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Aging muscle

Fabiola Zakia Mónica, Gilberto De Nucci
In men, lower urinary tract symptoms (LUTS) are primarily attributed to benign prostatic hyperplasia (BPH). Therapeutic options are targeted to relax prostate smooth muscle and/or reduce prostate enlargement. Areas covered: This article reviews the major preclinical and clinical data on PDE5 inhibitors with a specific focus on tadalafil. It includes details of the role of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) - PDE5 pathway in the LUT organs (bladder and prostate) in addition to the available data on tadalafil in patients with LUTS secondary to BPH with or without erectile dysfunction (ED)...
March 22, 2019: Expert Opinion on Pharmacotherapy
Kellen B Hart, Felipe A Ribeiro, Morgan L Henriott, Nicolas J Herrera, Chris R Calkins
The objective of this study was to evaluate the effects of feeding high protein corn distillers grains on fresh beef quality. Steers (n=60) were fed one of five diets for 190 d (6 pens with 10 cattle/pen/diet): a corn control (Control), 40% high protein dry distillers grains plus solubles (HP-DDGS), 40% dry distillers grains plus solubles (DDGS), 40% wet distillers grains plus solubles (WDGS), or 40% bran plus solubles (Bran). Eighteen Choice carcasses (3 cattle/pen) were randomly selected within each treatment, however, two carcasses were lost during carcass selection...
March 15, 2019: Journal of Animal Science
Magda R Hamczyk, Vicente Andrés
Lamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS). HGPS is caused by progerin, an aberrant form of lamin A that leads to premature death, typically from the complications of atherosclerotic disease. A key characteristic of HGPS is a severe loss of vascular smooth muscle cells (VSMCs) in the arteries. Various mouse models of HGPS have been created, but few of them feature VSMC depletion and none develops atherosclerosis, the death-causing symptom of the disease in humans...
December 2019: Nucleus
Maud Pradines, Mouna Ghedira, Raphaël Portero, Ingrid Masson, Christina Marciniak, Dawn Hicklin, Emilie Hutin, Pierre Portero, Jean-Michel Gracies, Nicolas Bayle
INTRODUCTION: The effects of long-term stretching (>6 months) in hemiparesis are unknown. This prospective, randomized, single-blind controlled trial compared changes in architectural and clinical parameters in plantar flexors of individuals with chronic hemiparesis following a 1-year guided self-stretch program, compared with conventional rehabilitation alone. METHODS: Adults with chronic stroke-induced hemiparesis (time since lesion >1 year) were randomized into 1 of 2, 1-year rehabilitation programs: conventional therapy (CONV) supplemented with the Guided Self-rehabilitation Contract (GSC) program, or CONV alone...
March 22, 2019: Neurorehabilitation and Neural Repair
William J Evans, Marc Hellerstein, Eric Orwoll, Steve Cummings, Peggy M Cawthon
Sarcopenia has been described as the age-associated decrease in skeletal muscle mass. However, virtually every study of sarcopenia has measured lean body mass (LBM) or fat free mass (FFM) rather than muscle mass, specifically. In a number of published sarcopenia studies, LBM or FFM is referred to as muscle mass, leading to an incorrect assumption that measuring LBM or FFM is an accurate measure of muscle mass. As a result, the data on the effects of changes in LBM or FFM in older populations on outcomes such as functional capacity, disability, and risk of injurious falls have been inconsistent resulting in the conclusion that muscle mass is only weakly related to these outcomes...
March 21, 2019: Journal of Cachexia, Sarcopenia and Muscle
Li-Chen Chen, Hann-Chorng Kuo
Overactive bladder (OAB) is a common condition. The International Continence Society defines OAB as a symptom complex characterized by urgency with or without urge incontinence, usually with frequency and nocturia. The first-line treatment for OAB includes behavioral therapy, such as caffeine reduction, fluid intake modification, weight reduction, bladder training, and pelvic floor muscle training, as well as treatment with antimuscarinic or β3 -adrenoceptor agonist medications. However, less than half of all cases achieve satisfactory outcomes following first-line treatment...
March 22, 2019: Lower Urinary Tract Symptoms
Fan Lian, Wenchuan Chen, Yiming Liu, Long Shen, Wenzhe Fan, Wei Cui, Yue Zhao, Jiaping Li, Yu Wang
OBJECTIVE: To evaluate the efficacy and safety of intra-arterial chemotherapy (IAC) combined with intravesical chemotherapy (IC) in non-muscle invasive bladder cancer (NMIBC) and identify the risk factors for recurrence and progression. METHODS: This is a retrospective cohort study of NMIBC patients in south China. Ninety-nine patients underwent IAC combined with transurethral resection of bladder tumor (TURBT) and IC, and 50 patients underwent TURBT plus IC without IAC...
March 21, 2019: Journal of Cancer Research and Clinical Oncology
Hsing-Hui Su, Jiuan-Miaw Liao, Yi-Hsin Wang, Ke-Min Chen, Chia-Wei Lin, I-Hui Lee, Yi-Ju Li, Jing-Yang Huang, Shen Kou Tsai, Jiin-Cherng Yen, Shiang-Suo Huang
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta 1 (TGF-β1) superfamily that reverses age-related cardiac hypertrophy, improves muscle regeneration and angiogenesis, and maintains progenitor cells in injured tissue. Recently, targeted myocardial delivery of the GDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia-reperfusion (I-R). No investigations have as yet explored the cardioprotective effect of exogenous recombinant GDF11 in acute I-R injury, despite the convenience of its clinical application...
March 21, 2019: Basic Research in Cardiology
Rasmus Feld Frisk, Jakob Lorentzen, Jens Bo Nielsen
Impaired plantar flexor muscle activation during push-off in late stance contributes importantly to reduced gait ability in adults with cerebral palsy (CP). Here we used low-intensity transcranial magnetic stimulation (TMS) to suppress soleus EMG activity during push-off as an estimate of corticospinal drive in CP adults and neurologically intact (NI) adults. Ten CP adults (age 34 years, SD 14.6, GMFCS I-II) and ten NI adults (age 33 years, SD 9.8) walked on a treadmill at their preferred walking speed. TMS of the leg motor cortex was elicited just prior to push-off during gait at intensities below threshold for motor-evoked potentials...
March 21, 2019: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Hyun Jin Kwon, Young Ah Lee, Choong Ho Shin, Kijeong Kim
Patients with type 1 diabetes mellitus (T1DM) tend to experience poor self-rated health. However, few studies have examined the association between physical activity and self-rated health in pediatric patients with T1DM. The purpose of this study was to investigate the association between regular physical activity, regular muscle strength exercise, and self-rated health in pediatric patients with T1DM who lacked diabetes care. The eligible participants for this study were 37 pediatric patients with T1DM aged 9 to 17 years...
February 2019: Journal of Exercise Rehabilitation
Ji-Eun Kim, Tae-Beom Seo, Young-Pyo Kim
The purpose of this study was to investigate the effect of a stretching program, based on the Janda approach and compared with a static stretching program, on range of motion (ROM), muscle strength and pain. Subjects for this study were 11 middle-aged women with self-reported muscular skeletal symptoms. The subjects were randomly divided into six women as an experimental group (stretching based on Janda approach group, SJAG) and five women as the comparison group (traditional static stretching group, TSSG)...
February 2019: Journal of Exercise Rehabilitation
Takuya Iyanaga, Hayata Abe, Takashi Oka, Tetsuya Miura, Rumiko Iwasaki, Mai Takase, Minoru Isatake, Atsushi Doi
The purpose of this study was to investigate the effect of recumbent cycling with integrated volitional control electrical stimulation (IVES) on gait ability in stroke patients. Six stroke patients (all male; average age, 55.7±8.3 years) participated. Recumbent cycling (R-cycling) was performed with and without IVES in the power assist (IVES-P) mode. The targeted muscle for electrostimulation was the tibialis anterior. Patients performed 10 min of IVES-P mode plus R-cycling (program A) or R-cycling alone (program B), once per day, 5 times per week...
February 2019: Journal of Exercise Rehabilitation
Bihter Akınoğlu, Tuğba Kocahan, Taşkın Özkan
The aim of this study is to determine the relationship between peripheral muscle strength, respiratory function and respiratory muscle strength in athletes. The study included a total of 150 elite athletes (judo, rowing, gymnastics) (age, 16.94±2.37 years; length, 167.70±12.23 cm; body weight, 62.87±17.33 kg; body mass index, 21.95±2.92 kg/m2 ). Isomed 2000 isokinetic dynamometer was used to assess peripheral muscle strength. The strength of the dominant side knee flexor and extensor muscles was evaluated at 60°/sec and 180°/sec...
February 2019: Journal of Exercise Rehabilitation
Susanne Beischer, Eric Hamrin Senorski, Christoffer Thomeé, Kristian Samuelsson, Roland Thomeé
Objectives: We investigated whether patient demographics, 4-month patient-reported outcomes (PRO) and muscle function predicted young athletes regaining symmetrical muscle function in five tests of muscle function 1 year after ACL reconstruction. Methods: We extracted data on patient demographics, PROs and the results of five tests of muscle function from a rehabilitation-specific register. Athletes were 15-30 years of age, involved in knee-strenuous sport and had undergone a primary ACL reconstruction...
2019: BMJ Open Sport & Exercise Medicine
Mauricio Mónaco, José A Gutiérrez Rincón, Bruno J Montoro Ronsano, Rodney Whiteley, Fernando Sanz-Lopez, Gil Rodas
The aim of this cohort study is to estimate the influence of position, category, and maturity status on the incidence and pattern of injury in handball players, across two seasons. Injury registration from 164 players-season (12-27 years) was conducted, and players were categorized into youth (133) and adults (31), and per position: 27 goalkeepers, 67 backs, 70 wings and pivots. Maturity status in youth players was also measured by testicular volume on clinical examination (32 immature, 101 mature). 190 injuries occurred during 34 221 hours of exposure...
March 2019: Biology of Sport
Kristin Taraldsen, A Stefanie Mikolaizak, Andrea B Maier, Elisabeth Boulton, Kamiar Aminian, Jeanine van Ancum, Stefania Bandinelli, Clemens Becker, Ronny Bergquist, Lorenzo Chiari, Lindy Clemson, David P French, Brenda Gannon, Helen Hawley-Hague, Nini H Jonkman, Sabato Mellone, Anisoara Paraschiv-Ionescu, Mirjam Pijnappels, Michael Schwenk, Chris Todd, Fan Bella Yang, Anna Zacchi, Jorunn L Helbostad, Beatrix Vereijken
INTRODUCTION: The European population is rapidly ageing. In order to handle substantial future challenges in the healthcare system, we need to shift focus from treatment towards health promotion. The PreventIT project has adapted the Lifestyle-integrated Exercise (LiFE) programme and developed an intervention for healthy young older adults at risk of accelerated functional decline. The intervention targets balance, muscle strength and physical activity, and is delivered either via a smartphone application (enhanced LiFE, eLiFE) or by use of paper manuals (adapted LiFE, aLiFE)...
March 20, 2019: BMJ Open
Volkan Karataşlı, İlker Çakır, Duygu Ayaz, Adnan Budak, Muzaffer Sancı
OBJECTIVE: To investigate the clinical outcomes and histopathological features of uterine smooth muscle tumors of uncertain malignant potential (STUMP). METHODS: The study analysed cases diagnosed with uterine STUMP in a tertiary center, between January 2003 and September 2018. We investigated the clinical, operative and histopatholologic data of the cases. Follow-up information and clinical outcomes were also examined. RESULTS: 28 cases with uterine STUMP were studied...
March 18, 2019: Journal of Gynecology Obstetrics and Human Reproduction
Randeep S Aujla, Shakil Patel, Annette Jones, Maneesh Bhatia
OBJECTIVES: The purpose of this study is to present outcomes and objective measures of assessment for acute Achilles tendon (AT) ruptures treated with an eight-week functional dynamic treatment protocol in a VACOped® boot with immediate full weight bearing mobilisation, the Leicester Achilles Management Protocol (LAMP). METHODS: A prospective study of all patients treated with the LAMP with minimum 12-month follow-up was performed. Patients completed the Achilles Tendon Rupture Score (ATRS) and in the latter part of the study, objective measures of the calf muscle girth and heel raise height were obtained...
March 11, 2019: Injury
Jing Gao, Jonathan M Rubin, Johnson Chen, Michael O'Dell
The aim of the study was to evaluate the feasibility of using ultrasound elastography to assess the effect of botulinum toxin A (BoNT-A) treatment on post-stroke spasticity of the upper limb. In this prospective study, we performed ultrasound elastography (strain imaging and acoustic radiation force impulse-based shear wave elastography) of the spastic biceps brachii muscle in seven patients (five men and two women, mean age: 45y) who underwent BoNT-A injection treatment for post-stroke spasticity of the upper limb...
March 18, 2019: Ultrasound in Medicine & Biology
Akio Kodama, Noriko Takahashi, Masayuki Sugimoto, Kiyoaki Niimi, Hiroshi Banno, Kimihiro Komori
OBJECTIVE: Open surgical repair (OSR) for abdominal aortic aneurysms is a more invasive approach than endovascular aneurysm repair but has more enduring results and may lead to a lower reintervention rate. Therefore, strict selection of patients should be based on assessments of both early and late outcomes. The controlling nutritional status (CONUT) score and skeletal muscle mass index (SMI) have been reported as indicators of nutritional status and muscle size, respectively. The aim of this study was to identify prognostic factors, including sarcopenia and nutritional status, for early and late outcomes...
March 19, 2019: Journal of Vascular Surgery
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