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JOURNAL ARTICLE
R Abbasi, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, J M Alameddine, A A Alves, N M Amin, K Andeen, T Anderson, G Anton, C Argüelles, Y Ashida, S Athanasiadou, S Axani, X Bai, A Balagopal V, S W Barwick, V Basu, S Baur, R Bay, J J Beatty, K-H Becker, J Becker Tjus, J Beise, C Bellenghi, S Benda, S BenZvi, D Berley, E Bernardini, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, M Boddenberg, F Bontempo, J Y Book, J Borowka, S Böser, O Botner, J Böttcher, E Bourbeau, F Bradascio, J Braun, B Brinson, S Bron, J Brostean-Kaiser, R T Burley, R S Busse, M A Campana, E G Carnie-Bronca, C Chen, Z Chen, D Chirkin, K Choi, B A Clark, K Clark, L Classen, A Coleman, G H Collin, A Connolly, J M Conrad, P Coppin, P Correa, D F Cowen, R Cross, C Dappen, P Dave, C De Clercq, J J DeLaunay, D Delgado López, H Dembinski, K Deoskar, A Desai, P Desiati, K D de Vries, G de Wasseige, T DeYoung, A Diaz, J C Díaz-Vélez, M Dittmer, H Dujmovic, M Dunkman, M A DuVernois, T Ehrhardt, P Eller, R Engel, H Erpenbeck, J Evans, P A Evenson, K L Fan, A R Fazely, A Fedynitch, N Feigl, S Fiedlschuster, A T Fienberg, C Finley, L Fischer, D Fox, A Franckowiak, E Friedman, A Fritz, P Fürst, T K Gaisser, J Gallagher, E Ganster, A Garcia, S Garrappa, L Gerhardt, A Ghadimi, C Glaser, T Glauch, T Glüsenkamp, N Goehlke, A Goldschmidt, J G Gonzalez, S Goswami, D Grant, T Grégoire, S Griswold, C Günther, P Gutjahr, C Haack, A Hallgren, R Halliday, L Halve, F Halzen, M Ha Minh, K Hanson, J Hardin, A A Harnisch, A Haungs, K Helbing, F Henningsen, E C Hettinger, S Hickford, J Hignight, C Hill, G C Hill, K D Hoffman, K Hoshina, W Hou, F Huang, M Huber, T Huber, K Hultqvist, M Hünnefeld, R Hussain, K Hymon, S In, N Iovine, A Ishihara, M Jansson, G S Japaridze, M Jeong, M Jin, B J P Jones, D Kang, W Kang, X Kang, A Kappes, D Kappesser, L Kardum, T Karg, M Karl, A Karle, U Katz, M Kauer, M Kellermann, J L Kelley, A Kheirandish, K Kin, J Kiryluk, S R Klein, A Kochocki, R Koirala, H Kolanoski, T Kontrimas, L Köpke, C Kopper, S Kopper, D J Koskinen, P Koundal, M Kovacevich, M Kowalski, T Kozynets, E Krupczak, E Kun, N Kurahashi, N Lad, C Lagunas Gualda, J L Lanfranchi, M J Larson, F Lauber, J P Lazar, J W Lee, K Leonard, A Leszczyńska, Y Li, M Lincetto, Q R Liu, M Liubarska, E Lohfink, C J Lozano Mariscal, L Lu, F Lucarelli, A Ludwig, W Luszczak, Y Lyu, W Y Ma, J Madsen, K B M Mahn, Y Makino, S Mancina, I C Mariş, I Martinez-Soler, R Maruyama, S McCarthy, T McElroy, F McNally, J V Mead, K Meagher, S Mechbal, A Medina, M Meier, S Meighen-Berger, Y Merckx, J Micallef, D Mockler, T Montaruli, R W Moore, K Morik, R Morse, M Moulai, T Mukherjee, R Naab, R Nagai, R Nahnhauer, U Naumann, J Necker, L V Nguyen, H Niederhausen, M U Nisa, S C Nowicki, D Nygren, A Obertacke Pollmann, M Oehler, B Oeyen, A Olivas, E O'Sullivan, H Pandya, D V Pankova, N Park, G K Parker, E N Paudel, L Paul, C Pérez de Los Heros, L Peters, J Peterson, S Philippen, S Pieper, A Pizzuto, M Plum, Y Popovych, A Porcelli, M Prado Rodriguez, B Pries, G T Przybylski, C Raab, J Rack-Helleis, A Raissi, M Rameez, K Rawlins, I C Rea, Z Rechav, A Rehman, P Reichherzer, R Reimann, G Renzi, E Resconi, S Reusch, W Rhode, M Richman, B Riedel, E J Roberts, S Robertson, G Roellinghoff, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk Cantu, I Safa, J Saffer, D Salazar-Gallegos, P Sampathkumar, S E Sanchez Herrera, A Sandrock, M Santander, S Sarkar, S Sarkar, K Satalecka, M Schaufel, H Schieler, S Schindler, T Schmidt, A Schneider, J Schneider, F G Schröder, L Schumacher, G Schwefer, S Sclafani, D Seckel, S Seunarine, A Sharma, S Shefali, N Shimizu, M Silva, B Skrzypek, B Smithers, R Snihur, J Soedingrekso, A Sogaard, D Soldin, C Spannfellner, G M Spiczak, C Spiering, M Stamatikos, T Stanev, R Stein, J Stettner, T Stezelberger, B Stokstad, T Stürwald, T Stuttard, G W Sullivan, I Taboada, S Ter-Antonyan, J Thwaites, S Tilav, F Tischbein, K Tollefson, C Tönnis, S Toscano, D Tosi, A Trettin, M Tselengidou, C F Tung, A Turcati, R Turcotte, C F Turley, J P Twagirayezu, B Ty, M A Unland Elorrieta, N Valtonen-Mattila, J Vandenbroucke, N van Eijndhoven, D Vannerom, J van Santen, J Veitch-Michaelis, S Verpoest, C Walck, W Wang, T B Watson, C Weaver, P Weigel, A Weindl, M J Weiss, J Weldert, C Wendt, J Werthebach, M Weyrauch, N Whitehorn, C H Wiebusch, N Willey, D R Williams, M Wolf, G Wrede, J Wulff, X W Xu, J P Yanez, E Yildizci, S Yoshida, S Yu, T Yuan, Z Zhang, P Zhelnin
The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4...
June 30, 2023: Science
#22
JOURNAL ARTICLE
Leora I Horwitz, Tanayott Thaweethai, Shari B Brosnahan, Mine S Cicek, Megan L Fitzgerald, Jason D Goldman, Rachel Hess, S L Hodder, Vanessa L Jacoby, Michael R Jordan, Jerry A Krishnan, Adeyinka O Laiyemo, Torri D Metz, Lauren Nichols, Rachel E Patzer, Anisha Sekar, Nora G Singer, Lauren E Stiles, Barbara S Taylor, Shifa Ahmed, Heather A Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C Bind, Lora J Black, Andra L Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W Charney, Benjamin K Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B Chibnik, Dominic C Chow, Helen Y Chu, Rebecca G Clifton, Shelby Collins, Maged M Costantine, Sushma K Cribbs, Steven G Deeks, John D Dickinson, Sarah E Donohue, Matthew S Durstenfeld, Ivette F Emery, Kristine M Erlandson, Julio C Facelli, Rachael Farah-Abraham, Aloke V Finn, Melinda S Fischer, Valerie J Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J Gallagher, Jennifer C Gander, Maria Laura Gennaro, Kelly S Gibson, Minjoung Go, Steven N Goodman, Joey P Granger, Frank L Greenway, John W Hafner, Jenny E Han, Michelle S Harkins, Kristine S P Hauser, James R Heath, Carla R Hernandez, On Ho, Matthew K Hoffman, Susan E Hoover, Carol R Horowitz, Harvey Hsu, Priscilla Y Hsue, Brenna L Hughes, Prasanna Jagannathan, Judith A James, Janice John, Sarah Jolley, S E Judd, Joy J Juskowich, Diane G Kanjilal, Elizabeth W Karlson, Stuart D Katz, J Daniel Kelly, Sara W Kelly, Arthur Y Kim, John P Kirwan, Kenneth S Knox, Andre Kumar, Michelle F Lamendola-Essel, Margaret Lanca, Joyce K Lee-Lannotti, R Craig Lefebvre, Bruce D Levy, Janet Y Lin, Brian P Logarbo, Jennifer K Logue, Michele T Longo, Carlos A Luciano, Karen Lutrick, Shahdi K Malakooti, Gail Mallett, Gabrielle Maranga, Jai G Marathe, Vincent C Marconi, Gailen D Marshall, Christopher F Martin, Jeffrey N Martin, Heidi T May, Grace A McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M Mullington, Girish N Nadkarni, Erica R Nahin, Robert B Neuman, Lisa T Newman, Amber Nguyen, Janko Z Nikolich, Igho Ofotokun, Princess U Ogbogu, Anna Palatnik, Kristy T S Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F Patterson, Ann Pearman, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, J Zachary Porterfield, John G Quigley, Davin K Quinn, Hengameh Raissy, Candida J Rebello, Uma M Reddy, Rebecca Reece, Harrison T Reeder, Franz P Rischard, Johana M Rosas, Clifford J Rosen, Nadine G Rouphael, Dwight J Rouse, Adam M Ruff, Christina Saint Jean, Grecio J Sandoval, Jorge L Santana, Shannon M Schlater, Frank C Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D Sesso, Dimpy P Shah, Eyal Shemesh, Zaki A Sherif, Daniel J Shinnick, Hyagriv N Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S Suthar, Larissa J Teunis, John M Thorp, Amberly Ticotsky, Alan T N Tita, Robin Tragus, Katherine R Tuttle, Alfredo E Urdaneta, P J Utz, Timothy M VanWagoner, Andrew Vasey, Suzanne D Vernon, Crystal Vidal, Tiffany Walker, Honorine D Ward, David E Warren, Ryan M Weeks, Steven J Weiner, Jordan C Weyer, Jennifer L Wheeler, Sidney W Whiteheart, Zanthia Wiley, Natasha J Williams, Juan P Wisnivesky, John C Wood, Lynn M Yee, Natalie M Young, Sokratis N Zisis, Andrea S Foulkes
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis...
2023: PloS One
#23
JOURNAL ARTICLE
Cassandra R Driscoll, Joshua A Grosser, Amelia L Davidson, Kelsey M Lloyd, Shamit S Prabhu, Adam J Katz
BACKGROUND: There is a growing presence of literature within plastic surgery that establishes best practice for postoperative antibiotics after implant-based breast reconstruction (IBBR), although it has not been widely adopted or translated into clinical practice. This study aims to determine how antibiotic and duration affects patient outcomes. We hypothesize that IBBR patients who receive a longer duration of postoperative antibiotics will demonstrate higher rates of antibiotic resistance as compared with the institutional antibiogram...
June 1, 2023: Annals of Plastic Surgery
#24
JOURNAL ARTICLE
Holly V Spitzer, Phillip M Kemp Bohan, Elizabeth L Carpenter, Alexandra M Adams, Shu-Ching Chang, Gary Grunkemeier, Timothy J Vreeland, Ching-Wei D Tzeng, Matthew H G Katz, Daniel W Nelson
BACKGROUND: Achieving optimal surgical outcomes in pancreatic adenocarcinoma requires a combination of both curative-intent resection to oncologic standards and stage-specific neoadjuvant or adjuvant therapy. This investigation sought to examine factors associated with receipt of standard-adherent surgery (SAS) and guideline-recommended therapy (GRT) and determine the impact of compliance on patient survival. PATIENTS AND METHODS: From the 2006-2016 National Cancer Database, 21,304 patients underwent resection for nonmetastatic pancreatic adenocarcinoma...
October 2023: Annals of Surgical Oncology
#25
JOURNAL ARTICLE
Adam E Roy, Charles S Carrier, Pierre-Emmanuel Schwab, Thomas S Thornhill, Elena Losina, Antonia F Chen, Jeffrey N Katz, Jeffrey K Lange
BACKGROUND: Spino-pelvic orientation (SPO) may affect dislocation risk following total hip arthroplasty (THA). It can be measured on lateral lumbo-pelvic radiographs. The sacro-femoro-pubic (SFP) angle, measured on an antero-posterior (AP) pelvis radiograph, is a reliable proxy for pelvic tilt (PT), a measurement of SPO measured on a lateral lumbo-pelvic radiograph. The purpose of this study was to investigate the relationship between SFP angle and dislocation following THA. METHODS: An Institutional Review Board-approved retrospective case-control study was conducted at a single academic center...
June 4, 2023: Journal of Arthroplasty
#26
JOURNAL ARTICLE
Tanayott Thaweethai, Sarah E Jolley, Elizabeth W Karlson, Emily B Levitan, Bruce Levy, Grace A McComsey, Lisa McCorkell, Girish N Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A Walker, Caitlin A Selvaggi, Daniel J Shinnick, Carolin C M Schulte, Rachel Atchley-Challenner, Leora I Horwitz, Andrea S Foulkes, George A Alba, Radica Alicic, Natasha Altman, Khamal Anglin, Urania Argueta, Hassan Ashktorab, Gaston Baslet, Ingrid V Bassett, Lucinda Bateman, Brahmchetna Bedi, Shamik Bhattacharyya, Marie-Abele Bind, Andra L Blomkalns, Hector Bonilla, Patricia A Bush, Mario Castro, James Chan, Alexander W Charney, Peter Chen, Lori B Chibnik, Helen Y Chu, Rebecca G Clifton, Maged M Costantine, Sushma K Cribbs, Sylvia I Davila Nieves, Steven G Deeks, Alexandria Duven, Ivette F Emery, Nathan Erdmann, Kristine M Erlandson, Kacey C Ernst, Rachael Farah-Abraham, Cheryl E Farner, Elen M Feuerriegel, Judes Fleurimont, Vivian Fonseca, Nicholas Franko, Vivian Gainer, Jennifer C Gander, Edward M Gardner, Linda N Geng, Kelly S Gibson, Minjoung Go, Jason D Goldman, Halle Grebe, Frank L Greenway, Mounira Habli, John Hafner, Jenny E Han, Keith A Hanson, James Heath, Carla Hernandez, Rachel Hess, Sally L Hodder, Matthew K Hoffman, Susan E Hoover, Beatrice Huang, Brenna L Hughes, Prasanna Jagannathan, Janice John, Michael R Jordan, Stuart D Katz, Elizabeth S Kaufman, John D Kelly, Sara W Kelly, Megan M Kemp, John P Kirwan, Jonathan D Klein, Kenneth S Knox, Jerry A Krishnan, Andre Kumar, Adeyinka O Laiyemo, Allison A Lambert, Margaret Lanca, Joyce K Lee-Iannotti, Brian P Logarbo, Michele T Longo, Carlos A Luciano, Karen Lutrick, Jason H Maley, Jai G Marathe, Vincent Marconi, Gailen D Marshall, Christopher F Martin, Yuri Matusov, Alem Mehari, Hector Mendez-Figueroa, Robin Mermelstein, Torri D Metz, Richard Morse, Jarrod Mosier, Christian Mouchati, Janet Mullington, Shawn N Murphy, Robert B Neuman, Janko Z Nikolich, Ighovwerha Ofotokun, Elizabeth Ojemakinde, Anna Palatnik, Kristy Palomares, Tanyalak Parimon, Samuel Parry, Jan E Patterson, Thomas F Patterson, Rachel E Patzer, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, John G Quigley, Uma Reddy, Rebecca Reece, Harrison Reeder, W B Reeves, Eric M Reiman, Franz Rischard, Jonathan Rosand, Dwight J Rouse, Adam Ruff, George Saade, Grecio J Sandoval, Shannon M Schlater, Fitzgerald Shepherd, Zaki A Sherif, Hyagriv Simhan, Nora G Singer, Daniel W Skupski, Amber Sowles, Jeffrey A Sparks, Fatima I Sukhera, Barbara S Taylor, Larissa Teunis, Robert J Thomas, John M Thorp, Paul Thuluvath, Amberly Ticotsky, Alan T Tita, Katherine R Tuttle, Alfredo E Urdaneta, Daisy Valdivieso, Timothy M VanWagoner, Andrew Vasey, Monica Verduzco-Gutierrez, Zachary S Wallace, Honorine D Ward, David E Warren, Steven J Weiner, Shelley Welch, Sidney W Whiteheart, Zanthia Wiley, Juan P Wisnivesky, Lynn M Yee, Sokratis Zisis
IMPORTANCE: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. OBJECTIVE: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections...
May 25, 2023: JAMA
#27
JOURNAL ARTICLE
Gideon Leibner, Shuli Brammli-Greenberg, David Katz, Yaakov Esayag, Nechama Kaufman, Adam J Rose
BACKGROUND: Patients admitted to internal medicine may be moved to more advanced-care settings when their condition deteriorates. In these advanced care settings, there may be higher levels of monitoring and greater ability to deliver Intensive Medical Treatments (IMTs). To the best of our knowledge, no previous study has examined the proportion of patients at different levels of care who receive different types of IMTs. METHODS: In this retrospective observational cohort study, we examined data from 56,002 internal medicine hospitalizations at Shaare Zedek Medical Center, between 01...
May 24, 2023: Israel Journal of Health Policy Research
#28
JOURNAL ARTICLE
Erin R Dwyer, Sarah K Holt, Erika M Wolff, Blair Stewart, Ronit Katz, Jason Reynolds, Adam J Gadzinski, John L Gore
BACKGROUND: Patients residing in rural areas with urologic cancers confront significant obstacles in obtaining oncologic care. In the Pacific Northwest, a sizeable portion of the population lives in a rural county. Telehealth offers a potential access solution. METHODS: Patients receiving urologic care through telehealth or an in-person appointment at the Fred Hutchinson Cancer Center in Seattle, Washington, were surveyed to assess appointment-related satisfaction and travel costs...
September 15, 2023: Cancer
#29
JOURNAL ARTICLE
Andrew Adams, Linda C Cendales, David K C Cooper, Emanuele Cozzi, John Gill, Eric Judd, Eliezer Katz, Allan D Kirk, Jay A Fishman, Peter P Reese, Anji Wall, James F Markmann
No abstract text is available yet for this article.
May 20, 2023: American Journal of Transplantation
#30
JOURNAL ARTICLE
Katherine L Stone, Emma Kulekofsky, David Hudesman, Samuel Kozloff, Feza Remzi, Jordan E Axelrad, Seymour Katz, Simon J Hong, Ariela Holmer, Mara A McAdams-DeMarco, Dorry L Segev, John Dodson, Aasma Shaukat, Adam S Faye
BACKGROUND: The COVID-19 pandemic led to the urgent implementation of telehealth visits in inflammatory bowel disease (IBD) care; however, data assessing feasibility remain limited. OBJECTIVES: We looked to determine the completion rate of telehealth appointments for adults with IBD, as well as to evaluate demographic, clinical, and social predictors of incomplete appointments. DESIGN: We conducted a retrospective analysis of all patients with IBD who had at least one scheduled telehealth visit at the NYU IBD Center between 1 March 2020 and 31 August 2021, with only the first scheduled telehealth appointment considered...
2023: Therapeutic Advances in Gastroenterology
#31
JOURNAL ARTICLE
Elias Englund, Matthias Schmidt, Alberto A Nava, Anna Lechner, Kai Deng, Renee Jocic, Yingxin Lin, Jacob Roberts, Veronica T Benites, Ramu Kakumanu, Jennifer W Gin, Yan Chen, Yuzhong Liu, Christopher J Petzold, Edward E K Baidoo, Trent R Northen, Paul D Adams, Leonard Katz, Satoshi Yuzawa, Jay D Keasling
Modular polyketide synthases (PKSs) are polymerases that employ α-carboxyacyl-CoAs as extender substrates. This enzyme family contains several catalytic modules, where each module is responsible for a single round of polyketide chain extension. Although PKS modules typically use malonyl-CoA or methylmalonyl-CoA for chain elongation, many other malonyl-CoA analogues are used to diversify polyketide structures in nature. Previously, we developed a method to alter an extension substrate of a given module by exchanging an acyltransferase (AT) domain while maintaining protein folding...
April 14, 2023: Journal of the American Chemical Society
#32
REVIEW
Kieran L Quinn, Grace Y Lam, Jillian F Walsh, Anne Bhéreur, Adam D Brown, Chung Wai Chow, Kit Yan Christie Chung, Juthaporn Cowan, Noah Crampton, Simon Décary, Emilia L Falcone, Lorraine Graves, Douglas P Gross, Kate Hanneman, Paula J Harvey, Sheila Holmes, Gabrielle M Katz, Parinaz Parhizgar, Abdu Sharkawy, Karen C Tran, Susan Waserman, Vanessa E Zannella, Angela M Cheung
Approximately 15% of adult Canadians with SARS-CoV-2 infection develop lingering symptoms beyond 12 weeks after acute infection, known as post-COVID condition or long COVID. Some of the commonly reported long COVID cardiovascular symptoms include fatigue, shortness of breath, chest pain, and palpitations. Suspected long-term cardiovascular complications of SARS-CoV-2 infection might present as a constellation of symptoms that can be challenging for clinicians to diagnose and treat. When assessing patients with these symptoms, clinicians need to keep in mind myalgic encephalomyelitis/chronic fatigue syndrome, postexertional malaise and postexertional symptom exacerbation, dysautonomia with cardiac manifestations such as inappropriate sinus tachycardia, and postural orthostatic tachycardia syndrome, and occasionally mast cell activation syndrome...
June 2023: Canadian Journal of Cardiology
#33
REVIEW
Bing Ren, Zhihua Jiang, Walter Lee Murfee, Adam J Katz, Dietmar Siemann, Yong Huang
Vascularization is essential for realizing thick and functional tissue constructs that can be utilized for in vitro study platforms and in vivo grafts. The vasculature enables the transport of nutrients, oxygen, and wastes and is also indispensable to organ functional units such as the nephron filtration unit, the blood-air barrier, and the blood-brain barrier. This review aims to discuss the latest progress of organ-like vascularized constructs with specific functionalities and realizations even though they are not yet ready to be used as organ substitutes...
March 2023: Biophysics reviews
#34
RANDOMIZED CONTROLLED TRIAL
Amrita Mukhopadhyay, Harmony R Reynolds, Lawrence M Phillips, Arielle R Nagler, William C King, Adam Szerencsy, Archana Saxena, Rod Aminian, Nathan Klapheke, Leora I Horwitz, Stuart D Katz, Saul Blecker
BACKGROUND: Mineralocorticoid receptor antagonists (MRAs) are underprescribed for patients with heart failure with reduced ejection fraction (HFrEF). OBJECTIVES: This study sought to compare effectiveness of 2 automated, electronic health record-embedded tools vs usual care on MRA prescribing in eligible patients with HFrEF. METHODS: BETTER CARE-HF (Building Electronic Tools to Enhance and Reinforce Cardiovascular Recommendations for Heart Failure) was a 3-arm, pragmatic, cluster-randomized trial comparing the effectiveness of an alert during individual patient encounters vs a message about multiple patients between encounters vs usual care on MRA prescribing...
April 11, 2023: Journal of the American College of Cardiology
#35
JOURNAL ARTICLE
Kyle M Hernandez, Kelli S Bramlett, Phaedra Agius, Jonathan Baden, Ru Cao, Omoshile Clement, Adam S Corner, Jonathan Craft, Dennis A Dean, Jonathan R Dry, Kristina Grigaityte, Robert L Grossman, James Hicks, Nikki Higa, Timothy R Holzer, Jeffrey Jensen, Donald J Johann, Sigrid Katz, Anand Kolatkar, Jennifer L Keynton, Jerry S H Lee, Dianna Maar, Jean-Francois Martini, Christopher G Meyer, Peter C Roberts, Matt Ryder, Lea Salvatore, Jeoffrey J Schageman, Stella Somiari, Daniel Stetson, Mark Stern, Liya Xu, Lauren C Leiman
The Blood Profiling Atlas in Cancer (BLOODPAC) Consortium is a collaborative effort involving stakeholders from the public, industry, academia, and regulatory agencies focused on developing shared best practices on liquid biopsy. This report describes the results from the JFDI (Just Freaking Do It) study, a BLOODPAC initiative to develop standards on the use of contrived materials mimicking cell-free circulating tumor DNA, to comparatively evaluate clinical laboratory testing procedures. Nine independent laboratories tested the concordance, sensitivity, and specificity of commercially available contrived materials with known variant-allele frequencies (VAFs) ranging from 0...
March 2023: Journal of Molecular Diagnostics: JMD
#36
JOURNAL ARTICLE
Abigail E Peoples, Alexandria R Waler, Mary L Duet, Shamit S Prabhu, Adam J Katz
BACKGROUND: Increasingly patients with unilateral breast cancer elect to undergo bilateral mastectomy with subsequent reconstruction. Studies have aimed to better identify the risks associated with performing mastectomy on the noncancerous breast. Our study aims to identify differences in complications between therapeutic and prophylactic mastectomy in patients undergoing implant-based breast reconstruction. METHODS: A retrospective analysis of implant-based breast reconstruction from 2015 to 2020 at our institution was completed...
February 20, 2023: Annals of Plastic Surgery
#37
JOURNAL ARTICLE
Jonathan E Katz, Leila Abdelrahman, Sirpi Nackeeran, Uche Ezeh, Ubbo Visser, Leslie A Deane
OBJECTIVE: To improve upon prior attempts to predict which patients will pass their obstructing ureteral stones, we developed a machine learning algorithm to predict the passage of obstructing ureteral stones using only the CT scan at a patient's initial presentation. METHODS: We obtained Institutional Review Board approval to conduct a retrospective study by extracting data from all patients with an obstructing 3-10 mm ureteral stone. We included patients with sufficient data to be categorized as having either passed or failed to pass an obstructing ureteral stone...
April 2023: Urology
#38
JOURNAL ARTICLE
John Fallon, Austen D Katz, Sohrab Vatsia, William DeGouveia, Junho Song, Adam Strigenz, Mitchell Seitz, Jeff Silber, David Essig, Sheeraz Qureshi, Sohrab Virk
OBJECTIVE: Paralumbar muscle volume has been indicated as an important factor for patients reporting back pain. Our goal was to determine if there is a statistically significant relationship between the duration of patients back pain symptoms (>12 weeks or ≤12 weeks) and paralumbar muscle volume (PLMV). METHODS: In this retrospective cohort study paralumbar muscles on axial T2-weighted lumbar MRIs were outlined using ImageJ to determine the Paralumbar cross-sectional area (PL-CSA) and lumbar indentation value (LIV) at the center of disc spaces from L1 to L5...
January 14, 2023: World Neurosurgery
#39
RANDOMIZED CONTROLLED TRIAL
Amrita Mukhopadhyay, Harmony R Reynolds, Yuhe Xia, Lawrence M Phillips, Rod Aminian, Ruth-Ann Diah, Arielle R Nagler, Adam Szerencsy, Archana Saxena, Leora I Horwitz, Stuart D Katz, Saul Blecker
BACKGROUND: Beart failure with reduced ejection fraction (HFrEF) is a leading cause of morbidity and mortality. However, shortfalls in prescribing of proven therapies, particularly mineralocorticoid receptor antagonist (MRA) therapy, account for several thousand preventable deaths per year nationwide. Electronic clinical decision support (CDS) is a potential low-cost and scalable solution to improve prescribing of therapies. However, the optimal timing and format of CDS tools is unknown...
April 2023: American Heart Journal
#40
JOURNAL ARTICLE
Michelle Mendiola Pla, Yuting Chiang, Alina Nicoara, Emily Poehlein, Cynthia L Green, Ryan Gross, Benjamin S Bryner, Jacob N Schroder, Mani A Daneshmand, Stuart D Russell, Adam D DeVore, Chetan B Patel, Jason N Katz, Carmelo A Milano, Muath Bishawi
OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurrent tricuspid valve surgery reduces postoperative right heart failure. The primary aim was to identify whether concurrent tricuspid valve surgery reduced the incidence of moderate or severe right heart failure within the first 6 months after left ventricular assist device implantation...
November 16, 2022: Journal of Thoracic and Cardiovascular Surgery
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