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JOURNAL ARTICLE
Nidhi Sood, Abdoul Hamide, Biswajit Dubashi, Yadav Nisha, Jayanthi Mathaiyan, A K Munirajan, Prasanth Ganesn, Smita Kayal
BACKGROUND: Multiple myeloma (MM), being the second most common hematological malignancy, has garnered significant attention. The ubiquitin proteasomal pathway (UPP), crucial for normal cell function, plays a pivotal role in myeloma pathophysiology, especially with the advent of bortezomib (BTZ). Dysregulation of the UPP has implications ranging from developmental abnormalities to cancer. OBJECTIVES: This study aimed to delineate the clinical characteristics of newly diagnosed multiple myeloma patients and investigate the influence of single nucleotide polymorphisms (SNPs) in NF-ĸB2 and TRAF3 genes on the risk and treatment response to bortezomib-based chemotherapy...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#2
Kalyani Deshmukh, Kajal Hatgoankar, Milind Pande, Parag Sabale, Nandkishor J Bankar
Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells in the bone marrow. It commonly presents with bone pain, anemia, renal failure, and hypercalcemia. Pleural effusion in MM usually has multiple causes, but it is rare for the effusion to be due to myelomatous deposition of the pleura. Here, we present a rare case in which the patient presented to the outpatient department with a dry cough, breathlessness, and generalized weakness. The patient was diagnosed with MM with myelomatous pleural effusion (MPE), highlighting the importance of considering MM as a differential diagnosis in patients with atypical presentations...
February 2024: Curēus
#3
JOURNAL ARTICLE
Hideshige Seki, Kensuke Narukawa, Yurika Mitsui, Yukari Shirasugi, Shigeki Morita, Tsuyoshi Takahashi
An 83-year-old man diagnosed with multiple myeloma presented with renal failure and hyperkalemia. The patient was treated with calcium polystyrene sulfonate (CPS; kalimate) for hyperkalemia. On the 10th day after starting CPS, airway obstruction due to the presence of a mass was observed, and the patient died on that same day. Autopsy revealed that the mass was located between the trachea and epiglottis and it was determined to consist of CPS-related mosaic crystals. There was a protrusion within the trachea surrounding the CPS crystals, inflammatory cells, and granulation tissue...
February 26, 2024: Internal Medicine
#4
JOURNAL ARTICLE
Ratna Malkan, Michael Baillio, Han T Gao, Shawn M Varney
BACKGROUND: The estimated serum osmolality is a measurement of solutes in the blood, including sodium, glucose, and urea, but also includes ethanol and toxic alcohols (e.g., methanol, ethylene glycol, diethylene glycol, isopropyl alcohol, propylene glycol) when present. These rarely measured toxic alcohols can elevate the serum osmolality, giving the true measured osmolality. The difference between that and a calculated osmolality is the osmolal gap, which can be elevated in many clinical scenarios such as renal failure, ingestion of toxic alcohols, diabetic ketoacidosis, shock, and others...
August 18, 2023: Journal of Emergency Medicine
#5
JOURNAL ARTICLE
Susan Jeffrey, Craig Hamilton, Paul R J Ames
An elderly woman with light chain myeloma presented with prolonged epistaxis and extensive cutaneous haematomas: her kappa/lambda ratio was high at 395, her coagulation screen, thrombin and reptilase times were abnormal, her FV and FX were in the low range in the absence of specific inhibitors, her Clauss fibrinogen was low at 0.95 g/l but antigenic FNG was 1.58 g/l. The patient denied treatment and died of progressive renal failure. We wish to describe the unusual association of FX and FV deficiency co-existing with an acquired dysfibrinogenaemia...
February 8, 2024: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
#6
Elise Kahn, Laila Nomani, Alexandra M Harrington, Nisar Asmi
In this case, we explore the diagnostic workup of a patient presenting with symptomatic hypercalcemia. Initially suspected to have multiple myeloma, the diagnostic evaluation instead unveiled non-germinal center (non-GC) diffuse large B-cell lymphoma (DLBCL). DLBCL is the most common histologic subtype of non-Hodgkin lymphoma and is heterogeneous in terms of presentation, genetic drivers, and morphology. As primary bone DLBCL is exceedingly rare, the case presented proved to be a diagnostic challenge. The patient presented with one week of weakness, one to two days of nausea, and leg pain...
January 2024: Curēus
#7
Ricardos Ghanem, Sylvie Glaisner, Arthur Bobin, Anne-Marie Ronchetti, Sophie Cereja, Bertrand Joly, Célia Salanoubat, Guillemette Fouquet
Posterior reversible encephalopathy syndrome (PRES) has rarely been described in myeloma, but chemotherapy is a known risk factor. We report 3 patients with myeloma who developed PRES, and analyzed them with 13 published cases, mostly women. The most frequent causative agents were proteasome inhibitors and autologous stem cell transplantation. Risk factors were frequently associated: hypertension, infection or renal failure. Symptoms included headache, blurred vision, altered mental status, seizures. Most patients experienced rapid clinical recovery, without relapse even after resuming treatment...
2024: Leukemia Research Reports
#8
REVIEW
Francesca Andreazzoli, Ilana Levy Yurkovski, Eran Ben-Arye, Massimo Bonucci
Multiple Myeloma (MM) is the second most prevalent hematologic malignancy, and its incidence has been increasing enormously in recent years. The prognosis of MM has changed radically with the introduction of new drugs that have improved life expectancy; recurrences are a common occurrence during the course of the disease and are characterized by an increase in refractory to treatment. Moreover, MM patients are challenged by quality of life-related concerns while limited conventional therapy may be offered. This includes bone pain and dialysis due to the complications of acute renal failure...
January 11, 2024: Nutrients
#9
JOURNAL ARTICLE
Nadine H Abdallah, Arjun Lakshman, Shaji K Kumar, Joselle Cook, Moritz Binder, Prashant Kapoor, Angela Dispenzieri, Morie A Gertz, Martha Q Lacy, Suzanne R Hayman, Francis K Buadi, David Dingli, Yi Lin, Taxiarchis Kourelis, Rahma Warsame, Leif Bergsagel, S Vincent Rajkumar
The approach to patients with high-risk smoldering multiple myeloma (SMM) varies among clinicians; while some advocate early intervention, others reserve treatment at progression to multiple myeloma (MM). We aimed to describe the myeloma-defining events (MDEs) and clinical presentations leading to MM diagnosis among SMM patients seen at our institution. We included 406 patients diagnosed with SMM between 2013-2022, seen at Mayo Clinic, Rochester, MN. The 2018 Mayo 20/2/20 criteria were used for risk stratification...
January 17, 2024: Blood Cancer Journal
#10
REVIEW
Francesco Maura, Peter Leif Bergsagel
Multiple myeloma is a malignancy of bone-marrow-localized, isotype-switched plasma cells that secrete a monoclonal immunoglobulin and cause hyperCalcemia, Anemia, Renal failure, and lytic Bone disease. It is preceded, often for decades, by a relatively stable monoclonal gammopathy lacking these clinical and malignant features. Both conditions are characterized by the presence of types of immunoglobulin heavy gene translocations that dysregulate a cyclin D family gene on 11q13 (CCND1), 6p21 (CCND3), or 12q11 (CCND2), a maf family gene on 16q23 (MAF), 20q11 (MAFB), or 8q24 (MAFA), or NSD2/FGFR3 on 4p16, or the presence of hyperdiploidy...
April 2024: Hematology/oncology Clinics of North America
#11
JOURNAL ARTICLE
Margot Egger, Anne Black, Christoph Robier
We report the case of a 66-year-old man with a known history of IgD multiple myeloma (MM) which was admitted to hospital because of acute renal failure. Routine PCR testing on admission yielded a positive result for SARS-CoV-2 infection. Examination of the peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and a few small plasma cells mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted plasma cells being consistent with a diagnosis of secondary plasma cell leukemia...
June 2023: Journal of Hematopathology
#12
Ahmed Bakhshwin, Leal Herlitz, Shaomin Hu, Shahzad Raza, Dane C Olevian, Ali Mehdi, Kenneth Friedman, Bijan Eghtesad, Koji Hashimoto, Jamak Modaresi Esfeh, Mohamed I El Hag
Immunotactoid deposition is a rare fibrillary deposition disease that is primarily seen in the kidney and is associated with paraproteinemia. Here, we report a case of hepatic immunotactoid deposition in a 67-year-old male with a history of smoldering myeloma and chronic kidney disease who underwent liver transplantation for metabolic dysfunction-related cirrhosis. Immunotactoid deposition was first identified in the explanted liver and recurred in the allograft within only 7 weeks following transplantation, presenting as ascites with normal liver function tests...
December 24, 2023: American Journal of Transplantation
#13
JOURNAL ARTICLE
Nadine H Abdallah, Hiroki Nagayama, Naoki Takahashi, Wilson Gonsalves, Amie Fonder, Angela Dispenzieri, David Dingli, Francis K Buadi, Martha Q Lacy, Miriam Hobbs, Morie A Gertz, Moritz Binder, Prashant Kapoor, Rahma Warsame, Suzanne R Hayman, Taxiarchis Kourelis, Yi L Hwa, Yi Lin, Robert A Kyle, S Vincent Rajkumar, Stephen M Broski, Shaji K Kumar
Measures of muscle and adipose tissue mass have been associated with outcomes in several malignancies, but studies in multiple myeloma (MM) are inconsistent. The aim of this study was to evaluate the association between muscle and fat areas and radiodensity, and overall survival (OS) in patients with newly diagnosed MM. We included 341 patients diagnosed with MM from 2010-2019 who had an 18 F-fluorodeoxyglucose positron emission tomography/computed tomography at diagnosis. A cross-sectional image at the third lumbar vertebrae was segmented into muscle and fat components...
December 12, 2023: Blood Cancer Journal
#14
Fakhrddine Amri, Youssef Bensalah, Abdelkrim Zazour, Hanane El Aggari, Hajar Koulali, Ouiam El Mqaddem, Imane Skiker, Zahi Ismaili, Ghizlane Kharrasse
Acute pancreatitis is a frequent gastrointestinal emergency seen in tertiary care hospitals. While gallstones and chronic alcohol consumption remain the most common causes, other etiologies can also be identified, notably hypercalcemia, which constitutes a rare yet deadly cause of acute pancreatitis. Herein, we report 4 cases of AP related to hypercalcemia from malignancies: 2 cases of multiple myeloma, one case of rectal malignancy, and 1 case of medullary thyroid carcinoma associated with a parathyroid adenoma...
February 2024: Radiology Case Reports
#15
JOURNAL ARTICLE
Laurent Frenzel, Olivier Decaux, Margaret Macro, Karim Belhadj-Merzoug, Salomon Manier, Cyrille Touzeau, Xavier Leleu, Corinne Frère, Thomas Lecompte, Aurore Perrot, Hervé Avet-Loiseau, Philippe Moreau, Emilie Chalayer
Venous thromboembolism (VTE) remains a critical issue in the management of patients with multiple myeloma (MM), particularly when immunomodulatory drugs (IMiDs) combined with dexamethasone therapy are being prescribed as first-line and relapse therapy. One possible explanation for the persistent high rates of VTE, is the use of inappropriate thromboprophylaxis strategies for patients starting antimyeloma treatment. To tackle the issue, the Intergroupe francophone du myélome (IFM) offered convenient guidance for VTE thromboprophylaxis in MM patients initiating systemic therapy...
December 2, 2023: Thrombosis Research
#16
JOURNAL ARTICLE
Joanna Kosałka-Węgiel, Sabina Lichołai, Renata Pacholczak-Madej, Sylwia Dziedzina, Mamert Milewski, Piotr Kuszmiersz, Anna Korona, Jolanta Gąsior, Aleksandra Matyja-Bednarczyk, Helena Kwiatkowska, Lech Zaręba, Andżelika Siwiec-Koźlik, Paweł Koźlik-Siwiec, Anita Wach, Weronika Pociej-Marciak, Marek Sanak, Jacek Musiał, Stanisława Bazan-Socha, Mariusz Korkosz
Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and is associated with increased levels of circulating inflammatory biomarkers. This study aims to analyze the serum concentrations of selected cytokines and evaluate their relationship with SSc clinics and the long-term course of the disease. This study included 43 SSc patients and 24 matched healthy controls. In both groups, we measured serum levels of inflammatory cytokines related to the inflammatory response, such as tumor necrosis factor (TNF)α, interferon (IFN)γ, interleukin (IL)-4, IL-6, IL-10, and IL-17, and fibroblast activation protein (FAP)...
December 5, 2023: Rheumatology International
#17
JOURNAL ARTICLE
Pellegrino Musto, Jon Salmanton-García, Nicola Sgherza, Rui Bergantim, Francesca Farina, Andreas Glenthøj, Guldane Cengiz Seval, Barbora Weinbergerová, Valentina Bonuomo, Yavuz M Bilgin, Jaap van Doesum, Ozren Jaksic, Benjamín Víšek, Iker Falces-Romero, Monia Marchetti, Julio Dávila-Valls, Sonia Martín-Pérez, Marcio Nucci, Alberto López-García, Federico Itri, Caterina Buquicchio, Luisa Verga, Klára Piukovics, Milan Navrátil, Graham P Collins, Moraima Jiménez, Nicola S Fracchiolla, Jorge Labrador, Lucia Prezioso, Elena Rossi, Natasha Čolović, Stef Meers, Austin Kulasekararaj, Annarosa Cuccaro, Ola Blennow, Toni Valković, Uluhan Sili, Marie-Pierre Ledoux, Josip Batinić, Francesco Passamonti, Marina Machado, Rafael F Duarte, Christian Bjørn Poulsen, Gustavo-Adolfo Méndez, Ildefonso Espigado, Fatih Demirkan, Martin Čerňan, Chiara Cattaneo, Verena Petzer, Gabriele Magliano, Carolina Garcia-Vidal, Shaimaa El-Ashwah, Maria Gomes-Da-Silva, Antonio Vena, Irati Ormazabal-Vélez, Jens van Praet, Michelina Dargenio, Cristina De-Ramón, Maria Ilaria Del Principe, Joyce Marques-De-Almeida, Dominik Wolf, Tomáš Szotkowski, Aleš Obr, Gökçe Melis Çolak, Anna Nordlander, Macarena Izuzquiza, Alba Cabirta, Giovanni Paolo Maria Zambrotta, Raul Cordoba, Pavel Žák, Emanuele Ammatuna, Jiří Mayer, Osman Ilhan, Ramón García-Sanz, Martina Quattrone, Elena Arellano, Raquel Nunes-Rodrigues, Ziad Emarah, Tommaso Francesco Aiello, Michaela Hanakova, Zdeněk Ráčil, Martina Bavastro, Alessandro Limongelli, Laman Rahimli, Francesco Marchesi, Oliver A Cornely, Livio Pagano
Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world...
December 4, 2023: Hematological Oncology
#18
JOURNAL ARTICLE
Lama M Almuhaysen, Amal Badr Abu Al Alaa
BACKGROUND: Renal impairment, often occurring as a result of multiple myeloma, poses a significant risk to patient health and quality of life. Therefore, the study was conducted with the objective of investigating the management of renal failure in patients diagnosed with multiple myeloma in Saudi Arabia. METHODS: A retrospective observational study was conducted during the period from January to August 2023 for the duration of eight months. The data were collected from the patients diagnosed with multiple myeloma, available from the medical records of Prince Sultan Military Medical City, Saudi Arabia...
October 2023: Curēus
#19
JOURNAL ARTICLE
Sushmita Khadka, Swetha Balaji, Japjeet Kaur, Dhanshree Solanki, Mariia Kasianchyk, Humayra Chowdhury, Ishani Patel, Muhammad Qasim, Maheshkumar Desai, Prakash Maiyani, Dharmeshkumar V Moradiya, Darshan Lal, Achint A Patel, Manidhar Lekkala
Background With the advent of novel treatments, there is a declining trend in the multiple myeloma (MM) mortality rate with an increasing hospitalization rate. However, there is limited population-based data on trends and outcomes of hospitalizations due to MM in the United States (US). Methods We analyzed the publicly available Nationwide Inpatient Sample (NIS) from 2007 to 2017 to identify MM hospitalizations. Results Hospitalizations for MM increased from 17,100 (8.71%) in 2007 to 19,490 (9.92%) in 2017...
October 2023: Curēus
#20
S Rajkumar, Nadine Abdallah, Arjun Lakshman, Shaji Kumar, Joselle Cook, Moritz Binder, Prashant Kapoor, Angela Dispenzieri, Morie Gertz, Martha Lacy, Suzanne Hayman, Francis Buadi, David Dingli, Yi Lin, Taxiarchis Kourelis, Rahma Warsame, P Leif Bergsagel
The approach to patients with high-risk smoldering multiple myeloma (SMM) varies among clinicians; while some advocate early intervention, others reserve treatment at progression to multiple myeloma (MM). We aimed to describe the myeloma-defining events (MDEs) and clinical presentations leading to MM diagnosis among SMM patients seen at our institution. We included 406 patients diagnosed with SMM between 2013-2022, seen at Mayo Clinic, Rochester, MN. The 2018 Mayo 20/2/20 criteria were used for risk stratification...
October 23, 2023: Research Square
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