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Maya Eiger-Moscovich, Oren Tomkins-Netzer, Radgonde Amer, Zohar Habot-Wilner, Ahmed Kasb, Ronit Friling, Michal Kramer
PURPOSE: To investigate the clinical course and visual outcome of macular edema (ME) in pediatric patients with chronic noninfectious uveitis. DESIGN: Retrospective case series. METHODS: The databases of the uveitis clinics of four tertiary medical centers in Israel and the UK were searched for all children treated for uveitic ME in 2005-2015. Data were collected from the medical records as follows: demographics, diagnosis, visual acuity, clinical and imaging findings, and treatment given specifically for ME...
February 14, 2019: American Journal of Ophthalmology
Amer Harky, Ewa Zywicka, Giovanni Santoro, Lucas Jullian, Mihika Joshi, Sameh Dimitri
OBJECTIVE: The purpose of this systematic review and meta-analysis was to assess the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) compared to computed tomography angiography (CTA) for the detection of endoleaks within endovascular aortic aneurysm repair (EVAR) surveillance at time of follow up. METHODS: A comprehensive literature search was undertaken among the four major databases (PubMed, Embase, Scopus and Ovid) to identify all articles assessing diagnostic specificity and accuracy with comparative modality (CEUS vs CTA) for endoleaks in adult patients at time of follow-up following EVAR...
February 15, 2019: Journal of Ultrasound
Amer Alam, Julia Kowal, Eugenia Broude, Igor Roninson, Kaspar P Locher
ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the plasma membrane of diverse cells, which contributes to cellular drug resistance and interferes with therapeutic drug delivery. We determined the 3.5-angstrom cryo-electron microscopy structure of substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the chemotherapeutic compound paclitaxel (Taxol) bound in a central, occluded pocket. A second structure of inhibited, human-mouse chimeric ABCB1 revealed two molecules of zosuquidar occupying the same drug-binding pocket...
February 15, 2019: Science
Bushra Rana, Shaun Robinson, Rajeevan Francis, Mark Toshner, Martin J Swaans, Sharad Agarwal, Ravi De Silva, Amer A Rana, Petros Nihoyannopoulos
Tricuspid regurgitation natural history and treatment remain poorly understood. Right ventricular function is a key factor in determining prognosis, timing for intervention and longer-term outcome. The right ventricle is a thin-walled chamber with a predominance of longitudinal fibres and a shared ventricular septum. In health, the low-pressure pulmonary circulation results in a highly compliant RV well equipped to respond to changes in preload but sensitive to even small alterations in afterload. In the first of two articles, discussion focuses on key principles of ventricular function assessment and the importance of right ventricular chamber size, volumes and ejection fraction, particularly in risk stratification in tricuspid regurgitation...
February 1, 2019: Echo Research and Practice
Taher Zaid, Suheir Ereqat, Abdelmajeed Nasereddin, Amer Al-Jawabreh, Ahmad Abdelkader, Ziad Abdeen
Tick-borne anaplasmosis and ehrlichiosis are clinically important emerging zoonoses usually overlooked by veterinarians and physicians alike. This study aimed at detecting and genetically characterizing Ehrlichia and Anaplasma species in ixodid ticks and their animal hosts from the West Bank, Palestine. A total of 723 ixodid ticks belonging to three genera (Rhipicephalus, Hyalomma, Haemaphysalis) were collected from dogs, sheep, goats and camels. In addition, 189 blood samples were collected from dogs, sheep, camels, horses and a goat from the West Bank, Palestine...
February 14, 2019: Veterinary Medicine and Science
Islam M Saadeldin, Ayman Abdel-Aziz Swelum, Mona Elsafadi, Amer Mahmood, Syed Hilal Yaqoob, Musaad Alfayez, Abdullah N Alowaimer
All-trans retinoic acid (RA) is a metabolite of vitamin A and has pleiotropic actions on many different biological processes, including cell growth and differentiation, and is involved in different aspects of fertility and developmental biology. In the current study, we investigated the effects of RA on camel (Camelus dromedarius) cumulus-oocyte complex in vitro maturation (IVM). IVM medium was supplemented with 0, 10, 20, and 40 µM RA. Application of 20 µM RA significantly reduced the proportion of degenerated oocytes and significantly improved oocyte meiosis and first polar body extrusion compared to the control and other experimental groups...
February 14, 2019: Journal of Reproduction and Development
Joshua D Ramsey, Momen Amer, Yu Feng
Optimization of a bioreactor design can be an especially challenging process. For instance, testing different bioreactor vessel geometries and different impeller and sparger types, locations, and dimensions can lead to an exceedingly large number of configurations and necessary experiments. Computational Fluid Dynamics (CFD), therefore, has been widely used to model multiphase flow in stirred-tank bioreactors to minimize the number of optimization experiments. In this current study, a multiphase CFD model with population balance equations is used to model gas-liquid mixing, as well as gas bubble distribution, in a 50 L single-use bioreactor vessel...
February 13, 2019: Biotechnology Progress
Katelyn A Born, Erin E Dooley, P Andy Cheshire, Lauren E McGill, Jonathon M Cosgrove, John L Ivy, John B Bartholomew
PURPOSE: The purpose of this study is to translate laboratory-based research on beverage-based supplements to a naturalistic, field setting in adolescent athletes. To this end, we tested the effects of two commercially-available drinks on strength in a field-based setting with both male and female high school athletes completing a summer training program. METHODS: One hundred and three high school athletes completed the study (M age = 15.3, SD = 1.2; 70...
February 12, 2019: Journal of the International Society of Sports Nutrition
Amer Harky, Mohamad Bashir, Ciaran Grafton-Clarke, Martin Lees, Sarah Fendius, Neil Roberts
Intraventricular conduction abnormalities following cardiac surgery have been thoroughly described, especially after valvular surgery. It is also widely known that several anesthetic factors can cause autonomic disturbances resulting in the unmasking of sinus node dysfunction, significant bradycardia, and cardiovascular collapse during the intraoperative period. However, little is known about asymptomatic episodes, especially those occurring prior to coronary artery bypass grafting (CABG). We report a rare occurrence of an intraventricular conduction defect that presented in an asymptomatic patient following non-ST-elevation myocardial infarction prior to urgent CABG...
July 2018: Journal of Tehran Heart Center
Asmaa Ty Kishawy, Shimaa A Amer, Mohamed E Abd El-Hack, Islam M Saadeldin, Ayman A Swelum
The current study aimed to replace soybean oil in broiler diets with linseed oil, which is rich in omega-3 fatty acid supplemented with pomegranate peel extract (PPE) and measured its effect on broiler performance, carcass traits, lipid profile, as well as fatty acids composition, phenols and flavonoids content of broiler muscles and immunity of broiler chicks. A total of 300 1-day-old Cobb chicks were randomly allotted into six experimental groups, T1 fed on basal diet with soybean oil without any additives, T2 fed on basal diet with soybean oil with addition of 0...
January 4, 2019: Asian-Australasian Journal of Animal Sciences
Hala B Othman, Rania M Abdel Halim, Fatma Alzahraa M Gomaa, Malaka Z Amer
AIM: To determine the distribution of vancomycin MIC and the frequency of S. aureus strains with reduced vancomycin susceptibility among Methicillin-Resistant Staphylococcus aureus (MRSA) isolates. METHODS: MRSA isolates (n = 100) were tested for reduced susceptibility to vancomycin using MIC broth microdilution method (BMD), vancomycin screening agar with different vancomycin concentrations with and without casein, and Vitek 2 system. RESULTS: BMD detected (22%) vancomycin-intermediate S...
January 15, 2019: Open Access Macedonian Journal of Medical Sciences
Kyle Caution, Alexander Pan, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Anup Vaidya, Hawin Gosu, Kylene Daily, Shady Estfanous, Mikhail A Gavrilin, Mark E Drew, Estelle Cormet-Boyaka, Xi Chen, David E Frankhouser, Ralf Bundschuh, Pearlly Yan, Duaa Dakhlallah, Amal O Amer
Autophagy is a highly regulated, biological process that provides energy during periods of stress and starvation. This conserved process also acts as a defense mechanism and clears microbes from the host cell. Autophagy is impaired in Cystic Fibrosis (CF) patients and CF mice, as their cells exhibit low expression levels of essential autophagy molecules. The genetic disorder in CF is due to mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene that encodes for a chloride channel. CF patients are particularly prone to infection by pathogens that are otherwise cleared by autophagy in healthy immune cells including Burkholderia cenocepacia (B...
February 5, 2019: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Pranav Murthy, Aatur D Singhi, Mark A Ross, Patricia Loughran, Pedram Paragomi, Georgios I Papachristou, David C Whitcomb, Amer H Zureikat, Michael T Lotze, Herbert J Zeh Iii, Brian A Boone
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic inflammation, and promoting pancreatic duct obstruction. The autophagy inhibitor chloroquine (CQ) inhibits NET formation; therefore, we investigated the impact of CQ mediated NET inhibition in murine models of pancreatitis and human correlative studies. Methods: L-arginine and choline deficient ethionine supplemented (CDE) diet models of acute pancreatitis were studied in wild type and PAD4-/- mice, incapable of forming NETs...
2019: Frontiers in Immunology
Amer A Alkhatib
No abstract text is available yet for this article.
February 4, 2019: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Matthew J Borrelli, Amer Youssef, Michael B Boffa, Marlys L Koschinsky
Interest in lipoprotein (a) [Lp(a)] has exploded over the past decade with the emergence of genetic and epidemiological studies pinpointing elevated levels of this unique lipoprotein as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). This review summarizes the most recent discoveries regarding therapeutic approaches to lower Lp(a) and presents these findings in the context of an emerging, although far from complete, understanding of the biosynthesis and catabolism of Lp(a)...
February 4, 2019: Trends in Pharmacological Sciences
Sebastian Mafeld, Jennifer A Logue, Steven Masson, Rohan Thakkar, Aimen Amer, Colin Wilson, Gorab Sen, Derek Manas, Steven White, Robin Williams
Pseudoaneurysms after visceral transplantation represent a significant risk to patients. We report the successful treatment of three transplant (pancreas, liver and kidney) artery anastomotic pseudoaneurysms using physician-modified fenestrated endovascular stent grafts. In all cases, surgical repair was considered high risk and would have compromised the arterial supply to the graft. The endovascular approach in all cases obviated the need for surgical intervention and maintained graft arterial supply.
February 6, 2019: Cardiovascular and Interventional Radiology
Y L He, W Haynes, C D Meyers, A Amer, Y Zhang, P Chen, A E Mendonza, S Ma, W Chutkow, E Bachman
BACKGROUND: There is an unmet need for a safer and more effective treatment for obesity. This study assessed the effects of licogliflozin, a dual inhibitor of sodium-glucose co-transporter (SGLT) 1/2, on body weight, metabolic parameters and incretin hormones in patients with T2DM and/or obesity. METHODS: Patients with obesity (BMI 35-50kg/m2 ) were enrolled into a 12-week study (N=88; licogliflozin 150 mg q.d.). Patients with type-2 diabetes-mellitus (T2DM) were enrolled into a second, two-part study, comprising a single-dose cross-over (N=12; 2...
February 5, 2019: Diabetes, Obesity & Metabolism
Pilar Andrés, Helena Vico, Aina Yáñez, Antònia Siquier, Guillermo Amer Ferrer
Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI). Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test. Results: The results revealed clear differences in recall performance between patients with aMCI and controls...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Thaís Malucelli Amatneeks, Amer Cavalheiro Hamdan
INTRODUCTION: There is evidence in the literature that cognitive impairment is more prevalent in individuals with chronic kidney disease (CKD) than in the general population. The Montreal Cognitive Assessment (MoCA) is an instrument with a good application profile for cognitive evaluation of patients with CKD-like impairments. The objective of this study is to perform a systematic review of MoCA use in the context of CKD. METHOD: The keywords "Montreal Cognitive Assessment", "Kidney Disease" and "Chronic Kidney Disease" were used to search the databases...
January 24, 2019: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Jan Philipp Bewersdorf, Rory Shallis, Maximilian Stahl, Amer M Zeidan
Epigenetics refers to the regulation of gene expression mainly by changes in DNA methylation and modifications of histone proteins without altering the actual DNA sequence. While epigenetic modifications are essential for normal cell differentiation, several driver mutations in leukemic pathogenesis have been identified in genes that affect epigenetic processes, such as DNA methylation and histone acetylation. Several therapeutic options to target epigenetic alterations in acute myeloid leukemia (AML) have been successfully tested in preclinical studies and various drugs have already been approved for use in clinical practice...
2019: Therapeutic Advances in Hematology
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