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COMMENT
Xavier Calvet
Chang L, Sultan S, Lembo A, et al. AGA clinical practice guideline on the pharmacological management of irritable bowel syndrome with constipation. Gastroenterology. 2022;163:118-36. 35738724.
November 2022: Annals of Internal Medicine
#62
COMMENT
Xavier Calvet
Lembo A, Sultan S, Chang L, et al. AGA clinical practice guideline on the pharmacological management of irritable bowel syndrome with diarrhea. Gastroenterology. 2022;163:137-51. 35738725.
November 2022: Annals of Internal Medicine
#63
JOURNAL ARTICLE
Chaohui Zhang, Yixin Yu, Shugao Shi, Manman Liang, Dongqin Yang, Ning Sui, William W Yu, Lina Wang, Zhiling Zhu
Androgenetic alopecia (AGA) is a common form of hair loss, which is mainly caused by oxidative stress induced dysregulation of hair follicles (HF). Herein, a highly efficient manganese thiophosphite (MnPS3 ) based superoxide dismutase (SOD) mimic was discovered using machine learning (ML) tools. Remarkably, the IC50 of MnPS3 is 3.61 μg·mL-1 , up to 12-fold lower than most reported SOD-like nanozymes. Moreover, a MnPS3 microneedle patch (MnMNP) was constructed to treat AGA that could diffuse into the deep skin where HFs exist and remove excess reactive oxygen species...
November 9, 2022: Nano Letters
#64
JOURNAL ARTICLE
Alessandro Paniccia, Patricio M Polanco, Brian A Boone, Abigail I Wald, Kevin McGrath, Randall E Brand, Asif Khalid, Nisa Kubiliun, Anne Marie O'Broin-Lennon, Walter G Park, Jason Klapman, Benjamin Tharian, Sumant Inamdar, Kenneth Fasanella, John Nasr, Jennifer Chennat, Rohit Das, John DeWitt, Jeffrey J Easler, Benjamin Bick, Harkirat Singh, Kimberly J Fairley, Savreet Sarkaria, Tarek Sawas, Wasseem Skef, Adam Slivka, Anna Tavakkoli, Shyam Thakkar, Victoria Kim, Hendrikus Dutch Vanderveldt, Allyson Richardson, Michael B Wallace, Bhaumik Brahmbhatt, Megan Engels, Charles Gabbert, Mohannad Dugum, Samer El-Dika, Yasser Bhat, Sanjay Ramrakhiani, Gennadiy Bakis, Daniil Rolshud, Gordon Millspaugh, Thomas Tielleman, Carl Schmidt, John Mansour, Wallis Marsh, Melanie Ongchin, Barbara Centeno, Sara E Monaco, N Paul Ohori, Sigfred Lajara, Elizabeth D Thompson, Ralph H Hruban, Phoenix D Bell, Katelyn Smith, Jennifer B Permuth, Christopher Vandenbussche, Wayne Ernst, Maria Grupillo, Cihan Kaya, Melissa Hogg, Jin He, Christopher L Wolfgang, Kenneth K Lee, Herbert Zeh, Amer Zureikat, Marina N Nikiforova, Aatur D Singhi
BACKGROUND & AIMS: Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful adjunct in the assessment of patients with pancreatic cyst. However, previous studies have been retrospective or single institutional experiences. The aim of this study was to prospectively evaluate NGS on a multi-institutional cohort of patients with pancreatic cyst in real time. METHODS: The performance of a 22-gene NGS panel (PancreaSeq) was first retrospectively confirmed and then within a 2-year timeframe, PancreaSeq testing was prospectively used to evaluate endoscopic ultrasound-guided fine-needle aspiration pancreatic cyst fluid from 31 institutions...
January 2023: Gastroenterology
#65
JOURNAL ARTICLE
Allyzain Ismail, Nikhil Jadawji, Philip Adebayo, Ahmed Jusabani, Kamran Hameed, Ali Akbar Zehri, Willy Kiviri, Athar Ali
Introduction: venous thromboembolism is a complication among admitted medical and surgical patients. International guidelines recommend patients are assessed upon admission and appropriate thromboprophylaxis should be initiated. However, studies have shown that thromboprophylaxis for patients at risk of venous thromboembolism is underutilized. Methods: this was a retrospective study conducted on hospitalized medical and surgical patients at Aga Khan Hospital Dar es salaam from January to June 2019...
2022: Pan African Medical Journal
#66
REVIEW
Syed Sameer Aga, Saniya Nissar
Writing an effective manuscript is one of the pivotal steps in the successful closure of the research project, and getting it published in a peer-reviewed and indexed journal adds to the academic profile of a researcher. Writing and publishing a scientific paper is a tough task that researchers and academicians must endure in staying relevant in the field. Success in translating the benchworks into the scientific content, which is effectively communicated within the scientific field, is used in evaluating the researcher in the current academic world...
2022: Biochemistry Research International
#67
JOURNAL ARTICLE
Aditya K. Gupta, Mary Bamimore
INTRODUCTION: Platelet-rich plasma (PRP) is a commonly used therapeutic option for androgenetic alopecia (AGA). Evidence syntheses for the impact of PRP on AGA has been handicapped by non-standardized protocols for its administration. We quantitatively synthesized the evidence base to determine the relative efficacy of PRP regimens with different frequencies of administration. We defined frequency as a vector of the (i) number of sessions and (ii) time interval between the sessions. METHODS: We systematically reviewed the peer-reviewed literature to obtain relevant data; we then conducted a multivariable meta-regression and network meta-analyses (NMAs)...
September 1, 2022: Journal of Drugs in Dermatology: JDD
#68
JOURNAL ARTICLE
Bastien Burat, Audrey Reynaerts, Dominique Baiwir, Maximilien Fléron, Sophie Gohy, Gauthier Eppe, Teresinha Leal, Gabriel Mazzucchelli
In clinical routine, the diagnosis of cystic fibrosis (CF) is still challenging regardless of international consensus on diagnosis guidelines and tests. For decades, the classical Gibson and Cooke test measuring sweat chloride concentration has been a keystone, yet, it may provide normal or equivocal results. As of now, despite the combination of sweat testing, CFTR genotyping, and CFTR functional testing, a small fraction (1-2%) of inconclusive diagnoses are reported and justifies the search for new CF biomarkers...
July 31, 2022: Cells
#69
JOURNAL ARTICLE
Bakhtawar M Hanif Khowaja, Anam Shahil Feroz, Sarah Saleem
INTRODUCTION: Drawing on the well-acknowledged evidence of community midwives services to address the issue of high maternal mortality, the Government of Pakistan initiated the Community Midwifery (CMW) programme in 2006 to provide skilled birth attendance to pregnant women living in rural areas. Despite a large investment in CMW programme, the availability of community midwives in rural areas following their training is a constant struggle. The concerns related to the training, support and acceptability of community midwives need to be studied in order to identify gaps in the provision of skilled maternal and newborn healthcare...
July 21, 2022: BMJ Open
#70
JOURNAL ARTICLE
Noman Ali, Hasnain Abbas Dharamshi, Syed Mustahsan, Suman Noorani
Objectives: To identify the etiology and outcomes of new onset seizure in adult patients presenting to the Emergency Department (ED), to improve knowledge among healthcare providers regarding diagnosis and hence improve the outcomes. Methods: This was a descriptive retrospective study conducted at the Emergency Department of Aga Khan University Hospital, Karachi, Pakistan. Adult patients (18 years and above), presented to the ED from January 01, 2019 to June 30, 2020, with new onset seizure were included consecutively...
May 2022: Pakistan Journal of Medical Sciences Quarterly
#71
JOURNAL ARTICLE
Anthony Lembo, Shahnaz Sultan, Lin Chang, Joel J Heidelbaugh, Walter Smalley, G Nicholas Verne
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder associated with significant disease burden. This American Gastroenterological Association Guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS with predominant diarrhea (IBS-D) and is an update of a prior technical review and guideline. METHODS: The Grading of Recommendations Assessment, Development and Evaluation framework was used to assess evidence and make recommendations...
July 2022: Gastroenterology
#72
JOURNAL ARTICLE
Lin Chang, Shahnaz Sultan, Anthony Lembo, G Nicholas Verne, Walter Smalley, Joel J Heidelbaugh
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline. METHODS: The Grading of Recommendations Assessment, Development and Evaluation framework was used to assess evidence and make recommendations...
July 2022: Gastroenterology
#73
REVIEW
Hassan Aziz, Alexandra W Acher, Somashekar G Krishna, Jordan M Cloyd, Timothy M Pawlik
IMPORTANCE: The identification of incidental pancreas cystic lesions (PCLs) has increased in recent decades with the expanded use and improved sensitivity of cross-sectional imaging. Because the overall risk of malignancy associated with PCLs is low, yet the relative morbidity of pancreatic surgery is high, evidence-based guidelines are necessary for appropriate surveillance and management. Therefore, this article provides a review of existing guidelines regarding surveillance and management of PCLs and highlights recent advances in the diagnostic evaluation of cysts and the postresection management of mucinous lesions...
August 1, 2022: JAMA Surgery
#74
JOURNAL ARTICLE
H J Gao, L J Zhong, X Y Yan, W X Zhang, Weixiang Shen
As widespread eradication treatment continues, the rate of ( Helicobacter pylori, H. pylori ) antibiotic resistance is increasing. Together with host CYP2C19 gene polymorphisms, H. pylori coccoid transformation, patient compliance, irregular treatment regimens or empirical repeated eradication therapy by physician, H. pylori eradication rates have gradually decreased. Personalized treatment is an effective measure to achieve successful eradication of H. pylori in the initial treatment. With the first approval of molecular diagnostic kit for H...
June 14, 2022: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#75
JOURNAL ARTICLE
Fahad Umer, Madiha Khan, Farhan Raza Khan, Karim Tejani
The presence of bacterial biofilms within dental unit waterlines (DUWLs) can cause secondary bacterial infections in immunocompromised patients. As a result, the management of biofilms within waterlines has always concerned medical and dental professionals. In February 2020, an internal audit identified the high bacterial counts within the DUWLs at the Aga Khan University Hospital, Karachi and this paper discusses a pragmatic approach to improving the water quality of DUWLs.A three-person committee was developed and the area for improvement was identified as the contaminated DUWLs...
June 2022: BMJ Open Quality
#76
JOURNAL ARTICLE
Shang Lyu, Yi Rao, Peng Liu, Shilin Yang, Wanyuan Chen, Huajie Yang, Shiwen Ke, Hui OuYang, Mingzhen He, Yulin Feng
OBJECTIVES: The gouty arthritis (GA) progression was multistage, yet the GA clinical diagnosis guidelines were more inclined to suitable for acute gouty arthritis (AGA), thus neglecting of the progress of GA. This study aimed to identify specific biomarkers that were competent for reflecting the progression of GA and attempted to provide evidence for seasonable intervention of appropriate clinical treatment. METHODS: A total of 547 patients with GA at sequential stages and healthy volunteers were divided into a training set (n = 347) and a validation set (n = 200)...
August 2022: Seminars in Arthritis and Rheumatism
#77
JOURNAL ARTICLE
Shabina Ariff, Khushboo Q Ali, Mark O Tessaro, Uzair Ansari, Shaun Morris, Sajid Bashir Soofi, Hasan S Merali
INTRODUCTION: Point-of-care ultrasound (POCUS) is a valuable tool to determine endotracheal tube (ETT) placement; however, few studies have compared it with standard confirmation methods. We evaluated the diagnostic accuracy of POCUS and time-to-interpretation for correct identification of tracheal versus esophageal intubations compared to a composite of standard-of-care methods in neonates. METHODS: A cross-sectional study was conducted in the Neonatal Intensive Care Unit (NICU) at Aga Khan University Hospital Karachi, Pakistan...
July 2022: Pediatric Pulmonology
#78
JOURNAL ARTICLE
Sana Zeeshan, Tayyab Siddiqiui, Fatima Shaukat, Muhammad Usman Tariq, Nargis Khan, Lubna Vohra
Introduction Male breast cancer is uncommon and managed on the guidelines of female breast cancer due to tumor rarity. We sought to identify the incidence, clinicopathological features, and survival of all male breast cancer patients managed in our hospital. Methods A retrospective cross-sectional study was conducted at Aga Khan University Hospital (AKUH), Karachi, Pakistan, from January 1986 to December 2018. Demographic data, treatment records, and follow-up data of all male breast cancer patients who were treated at AKUH was reviewed...
February 2022: Curēus
#79
JOURNAL ARTICLE
William D Chey, Jana G Hashash, Laura Manning, Lin Chang
DESCRIPTION: Irritable bowel syndrome (IBS) is a commonly diagnosed gastrointestinal disorder that can have a substantial impact on quality of life. Most patients with IBS associate their gastrointestinal symptoms with eating food. Mounting evidence supports dietary modifications, such as the low-fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) diet, as a primary treatment for IBS symptoms. The aim of this American Gastroenterological Association (AGA) Clinical Practice Update (CPU) is to provide best practice advice statements, primarily to clinical gastroenterologists, covering the role of diet in IBS treatment...
May 2022: Gastroenterology
#80
JOURNAL ARTICLE
Aditya K Gupta, Mary A Bamimore
BACKGROUND: Some studies have shown that platelet-rich plasma (PRP) improves androgenetic alopecia (AGA)-while others do not. We determined whether the placebo effect significantly varies between split-scalp and whole-head trials on PRP monotherapy for AGA. Our rationale was based on the plausibility of PRP diffusing to the control (i.e., 'placebo') side of split-scalp trials. This is not possible in whole head studies. METHODS: We systematically searched the literature for available data...
January 31, 2022: Journal of Cosmetic Dermatology
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