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Keywords Diabetic Cardiovascular Autono...

Diabetic Cardiovascular Autonomic Neuropathy

https://read.qxmd.com/read/37926016/sudoscan-as-substitute-for-quantitative-sudomotor-axon-reflex-test-in-composite-autonomic-scoring-scale-and-its-correlation-with-composite-autonomic-symptom-scale-31-in-type-2-diabetes
#21
JOURNAL ARTICLE
Chih-Cheng Huang, Yun-Ru Lai, Ben-Chung Cheng, Wen-Chan Chiu, Ting Yin Lin, Hui Ching Chiang, Chun-En Aurea Kuo, Cheng-Hsien Lu
OBJECTIVE: This study aims to evaluate the feasibility of substituting electrochemical skin conductance measurement using SUDOSCAN for sudomotor function testing in the Composite Autonomic Scoring Scale (CASS) and to correlate the results with the Composite Autonomic Symptom Scale 31 (COMPASS 31) among patients with type 2 diabetes mellitus (T2DM). METHODS: Fifty patients with T2DM underwent cardiovascular autonomic function testing and the SUDOSCAN test and completed the COMPASS 31 questionnaire...
November 3, 2023: Clinical Neurophysiology
https://read.qxmd.com/read/37867983/cardiac-autonomic-neuropathy-in-prediabetes-a-case-control-study
#22
JOURNAL ARTICLE
Pavan Gujjar, Y S Ravikumar, Lakshmi Nagendra, Hiya Boro, Saptarshi Bhattacharya
INTRODUCTION: Early detection and diagnosis of diabetic autonomic neuropathy, especially cardiac autonomic neuropathy (CAN), have gained attention recently because of their elevated cardiovascular mortality risk. Although the connection between type 2 diabetes mellitus and autonomic neuropathy is well established, evidence is emerging that the association might predate the stage of prediabetes. OBJECTIVE: The present study was undertaken to compare the prevalence of CAN in prediabetes versus that in normoglycemic controls...
2023: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/37854193/determinants-of-the-heart-rate-variability-in-type-1-diabetes-mellitus
#23
JOURNAL ARTICLE
Máté Hajdu, Konstandia Garmpis, Vivien Vértes, Noémi Vorobcsuk-Varga, Gergő Attila Molnár, László Hejjel, István Wittmann, Réka Faludi
BACKGROUND: Evaluation of heart rate variability (HRV) detects the early subclinical alterations of the autonomic nervous system. Thus, impaired HRV is the earliest subclinical marker of cardiac autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM). OBJECTIVES: We aimed to explore the HRV parameters in asymptomatic T1DM patients and compare them with the results obtained in healthy subjects. Potential associations between HRV parameters and the established risk factors for CAN and cardiovascular diseases were also investigated...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37851036/diabetic-neuropathies
#24
JOURNAL ARTICLE
Melissa A Elafros, Brian C Callaghan
OBJECTIVE: This article provides an up-to-date review of the diagnosis and management of the most common neuropathies that occur in patients with diabetes. LATEST DEVELOPMENTS: The prevalence of diabetes continues to grow worldwide and, as a result, the burden of diabetic neuropathies is also increasing. Most diabetic neuropathies are caused by hyperglycemic effects on small and large fiber nerves, and glycemic control in individuals with type 1 diabetes reduces neuropathy prevalence...
October 1, 2023: Continuum: Lifelong Learning in Neurology
https://read.qxmd.com/read/37830705/the-effect-of-exercise-on-cardiovascular-autonomic-nervous-function-in-patients-with-diabetes-a-systematic-review
#25
REVIEW
Hidetaka Hamasaki
BACKGROUND: Diabetic neuropathy, including autonomic neuropathy, is a severe complication in patients with poorly controlled diabetes. Specifically, cardiovascular autonomic neuropathy (CAN) plays a significant prognostic role in cardiovascular morbidity and mortality. Exercise, an essential component of diabetes treatment, may have a therapeutic effect on patients with diabetes complicated by CAN. However, it remains unclear whether exercise has a therapeutic or protective effect in diabetes patients with CAN...
October 1, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37830346/cardiac-autonomic-dysfunction-and-risk-of-silent-myocardial-infarction-among-adults-with-type-2-diabetes
#26
JOURNAL ARTICLE
Arnaud D Kaze, Gregg C Fonarow, Justin B Echouffo-Tcheugui
Background There is a paucity of large-scale epidemiological studies on the link between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI) in type 2 diabetes. We evaluated the association between CAN and the risk of SMI in a large sample of adults with type 2 diabetes. Methods and Results Participants with type 2 diabetes from the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study without atherosclerotic cardiovascular disease at baseline were included. CAN was ascertained using heart rate variability indices calculated from 10-s resting electrocardiograms...
October 17, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37664832/a-three-month-physical-training-program-improves-cardiovascular-autonomic-function-in-patients-with-metabolic-syndrome-with-and-without-diabetes-a-pilot-study
#27
JOURNAL ARTICLE
Anna Vágvölgyi, Judit Erzsébet Ábrahám, Éva Máthéné Köteles, Andrea Korom, Mária Barnai, Mónika Szűcs, Andrea Orosz, Péter Kempler, Adrienn Menyhárt, Attila Nemes, Tamás Várkonyi, István Baczkó, István Kósa, Csaba Lengyel
INTRODUCTION: Vascular complications and neuropathy may develop in the presence of metabolic syndrome. The aim of our study was to measure the cardiovascular autonomic function following physical training in patients with metabolic syndrome with and without diabetes. SUBJECTS AND METHODS: 56 patients with metabolic syndrome (32 men/24 women, 40 non-diabetic patients (NDMetS)/16 diabetic patients (DMetS) [mean ± SD]: age: 50.35 ± 8.03 vs. 56.8 ± 9...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37620935/machine-learning-profiles-of-cardiovascular-risk-in-patients-with-diabetes-mellitus-the-silesia-diabetes-heart-project
#28
JOURNAL ARTICLE
Hanna Kwiendacz, Agata M Wijata, Jakub Nalepa, Julia Piaśnik, Justyna Kulpa, Mikołaj Herba, Sylwia Boczek, Kamil Kegler, Mirela Hendel, Krzysztof Irlik, Janusz Gumprecht, Gregory Y H Lip, Katarzyna Nabrdalik
AIMS: As cardiovascular disease (CVD) is a leading cause of death for patients with diabetes mellitus (DM), we aimed to find important factors that predict cardiovascular (CV) risk using a machine learning (ML) approach. METHODS AND RESULTS: We performed a single center, observational study in a cohort of 238 DM patients (mean age ± SD 52.15 ± 17.27 years, 54% female) as a part of the Silesia Diabetes-Heart Project. Having gathered patients' medical history, demographic data, laboratory test results, results from the Michigan Neuropathy Screening Instrument (assessing diabetic peripheral neuropathy) and Ewing's battery examination (determining the presence of cardiovascular autonomic neuropathy), we managed use a ML approach to predict the occurrence of overt CVD on the basis of five most discriminative predictors with the area under the receiver operating characteristic curve of 0...
August 24, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/37597048/incretins-and-microvascular-complications-of-diabetes-neuropathy-nephropathy-retinopathy-and-microangiopathy
#29
REVIEW
Jonathan Goldney, Jack A Sargeant, Melanie J Davies
Glucagon-like peptide-1 receptor agonists (GLP-1RAs, incretin mimetics) and dipeptidyl peptidase-4 inhibitors (DPP-4is, incretin enhancers) are glucose-lowering therapies with proven cardiovascular safety, but their effect on microvascular disease is not fully understood. Both therapies increase GLP-1 receptor agonism, which is associated with attenuation of numerous pathological processes that may lead to microvascular benefits, including decreased reactive oxygen species (ROS) production, decreased inflammation and improved vascular function...
August 19, 2023: Diabetologia
https://read.qxmd.com/read/37593120/the-composite-autonomic-symptom-score-31-questionnaire-a-sensitive-test-to-detect-risk-for-autonomic-neuropathy
#30
JOURNAL ARTICLE
Sondre Meling, Erling Tjora, Heike Eichele, Niels Ejskjaer, Siri Carlsen, Pål Rasmus Njølstad, Christina Brock, Eirik Søfteland
BACKGROUND AND AIMS: Autonomic neuropathy is a common but often neglected complication of diabetes, prediabetes, and even in individuals with an elevated risk of diabetes. The Composite Autonomic Symptom Score (COMPASS) 31 is a validated and easy-to-use questionnaire regarding autonomic symptoms. We aimed to use a digitally, Norwegian version of the COMPASS 31 in people with different durations of diabetes and healthy controls to consider feasibility and to investigate if scores could discriminate between positive and negative outcomes for established tests for diabetic neuropathy, including cardiovascular autonomic neuropathy (CAN) and a novel method of examining the gastrointestinal visceral sensitivity...
2023: Journal of Diabetes Research
https://read.qxmd.com/read/37545646/can-the-change-of-vasomotor-activity-in-irritable-bowel-syndrome-patients-be-detected-via-color-doppler-ultrasound
#31
JOURNAL ARTICLE
Omer Kazci, Fahrettin Ege, Huseyin Aydemir, Saliha Kazci, Sonay Aydin
BACKGROUND: Irritable bowel syndrome (IBS) is one of the most frequently referred conditions to the gastrointestinal outpatient clinic. The pathophysiology of IBS has not been determined with certainty. Visceral hypersensitivity is indicated as one of the pathophysiologies. The sympathetic nervous system is primarily in charge of controlling the arteries, and its effect is vasospasm in the medium and large arteries, resulting in decreased blood flow. AIM: To demonstrate, using Doppler evaluation of the brachial artery, that sympathetic activity impairs vasomotor performance due to autonomic neuropathy, which we believe is associated with IBS...
July 28, 2023: World Journal of Radiology
https://read.qxmd.com/read/37539131/sudomotor-dysfunction-in-diabetic-peripheral-neuropathy-dpn-and-its-testing-modalities-a-literature-review
#32
REVIEW
Muhammad Akbar, Alvian Wandy, Gita Vita Soraya, Yudy Goysal, Mimi Lotisna, Muhammad Iqbal Basri
Long term consequences of diabetes mellitus (DM) may include multi-organ complications such as retinopathy, cardiovascular disease, neuronal, and kidney damage. One of the most prevalent complication is diabetic peripheral neuropathy (DPN), occurring in half of all diabetics, and is the main cause of disability globally with profound impact on a patient's quality of life. Small fiber neuropathy (SFN) can develop in the pre-diabetes stage preceding large fiber damage in DPN. Asymptomatic SFN is difficult to diagnose in early stages, with sudomotor dysfunction considered one of the earliest manifestations of autonomic neuropathy...
July 2023: Heliyon
https://read.qxmd.com/read/37487784/atg5-gene-expression-analysis-supports-the-involvement-of-autophagy-in-microangiopathic-complications-of-type-2-diabetes
#33
JOURNAL ARTICLE
Giada De Benedittis, Andrea Latini, Vincenza Spallone, Giuseppe Novelli, Paola Borgiani, Cinzia Ciccacci
BACKGROUND AND AIMS: Type 2 diabetes (T2D) hyperglycaemia alters basal autophagy. Since autophagy is an essential cellular process, our aim was to investigate the ATG5 (autophagy-related 5) gene expression level and genetic variants in a cohort of diabetic patients, characterized for the presence of microangiopathic complications. METHODS AND RESULTS: the expression levels of ATG5 were evaluated in PBMCs from 48 T2D patients with an extensive evaluation for microangiopathic complications...
June 24, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/37478166/intramyocellular-triglyceride-content-during-the-early-course-of-type-1-and-type-2-diabetes-mellitus
#34
JOURNAL ARTICLE
Martin Schön, Oana P Zaharia, Klaus Strassburger, Yuliya Kupriyanova, Kálmán Bódis, Geronimo Heilmann, Alexander Strom, Gidon J Bönhof, Filippo Michelotti, Iryna Yurchenko, Clara Möser, Maximilian Huttasch, Maria Bombrich, Malte Kelm, Volker Burkart, Vera B Schrauwen-Hinderling, Robert Wagner, Michael Roden
Intramyocellular lipid content (IMCL) is elevated in insulin-resistant humans, but its changes over time and relationships with comorbidities remain unclear. We examined IMCL during the initial course of diabetes and its associations with complications. Participants of the German Diabetes Study (GDS) with recent-onset type 1 (n=132) or type 2 diabetes (n=139) and glucosetolerant controls (n=128) underwent 1H-magnetic resonance spectroscopy to measure IMCL and muscle volume, whole-body insulin sensitivity (hyperinsulinemic-euglycemic clamps; Mvalue) and cycling spiroergometry (VO2max)...
July 21, 2023: Diabetes
https://read.qxmd.com/read/37470302/neuropathy-in-prediabetes
#35
REVIEW
Dan Ziegler, Christian Herder, Nikolaos Papanas
Diabetic neuropathies are the most frequent complications of diabetes, contributing to high morbidity, excess mortality, reduced quality of life, and increased healthcare costs. Prediabetes is characterised by glucose levels within an intermediate range above normoglycaemia yet below the diagnostic threshold for diabetes. In 2021, 10.6% and 6.2% of adults worldwide were estimated to have impaired glucose tolerance and impaired fasting glucose, respectively, the majority of whom are unaware of having prediabetes...
July 20, 2023: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/37467433/cardiovascular-autonomic-neuropathy-and-risk-of-kidney-function-decline-in-type-1-and-type-2-diabetes-findings-from-the-perl-and-accord-cohorts
#36
JOURNAL ARTICLE
Yaling Tang, Lynn Ang, Mamta Jaiswal, Brendan R Dillon, Nazanene H Esfandiari, Hetal S Shah, Cathie Spino, Cindy Plunkett, Bruce A Perkins, Rodica Pop Busui, Alessandro Doria
Previous studies have suggested that cardiovascular autonomic neuropathy (CAN) may predict rapid kidney function decline among persons with diabetes. We analyzed the association between baseline CAN and subsequent glomerular filtration rate (GFR) decline among individuals with type 1 diabetes (T1D) from the Preventing Early Renal Loss in Diabetes (PERL) study (N=469) and with type 2 diabetes (T2D) from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study (N=7,973). Baseline CAN was ascertained using ECG-derived heart rate variability indices...
July 19, 2023: Diabetes
https://read.qxmd.com/read/37449440/cardiovascular-autonomic-neuropathy-in-patients-with-type-2-diabetes-with-and-without-sensorimotor-polyneuropathy
#37
Emil Peters, Mustapha Itani, Alexander G Kristensen, Astrid Juhl Terkelsen, Thomas Krøigård, Hatice Tankisi, Troels S Jensen, Nanna B Finnerup, Sandra Sif Gylfadottir
BACKGROUND AND AIMS: Cardiovascular autonomic neuropathy (CAN) in patients with diabetes is associated with poor prognosis. We aimed to assess signs of CAN and autonomic symptoms and to investigate the impact of sensorimotor neuropathy on CAN by examining type 2 diabetes patients with (DPN [distal sensorimotor polyneuropathy]) and without distal sensorimotor polyneuropathy (noDPN) and healthy controls (HC). Secondarily, we aimed to describe the characteristics of patients with CAN. METHODS: A population of 374 subjects from a previously described cohort of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) were included...
September 2023: Journal of the Peripheral Nervous System: JPNS
https://read.qxmd.com/read/37443134/adynamic-response-to-cold-pain-reflects-dysautonomia-in-type-1-diabetes-and-polyneuropathy
#38
JOURNAL ARTICLE
Thomas Arendt Nielsen, Søren Lundbye-Christensen, Yoanna Krasimirova Dimitrova, Sam Riahi, Birgitte Brock, Asbjørn Mohr Drewes, Christina Brock
Cardiac autonomic neuropathy (CAN), widely assessed by heart rate variability (HRV), is a common complication of long-term diabetes. We hypothesized that HRV dynamics during tonic cold pain in individuals with type 1 diabetes mellitus (T1DM) could potentially demask CAN. Forty-eight individuals with long-term T1DM and distal symmetrical polyneuropathy and 21 healthy controls were included. HRV measures were retrieved from 24-h electrocardiograms. Moreover, ultra-short-term HRV recordings were used to assess the dynamic response to the immersion of the hand into 2 °C cold water for 120 s...
July 13, 2023: Scientific Reports
https://read.qxmd.com/read/37442682/features-characterising-cardiac-autonomic-neuropathy-in-diabetes-using-ensembled-classification
#39
JOURNAL ARTICLE
Rasmus Bach Nedergaard, Matthew Scott, Anne-Marie Wegeberg, Tina Okdahl, Joachim Størling, Birgitte Brock, Asbjørn Mohr Drewes, Christina Brock
OBJECTIVE: Using supervised machine learning to classify the severity of cardiovascular autonomic neuropathy (CAN). The aims were 1) to investigate which features contribute to characterising CAN 2) to generate an ensembled set of features that best describes the variation in CAN classification. METHODS: Eighty-two features from demographic, beat-to-beat, biochemical, and inflammation were obtained from 204 people with diabetes and used in three machine-learning-classifiers, these are: support vector machine, decision tree, and random forest...
June 30, 2023: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/37403864/effects-of-inspiratory-muscle-training-in-type-2-diabetes-a-systematic-review
#40
REVIEW
Nathalea Spode de Arruda, Náthali de Mello Peixoto, Carine Cristina Callegaro, Maria Elaine Trevisan, Rodrigo Boemo Jaenisch
INTRODUCTION: People with type 2 diabetes mellitus present multiple complications and comorbidities, such as peripheral autonomic neuropathies and reduced peripheral force and functional capacity. Inspiratory muscle training is a widely used intervention with numerous benefits for various disorders. The present study aimed to conduct a systematic review to identify inspiratory muscle training effects on functional capacity, autonomic function, and glycemic indexes in patients with type 2 diabetes mellitus...
July 4, 2023: Brazilian Journal of Cardiovascular Surgery
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