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Ryo Kato, Kiyokazu Nakajima, Tsuyoshi Takahashi, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Masaki Mori, Yuichiro Doki
BACKGROUND: The fourth edition of New Japanese classification system for esophageal achalasia was revised after a long interval of 30 years in 2012. In this new system, achalasia is morphologically classified into 3 types, based on its X-ray findings. However, the system has been limitedly used in Japan and has not been fully validated in terms of its predictive capability of postoperative outcomes. The purpose of this study was to clarify the validity of new Japanese classification system for esophageal achalasia, as an index of patient characteristics and as a predictor of operative and mid/long-term postoperative outcomes...
February 15, 2019: Esophagus: Official Journal of the Japan Esophageal Society
Sachin Wani, Samuel Han, Violette Simon, Matthew Hall, Dayna Early, Eva Aagaard, Wasif M Abidi, Subhas Banerjee, Todd H Baron, Michael Bartel, Erik Bowman, Brian C Brauer, Jonathan M Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A Coté, Koushik K Das, Christopher J DiMaio, Andrew M Dries, Steven A Edmundowicz, Abdul Hamid El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S Gan, Lisa Gangarosa, Bhargava Gannavarapu, Stuart R Gordon, Nalini M Guda, Hazem T Hammad, Cynthia Harris, Sujai Jalaj, Paul Jowell, Sana Kenshil, Jason Klapman, Michael L Kochman, Sri Komanduri, Gabriel Lang, Linda S Lee, David E Loren, Frank Lukens, Daniel Mullady, Raman V Muthusamy, Andrew S Nett, Mojtaba S Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M Scheiman, Isaiah Schuster, Raj J Shah, Rishi Sharma, Joshua P Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H Tabibian, Demetrios Tzimas, Dushant S Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Rajesh N Keswani
BACKGROUND AND AIMS: Minimum EUS and ERCP volumes that should be offered per trainee in "high quality" advanced endoscopy training programs (AETPs) are not established. We aimed to define the number of procedures required by an "average" advanced endoscopy trainee (AET) to achieve competence in technical and cognitive EUS and ERCP tasks to help structure AETPs. METHODS: ASGE-recognized AETPs were invited to participate; AETs were graded on every fifth EUS and ERCP examination using a validated tool...
February 7, 2019: Gastrointestinal Endoscopy
Deaglan McHugh, Mario Eisenberger, Elisabeth I Heath, Justine Bruce, Daniel C Danila, Dana E Rathkopf, Jarett Feldman, Susan F Slovin, Banmeet Anand, Rong Chu, Jacqueline Lackey, Leonard Reyno, Emmanuel S Antonarakis, Michael J Morris
Background Antibody drug conjugates (ADC) offer the potential of maximizing efficacy while minimizing systemic toxicity. ASG-5ME, an SLC44A4-targeting antibody carrying monomethyl auristatin E (MMAE), a microtubule-disrupting agent, was investigated in men with metastatic castration resistant prostate cancer. Methods The primary objective of this phase I study was to determine maximum tolerated dose (MTD) and recommended phase II dose. Secondary objectives were safety, antitumor activity, pharmacokinetic properties, immunogenicity, and the detection of SLC44A4 on circulating tumor cells...
February 6, 2019: Investigational New Drugs
Alberto Mariani, Simone Segato, Andrea Anderloni, Gianpaolo Cengia, Marco Parravicini, Teresa Staiano, Gian Eugenio Tontini, Davide Lochis, Paolo Cantù, Guido Manfredi, Arnaldo Amato, Stefano Bargiggia, Giordano Bernasconi, Fausto Lella, Marcella Berni Canani, Paolo Beretta, Luca Ferraris, Sergio Signorelli, Giuseppe Pantaleo, Gianpiero Manes, Pier Alberto Testoni
BACKGROUND: Prospective studies about endoscopic retrograde cholangio-pancreatography (ERCP) in a community setting are rare. AIM: To assess success and complication rates of routinely-performed ERCP in a regional setting, and the priority quality indicators for ERCP practice. METHODS: Prospective region wide observational study on consecutive patients undergoing ERCP during a 6-month period. A centralized online ERCP questionnaire was built and used for data storage...
January 17, 2019: Digestive and Liver Disease
Zane Z Young, Mark D Balceniuk, Khurram Rasheed, Doran Mix, Antoinette Esce, Jennifer L Ellis, Roan J Glocker, Adam J Doyle, Kathleen Raman, Michael C Stoner
BACKGROUND: Anatomic severity grade (ASG) can be used to assess abdominal aortic aneurysm (AAA) anatomic complexity. High ASG is associated with complications following endovascular repair of AAAs and we have demonstrated that ASG correlates with resource utilization. The hypothesis of this study is that ASG is directly related to midterm mortality in patients undergoing AAA repair. METHODS: Patients who underwent infrarenal AAA repairs between July 2007 and August 2014 were retrospectively reviewed and ASG scores were calculated using 3-dimensional computed tomography reconstructions...
February 4, 2019: Vascular and Endovascular Surgery
Keith Siau, James Hodson, Srivathsan Ravindran, Matthew D Rutter, Marietta Iacucci, Paul Dunckley
BACKGROUND AND AIMS: The cecal intubation rate (CIR) is a widely accepted key performance indicator (KPI) in colonoscopy but lacks a universal calculation method. We aimed to assess whether differences in CIR calculation methods could impact on perceived trainee outcomes. METHODS: A systematic review of CIR calculation methods was conducted on major societal guidelines (United Kingdom, European Society of Gastrointestinal Endoscopy [ESGE] and American Society for Gastrointestinal Endoscopy [ASGE]) and trainee-inclusive studies...
January 16, 2019: Gastrointestinal Endoscopy
Burcu Gul, Alexandra Lansky, Matthew J Budoff, David Sharp, Bruce Maniet, Lee Herman, Jane Z Kuo, Lin Huang, Mark Monane, Joseph A Ladapo
BACKGROUND: Evaluating women with symptoms suggestive of coronary artery disease (CAD) remains challenging. A blood-based precision medicine test yielding an age/sex/gene expression score (ASGES) has shown clinical validity in the diagnosis of obstructive CAD. We assessed the effect of the ASGES on the management of women with suspected obstructive CAD in a community-based registry. MATERIALS AND METHODS: The prospective PRESET (A Registry to Evaluate Patterns of Care Associated with the Use of Corus® CAD in Real World Clinical Care Settings) Registry (NCT01677156) enrolled 566 patients presenting with symptoms suggestive of stable obstructive CAD from 21 United States primary care practices from 2012 to 2014...
January 17, 2019: Journal of Women's Health
Juan E Corral, Tara Keihanian, Liege I Diaz, Douglas R Morgan, Daniel A Sussman
Objective: Recent guidelines on endoscopic sampling recommend complete gastric polyp removal for solitary fundic polyps >10 mm, hyperplastic polyps >5 mm and all adenomatous polyps. We aim to describe endoscopic approach to polyps in the time period prior to the American Society of Gastrointestinal Endoscopy (ASGE) guidelines and to identify opportunities for clinical practice improvements. Design: Retrospective review of the Clinical Outcome Research Initiative (CORI) database, including all oesophagogastroduodenoscopies (OGDs)...
January 2019: Frontline Gastroenterology
Khashayar Arianpour, Suzanne N Forman, Patrick Karabon, Prasad John Thottam
OBJECTIVES: Numerous risk factors have been characterized for acquired subglottic stenosis (ASGS) in the pediatric population. This analysis explores the comorbidities of hospitalized ASGS patients in the United States and associated costs and length of stay (LOS). METHODS: A retrospective analysis of the Kids' Inpatient Database (KID) from 2009 to 2012 for inpatients ≤ 20 years of age who were diagnosed with ASGS. International Classification of Diseases, Clinical Modification, Version 9 diagnosis codes were used to extract diagnoses of interest from 14, 045, 425 weighted discharges across 4179 hospitals in the United States...
November 13, 2018: International Journal of Pediatric Otorhinolaryngology
Xin Wang, Yi Li, Qingsong Liu, Xiaoyin Tan, Xiaoqian Xie, Qingyou Xia, Ping Zhao
The Filippi's gland, also called the Lyonet's gland, is in truth a pair of tiny glands that are unique to lepidopteran insects. Although the ultrastructure of the Filippi's gland has been well-understood, the specific biological function of this gland in silk spinning is still unclear. Previous studies proposed a hypothesis that this gland might synthesize and secrete some substances into the anterior silk gland (ASG) to help silk spinning. In order to identify these metabolites, a GC/MS-based metabolomics technique was introduced...
December 18, 2018: Insect Biochemistry and Molecular Biology
Myung-Jin Moon
Among the triad spinning units for capture thread producing system in the orb-web spiders, aqueous gluey substances are produced from two pairs of aggregate silk glands (ASG). Although biochemical analysis of glue substance is produced by way of their passage through the ASG, its structural modifications in the nodular area have been nearly neglected till now. This paper focused on identifying the fine structural characteristics of the aggregate nodules in the golden orb-web spider Nephila clavata using both of light and transmission electron microscopes...
2018: Animal Cells and Systems
Sabyasachi Patra, Chhavi Agarwal, Sanhita Chaudhury
Large volume radioactive waste drums with low/intermediate level of alpha activity, generated in radiochemical laboratories, are in general screened for special nuclear materials (SNM) in a segmented gamma scanner (SGS) before disposal. The assay methodology traditionally requires a standard drum of identical geometry and thereby making the procedure relying on the availability of a true standard, which is often difficult to organize. Here, we report a non-conventional absolute segmented gamma scanning (ASGS) methodology for the assay of 200 L waste drums, avoiding the use of a standard drum...
November 27, 2018: Applied Radiation and Isotopes
Marco Falcone, Alessandro Russo, Yuichiro Shindo, Alessio Farcomeni, Filippo Pieralli, Roberto Cangemi, Jinliang Liu, Jingyan Xia, Junya Okumura, Masahiro Sano, Christopher Jones, Vieri Vannucchi, Massimo Mancone, Scott Micek, Feng Xu, Francesco Violi, Marin Kollef
Objectives. While the inflammatory response to severe pneumonia is paramount in reining in and resolving the infection, the excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP), treated with macrolides and aspirin, would receive benefit beyond conventional antibiotic therapy. Methods. An observational study was conducted on patients with severe CAP. All patients were admitted to 5 teaching hospitals (in Italy, USA, Japan, and China), and data were gathered from their electronic medical records...
December 3, 2018: Antimicrobial Agents and Chemotherapy
Ming Liu, Jian-Qiang Kong
Herein we describe the discovery and functional characterization of a steroidal glycosyltransferase (SGT) from Ornithogalum saundersiae and a steroidal glycoside acyltransferase (SGA) from Escherichia coli and their application in the biosynthesis of acylated steroidal glycosides (ASGs). Initially, an SGT gene, designated as OsSGT1, was isolated from O. saundersiae . OsSGT1-containing cell free extract was then used as the biocatalyst to react with 49 structurally diverse drug-like compounds. The recombinant OsSGT1 was shown to be active against both 3 β - and 17 β -hydroxyl steroids...
October 2018: Acta Pharmaceutica Sinica. B
Donevan Westerveld, April Goddard, Nieka Harris, Vikas Khullar, Justin Forde, Peter V Draganov, Chris E Forsmark, Dennis Yang
BACKGROUND AND AIMS: Various gastrointestinal societies have released guidelines on the evaluation of asymptomatic pancreatic cysts (PCs). These guidelines differ on several aspects, which create a conundrum for clinicians. The aim of this study was to evaluate preferences and practice patterns in the management of incidental PCs in light of these societal recommendations. METHODS: An electronic survey distributed to members of the American Society for Gastrointestinal Endoscopy (ASGE)...
November 13, 2018: Digestive Diseases and Sciences
Julio F León Moreno
Background and study aims  High-quality colonoscopy is fundamental for preventing colorectal cancer (CRC). The adenoma detection rate (ADR) is a key colonoscopy quality measure. The aim of this study was to establish the screening colonoscopy ADR of a tertiary referral center in Peru, identify the relationship between the ADR and patient age, sex and the colonoscopist, and determine the endoscopic and histopathological characteristics of the lesions found. Patients and methods  A retrospective observational longitudinal study was undertaken between January 2016 and June 2017...
November 2018: Endoscopy International Open
Rabindra R Watson, Mansour A Parsi, Harry R Aslanian, Adam J Goodman, David R Lichtenstein, Joshua Melson, Udayakumar Navaneethan, Rahul Pannala, Amrita Sethi, Shelby A Sullivan, Nirav C Thosani, Guru Trikudanathan, Arvind J Trindade, John T Maple
Background and Aims: Lithotripsy is a procedure for fragmentation or destruction of stones to facilitate their removal or passage from the biliary or pancreatic ducts. Although most stones may be removed endoscopically using conventional techniques such as endoscopic sphincterotomy in combination with balloon or basket extraction, lithotripsy may be required for clearance of large, impacted, or irregularly shaped stones. Several modalities have been described, including intracorporeal techniques such as mechanical lithotripsy (ML), electrohydraulic lithotripsy (EHL), and laser lithotripsy, as well as extracorporeal shock-wave lithotripsy (ESWL)...
November 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Mafalda Sousa, Rolando Pinho, Luísa Proença, Jaime Rodrigues, João Silva, Catarina Gomes, João Carvalho
BACKGROUND AND AIMS: The guidelines by the American Society for Gastrointestinal Endoscopy (ASGE) suggest that in patients with gallbladder in situ, endoscopic retrograde cholangiopancreatography (ERCP) should be performed in the presence of high-risk criteria for choledocholithiasis, after biochemical tests and abdominal ultrasound. There are no specific recommendations for cholecystectomized patients. The aim of this study was to evaluate the applicability of ASGE criteria for ERCP in cholecystectomized patients with suspected choledocholithiasis...
October 6, 2018: Digestive and Liver Disease
Sijun Liu, Purushottam R Lomate, Bryony C Bonning
The phytophagous stink bug, Nezara viridula (L.) infests multiple plant species and impacts agricultural production worldwide. We analyzed the transcriptomes of N. viridula accessory salivary gland (ASG), principal salivary gland (PSG) and gut, with a focus on putative digestive proteases and nucleases that present a primary obstacle for the stability of protein- or nucleic acid-based stink bug control approaches. We performed high throughput Illumina sequencing followed by de novo transcriptome assemblies...
October 21, 2018: Insect Biochemistry and Molecular Biology
Nirav P Patel, Mallika Sanyal, Naveen Sharma, Dinesh S Patel, Pranav S Shrivastav, Bhavin N Patel
A highly selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been described for the determination of asenapine (ASE) in presence of its inactive metabolites N -desmethyl asenapine (DMA) and asenapine- N -glucuronide (ASG). ASE, and ASE 13C-d3, used as internal standard (IS), were extracted from 300 µL human plasma by a simple and precise liquid-liquid extraction procedure using methyl tert -butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP8e (100 mm × 4...
October 2018: Journal of Pharmaceutical Analysis
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