keyword
https://read.qxmd.com/read/36336195/2022-international-consensus-on-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-science-with-treatment-recommendations-summary-from-the-basic-life-support-advanced-life-support-pediatric-life-support-neonatal-life-support-education-implementation
#21
JOURNAL ARTICLE
Myra H Wyckoff, Robert Greif, Peter T Morley, Kee-Chong Ng, Theresa M Olasveengen, Eunice M Singletary, Jasmeet Soar, Adam Cheng, Ian R Drennan, Helen G Liley, Barnaby R Scholefield, Michael A Smyth, Michelle Welsford, David A Zideman, Jason Acworth, Richard Aickin, Lars W Andersen, Diane Atkins, David C Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W Böttiger, Richard N Bradley, Janet E Bray, Jan Breckwoldt, Clifton W Callaway, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Charles D Deakin, Therese Djärv, Michael W Donnino, Matthew J Douma, Jonathan P Duff, Cody L Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G Fabres, Joe Fawke, Judith Finn, Elizabeth E Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J Johnson, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Henry C Lee, Yiqun Jeffrey Lin, Andrew S Lockey, Ian K Maconochie, R John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J D McKinlay, Daniel Meyran, Patrick Morgan, Laurie J Morrison, Vinay Nadkarni, Firdose L Nakwa, Kevin J Nation, Ziad Nehme, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A Nuthall, Brian J O'Neill, Yong-Kwang Gene Ong, Aaron M Orkin, Edison F Paiva, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Amelia G Reis, Joshua C Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C Roehr, Mario Rüdiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L Sawyer, Steve M Schexnayder, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Takahiro Sugiura, Janice A Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M Weiner, Jonathan P Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P Nolan, Katherine M Berg
This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimising pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest...
December 2022: Resuscitation
https://read.qxmd.com/read/36335011/structural-evaluation-of-child-physical-abuse-in-trauma-social-determinants-of-health-at-the-population-level
#22
JOURNAL ARTICLE
Philip Kyung Woo Hong, Juan Pablo Santana, Shawn D Larson, Amy Berger, Moiz M Mustafa, Janice A Taylor, Saleem Islam, Dan Neal, Robin T Petroze
PURPOSE: Child physical abuse (CPA) is closely linked to social factors like insurance status with limited evaluation at a structural population-level. This study evaluates the role of social determinants of health within the built environment on CPA. METHODS: A single-institution retrospective review of pediatric trauma patients was conducted between January 2016 and December 2020. Patient address was geocoded to the census-tract level. Socioeconomic metrics, including poverty rate, supermarket access and Social Vulnerability Index (SVI) were estimated from the Food Access Research Atlas...
September 26, 2022: Journal of Pediatric Surgery
https://read.qxmd.com/read/36325905/2022-international-consensus-on-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-science-with-treatment-recommendations-summary-from-the-basic-life-support-advanced-life-support-pediatric-life-support-neonatal-life-support-education-implementation
#23
REVIEW
Myra H Wyckoff, Robert Greif, Peter T Morley, Kee-Chong Ng, Theresa M Olasveengen, Eunice M Singletary, Jasmeet Soar, Adam Cheng, Ian R Drennan, Helen G Liley, Barnaby R Scholefield, Michael A Smyth, Michelle Welsford, David A Zideman, Jason Acworth, Richard Aickin, Lars W Andersen, Diane Atkins, David C Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W Böttiger, Richard N Bradley, Janet E Bray, Jan Breckwoldt, Clifton W Callaway, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Charles D Deakin, Therese Djärv, Michael W Donnino, Matthew J Douma, Jonathan P Duff, Cody L Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G Fabres, Joe Fawke, Judith Finn, Elizabeth E Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J Johnson, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Henry C Lee, Yiqun Jeffrey Lin, Andrew S Lockey, Ian K Maconochie, R John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J D McKinlay, Daniel Meyran, Patrick Morgan, Laurie J Morrison, Vinay Nadkarni, Firdose L Nakwa, Kevin J Nation, Ziad Nehme, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A Nuthall, Brian J O'Neill, Yong-Kwang Gene Ong, Aaron M Orkin, Edison F Paiva, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Amelia G Reis, Joshua C Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C Roehr, Mario Rüdiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L Sawyer, Steve M Schexnayder, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Takahiro Sugiura, Janice A Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M Weiner, Jonathan P Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P Nolan, Katherine M Berg
This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimizing pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest...
December 20, 2022: Circulation
https://read.qxmd.com/read/36227841/ten-simple-rules-for-creating-and-sustaining-antiracist-graduate-programs
#24
JOURNAL ARTICLE
Edgar Perez-Lopez, Larisa Gavrilova, Janice Disla, Melissa Goodlad, Dalena Ngo, Arabi Seshappan, Farhana Sharmin, Jesus Cisneros, Christopher T Kello, Asmeret Asefaw Berhe
In 2020, the combination of police killings of unarmed Black people, including George Floyd, Breonna Taylor, and Ahmaud Arbery, and the Coronavirus Disease 2019 (COVID-19) pandemic brought about public outrage over long-standing inequalities in society. The events of 2020 ignited global attention to systemic racism and racial inequalities, including the lack of diversity, equity, and inclusion in the academy and especially in science, technology, engineering, mathematics, and medicine (STEMM) fields. Racial and ethnic diversity in graduate programs in particular warrants special attention as graduate students of color report experiencing alarming rates of racism, discrimination, microaggressions, and other exclusionary behaviors...
October 2022: PLoS Computational Biology
https://read.qxmd.com/read/36174128/electron-beam-induced-emergence-of-mesoscopic-ordering-in-layered-mnps-3
#25
JOURNAL ARTICLE
Kevin M Roccapriore, Nan Huang, Mark P Oxley, Vinit Sharma, Timothy Taylor, Swagata Acharya, Dimitar Pashov, Mikhail I Katsnelson, David Mandrus, Janice L Musfeldt, Sergei V Kalinin
Ordered mesoscale structures in 2D materials induced by small misorientations have allowed for a wide variety of electronic, ferroelectric, and quantum phenomena to be explored. Until now, the only mechanism to induce this periodic ordering was via mechanical rotations between the layers, with the periodicity of the resulting moiré pattern being directly related to twist angle. Here we report a fundamentally distinct mechanism for emergence of mesoscopic periodic patterns in multilayer sulfur-containing metal phosphorus trichalcogenide, MnPS3 , induced by the electron beam...
September 29, 2022: ACS Nano
https://read.qxmd.com/read/36164929/understanding-student-run-health-initiatives-in-the-context-of-community-based-services-a-concept-analysis-and-proposed-definitions
#26
REVIEW
Daniel A Nagel, Taylor T Naccarato, Mark T Philip, Victoria K Ploszay, Janice Winkler, Diana C Sanchez-Ramirez, Jamie L Penner
BACKGROUND: Student-run health initiatives in the community setting have been utilized to provide practical experience for undergraduate students to develop professional competencies, gain exposure to diverse populations, and to engage in activities of social accountability. There is much literature on student-run health initiatives; however, there is no consensus on a definition of this concept or a comprehensive synthesis of the literature that describes student-run health initiatives offered by students in pre-licensure healthcare education programs...
January 2022: Journal of Primary Care & Community Health
https://read.qxmd.com/read/36126188/a-qualitative-descriptive-study-of-effective-leadership-and-leadership-development-strategies-used-by-nurse-leaders-in-european-island-countries
#27
JOURNAL ARTICLE
Victoria Hughes, Rebecca Wright, Janice Taylor, Claire Petchler, Catherine Ling
AIM: Nurse leaders influence workplace culture; however, little is known about ethnic cultural influences on nurse leader development. This research aims to identify personal strategies promoting effective leadership by nurse leaders from European small island countries. DESIGN: Descriptive qualitative study. METHODS: In 2017, nineteen semi-structured interviews with nurse leaders from England, Greece, Republic of Ireland and Malta explored leadership journeys, strategies employed to support their growth and development, and how cultural identity played a role...
September 20, 2022: Nursing Open
https://read.qxmd.com/read/36031449/social-determinants-of-health-in-pediatric-scald-burns-is-food-access-an-issue
#28
JOURNAL ARTICLE
Philip Kyung Woo Hong, Juan Pablo Santana, Shawn D Larson, Amy M Berger, Lauren A Indelicato, Janice A Taylor, Moiz M Mustafa, Saleem Islam, Dan Neal, Robin T Petroze
BACKGROUND: Burn injury risk, severity, and outcomes have been associated with socioeconomic status. Limited data exist to evaluate health access-related influences at a structural population level. This study evaluated factors at the Census-tract level, specifically evaluating food access and social vulnerability in pediatric scald burns. METHODS: A single-institution retrospective review using the trauma registry and electronic medical record was conducted of pediatric burns between 2016 and 2020...
August 25, 2022: Surgery
https://read.qxmd.com/read/35977345/applying-the-rime-framework-to-level-nurse-practitioner-curriculum-competencies
#29
JOURNAL ARTICLE
Heather L Johnson, Jonathan R Beatty, Holly R Archer, Natasha I Best, Jennifer L Trautmann, Janice K Williams, John M Williamson, Diane C Seibert, Laura A Taylor
BACKGROUND: Nurse practitioner (NP) faculty assess student acquisition of knowledge through examinations, simulation, and clinical performance. PROBLEM: Developing appropriately leveled curriculum, assessments, and clinical expectations that accurately capture student maturation presents a challenge. APPROACH: The Reporter, Interpreter, Manager, Educator (RIME) provided the framework for doctor of nursing practice NP curriculum redesign to enhance student performance and content mastery...
July 19, 2022: Nurse Educator
https://read.qxmd.com/read/35970449/insulin-increases-placental-triglyceride-as-a-potential-mechanism-for-fetal-adiposity-in-maternal-obesity
#30
JOURNAL ARTICLE
Anika K Anam, Katherine M Cooke, Milana Bochkur Dratver, Jane V O'Bryan, Lauren E Perley, Seth M Guller, Janice J Hwang, Hugh S Taylor, Leigh Goedeke, Harvey J Kliman, Daniel F Vatner, Clare A Flannery
OBJECTIVE: Maternal obesity increases the incidence of excess adiposity in newborns, resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to maternal hyperglycemia; however, this hypothesis does not account for the increased adiposity seen in newborns of mothers with obesity who have euglycemia. We aimed to explore the placental response to maternal hyperinsulinemia and the effect of insulin-like growth factor 2 (IGF-2) in promoting fetal adiposity by increasing storage and availability of nutrients to the fetus...
August 12, 2022: Molecular Metabolism
https://read.qxmd.com/read/35953441/covid-19-transmission-to-health-care-personnel-during-tracheostomy-under-a-multidisciplinary-safety-protocol
#31
JOURNAL ARTICLE
Taylor C Standiford, Janice L Farlow, Michael J Brenner, Ross Blank, Venkatakrishna Rajajee, Noel R Baldwin, Steven B Chinn, Jessica A Cusac, Jose De Cardenas, Kelly M Malloy, Kelli L McDonough, Lena M Napolitano, Michael W Sjoding, Emily K Stoneman, Laraine L Washer, Pauline K Park
BACKGROUND: Tracheostomies are highly aerosolizing procedures yet are often indicated in patients with COVID-19 who require prolonged intubation. Robust investigations of the safety of tracheostomy protocols and provider adherence and evaluations are limited. OBJECTIVES: To determine the rate of COVID-19 infection of health care personnel involved in COVID-19 tracheostomies under a multidisciplinary safety protocol and to investigate health care personnel's attitudes and suggested areas for improvement concerning the protocol...
November 1, 2022: American Journal of Critical Care
https://read.qxmd.com/read/35846467/assessing-author-willingness-to-enter-study-information-into-structured-data-templates-as-part-of-the-manuscript-submission-process-a-pilot-study
#32
JOURNAL ARTICLE
A Amina Wilkins, Paul Whaley, Amanda S Persad, Ingrid L Druwe, Janice S Lee, Michele M Taylor, Andrew J Shapiro, Natalie Blanton Southard, Courtney Lemeris, Kristina A Thayer
Background: Environmental health and other researchers can benefit from automated or semi-automated summaries of data within published studies as summarizing study methods and results is time and resource intensive. Automated summaries can be designed to identify and extract details of interest pertaining to the study design, population, testing agent/intervention, or outcome (etc.). Much of the data reported across existing publications lack unified structure, standardization and machine-readable formats or may be presented in complex tables which serve as barriers that impede the development of automated data extraction methodologies...
March 2022: Heliyon
https://read.qxmd.com/read/35792801/common-trajectories-of-highly-effective-cd19-specific-car-t-cells-identified-by-endogenous-t-cell-receptor-lineages
#33
JOURNAL ARTICLE
Taylor L Wilson, Hyunjin Kim, Ching-Heng Chou, Deanna Langfitt, Robert C Mettelman, Anastasia A Minervina, E Kaitlynn Allen, Jean-Yves Metais, Mikhail V Pogorelyy, Janice M Riberdy, M Paulina Velasquez, Pratibha Kottapalli, Sanchit Trivedi, Scott R Olsen, Timothy Lockey, Catherine Willis, Michael M Meagher, Brandon M Triplett, Aimee C Talleur, Stephen Gottschalk, Jeremy Chase Crawford, Paul G Thomas
Current chimeric antigen receptor-modified (CAR) T cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and T cell receptor (TCR) sequencing dataset using pre- and post-infusion CD19-CAR T cells from blood and bone marrow samples of pediatric patients with B cell acute lymphoblastic leukemia (B-ALL). We identified cytotoxic post-infusion cells with identical TCRs to a subset of pre-infusion CAR T cells. These effector precursor cells exhibited a unique transcriptional profile compared to other pre-infusion cells, corresponding to an unexpected surface phenotype (TIGIT+, CD62Llo, CD27-)...
July 6, 2022: Cancer Discovery
https://read.qxmd.com/read/35727064/using-machine-learning-algorithms-to-enhance-the-diagnostic-performance-of-electrical-impedance-myography
#34
JOURNAL ARTICLE
Sarbesh R Pandeya, Janice A Nagy, Daniela Riveros, Carson Semple, Rebecca S Taylor, Alice Hu, Benjamin Sanchez, Seward B Rutkove
INTRODUCTION/AIMS: We assessed the classification performance of machine learning (ML) using multifrequency electrical impedance myography (EIM) values to improve upon diagnostic outcomes as compared to those based on a single EIM value. METHODS: EIM data was obtained from unilateral excised gastrocnemius in eighty diseased mice (26 D2-mdx, Duchenne muscular dystrophy model, 39 SOD1G93A ALS model, and 15 db/db, a model of obesity-induced muscle atrophy) and 33 wild-type (WT) animals...
September 2022: Muscle & Nerve
https://read.qxmd.com/read/35639485/sponsorship-and-negotiation-for-women-otolaryngologists-at-midcareer-a-content-analysis
#35
JOURNAL ARTICLE
Janice L Farlow, Nicole M Mott, Taylor C Standiford, Sarah M Dermody, Stacey L Ishman, Dana M Thompson, Kelly M Malloy, Carol R Bradford, Sonya Malekzadeh
OBJECTIVE: To explore challenges and opportunities for supporting midcareer women otolaryngologists in the areas of negotiation and sponsorship. STUDY DESIGN: Qualitative approach using semistructured interviews. SETTING: Online multi-institutional interviews. METHODS: This study was performed from June to August 2021. Women otolaryngologists representing diverse subspecialties, training, and practice environments were recruited via a purposive criterion-based sampling approach...
May 31, 2022: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/35584336/elacestrant-oral-selective-estrogen-receptor-degrader-versus-standard-endocrine-therapy-for-estrogen-receptor-positive-human-epidermal-growth-factor-receptor-2-negative-advanced-breast-cancer-results-from-the-randomized-phase-iii-emerald-trial
#36
RANDOMIZED CONTROLLED TRIAL
Francois-Clement Bidard, Virginia G Kaklamani, Patrick Neven, Guillermo Streich, Alberto J Montero, Frédéric Forget, Marie-Ange Mouret-Reynier, Joo Hyuk Sohn, Donatienne Taylor, Kathleen K Harnden, Hung Khong, Judit Kocsis, Florence Dalenc, Patrick M Dillon, Sunil Babu, Simon Waters, Ines Deleu, José A García Sáenz, Emilio Bria, Marina Cazzaniga, Janice Lu, Philippe Aftimos, Javier Cortés, Shubin Liu, Giulia Tonini, Dirk Laurent, Nassir Habboubi, Maureen G Conlan, Aditya Bardia
PURPOSE: Patients with pretreated estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer have poor prognosis. Elacestrant is a novel, oral selective ER degrader that demonstrated activity in early studies. METHODS: This randomized, open-label, phase III trial enrolled patients with ER-positive/HER2-negative advanced breast cancer who had one-two lines of endocrine therapy, required pretreatment with a cyclin-dependent kinase 4/6 inhibitor, and ≤ 1 chemotherapy...
October 1, 2022: Journal of Clinical Oncology
https://read.qxmd.com/read/35536696/pulmonary-function-and-blood-dna-methylation-a-multiancestry-epigenome-wide-association-meta-analysis
#37
JOURNAL ARTICLE
Mikyeong Lee, Tianxiao Huan, Daniel L McCartney, Geetha Chittoor, Maaike de Vries, Lies Lahousse, Jennifer N Nguyen, Jennifer A Brody, Juan Castillo-Fernandez, Natalie Terzikhan, Cancan Qi, Roby Joehanes, Josine L Min, Gordon J Smilnak, Jessica R Shaw, Chen Xi Yang, Elena Colicino, Thanh T Hoang, Mairead L Bermingham, Hanfei Xu, Anne E Justice, Cheng-Jian Xu, Stephen S Rich, Simon R Cox, Judith M Vonk, Ivana Prokić, Nona Sotoodehnia, Pei-Chien Tsai, Joel D Schwartz, Janice M Leung, Sinjini Sikdar, Rosie M Walker, Sarah E Harris, Diana A van der Plaat, David J Van Den Berg, Traci M Bartz, Tim D Spector, Pantel S Vokonas, Riccardo E Marioni, Adele M Taylor, Yongmei Liu, R Graham Barr, Leslie A Lange, Andrea A Baccarelli, Ma'en Obeidat, Myriam Fornage, Tianyuan Wang, James M Ward, Alison A Motsinger-Reif, Gibran Hemani, Gerard H Koppelman, Jordana T Bell, Sina A Gharib, Guy Brusselle, H Marike Boezen, Kari E North, Daniel Levy, Kathryn L Evans, Josée Dupuis, Charles E Breeze, Ani Manichaikul, Stephanie J London
Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1 , FVC, and FEV1 /FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics...
August 1, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/35468019/colorectal-cancer-performance-and-evaluation-for-ct-colonography-screening-a-multicenter-cluster-randomized-controlled-trial
#38
Anu E Obaro, Andrew A Plumb, Steve Halligan, Susan Mallett, Paul Bassett, Paul McCoubrie, Rachel Baldwin-Cleland, Carmen Ugarte-Cano, Phillip Lung, Janice Muckian, Rajapandian Ilangovan, Arun Gupta, Charlotte Robinson, Antony Higginson, Ingrid Britton, Rebecca Greenhalgh, Uday Patel, Evgenia Mainta, Anmol Gangi, Stuart A Taylor, David Burling
No abstract text is available yet for this article.
May 2022: Radiology
https://read.qxmd.com/read/35325628/cost-effectiveness-of-a-physical-activity-and-behaviour-maintenance-programme-on-functional-mobility-decline-in-older-adults-an-economic-evaluation-of-the-react-retirement-in-action-trial
#39
RANDOMIZED CONTROLLED TRIAL
Tristan M Snowsill, Afroditi Stathi, Colin Green, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Selena Gray, Heidi Johansen-Berg, James L J Bilzon, Jolanthe L de Koning, Jessica C Bollen, Sarah J Moorlock, Max J Western, Jack M Guralnik, W Jack Rejeski, Kenneth R Fox, Antonieta Medina-Lara
BACKGROUND: Mobility limitations in older populations have a substantial impact on health outcomes, quality of life, and social care costs. The Retirement in Action (REACT) randomised controlled trial assessed a 12-month community-based group physical activity and behaviour maintenance intervention to help prevent decline in physical functioning in older adults at increased risk of mobility limitation. We aimed to do an economic evaluation of the REACT trial to investigate whether the intervention is cost-effective...
April 2022: Lancet. Public Health
https://read.qxmd.com/read/35325627/effect-of-a-physical-activity-and-behaviour-maintenance-programme-on-functional-mobility-decline-in-older-adults-the-react-retirement-in-action-randomised-controlled-trial
#40
RANDOMIZED CONTROLLED TRIAL
Afroditi Stathi, Colin J Greaves, Janice L Thompson, Janet Withall, Peter Ladlow, Gordon Taylor, Antonieta Medina-Lara, Tristan Snowsill, Selena Gray, Colin Green, Heidi Johansen-Berg, Claire E Sexton, James L J Bilzon, Jolanthe deKoning, Jessica C Bollen, Sarah J Moorlock, Max J Western, Naiara Demnitz, Poppy Seager, Jack M Guralnik, W Jack Rejeski, Melvyn Hillsdon, Kenneth R Fox
BACKGROUND: Mobility limitations in old age can greatly reduce quality of life, generate substantial health and social care costs, and increase mortality. Through the Retirement in Action (REACT) trial, we aimed to establish whether a community-based active ageing intervention could prevent decline in lower limb physical functioning in older adults already at increased risk of mobility limitation. METHODS: In this pragmatic, multicentre, two-arm, single-blind, parallel-group, randomised, controlled trial, we recruited older adults (aged 65 years or older and who are not in full-time employment) with reduced lower limb physical functioning (Short Physical Performance Battery [SPPB] score 4-9) from 35 primary care practices across three sites (Bristol and Bath; Birmingham; and Devon) in England...
April 2022: Lancet. Public Health
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