keyword
Keywords The important role of Acetylch...

The important role of Acetylcholine

https://read.qxmd.com/read/38331584/cholinergic-sensitive-theta-oscillations-in-memory-encoding-in-mice
#21
JOURNAL ARTICLE
Zhenglin Gu, Korey D Stevanovic, Jesse D Cushman, Jerrel L Yakel
Cholinergic regulation of hippocampal theta oscillations has long been proposed to be a potential mechanism underlying hippocampus-dependent memory encoding processes. However, cholinergic transmission has been traditionally associated with type II theta under urethane anesthesia. The mechanisms and behavioral significance of cholinergic regulation of type I theta in freely exploring animals is much less clear. In this study, we examined the potential behavioral significance of cholinergic regulation of theta oscillations in the object location task in male mice that involves training and testing trials and provides an ideal behavioral task to study the underlying memory encoding and retrieval processes, respectively...
February 8, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38331019/unlocking-the-role-of-dorsal-hippocampal-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-in-ethanol-induced-conditioned-place-preference-in-mice
#22
JOURNAL ARTICLE
Paola Palombo, Roberta Maeda, Caroline Riberti Zanibon, Sheila Antonagi Engi, Thais Yokoyama, Natalia Bonetti Bertagna, Agusto Anesio, Paula Cristina Bianchi, Thamires Riggi, Gabrielle Emily Boaventura Tavares, Fernando Bezerra Romualdo da Silva Caden Souccar, Fabio Cardoso Cru
Alcohol Use Disorder (AUD) presents a significant and challenging public health concern, marked by a dearth of effective pharmacological treatments. Understanding the neurobiological underpinnings of AUD is of paramount importance for the development of efficacious interventions. The process of addiction entails the acquisition of associative behaviors, prominently engaging the dorsal region of the hippocampus for encoding these associative memories. Nicotinic receptor systems have been implicated in mediating the rewarding effects of ethanol, as well as memory and learning processes...
February 6, 2024: Neuroscience Letters
https://read.qxmd.com/read/38307188/botulinum-toxin-type-a-blocks-aquaporin-5-trafficking-by-decreasing-synaptosomal-associated-protein-23-in-submandibular-acinar-cells
#23
JOURNAL ARTICLE
Hui Xu, Huabing Ge, Zhigang Cai
The trafficking of aquaporin 5 (AQP5) is critical for salivary secretion. Synaptosomal-associated protein 23 (SNAP23) is an important regulator in the process of membrane fusion. However, the role of SNAP23 on AQP5 trafficking has not been explored. Botulinum toxin type A (BoNT/A) is a bacterial toxin that effectively treats sialorrhea. We previously reported that BoNT/A induced AQP5 redistribution in cultured acinar cells, but the mechanism remained unclear. In this study, SNAP23 was predominantly localized to the plasma membrane of acinar cells in the rat submandibular gland (SMG) and colocalized with AQP5 at the apical membrane of acinar cells...
January 31, 2024: Experimental Cell Research
https://read.qxmd.com/read/38302679/%C3%AE-7nachr-activation-combined-with-endothelial-progenitor-cell-transplantation-attenuates-lung-injury-in-diabetic-rats-with-sepsis-through-the-nf-%C3%AE%C2%BAb-pathway
#24
JOURNAL ARTICLE
Xiaoyun Zhang, Haixu Wang, Xuemin Cai, Aijia Zhang, Enran Liu, Zhiyuan Li, Tao Jiang, Dongmei Li, Wengang Ding
Chronic diabetes mellitus compromises the vascular system, which causes organ injury, including in the lung. Due to the strong compensatory ability of the lung, patients always exhibit subclinical symptoms. Once sepsis occurs, the degree of lung injury is more severe under hyperglycemic conditions. The α7 nicotinic acetylcholine receptor (α7nAChR) plays an important role in regulating inflammation and metabolism and can improve endothelial progenitor cell (EPC) functions. In the present study, lung injury caused by sepsis was compared between diabetic rats and normal rats...
February 1, 2024: Inflammation
https://read.qxmd.com/read/38296163/impact-of-micronutrients-and-nutraceuticals-on-cognitive-function-and-performance-in-alzheimer-s-disease
#25
REVIEW
Lorenza Guarnieri, Francesca Bosco, Antonio Leo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro, Vincenzo Mollace
Alzheimer's disease (AD) is a major global health problem today and is the most common form of dementia. AD is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary clusters, leading to decreased brain acetylcholine levels in the brain. Another mechanism underlying the pathogenesis of AD is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary aggregates, and the areas most affected by this pathological process are usually the cholinergic neurons in cortical, subcortical, and hippocampal areas...
January 29, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38289455/histone-methyltransferase-g9a-plays-an-essential-role-on-nicotine-preference-in-zebrafish
#26
JOURNAL ARTICLE
Maria Paula Faillace, Joaquin Ortiz, Leandro Rocco, Ramon Bernabeu
Psychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNA methylation and histone deacetylase (HDAC) inhibition abolish nicotine-induced conditioned place preference (CPP) but little is known about the role of histone methylation in addictive-like behaviors. To assess the influence of histone methylation on nicotine-CPP, zebrafish were treated with a histone (H3) lysine-9 (K9) dimethyltransferase G9a/GLP inhibitor, BIX-01294 (BIX), which was administered before conditioning sessions...
January 30, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38245966/the-conducted-vascular-response-as-a-mediator-of-hypercapnic-cerebrovascular-reactivity-a-modelling-study
#27
JOURNAL ARTICLE
Ali Daher, Stephen Payne
It is well established that the cerebral blood flow (CBF) shows exquisite sensitivity to changes in the arterial blood partial pressure of CO2 ( [Formula: see text] ), which is reflected by an index termed cerebrovascular reactivity. In response to elevations in [Formula: see text] (hypercapnia), the vessels of the cerebral microvasculature dilate, thereby decreasing the vascular resistance and increasing CBF. Due to the challenges of access, scale and complexity encountered when studying the microvasculature, however, the mechanisms behind cerebrovascular reactivity are not fully understood...
January 18, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38241174/acetylcholine-modulates-the-precision-of-prediction-error-in-the-auditory-cortex
#28
JOURNAL ARTICLE
David Pérez-González, Ana Belén Lao-Rodríguez, Cristian Aedo-Sánchez, Manuel S Malmierca
A fundamental property of sensory systems is their ability to detect novel stimuli in the ambient environment. The auditory brain contains neurons that decrease their response to repetitive sounds but increase their firing rate to novel or deviant stimuli; the difference between both responses is known as stimulus-specific adaptation or neuronal mismatch (nMM). Here, we tested the effect of microiontophoretic applications of ACh on the neuronal responses in the auditory cortex (AC) of anesthetized rats during an auditory oddball paradigm, including cascade controls...
January 19, 2024: ELife
https://read.qxmd.com/read/38229103/circulating-acetylcholine-serves-as-a-potential-biomarker-role-in-pulmonary-hypertension
#29
JOURNAL ARTICLE
Yicheng Yang, Jing Xu, Songren Shu, Peizhi Wang, Yanru Liang, Bingyang Liu, Beilan Yang, Hanwen Zhang, Qing Zhao, Zhihui Zhao, Qin Luo, Zhihong Liu, Qixian Zeng, Changming Xiong
BACKGROUND: An increased acetylcholine (ACh) level in the right ventricle tissue of pulmonary hypertension (PH) was revealed, which indicated the important role of ACh in disease pathogenesis. However, the relationship between plasma ACh levels and disease conditions and patients' prognosis has not been investigated. We aimed to explore the association between plasma ACh levels and the prognosis of patients with PH. We also discussed the feasibility of plasma ACh as a biomarker, which may contribute to the management of PH patients in the future...
January 16, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38223947/association-between-myasthenia-gravis-and-alzheimer-s-disease
#30
JOURNAL ARTICLE
M I Morales-Casado, A M Diezma-Martín, F Muñoz-Escudero, S Ronsenstone-Calvo, B Mondéjar-Marín, A Vadillo-Bermejo, C Marsal-Alonso, P Beneyto-Martín
INTRODUCTION: Myasthenia gravis (MG) and Alzheimer's disease (AD) are two of the most important diseases where the dysregulation of acetylcholine activity plays a crucial role. In the first, this dysregulation happens at the level of the neu-romuscular junction and in the second, in the central nervous system (CNS). AIM: To analyze the possible relationship between these two pathologies, analyzing the prevalence and the odds ratio of AD within patients previously diagnosed with MG...
January 16, 2024: Revista de Neurologia
https://read.qxmd.com/read/38218363/the-role-of-%C3%AE-7-nicotinic-acetylcholine-receptors-in-post-acute-sequelae-of-covid-19
#31
JOURNAL ARTICLE
Maryna Skok
Post-Acute Sequelae of COVID-19 or Long COVID becomes evident some weeks to months following acute COVID-19. Symptoms include cognitive impairment and varying degrees of memory loss with no definitive etiologies or efficacious therapies forthcoming even after four years of the SARS-Cov2 pandemic virus. The aim of this review is to demonstrate the important role of α7 nicotinic acetylcholine receptors in both acute COVID-19 and Long COVID. Evidence presented implicates immune mechanisms stimulated by SARS-Cov-2 S-protein fragment 674-685 that possesses homology with α7-specific ligands...
January 11, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38213171/synapsin-1-ameliorates-cognitive-impairment-and-neuroinflammation-in-rats-with-alzheimer-s-disease-an-experimental-and-bioinformatics-study
#32
JOURNAL ARTICLE
Wei Ma, Kui Lu, Hua-Min Liang, Jin-Yuan Zhang
BACKGROUND: Alzheimer's disease (AD) is a persistent neuropathological injury that manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation, and apoptosis. Synapsin 1 (SYN1), a neuronal phosphoprotein, is believed to be responsible for the pathology of AD. OBJECTIVE: This study aimed to elucidate the exact role of SYN1 in ameliorating AD and its potential regulatory mechanisms. METHODS: The AD dataset GSE48350 was downloaded from the GEO database, and SYN1 was focused on differential expression analysis and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses...
January 11, 2024: Current Alzheimer Research
https://read.qxmd.com/read/38196348/optical-imaging-probes-for-selective-detection-of-butyrylcholinesterase
#33
REVIEW
Musa Dirak, Jefferson Chan, Safacan Kolemen
Butyrylcholinesterase (BChE), a member of the human serine hydrolase family, is an essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of acetylcholine. It also plays central roles in apoptosis, lipid metabolism, and xenobiotic detoxification. On the other side, abnormal levels of BChE are directly associated with the formation of pathogenic states such as neurodegenerative diseases, psychiatric and cardiovascular disorders, liver damage, diabetes, and cancer. Thus, selective and sensitive detection of BChE level in living organisms is highly crucial and is of great importance to further understand the roles of BChE in both physiological and pathological processes...
January 10, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38178134/cholinergic%C3%A2-signaling%C3%A2-via-the-%C3%AE-7-nicotinic-acetylcholine-receptor%C3%A2-regulates-the-migration-of-monocyte-derived-macrophages-during-acute-inflammation
#34
JOURNAL ARTICLE
Kasey R Keever, Kui Cui, Jared L Casteel, Sanjay Singh, Donald B Hoover, David L Williams, Valentin A Pavlov, Valentin P Yakubenko
BACKGROUND: The involvement of the autonomic nervous system in the regulation of inflammation is an emerging concept with significant potential for clinical applications. Recent studies demonstrate that stimulating the vagus nerve activates the cholinergic anti-inflammatory pathway that inhibits pro-inflammatory cytokines and controls inflammation. The α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages plays a key role in mediating cholinergic anti-inflammatory effects through a downstream intracellular mechanism involving inhibition of NF-κB signaling, which results in suppression of pro-inflammatory cytokine production...
January 4, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38161283/analogs-of-%C3%AE-conotoxin-pnic-selectively-inhibit-%C3%AE-7%C3%AE-2-over-%C3%AE-7-only-subtype-nicotinic-acetylcholine-receptors-via-a-novel-allosteric-mechanism
#35
JOURNAL ARTICLE
Andrew A George, Sabin J John, Linda M Lucero, J Brek Eaton, Ekta Jaiswal, Sean B Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M Olivera, Wonpil Im, J Michael McIntosh, Paul Whiteaker
This study was undertaken to identify and characterize the first ligands capable of selectively identifying nicotinic acetylcholine receptors containing α7 and β2 subunits (α7β2-nAChR subtype). Basal forebrain cholinergic neurons express α7β2-nAChR. Here, they appear to mediate neuronal dysfunction induced by the elevated levels of oligomeric amyloid-β associated with early Alzheimer's disease. Additional work indicates that α7β2-nAChR are expressed across several further critically important cholinergic and GABAergic neuronal circuits within the central nervous system...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38132895/the-ma-helix-is-important-for-receptor-assembly-and-function-in-the-%C3%AE-4%C3%AE-2-nach-receptor
#36
JOURNAL ARTICLE
Dorottya I Fricska, Susanne M Mesoy, Sarah C R Lummis
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the central and peripheral nervous systems of vertebrates and modulate many aspects of human health and disease. Recent structural and computational data indicate that cation-selective pLGICs contain a long helical extension (MA) of one of the transmembrane helices. The MA helix has been shown to affect both the membrane expression of, and ion conductance levels through, these pLGICs. Here we probe the functional effects of 68 mutations in the MA region of the α4β2 nicotinic acetylcholine receptor (nAChR), using a voltage-sensitive membrane dye and radioligand binding to measure receptor function and expression/assembly...
November 29, 2023: Membranes
https://read.qxmd.com/read/38092222/site-specific-autonomic-vasomotor-responses-and-their-interactions-in-rat-gingiva
#37
JOURNAL ARTICLE
Yunosuke Okada, Toshiya Sato, Syed Taufiqul Islam, Hanako Ohke, Masato Saitoh, Hisayoshi Ishii
Blood flow in the gingiva, comprising the interdental papilla as well as attached and marginal gingiva, is important for maintaining of gingival function and is modulated by risk factors such as stress that may lead to periodontal disease. Marked blood flow changes mediated by the autonomic (parasympathetic and sympathetic) nervous system may be essential for gingival hemodynamics. However, differences in autonomic vasomotor responses and their functional significance in different parts of the gingiva are unclear...
December 11, 2023: Microvascular Research
https://read.qxmd.com/read/38081868/interleukin-31-receptor-%C3%AE-promotes-smooth-muscle-cell-contraction-and-airway-hyperresponsiveness-in-asthma
#38
JOURNAL ARTICLE
Santhoshi V Akkenepally, Dan J K Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak A Deshpande, Francis X McCormack, Satish K Madala
Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mechanisms underlying the effects of these cytokines remain unclear. Here, we report a significant increase in the expression of IL-31RA, but not its cognate ligand IL-31, in mouse models of allergic asthma. In support of this, IFNγ, IL-4, and IL-13 upregulated IL-31RA but not IL-31 in both human and mice primary airway smooth muscle cells (ASMC) isolated from the airways of murine and human lungs...
December 11, 2023: Nature Communications
https://read.qxmd.com/read/38061511/do-microbial-gut-muscle-mediated-by-scfas-microbial-gut-brain-axis-mediated-by-insulin-simultaneously-regulate-yak-imf-deposition
#39
JOURNAL ARTICLE
Lin Xiong, Xixi Yao, Jie Pei, Xingdong Wang, Shaoke Guo, Mengli Cao, Pengjia Bao, Hui Wang, Ping Yan, Xian Guo
Ruminant rumen plays an important role in the digestibility of cellulose, hemicellulose, starch and fat. In this study, the yaks under graze and stall feeding were chosen as the models of different rumen bacteria and intramuscular fat (IMF). The characteristics of IMF deposition, serum indexes in yaks were detected; the bacteria, metabolites in rumen was explored by 16S rRNA sequencing technology, untargeted metabolomics based on liquid chromatography-mass spectrometer and gas chromatography, respectively; the transcriptome of longissimus thoracis was identified by RNA-Sequencing analysis...
December 5, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38048912/possible-role-of-exercise-therapy-on-depression-effector-neurotransmitters-as-key-players
#40
REVIEW
Hamed Alizadeh Pahlavani
About 280 million people suffer from depression as the most common neurological disorder and the most common cause of death worldwide. Exercise with serotonin released in the brain by the 5-HT3-IGF-1 mechanism can lead to antidepressant effects. Swimming exercise has antidepressant effects by increasing the sensitivity of serotonin 5-HT2 receptors and postsynaptic 5-HT1A receptors, increasing 5-HT and 5HIAA levels, increasing TPH and serotonin, and decreasing inflammatory levels of IFN-γ and TNF-α...
February 29, 2024: Behavioural Brain Research
keyword
keyword
169867
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.