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Roger Dmochowski, Benjamin M Brucker, Emily Cole, Steve Kawahara, Riya Pulicharam, Caroline Burk, Amy Tung, Douglass Hale
BACKGROUND: Nocturia is considered to be a very bothersome lower urinary tract disorder. Yet, to date, the economic burden attributable to this poor health condition remains less well known. OBJECTIVE: To compare differences in health care resource utilization (HCRU), health care costs, and work productivity in adult patients with differing frequencies of nocturia episodes (i.e., < 2 vs. ≥ 2 nocturia episodes per night). METHODS: Adult patients with nocturia enrolled in an integrated proprietary database were recruited to complete a survey on their demographics, nocturia characteristics, and work productivity...
January 24, 2019: Journal of Managed Care & Specialty Pharmacy
Abhishek Goyal, Abhijit Pakhare, Poonam Chaudhary
Study Objectives: This study was done to find whether a history of nocturia is associated with severity of obstructive sleep apnea (OSA) and also whether patients with nocturia constitute a separate phenotype of OSA. Materials and Methods: Retrospective chart review was done in consecutive OSA patients who were diagnosed in sleep laboratory of our institute. Detailed sleep history, examination, biochemical investigations, and polysomnography reports were taken for the analysis...
January 2019: Lung India: Official Organ of Indian Chest Society
Jason B Bennett, Kristin Khalaf Gillard, Benjamin Banderas, Steven Abrams, Linda Cheng, Seymour Fein
AIMS: To psychometrically evaluate the Impact of Nighttime Urination (INTU) questionnaire, a new patient-reported outcome measure developed to assess the impact of nocturia on health and functioning in a multicenter, behavioral modification (fluid restriction) study. METHODS: Participants aged 50-95 years with at least two voiding episodes/night for ≥6 months completed voiding diaries and the INTU on 3 consecutive days during weeks 1 and 2 (same day recall) and completed the Pittsburgh Sleep Quality Index (PSQI) and Nocturia Quality of Life Questionnaire (N-QOL) at baseline and days 8 and 15...
June 2018: Neurourology and Urodynamics
Jonathan C L Rodrigues, Antonio Matteo Amadu, Amardeep Ghosh Dastidar, Iwan Harries, Amy E Burchell, Laura E K Ratcliffe, Emma C Hart, Mark C K Hamilton, Julian F R Paton, Angus K Nightingale, Nathan E Manghat
We investigate the impact of dipper status on cardiac structure with cardiovascular magnetic resonance (CMR). Ambulatory blood pressure monitoring and 1.5T CMR were performed in 99 tertiary hypertension clinic patients. Subgroup analysis by extreme dipper (n = 9), dipper (n = 39), non-dipper (n = 35) and reverse dipper (n = 16) status was performed, matched in age, gender and BMI. Left ventricular (LV) mass was significantly higher for extreme dippers than dippers after correction for covariates (100 ± 6 g/m2 vs 79 ± 3 g/m2 , P = ...
April 2018: Journal of Clinical Hypertension
Iane Glauce Ribeiro Melotti, Cássia Raquel Teatin Juliato, Mariana Tanaka, Cassio Luiz Zanettini Riccetto
AIM: Depression and anxiety are prevalent psychiatric conditions and are associated with overactive bladder. The objective of this study was to determine prevalence and severity of anxiety and depression associated with overactive bladder (OAB) in women. METHODS: 274 women with clinical diagnosis of OAB were recruited from 2012 to 2015. They were submitted to the International Consultation on Incontinence Questionnaire-Overactive Bladder (ICIQ-OAB), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI)...
January 2018: Neurourology and Urodynamics
Hermann Zinner
The noctural desert elapid Walterinnesia aegyptia Lataste was observed in the habitat and in captivity. This species is of extremely poor sight and finds its prey mainly by its olfactory sense. It is active around midnight at temperatures down to 10°C and collects various kinds of diurnal and crepuscular reptiles, which are pulled out of their hidingplaces. Its extremely semantic coloration serves as a defense device and does not come in to conflict with its specialized way of foraging.
September 1971: Oecologia
A D Rijnsdorp
Data in the literature that in the Netherlands Carabus problematicus is an autumn breeder with overwintering larvae and adults have been confirmed. Pitfall catches show two peaks of adult beetles. The first small peak of activity is realized in May, the significance of which is not yet understood. The second higher peak occurs from the end of August till the beginning of October: the reproduction period. In this period at least three age classes are present. Some females were shown to take part in reproduction for at least two seasons...
May 1980: Oecologia
Andrew D Krystal, Xavier A Preud'homme
STUDY OBJECTIVES: Nocturia, voids which disturb sleep, is the most common cause of awakenings and is associated with daytime sleepiness. Because the standard treatments for the most common causes of nocturia are relatively ineffective, many treated patients with nocturia are left with residual sleepiness. We carried out this pilot study to evaluate the potential of Armodafinil to be an effective means of addressing the sleepiness that persists in many nocturia patients despite their receiving standard therapy...
September 9, 2016: Sleep
Sean A Martin, Sarah L Appleton, Robert J Adams, Anne W Taylor, Peter G Catcheside, Andrew Vakulin, R Douglas McEvoy, Nick A Antic, Gary A Wittert
OBJECTIVES: To examine the influence of obstructive sleep apnea (OSA) on nocturia, controlling for their shared co-morbidities, in a population of community-based middle aged to elderly men. METHODS: Participants were drawn from a randomly selected, community-dwelling cohort of men in Adelaide, Australia. Seven hundred and eight men (mean: 60.7 [41.6-88.2] years) who had polysomnography recordings, complete lower urinary tract symptoms (LUTS) measures (International Prostate Symptom Score), without prostate or bladder cancer and/or surgery, and no prior OSA diagnosis were selected...
November 2016: Urology
Marie-Astrid Denys, Elke Bruneel, Steven Van Laecke, Jens Peter Nørgaard, Karel Everaert
OBJECTIVES: Describe current shortcomings in clinical research on the treatment of nocturia in adults, and suggest new directions for future studies in this field. METHODS: A literature search was conducted using the keywords 'nocturia,' 'nocturnal polyuria,' 'sleep,' and 'hypertension.' RESULTS: Nocturia, or waking up at night to void, is a highly prevalent and bothersome lower urinary tract symptom (LUTS) affecting up to 40% of adults. Since the majority of patients are diagnosed with nocturnal polyuria (NP) as one of the underlying causes, it is not surprising that the effect of treatments for overactive bladder (OAB) and bladder outlet obstruction (BOO) are disappointing with regard to nocturia...
February 2017: Acta Clinica Belgica
Avita K Pahwa, Uduak U Andy, Diane K Newman, Hanna Stambakio, Kathryn H Schmitz, Lily A Arya
PURPOSE: We determined the association of urinary symptoms with fall risk and physical limitations in older community dwelling women with urinary incontinence. MATERIALS AND METHODS: We performed an in-depth assessment of daytime and nighttime urinary symptoms, fall risk, physical function, physical performance tests and mental function in older community dwelling women with urinary incontinence who had not sought care for urinary symptoms. All assessments were performed in participant homes...
May 2016: Journal of Urology
Angela R Shih, Mandakolathur R Murali
The complement pathway is a cascade of proteases that is involved in immune surveillance and innate immunity, as well as adaptive immunity. Dysfunction of the complement cascade may be mediated by aberrations in the pathways of activation, complement regulatory proteins, or complement deficiencies, and has been linked to a number of hematologic disorders, including paroxysmal noctural hemoglobinuria (PNH), hereditary angioedema (HAE), and atypical hemolytic-uremic syndrome (aHUS). Here, current laboratory tests for disorders of the complement pathway are reviewed, and their utility and limitations in hematologic disorders and systemic diseases are discussed...
December 2015: American Journal of Hematology
Hiromitsu Negoro, Yoshio Sugino, Koji Nishizawa, Takeshi Soda, Yosuke Shimizu, Kenichi Yoshimura, Osamu Ogawa, Koji Yoshimura
BACKGROUND: Although nocturia has been reported to increase mortality in elderly individuals, the particular risk factors that are associated with this event are unclear. Therefore, we evaluated risk factors for death in outpatients with nocturia. METHODS: Between October 2002 and December 2009, 250 consecutive patients with nocturia were enrolled in two general hospitals in Japan. Among them, 193 patients were able to be followed for at least 1 year and up to 9 years (median 4...
September 29, 2015: BMC Research Notes
Mariadelina Simeoni, Paola Cianfrone, Nicola Comi, Innocenza Gentile, Flora Fortunata Fabiano, Valentina Piraina, Roberta Talarico, Gaetano Lucisano, Laura Rivoli, Michele Andreucci, Laura Fuiano, Daniela Foti, Elio Gulletta, Giorgio Fuiano
BACKGROUND: Ramipril administered once daily is characterized by an attenuation of its pharmacological activity in the following 24 hours, whose effects on antiproteinuric activity have not yet been investigated. METHODS: The antiproteinuric efficacy of Ramipril has been evaluated in a cross-over study in 20 patients with renal disease, proteinuria and hypertension (GFR50 mL / min, proteinuria <3 g / day; SBP/DBP 150/90 mmHg). Proteinuria was measured over 24 hours on three consecutive urine collections (morning, afternoon and night) in the absence of antiproteinuric drugs and after ten days of treatment with single morning administration of Ramipril 2...
January 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Mitsuru Kawai
In neuromuscular diseases, respiratory disorder is related to sleep disorder. In Duchenne muscular dystrophy, respiratory muscle disorder progresses and induces alveolar hypoventilation. Hypoxemia and hypercapnia develop, requiring appropriate management. Hypoxemia first appears during sleep, initially occurring during the REM period, and it progresses and becomes persistent. Not only a decrease in the respiratory muscle strength but also upper respiratory tract obstruction due to soft palatal hypertrophy or a decrease in the muscle tension during sleep causes noctural ventilatory impairment...
2014: Rinshō Shinkeigaku, Clinical Neurology
Karl Peltzer, Supa Pengpid
BACKGROUND: The aim of this study is to estimate the prevalence of nocturnal sleeping problems and its associated factors among university students in mainly low- and middle-income countries. METHODS: A cross-sectional survey was conducted with 20,222 undergraduate university students (mean age, 20.8; SD = 2.8) from 27 universities in 26 countries across Asia, Africa and the Americas. RESULTS: Overall, 10.4% reported severe or extreme nocturnal sleeping problems (male, 10...
May 2015: Sleep & Breathing, Schlaf & Atmung
D J Von Willert, E Brinckmann, B M Eller, B Scheitler
The responses of CO2 exchange and overnight malate accumulation of leaf and stem succulent CAM-plants to water stress and the particular climatic conditiens of fog and föhn in the southern Namib desert have been investigated. In most of the investigated CAM plants a long term water stress gradually attenuated any uptake of external CO2 and led to CO2 release throughout day and night. No CAM-idling was observed. Rainfall or irrigation immediately restored daytime CO2 uptake while the recovery of the noctural CO2 uptake was delayed...
January 1983: Photosynthesis Research
J L Phillips, S Waddingham, D A Spiva
Lymphocytes were obtained from two patients with paroxysmal nocturnal hemoglobinuria as well as from apparently healthy controls and from patients with acute lymphoblastic leukemia and chronic lymphocytic leukemia. Subsequently, several aspects of zinc metabolism were studied in vitro in short-term cultures of these lymphocytes in order to assess lymphocyte functional capacity. The results of mitogen stimulation and zinc uptake studies for lymphocytes from donors with paroxysmal nocturnal hemoglobinuria were similar to those obtained for leukemic lymphocytes...
February 1983: Biological Trace Element Research
Cenk Murat Yazici, Remzi Abali, Nicel Tasdemir, Cagri Dogan, Tülin Yildiz
INTRODUCTION AND HYPOTHESIS: Nocturia and nocturnal enuresis (NE) share similar aetiopathological factors, and may represent two different situations involving the same underlying issue. In this study, we tried to evaluate the relation between NE of childhood and nocturia of young adulthood. METHODS: A total of 577 female university students aged 17-24 years were included in the survey. A face-to-face questionnaire was administered concerning present nocturia and past NE history...
February 2014: International Urogynecology Journal
Sarah Konefal, Mick Elliot, Bernard Crespi
Adult neurogenesis in mammals is predominantly restricted to two brain regions, the dentate gyrus (DG) of the hippocampus and the olfactory bulb (OB), suggesting that these two brain regions uniquely share functions that mediate its adaptive significance. Benefits of adult neurogenesis across these two regions appear to converge on increased neuronal and structural plasticity that subserves coding of novel, complex, and fine-grained information, usually with contextual components that include spatial positioning...
2013: Frontiers in Neuroanatomy
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