinical outcomes in patients undergoing leadless pacemaker implantation. METHODS: We included adult patients who underwent leadless pacemaker implantation using the National Inpatient Sample from 2017 to 2019...
February 2024: Heart rhythm O2
https://read.qxmd.com/read/38544808/intracardiac-echocardiography-guided-left-atrial-appendage-occlusion
#10
REVIEW
Juan Carlos Diaz, Mauricio Duque, Jorge Marin, Julian Aristizabal, Cesar Niño, Oriana Bastidas, Carlos D Matos, Carolina Hoyos, Daniela Hincapie, Jorge E Romero
Left atrial appendage occlusion (LAAO) is a suitable alternative to oral anticoagulant therapy to prevent stroke in patients with AF. Most procedures are performed under transoesophageal echocardiography (TOE) guidance, which facilitates transseptal puncture, reduces the risk of procedurerelated complications and provides an additional method for device selection and real-time monitoring during device deployment. However, TOE has significant shortcomings, including the need for general anaesthesia/deep sedation as well as a significant risk of procedure-related adverse events...
2024: Arrhythmia & Electrophysiology Review
https://read.qxmd.com/read/38544413/five-year-outcomes-of-the-gore-viabahn-endoprosthesis-for-the-treatment-of-complex-femoropopliteal-lesions-from-a-japanese-postmarket-surveillance-study
#11
JOURNAL ARTICLE
Osamu Iida, Takao Ohki, Yoshimitsu Soga, Nobuhiro Suematsu, Tatsuya Nakama, Terutoshi Yamaoka, Kazuki Tobita, Shigeo Ichihashi
Introduction: The safety and effectiveness of the GORE VIABAHN Endoprosthesis for treatment of symptomatic patients with peripheral artery disease (PAD) and complex femoropopliteal (FP) lesions was assessed in a real-world Japanese practice setting. Methods : A prospective, multicenter, postmarket surveillance study was conducted from 2016 to 2017 at 64 sites in Japan. Symptomatic patients with PAD and FP lesions ⩾ 10 cm and reference vessel diameters ranging from 4.0 to 7.5 mm were eligible for enrollment...
March 27, 2024: Vascular Medicine
https://read.qxmd.com/read/38544134/ultra-long-term-eeg-monitoring-ulteem-systems-towards-user-friendly-out-of-hospital-recordings-of-electrical-brain-signals-in-epilepsy
#12
JOURNAL ARTICLE
Gürkan Yilmaz, Andrea Seiler, Olivier Chételat, Kaspar A Schindler
Epilepsy is characterized by the occurrence of epileptic events, ranging from brief bursts of interictal epileptiform brain activity to their most dramatic manifestation as clinically overt bilateral tonic-clonic seizures. Epileptic events are often modulated in a patient-specific way, for example by sleep. But they also reveal temporal patterns not only on ultra- and circadian, but also on multidien scales. Thus, to accurately track the dynamics of epilepsy and to thereby enable and improve personalized diagnostics and therapies, user-friendly systems for long-term out-of-hospital recordings of electrical brain signals are needed...
March 14, 2024: Sensors
https://read.qxmd.com/read/38543588/mortality-and-costs-of-cardiac-implantable-electronic-device-cied-infections-according-to-the-therapeutic-approach-a-single-center-cohort-study
#13
JOURNAL ARTICLE
Encarnación Gutiérrez-Carretero, Eduardo Arana-Rueda, Antonio Ortiz-Carrellán, Alonso Pedrote-Martínez, Mariano García-de-la-Borbolla, Arístides De Alarcón
Background: Cardiac device infections are serious adverse events associated with considerable morbidity and mortality, significant costs, and increased healthcare utilization. The aim of this study is to calculate the costs of treatment of cardiac implantable electrostimulation device (CIED)-related infections for different types of infection (local or systemic) and therapeutic approaches. Patients and Methods : Single-center cohort (1985-2018). The costs of the CIED-related infections were analyzed according to initial treatment (antimicrobial treatment exclusively, local approach, or transvenous lead extraction (TLE))...
March 7, 2024: Microorganisms
https://read.qxmd.com/read/38543241/state-of-the-art-review-on-inhalable-lipid-and-polymer-nanocarriers-design-and-development-perspectives
#14
REVIEW
Gabriella Costabile, Gemma Conte, Susy Brusco, Pouria Savadi, Agnese Miro, Fabiana Quaglia, Ivana d'Angelo, Francesca Ungaro
Nowadays, the interest in research towards the local administration of drugs via the inhalation route is growing as it enables the direct targeting of the lung tissue, at the same time reducing systemic side effects. This is of great significance in the era of nucleic acid therapeutics and personalized medicine for the local treatment of severe lung diseases. However, the success of any inhalation therapy is driven by a delicate interplay of factors, such as the physiochemical profile of the payload, formulation, inhalation device, aerodynamic properties, and interaction with the lung fluids...
March 1, 2024: Pharmaceutics
https://read.qxmd.com/read/38543080/a-drug-safety-briefing-ii-in-transplantation-from-real-world-individual-pharmacotherapy-management-to-prevent-patient-and-graft-from-polypharmacy-risks-at-the-very-earliest-stage
#15
REVIEW
Ursula Wolf
For early and long-term patient and graft survival, drug therapy in solid organ and hematopoietic stem cell transplantation inevitably involves polypharmacy in patients with widely varying and even abruptly changing conditions. In this second part, relevant medication briefing is provided, in addition to the scores defined in the previously published first part on the design of the Individual Pharmacotherapy Management (IPM). The focus is on the growing spectrum of contemporary polypharmacy in transplant patients, including early and long-term follow-up medications...
February 25, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542754/nutritional-status-predicts-the-length-of-stay-and-mortality-in-patients-undergoing-electrotherapy-procedures
#16
JOURNAL ARTICLE
Joanna Popiolek-Kalisz, Tomasz Chrominski, Marcin Szczasny, Piotr Blaszczak
(1) Background: Nutritional status is a factor that impacts the patients' outcomes in various medical conditions including cardiovascular patients or surgical procedures. However, there is limited available information about its impact on the short-term outcomes of cardiac implantable electronic device (CIED) implantations. This study aimed to assess the relationship between nutritional status, complications, mortality risk, and length of stay at the hospital in patients undergoing CIED implantations. (2) Material and Methods: 588 patients who underwent CIED implantation in 2022 and 2023 were included in the retrospective analysis...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542371/xanthohumol-a-miracle-molecule-with-biological-activities-a-review-of-biodegradable-polymeric-carriers-and-naturally-derived-compounds-for-its-delivery
#17
REVIEW
Ewa Oledzka
Xanthohumol (Xn), a prenylated chalcone found in Hop ( Humulus lupulus L.), has been shown to have potent anti-aging, diabetes, inflammation, microbial infection, and cancer properties. Unfortunately, this molecule has undesirable characteristics such as inadequate intake, low aqueous solubility, and a short half-life. To address these drawbacks, researchers have made numerous attempts to improve its absorption, solubility, and bioavailability. Polymeric drug delivery systems (PDDSs) have experienced significant development over the last two decades...
March 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542088/beyond-quadruple-therapy-and-current-therapeutic-strategies-in-heart-failure-with-reduced-ejection-fraction-medical-therapies-with-potential-to-become-part-of-the-therapeutic-armamentarium
#18
REVIEW
Christos Kourek, Alexandros Briasoulis, Adamantia Papamichail, Andrew Xanthopoulos, Elias Tsougos, Dimitrios Farmakis, Ioannis Paraskevaidis
Heart failure with reduced ejection fraction (HFrEF) is a complex clinical syndrome with significant morbidity and mortality and seems to be responsible for approximately 50% of heart failure cases and hospitalizations worldwide. First-line treatments of patients with HFrEF, according to the ESC and AHA guidelines, include β-blockers, angiotensin receptor/neprilysin inhibitors, sodium-glucose cotransporter 2 inhibitors, and mineralocorticoid receptor antagonists. This quadruple therapy should be initiated during hospital stay and uptitrated to maximum doses within 6 weeks after discharge according to large multicenter controlled trials...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542032/safety-and-feasibility-of-the-bycross-%C3%A2-atherectomy-device-for-the-treatment-of-femoropopliteal-arterial-obstructions-single-center-short-term-outcomes
#19
JOURNAL ARTICLE
Goudje L van Leeuwen, Reinoud P H Bokkers, Job Oldenziel, Richte C L Schuurmann, Cornelis G Vos, Jean-Paul P M de Vries
Background: Endovascular techniques have gained preference over peripheral arterial bypass surgery due to their minimally invasive nature; however, endovascular treatments often show limited efficacy in arterial segments with a high atherosclerotic load. The use of atherectomy devices enables the removal of calcified plaque material and may promote arterial wall remodeling. This study assessed the technical success, safety, and feasibility of the BYCROSS® atherectomy device in femoropopliteal lesions. Methods: This single-center, retrospective cohort study analyzed elective patients undergoing BYCROSS® atherectomy for chronic peripheral arterial disease from March 2022 to May 2023...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541962/the-influence-of-arrhythmias-and-metabolic-profile-on-inpatient-mortality-in-patients-with-left-ventricular-assist-devices
#20
JOURNAL ARTICLE
Daniel Antwi-Amoabeng, Bryce David Beutler, Tokunbo David Gbadebo
Background: In patients with end-stage heart failure, durable Left Ventricular Assist Devices (LVADs) can be used as a bridge to transplant or destination therapy. LVADs have been shown to improve survival for patients with heart failure (HF). HF is associated with electrolyte abnormalities and the development of sustained arrhythmias. However, data on the influence of arrhythmias and electrolyte imbalances on inpatient outcomes in LVAD patients are lacking. Furthermore, previous works assessing inpatient outcomes focused mainly on the role of chronic comorbidities in those outcomes...
March 17, 2024: Journal of Clinical Medicine
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