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Irritable bowel syndrome, ibs, functional dyspepsia

Ming-Wun Wong, Ming-Jong Bair, Wei-Chuan Chang, Ching-Sheng Hsu, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Michael F Vaezi, C Prakash Gyawali, Chien-Lin Chen
BACKGROUND AND AIM: Laryngopharyngeal reflux (LPR) defined as reflux of gastric content reaching above the upper esophageal sphincter is frequently found in patients with gastroesophageal reflux disease (GERD). This study aimed to investigate clinical and psychological differences between GERD patients with or without LPR symptoms. METHODS: This study enrolled 303 consecutive patients with PPI treatment-naïve scheduled for upper endoscopy due to troublesome reflux symptoms and recognized as GERD by non-dyspepsia reflux disease questionnaire (RDQ) score...
March 8, 2019: Journal of Gastroenterology and Hepatology
Grace Burns B Biomed, Georgia Carroll, Andrea Mathe, Jay Horvat, Paul Foster, Marjorie M Walker, Nicholas J Talley, Simon Keely
BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation...
March 2019: American Journal of Gastroenterology
John M Wilkinson, Elizabeth W Cozine, Conor G Loftus
Gas, bloating, and belching are associated with a variety of conditions but are most commonly caused by functional gastrointestinal disorders. These disorders are characterized by disordered motility and visceral hypersensitivity that are often worsened by psychological distress. An organized approach to the evaluation of symptoms fosters trusting therapeutic relationships. Patients can be reliably diagnosed without exhaustive testing and can be classified as having gastric bloating, small bowel bloating, bloating with constipation, or belching disorders...
March 1, 2019: American Family Physician
Fermin Estremera-Arevalo, Marta Barcelo, Blanca Serrano, Enrique Rey
BACKGROUND: Irritable bowel syndrome (IBS) is a highly prevalent condition. It is diagnosed on the basis of chronic symptoms after the clinical and/or investigative exclusion of organic diseases that can cause similar symptoms. There is no reproducible non-invasive test for the diagnosis of IBS, and this raises diagnostic uncertainty among physicians and hinders acceptance of the diagnosis by patients. Functional gastrointestinal (GI) syndromes often present with overlapping upper and lower GI tract symptoms, now believed to be generated by visceral hypersensitivity...
February 21, 2019: World Journal of Gastroenterology: WJG
Mehrbud Vakhshuury, Alireza Khoshdel
Background: Assessing the relation between dietary habits and functional gastrointestinal disorders (FGIDs) is less investigated among military personnel. In this study, we aimed to evaluate the association of certain eating patterns and FGIDs in Iranian army men. Materials and Methods: This cross-sectional study was performed on 600 army personnel working in Kerman ground forces military station number 05, Iran. Participants were asked to define their weekly breakfast consumption, lunch intake time, and chewing efficiency...
2019: Advanced Biomedical Research
Rabia Miray Kisla Ekinci, Sibel Balcı, Eray Akay, Gokhan Tumgor, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz
INTRODUCTION: Familial Mediterranean fever (FMF) is characterized by self-limiting fever episodes usually accompanied by serositis, arthralgia, and arthritis. Functional gastrointestinal disorders (FGIDs) are diseases in which brain-gut axis and low-grade inflammation take part in pathogenesis. We aimed to study the FGIDs frequencies and possible risk factors for FGIDs in children with FMF. METHOD: This case-control study included 103 children with FMF followed up between July 2016 and July 2018 and 100 healthy controls...
January 31, 2019: Clinical Rheumatology
Ashok K Tuteja, Nicholas J Talley, Gregory J Stoddard, Matthew H Samore, G Nicholas Verne
BACKGROUND: Gastroenteritis is a risk factor for irritable bowel syndrome (IBS), but its role in other functional gastrointestinal disorders (FGIDs) is less clear. The aim of this study was to determine the prevalence of FGIDs in Gulf War (GW) Veterans before, during, and after deployment and to determine whether gastroenteritis was a risk factor for upper and lower FGIDs. METHODS: The Veterans who served during the Persian GW were mailed validated questionnaires inquiring about their bowel habits, psychological and extra-intestinal symptoms, and quality of life (QOL)...
January 29, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Natasha Koloski, Michael Jones, Marjorie M Walker, Martin Veysey, Alkesh Zala, Simon Keely, Gerald Holtmann, Nicholas J Talley
BACKGROUND: The pathogenesis of functional GI disorders (FGIDs) is uncertain. However, underlying immune activation and psychological distress has been documented in irritable bowel syndrome (IBS) and functional dyspepsia (FD). Epidemiological data from the UK suggest that FGIDs are linked to atopy and certain autoimmune diseases but this has not been confirmed. AIM: To test if allergic or autoimmune diseases are independently associated with FGIDs, irrespective of psychological distress in a large population based study...
January 27, 2019: Alimentary Pharmacology & Therapeutics
Judy Nee, Saikiran Kilaru, John Kelley, Sveta S Oza, William Hirsch, Sarah Ballou, Anthony Lembo, Jacqueline Wolf
BACKGROUND AND AIMS: Prior studies have shown a high prevalence of gastrointestinal (GI) symptoms, diagnoses of functional GI diseases (FGIDs), and pelvic floor symptoms associated with Ehlers-Danlos syndrome (EDS). It is unclear if Marfan syndrome (MFS), another common hereditary noninflammatory connective tissue disorder, is also associated these symptoms. This study evaluates the prevalence of and compares FGIDs and pelvic floor symptoms in a national cohort of EDS and MFS patients...
January 21, 2019: Journal of Clinical Gastroenterology
Marianne Bonnert, Ola Olén, Maria Lalouni, Erik Hedman-Lagerlöf, Josefin Särnholm, Eva Serlachius, Brjánn Ljótsson
Functional abdominal pain (FAP) and functional dyspepsia (FD) are common in adolescents and associated with low quality of life. Exposure-based cognitive-behavioral therapy (CBT) is efficient for adult and adolescent irritable bowel syndrome (IBS), but has never been evaluated for adolescent FAP/FD. The aim of this study was to evaluate the feasibility and potential efficacy of a novel disorder-specific Internet-delivered CBT (Internet-CBT) for adolescents with FAP or FD, using an uncontrolled open pilot including 31 adolescents...
January 2019: Behavior Therapy
Manori Vijaya Kumari, Niranga Manjuri Devanarayana, Lakmali Amarasiri, Shaman Rajindrajith
AIM: To find the association between asthma and different types of functional abdominal pain disorders (FAPDs) among teenagers.METHODA cross-sectional study was conducted among 13 to 15-year-old children from six randomly selected schools in Anuradhapura district of Sri Lanka. Data were collected using translated and validated self-administered questionnaires (Rome III questionnaire, International Study on Asthma and Allergies in Childhood questionnaire, and Pediatric Quality of Life Inventory 4...
December 6, 2018: World Journal of Clinical Cases
Valeria Schindler, Stéphanie Giezendanner, Simon Bütikofer, Fritz Murray, Daniel Runggaldier, Larissa Schnurre, Annina Zweig, Michael Fried, Daniel Pohl
BACKGROUND AND AIM: Functional dyspepsia (FD) is a common disorder of gut-brain interaction with incompletely understood pathophysiology. Consequently, heterogeneous expert opinions on diagnostic tests and assessment of treatment efficacies exist. So far, no consensus about the most relevant diagnostic and outcome tool has been reached. In this study, we aimed to analyze the significance of a combined lactulose hydrogen breath test (LHBT) and liquid meal, yet representing a standardized test in irritable bowel syndrome (IBS), in FD...
November 22, 2018: Journal of Gastroenterology and Hepatology
Nicola Poloni, Marta Ielmini, Ivano Caselli, Francesca Ceccon, Lucia Bianchi, Celeste Isella, Camilla Callegari
Introduction: "Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. Materials and Methods: This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Socio-demographic and clinical variables were evaluated: gender, age, diagnosis or diagnostic hypothesis, presence of psychiatric comorbidities, psychiatric evaluation, pharmacological treatment, number of admissions/visits...
2018: Frontiers in Psychiatry
Vladimir Ivashkin, Arkady Sheptulin, Oleg Shifrin, Elena Poluektova, Chavdar Pavlov, Konstantin Ivashkin, Alexandra Drozdova, Olga Lyashenko, Alexandr Korolev
BACKGROUND AND AIM: physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the '7x7' questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of functional gastrointestinal disorders, using the Clinical Global Impressions scale as the reference standard. METHODS: fifty inpatients aged from 18 to 64 with a confirmed diagnosis of irritable bowel syndrome (26 patients, 52%), functional dyspepsia (15 patients, 30%) or both (9 patients, 18%) were prospectively enrolled in the study...
November 21, 2018: Journal of Gastroenterology and Hepatology
Renato Tambucci, Paolo Quitadamo, Michela Ambrosi, Paola De Angelis, Giulia Angelino, Stefano Stagi, Albero Verrotti, Annamaria Staiano, Giovanni Farello
OBJECTIVE: Although emerging data indicate that obese/overweight children are more likely to develop functional gastrointestinal disorders (FGIDs) than normal-weight peers, contrasting results have been reported. The present observational, case-control study aimed at estimating the prevalence of FGIDs in obese/overweight children compared to normal-weight peers. METHODS: Consecutive obese and overweight children aged 4-18 years attending the obesity outpatient clinic were enrolled as study cases...
November 15, 2018: Journal of Pediatric Gastroenterology and Nutrition
Grace Burns, Georgia Carroll, Andrea Mathe, Jay Horvat, Paul Foster, Marjorie M Walker, Nicholas J Talley, Simon Keely
BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation...
November 14, 2018: American Journal of Gastroenterology
Nicola de Bortoli, Salvatore Tolone, Marzio Frazzoni, Irene Martinucci, Giulia Sgherri, Eleonora Albano, Linda Ceccarelli, Cristina Stasi, Massimo Bellini, Vincenzo Savarino, Edoardo V Savarino, Santino Marchi
Several studies have indicated an overlap between gastroesophageal reflux disease (GERD) and various functional gastrointestinal disorders (FGIDs). The overlapping conditions reported have mainly been functional dyspepsia (FD) and irritable bowel syndrome (IBS). The available literature is frequently based on symptomatic questionnaires or endoscopic procedures to diagnose GERD. Rarely, among patients with heartburn, pathophysiological evaluations have been considered to differentiate those with proven GERD from those without...
November 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Moritz von Wulffen, Nicholas J Talley, Johann Hammer, Jessica McMaster, Graeme Rich, Ayesha Shah, Natasha Koloski, Bradley J Kendall, Mike Jones, Gerald Holtmann
BACKGROUND: According to Rome IV criteria, functional dyspepsia (FD) and irritable bowel syndrome (IBS) are distinct functional gastrointestinal disorders (FGID); however, overlap of these conditions is common in population-based studies, but clinical data are lacking. AIMS: To determine the overlap of FD and IBS in the clinical setting and define risk factors for the overlap of FD/IBS. METHODS: A total of 1127 consecutive gastroenterology outpatients of a tertiary center were recruited and symptoms assessed with a standardized validated questionnaire...
October 27, 2018: Digestive Diseases and Sciences
Shravan Kumar Porika, Krishna Chaitanya Veligandla, Shashi Kanth Muni, Shivani Acharya, Suyog C Mehta, Akhilesh D Sharma
INTRODUCTION: Functional dyspepsia (FD) is a highly prevalent condition which reduces patients' quality of life (QoL) and imparts a significant economic burden on the healthcare system. Acotiamide is a novel prokinetic agent useful in treatment of FD, and this study evaluated the effectiveness of acotiamide hydrochloride hydrate in management of FD over a 4-week period in a real-world setting. METHODS: This study was a prospective, observational, real-world data collection of 132 patients (85 male, 47 female) over 18 years of age diagnosed with FD as per Rome III criteria and treated with acotiamide for 4 weeks at a gastroenterology unit of a medical school in India...
October 22, 2018: Advances in Therapy
Ivana Trivić, Iva Hojsak
Purpose: The aim of this study was to describe functional gastrointestinal disorders (FGID) presented in a tertiary medical center, characteristics of patients and results of the diagnostic work-up together with an outcome during the follow up. Methods: This was a retrospective, single center, observational study including all patients who were diagnosed with FGID based on Rome III criteria from January to December 2015 in tertiary medical center. Results: Overall 294 children were included (mean age, 8...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
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