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Egfr exon20

Andrés F Cardona, Leonardo Rojas, Zyanya Lucia Zatarain-Barrón, Helano C Freitas, Sara T Granados, Omar Castillo, George Oblitas, Luis Corrales, Christian D Castro, Alejandro Ruiz-Patiño, Claudio Martín, María Angelina Pérez, Lisde González, Luis Chirinos, Carlos Vargas, Hernán Carranza, Jorge Otero, July Rodriguez, Jenny Rodriguez, Pilar Archila, Mauricio Lema, José Acosta Madiedo, Niki Karachaliu, Beatriz Wills, Luis E Pino, Vladimir de Lima, Rafael Rosell, Oscar Arrieta
OBJECTIVES: Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting therapeutic options and impoverishing the prognosis compared to other EGFRm. We sought to extensively characterize exon20ins from a large cohort of lung adenocarcinomas in Hispanic patients. MATERIALS AND METHODS: This was a region-wide, observational longitudinal cohort study to evaluate characteristics and outcomes of patients with exon20ins in lung adenocarcinoma, based on a secondary analysis of electronic records from the Geno1...
November 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Y Li, L A Chen
Precise medicine is an emerging clinical therapeutic concept based on genomic and genetic information of patients. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is an important component of precise therapy for lung cancer patients. EGFR mutations occur mainly in exon 18 to 21, in which exon 19 deletion and exon 21 L858R point mutation that are known as sensitive mutations account for nearly 45% and 40%, respectively. Except for the above two mutations and T790M point mutation, the rest are rare mutations, including Ins19, Ins20, E709, G719, S768, L861 and some compound mutations...
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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