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https://read.qxmd.com/read/30772843/can-differences-in-length-of-stay-between-dutch-university-hospitals-and-other-hospitals-be-explained-by-patient-characteristics-a-cross-sectional-study
#1
Janine Ghielen, Sezgin Cihangir, Karin Hekkert, Ine Borghans, Rudolf Bertijn Kool
OBJECTIVES: The indicator unexpectedly long length of stay (UL-LOS) is used to gain insight into quality and safety of care in hospitals. The calculation of UL-LOS takes patients' age, main diagnosis and main procedure into account. University hospitals have relatively more patients with a UL-LOS than other hospitals. Our main research question is whether the high number of patients with a UL-LOS in university hospitals is caused by differences in additional patient characteristics between university hospitals and other hospitals...
February 15, 2019: BMJ Open
https://read.qxmd.com/read/30772813/report-a-case-report-on-nevirapine-induced-exfoliative-dermatitis
#2
Thattakudian Sheikuduman Mohamed Saleem, Kakavakam Jyothi, S Chandra Babu
Drug induced adverse drug reactions is more common in long term therapy particularly in immune compromised patients. Most of the drugs causing dermatological reactions like skin rashes, pruritus, steven johnson syndrome and exfoliative dermatitis. Nevirapine is the first line drug for human immunodeficiency virus (HIV) infection from the category of non-nucleoside reverse transcriptase enzyme inhibitor (NNRTI). In the present cases, we have reported the nevirapine induced severe exfoliative dermatitis. A patient admitted in the hospital with the symptoms of scaling on the skin and he received Nevirapine as a drug for his diagnosis of HIV for past three years...
January 2019: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/30772278/development-of-evidence-based-quality-indicators-for-deep-brain-stimulation-in-patients-with-parkinson-s-disease-and-first-year-experience-of-implementation-of-a-nation-wide-registry
#3
Kirsten Haas, Stephanie Stangl, Frank Steigerwald, Cordula Matthies, Doreen Gruber, Andrea A Kühn, Joachim K Krauss, Friederike Sixel-Döring, Kajetan von Eckardstein, Günther Deuschl, Joseph Classen, Dirk Winkler, Jürgen Voges, Imke Galazky, Wolfgang Oertel, Andres O Ceballos-Baumann, Max Lange, Alireza Gharabaghi, Daniel T Weiss, Jens Volkmann, Peter U Heuschmann
INTRODUCTION: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking. METHODS: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016. The process was initiated by the German Parkinson Society and followed international recommendations for developing QIs including: a systematic literature search; an appraisal of the published evidence; a consensus-based selection of the QI set; and a pilot study to assess the feasibility in implementing the QIs in clinical routine...
February 5, 2019: Parkinsonism & related Disorders
https://read.qxmd.com/read/30772254/ten-year-outcomes-after-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-an-observational-nonrandomized-cohort-study
#4
Amanda Jiménez, Ainitze Ibarzabal, Violeta Moizé, Adriana Pané, Alba Andreu, Judith Molero, Ana de Hollanda, Lilliam Flores, Emilio Ortega, Antonio Lacy, Josep Vidal
BACKGROUND: Sleeve gastrectomy (SG) has replaced Roux-en-Y gastric bypass (RYGB) as the most commonly performed bariatric surgery procedure. Data on the long-term (up to 10 yr) outcomes after SG is scarce. No previous study has compared the long-term outcomes between RYGB and SG. OBJECTIVE: To compare 10-year weight lost and 10-year remission rates of type 2 diabetes, hypertension, and dyslipidemia between RYGB and SG. SETTING: University hospital, Spain...
January 29, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://read.qxmd.com/read/30772241/experiences-with-the-daily-use-of-medications-among-chronic-hepatitis-c-patients
#5
Yone de Almeida Nascimento, Luciana Diniz Silva, Djenane Ramalho de Oliveira
BACKGROUND: Subjective experiences with medication use are individual experiences that can impact health outcomes by contributing to problems related to such use. OBJETIVES: The aim of the present study was to understand the experiences of chronic hepatitis C patients who were taking chronic medications, based on the phenomenology proposed by Merleau-Ponty and connection among this experience with the essential structures of the experience. METHODS: Data were gathered from interviews conducted with ten individuals taking long-term medications at the Viral Hepatitis Outpatient Clinic of the Alfa Gastroenterology Institute of the Hospital das Clínicas, Federal University of Minas Gerais, Brazil...
February 1, 2019: Research in Social & Administrative Pharmacy: RSAP
https://read.qxmd.com/read/30772216/long-term-outcomes-after-aortic-valve-surgery-in-patients-with-asymptomatic-chronic-aortic-regurgitation-and-preserved-lvef-impact-of-baseline-and-follow-up-global-longitudinal-strain
#6
Alaa Alashi, Tamanna Khullar, Amgad Mentias, A Marc Gillinov, Eric E Roselli, Lars G Svensson, Zoran B Popovic, Brian P Griffin, Milind Y Desai
OBJECTIVES: This study sought to determine whether baseline left ventricular global longitudinal strain (LV-GLS) and changes in left ventricular ejection fraction (LVEF) in a subgroup of subjects at post-operative follow-up added prognostic value in patients undergoing aortic valve (AV) surgery. BACKGROUND: In patients with chronic severe aortic regurgitation (AR) and preserved LVEF, sensitive markers are needed to decide timing of AV surgery. METHODS: This was an observational study in 865 patients (asymptomatic/mildly symptomatic, 52 ± 15 years of age, 79% men) with ≥3+ chronic AR and preserved LVEF of ≥50% who underwent AV surgery between 2003 and 2015...
February 11, 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/30772206/continuing-pharmacy-education-practices-in-geriatric-care-among-pharmacists-in-the-upper-midwest
#7
Marketa Marvanova, Paul Jacob Henkel
OBJECTIVES: To summarize select continuing pharmacy education (CPE) topics and hours related to geriatric care completed by community, hospital/clinic, and long-term care (LTC)/consultant pharmacists in the previous 12 months, whether pharmacy workplace influenced topic selection or completion, and to describe CPE sources used by community versus hospital/clinic pharmacists. DESIGN: Cross-sectional survey (2017). SETTING AND PARTICIPANTS: Licensed pharmacists in North Dakota, South Dakota, Minnesota, Iowa, and Nebraska with primary practice settings in community pharmacies, hospitals, or clinics or those practicing as consultant pharmacists...
February 13, 2019: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/30771429/experts-consensus-on-intraoperative-radiotherapy-for-pancreatic-cancer
#8
Yexiong Li, Qinfu Feng, Jing Jin, Susheng Shi, Zhihui Zhang, Xu Che, Jianwei Zhang, Yingtai Chen, Xiuhong Wu, Rufu Chen, Shengping Li, Jing Wang, Guang Li, Fei Li, Menghua Dai, Lei Zheng, Chengfeng Wang
Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Approximately 30-40% of patients present with locally advanced, unresectable pancreatic cancer because of invasion of mesenteric vessels or adjacent organs. The first patient with unresectable pancreatic cancer was treated with Intraoperative radiotherapy (IORT) in 1959[ 1 ] ...
February 13, 2019: Cancer Letters
https://read.qxmd.com/read/30771366/effects-of-nicotinamide-on-spatial-memory-and-inflammation-after-juvenile-traumatic-brain-injury
#9
Aidan C Smith, Ryan C Holden, Sherry M Rasmussen, Michael R Hoane, Michael J Hylin
Age is a consistent predictor of outcome following traumatic brain injury (TBI). Although children and adolescents have the highest rate of hospitalizations and long-term disabilities, few preclinical studies have attempted to model and treat TBI in this population. Studies using nicotinamide (NAM), a soluble B-group vitamin, in older animals (3-6 months) have shown improved functional recovery in experimental models of TBI. The purpose of this study was two-fold: to examine the preclinical efficacy of NAM at different doses on behavioral outcomes in juvenile rats and examine the microglial response over time...
February 13, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30771246/long-term-follow-up-of-a-multicentre-cohort-study-on-laparoscopic-peritoneal-lavage-for-perforated-diverticulitis
#10
D Sneiders, D P V Lambrichts, H A Swank, C F J M Blanken-Peeters, S W Nienhuijs, M J P M Govaert, M F Gerhards, A G M Hoofwijk, R J I Bosker, J D W van der Bilt, B H M Heijnen, H O Ten Cate Hoedemaker, G J Kleinrensink, J F Lange, W A Bemelman
AIM: Laparoscopic peritoneal lavage has increasingly been investigated as a promising alternative to sigmoidectomy for perforated diverticulitis with purulent peritonitis. Most studies only reported outcomes up to 12 months. Therefore, the objective of this study was to evaluate long-term outcomes of patients treated with laparoscopic lavage. METHODS: Between 2008 and 2010, 38 patients treated with laparoscopic lavage for perforated diverticulitis in ten Dutch teaching hospitals were included...
February 16, 2019: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://read.qxmd.com/read/30771069/european-association-for-endoscopic-surgery-eaes-consensus-statement-on-single-incision-endoscopic-surgery
#11
Salvador Morales-Conde, Andrea Peeters, Yannick M Meyer, Stavros A Antoniou, Isaías Alarcón Del Agua, Alberto Arezzo, Simone Arolfo, Amir Ben Yehuda, Luigi Boni, Elisa Cassinotti, Giovanni Dapri, Tao Yang, Sofie Fransen, Antonello Forgione, Shahab Hajibandeh, Shahin Hajibandeh, Michele Mazzola, Marco Migliore, Christof Mittermair, Doris Mittermair, Antonio Morandeira-Rivas, Carlos Moreno-Sanz, Andrea Morlacchi, Eran Nizri, Myrthe Nuijts, Jonas Raakow, Francisco M Sánchez-Margallo, Juan A Sánchez-Margallo, Amir Szold, Helmut Weiss, Michael Weiss, Ricardo Zorron, Nicole D Bouvy
BACKGROUND: Laparoscopic surgery changed the management of numerous surgical conditions. It was associated with many advantages over open surgery, such as decreased postoperative pain, faster recovery, shorter hospital stay and excellent cosmesis. Since two decades single-incision endoscopic surgery (SIES) was introduced to the surgical community. SIES could possibly result in even better postoperative outcomes than multi-port laparoscopic surgery, especially concerning cosmetic outcomes and pain...
February 15, 2019: Surgical Endoscopy
https://read.qxmd.com/read/30771053/assessing-sustainable-effectiveness-of-the-adjustment-mechanism-of-a-ubiquitous-clinic-recommendation-system
#12
Min-Chi Chiu, Tin-Chih Toly Chen
Advances in computer and communication technologies have engendered opportunities for developing an improved ubiquitous health care environment. One of the crucial applications is a ubiquitous clinic recommendation system, which entails recommending a suitable clinic to a mobile patient based on his/her location, hospital department, and preferences. However, patients may not be willing or able to express their preferences. To overcome this problem, some ubiquitous clinic recommendation systems mine the historical data of patients to learn their preferences, and they apply an algorithm to adjust the recommendation algorithm after receiving more patient data...
February 15, 2019: Health Care Management Science
https://read.qxmd.com/read/30770753/repeat-hepatectomy-with-systemic-chemotherapy-might-improve-survival-of-recurrent-liver-metastasis-from-colorectal-cancer-a-retrospective-observational-study
#13
Hiroshi Matsuoka, Zenichi Morise, Chihiro Tanaka, Takahiro Hayashi, Yoshiaki Ikeda, Koutarou Maeda, Koji Masumori, Yoshikazu Koide, Hidetoshi Katsuno, Yoshinao Tanahashi, Sanae Nakajima, Tsunekazu Hanai, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama
BACKGROUND: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. However, whether chemotherapy and repeat hepatectomy combination therapy improve survival or not is still unclear...
February 15, 2019: World Journal of Surgical Oncology
https://read.qxmd.com/read/30770356/treatment-of-neurotrophic-keratopathy-with-minimally-invasive-corneal-neurotisation-long-term-clinical-outcomes-and-evidence-of-corneal-reinnervation
#14
Joseph Catapano, Simon S M Fung, William Halliday, Cecilia Jobst, Douglas Cheyne, Emily S Ho, Ronald M Zuker, Gregory H Borschel, Asim Ali
AIM: To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face. METHODS: Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected...
February 15, 2019: British Journal of Ophthalmology
https://read.qxmd.com/read/30770324/neuropsychiatric-symptoms-in-tanzanian-hiv-infected-children-receiving-long-term-efavirenz-treatment-a-multicentre-cross-sectional-observational-study
#15
Lisa Van de Wijer, Deborah N Mchaile, Quirijn de Mast, Blandina T Mmbaga, Nanda N J Rommelse, Ashanti Duinmaijer, André J A M van der Ven, Arnt F A Schellekens, Grace D Kinabo
BACKGROUND: Efavirenz is commonly prescribed for children with HIV infection, yet little is known about risks of neuropsychiatric side-effects. We aimed to compare competence (social involvement, activities, and school performance) and psychopathology (internalising and externalising problems), cognitive performance (intelligence and working memory), and adherence in Tanzanian children on an efavirenz-based versus a non-efavirenz-based regimen. METHODS: In this multicentre, cross-sectional, observational study, we included consecutive children (aged 6-12 years) with HIV infection, on combination antiretroviral therapy (cART) for at least 6 months, and with viral loads of less than 1000 copies per mL from HIV care clinics of three primary health facilities and three referral hospitals in Moshi, Kilimanjaro, Tanzania...
February 12, 2019: Lancet HIV
https://read.qxmd.com/read/30770270/vacuum-extraction-in-preterm-deliveries-and-long-term-neurological-outcome-of-the-offspring
#16
Polina Schwarzman, Eyal Sheiner, Tamar Wainstock, Salvatore Andrea Mastrolia, Idit Segal, Daniella Landau, Asnat Walfisch
BACKGROUND: Concern exists regarding a possible harmful impact of vacuum extraction on the preterm newborn. We aimed to evaluate the long-term pediatric neurodevelopmental outcomes of the preterm offspring after vacuum extraction. METHODS: A population-based cohort analysis was performed comparing the risk for long-term neurological morbidity (up to age 18 years) in preterm (less than 37 completed weeks of gestation) children born via following three delivery modes: vacuum extraction, spontaneous delivery, and cesarean delivery performed during the second stage of labor...
January 15, 2019: Pediatric Neurology
https://read.qxmd.com/read/30770123/surgical-treatment-with-cannulated-screws-for-pediatric-femoral-neck-fractures-a-case-series
#17
Vito Pavone, Gianluca Testa, Maria Riccioli, Antonio Di Stefano, Giuseppe Condorelli, Giuseppe Sessa
INTRODUCTION: Femoral neck fractures are uncommon injuries in children, but the high incidence of long-term complications makes it important clinical entity. Early surgical treatment to achieve optimal results and to avoid a high rate of complications is widely advised. The purpose of this study was to retrospectively analyze the outcome of 8 children who sustained a femoral neck fracture. PATIENTS AND METHODS: The patients (6 boys and 2 girls with an average age of 9...
February 2, 2019: Injury
https://read.qxmd.com/read/30770034/pilot-testing-a-robot-for-reducing-pain-in-hospitalized-preterm-infants
#18
Nicholas Williams, Karon MacLean, Ling Guan, Jean Paul Collet, Liisa Holsti
Optimizing neurodevelopment is a key goal of neonatal occupational therapy. In preterm infants, repeated procedural pain is associated with adverse effects on neurodevelopment long term. Calmer is a robot designed to reduce infant pain. The objective of this study was to examine the effects of Calmer on heart rate variability (HRV) during routine blood collection in preterm infants. In a randomized controlled pilot trial, 10 infants were assigned to either standard care ( n = 5, facilitated tucking [FT]) or Calmer treatment ( n = 5)...
February 15, 2019: OTJR: Occupation, Participation and Health
https://read.qxmd.com/read/30769063/a-randomized-controlled-trial-comparing-crude-versus-heparin-bonded-prfe-graft-in-below-the-knee-bypass-surgery-for-critical-limb-ischemia-replace-trial-design-and-protocol
#19
Yann Gouëffic, Jean-Pierre Favre, Eric Steinmetz, Aline Ordureau, Valéry-Pierre Riche, Béatrice Guyomarch, Eugenio Rosset
BACKGROUND: While autogenous venous graft is preferable in below the knee bypass surgery for patients in critical limb ischemia, some 20% of patients will have no suitable vein for grafting, compelling a resort to artificial graft materials. Retrospective sub-group analyses within published studies comparing heparin-bonded PTFE with crude PFTE graft in below the knee bypass suggest that heparin-bonded graft offers superior long-term patency rates, but this has not been prospectively verified in patients with critical limb ischemia...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30768777/survival-and-functional-outcomes-of-molecularly-defined-childhood-posterior-fossa-ependymoma-cure-at-a-cost
#20
Michal Zapotocky, Kiran Beera, Jenny Adamski, Normand Laperierre, Sharon Guger, Laura Janzen, Alvaro Lassaletta, Liana Figueiredo Nobre, Ute Bartels, Uri Tabori, Cynthia Hawkins, Stacey Urbach, Derek S Tsang, Peter B Dirks, Michael D Taylor, Eric Bouffet, Donald J Mabbott, Vijay Ramaswamy
BACKGROUND: Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years. METHODS: Demographic, survival, and neurocognitive data were collected from consecutive patients diagnosed with PFE from 1985 through 2014 at the Hospital for Sick Children in Toronto, Ontario, Canada...
February 15, 2019: Cancer
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