Mariadelina Simeoni, Paola Cianfrone, Nicola Comi, Innocenza Gentile, Flora Fortunata Fabiano, Valentina Piraina, Roberta Talarico, Gaetano Lucisano, Laura Rivoli, Michele Andreucci, Laura Fuiano, Daniela Foti, Elio Gulletta, Giorgio Fuiano
BACKGROUND: Ramipril administered once daily is characterized by an attenuation of its pharmacological activity in the following 24 hours, whose effects on antiproteinuric activity have not yet been investigated. METHODS: The antiproteinuric efficacy of Ramipril has been evaluated in a cross-over study in 20 patients with renal disease, proteinuria and hypertension (GFR50 mL / min, proteinuria <3 g / day; SBP/DBP 150/90 mmHg). Proteinuria was measured over 24 hours on three consecutive urine collections (morning, afternoon and night) in the absence of antiproteinuric drugs and after ten days of treatment with single morning administration of Ramipril 2...
January 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia