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Janice A Taylor

Lisa A Cranley, Janice M Keefe, Deanne Taylor, Genevieve Thompson, Amanda M Beacom, Janet E Squires, Carole A Estabrooks, James W Dearing, Peter G Norton, Whitney B Berta
BACKGROUND: Interpersonal relationships among professionals drive both the adoption and rejection of consequential innovations. Through relationships, decision-makers learn which colleagues are choosing to adopt innovations, and why. The purpose of our study was to understand how and why long-term care (LTC) leaders in a pan-Canadian interpersonal network provide and seek advice about care improvement innovations, for the eventual dissemination and implementation of these innovations...
January 30, 2019: Implementation Science: IS
Michael Taylor, John Jefferies, Barry Byrne, Joao Lima, Bharath Ambale-Venkatesh, Mohammad R Ostovaneh, Raj Makkar, Bryan Goldstein, Rachel Ruckdeschel Smith, James Fudge, Konstantinos Malliaras, Brian Fedor, Jeff Rudy, Janice M Pogoda, Linda Marbán, Deborah D Ascheim, Eduardo Marbán, Ronald G Victor
OBJECTIVE: To assess the feasibility, safety, and efficacy of intracoronary allogeneic cardiosphere-derived cells (CAP-1002) in patients with Duchenne muscular dystrophy (DMD). METHODS: The Halt Cardiomyopathy Progression (HOPE)-Duchenne trial is a phase I/II, randomized, controlled, open-label trial (NCT02485938). Patients with DMD >12 years old, with substantial myocardial fibrosis, were randomized (1:1) to usual care (control) or global intracoronary infusion of CAP-1002 (75 million cells)...
February 19, 2019: Neurology
Ulrich Keilholz, Janice M Mehnert, Sebastian Bauer, Hugues Bourgeois, Manish R Patel, Donald Gravenor, John J Nemunaitis, Matthew H Taylor, Lucjan Wyrwicz, Keun-Wook Lee, Vijay Kasturi, Kevin Chin, Anja von Heydebreck, James L Gulley
BACKGROUND: We report phase 1b data from patients enrolled in the JAVELIN Solid Tumor clinical trial (NCT01772004) with unresectable stage IIIC or IV melanoma that had progressed after ≥1 line of therapy for metastatic disease. PATIENTS AND METHODS: Patients received avelumab (10 mg/kg)-a human anti-PD-L1 antibody. Assessments included objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and safety. RESULTS: As of December 31, 2016, 51 patients were treated and followed for a median of 24...
January 16, 2019: Journal for Immunotherapy of Cancer
Ceri E Oldreive, Philip J Byrd, Grant S Stewart, Alexander J Taylor, Sana Farhat, Anna Skowronska, Edward Smith, Manoj Raghavan, Dragana Janic, Lidija Dokmanovic, Sam Clokie, Nicholas Davies, Marwan Kwok, Guy Pratt, Shankara Paneesha, Paul Moss, Tatjana Stankovic, Malcolm Taylor
No abstract text is available yet for this article.
January 7, 2019: Leukemia & Lymphoma
Barry Snow, Eoin Mulroy, Arnold Bok, Mark Simpson, Andrew Smith, Kenneth Taylor, Michelle Lockhart, Bb Janice Lam, Christopher Frampton, Patrick Schweder, Benson Chen, Gregory Finucane, Adele McMahon, Lorraine Macdonald
INTRODUCTION: Regenerative therapies in Parkinson's disease aim to slow neurodegeneration and re-establish damaged neuronal circuitry. Neurotrophins are potent endogenous regulators of neuronal survival, development and regeneration. They represent an attractive regenerative treatment option in Parkinson's disease. Porcine choroid plexus produces a number of neurotrophins, and can be safely delivered to the striatum in an encapsulated formulation (termed NTCELL® ) to protect them from immune attack...
November 13, 2018: Parkinsonism & related Disorders
Mary K Bryson, Evan T Taylor, Lorna Boschman, Tae L Hart, Jacqueline Gahagan, Genevieve Rail, Janice Ristock
Canadian and American population-based research concerning sexual and/or gender minority populations provides evidence of persistent breast and gynecologic cancer-related health disparities and knowledge divides. The Cancer's Margins research investigates the complex intersections of sexual and/or gender marginality and incommensurabilities and improvisation in engagements with biographical and biomedical cancer knowledge. The study examines how sexuality and gender are intersectionally constitutive of complex biopolitical mappings of cancer health knowledge that shape knowledge access and its mobilization in health and treatment decision-making...
November 29, 2018: Journal of Medical Humanities
Faraz A Khan, Nadine Zeidan, Shawn D Larson, Janice A Taylor, Saleem Islam
PURPOSE: Inguinal hernias have been reported in as many as 10-30% premature neonates, making inguinal herniorrhaphy (IHR) one of the most commonly performed surgical procedures. The timing of surgery remains controversial. The purpose of this report is to compare outcomes of IHR while in the NICU (inpatient) versus repair following discharge (outpatient) to determine optimal timing. METHODS: Premature neonates having undergone IHR over a 5-year period were identified and a retrospective case cohort analysis was performed...
November 2018: Pediatric Surgery International
Kush Kapur, Janice A Nagy, Rebecca S Taylor, Benjamin Sanchez, Seward B Rutkove
INTRODUCTION: A method for quantifying myofiber size noninvasively would find wide use, including primary diagnosis and evaluating response to therapy. METHODS: Using prediction algorithms, including the least absolute shrinkage and selection operator, we applied multifrequency electrical impedance myography (EIM) to amyotrophic lateral sclerosis superoxide dismutase 1 G93A mice of different ages and assessed myofiber size histologically. RESULTS: Multifrequency EIM data provided highly accurate predictions of myofiber size, with a root mean squared error (RMSE) of only 14% in mean myofiber area (corresponding to ± 207 µm2 for a mean area of 1,488 µm2 ) and an RMSE of only 8...
November 2018: Muscle & Nerve
Janice A Nagy, Kush Kapur, Rebecca S Taylor, Benjamin Sanchez, Seward B Rutkove
Aim: We sought to determine the sensitivity of electrical impedance myography (EIM) to myofiber hypertrophy induced by treatment with various doses of ActRIIB-mFc, an inhibitor of myostatin signaling. Methods: Wild-type C57BL/6 J mice (n = 40, male) were treated with three different doses of ActRIIB-mFc (i.e., RAP-031) or vehicle twice weekly for 5 weeks. End point assessments included gastrocnemius EIM, force measurements, muscle mass and myofiber size quantification...
July 2018: Future Science OA
Suniah S Ayub, Saleem Islam, Cynthia D Downard, Adam B Goldin, David M Powell, Janice A Taylor
PURPOSE: American Pediatric Surgical Association (APSA) committees send monthly email blasts to members with links to peer-reviewed publications. This study assesses the utilization of this service. METHODS: Email-opening and click-through rates were analyzed from 5/2012 to 4/2017 and compared to APSA and industry standards. Access was analyzed based on subject, disease type, journal, impact factor, and committee. CME questions were added in 10/2014 and emails consolidated in 1/2016...
June 22, 2018: Journal of Pediatric Surgery
Anju Devianee Keetharuth, Elizabeth Taylor Buck, Catherine Acquadro, Katrin Conway, Janice Connell, Michael Barkham, Jill Carlton, Thomas Ricketts, Rosemary Barber, John Brazier
While it is important to treat symptoms, there is growing recognition that in order to help people with mental health problems lead meaningful and fulfilling lives, it is crucial to capture the impact of their conditions on wider aspects of their social lives. We constructed two versions of the Recovering Quality of Life (ReQoL) measure—ReQoL-10 and ReQoL-20—for use in routine settings and clinical trials from a larger pool of items by combining qualitative and quantitative evidence covering six domains...
June 26, 2018: International Journal of Environmental Research and Public Health
Kamala Thriemer, Albino Bobogare, Benedikt Ley, Clarice Samo Gudo, Mohammad Shafiul Alam, Nick M Anstey, Elizabeth Ashley, J Kevin Baird, Charlotte Gryseels, Elodie Jambert, Marcus Lacerda, Ferdinand Laihad, Jutta Marfurt, Ayodhia Pitaloka Pasaribu, Jeanne Rini Poespoprodjo, Inge Sutanto, Walter R Taylor, Christel van den Boogaard, Katherine E Battle, Lek Dysoley, Prakash Ghimire, Bill Hawley, Jimee Hwang, Wasif Ali Khan, Rose Nani Binti Mudin, Maria Endang Sumiwi, Rukhsana Ahmed, M M Aktaruzzaman, Kiran Raj Awasthi, Azucena Bardaji, David Bell, Leonard Boaz, Faustina Helen Burdam, Daniel Chandramohan, Qin Cheng, Keobouphaphone Chindawongsa, Janice Culpepper, Santasabuj Das, Raffy Deray, Meghna Desai, Gonzalo Domingo, Wang Duoquan, Stephan Duparc, Rustini Floranita, Emily Gerth-Guyette, Rosalind E Howes, Cecilia Hugo, George Jagoe, Elvieda Sariwati, Sanya Tahmina Jhora, Wu Jinwei, Harin Karunajeewa, Enny Kenangalem, Bibek Kumar Lal, Chandra Landuwulang, Emmanuel Le Perru, Sang-Eun Lee, Leo Sora Makita, James McCarthy, Asrat Mekuria, Neelima Mishra, Esau Naket, Simone Nambanya, Johnny Nausien, Thang Ngo Duc, Thuan Nguyen Thi, Rinitis Noviyanti, Daniel Pfeffer, Gao Qi, Annisa Rahmalia, Stephen Rogerson, Iriani Samad, Jetsumon Sattabongkot, Ari Satyagraha, Dennis Shanks, Surender Nath Sharma, Carol Hopkins Sibley, Ali Sungkar, Din Syafruddin, Arunansu Talukdar, Joel Tarning, Feiko Ter Kuile, Suman Thapa, Minerva Theodora, Tho Tran Huy, Edward Waramin, Govert Waramori, Adugna Woyessa, Chansuda Wongsrichanalai, Nguyen Xuan Xa, Joon Sup Yeom, Lukas Hermawan, Angela Devine, Spike Nowak, Indra Jaya, Supargiyono Supargiyono, Koen Peeters Grietens, Ric N Price
The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported...
June 20, 2018: Malaria Journal
Taylor Z Mann, Lisa B Haddad, Tonya R Williams, Susan L Hills, Jennifer S Read, Deborah L Dee, Eric J Dziuban, Janice Pérez-Padilla, Denise J Jamieson, Margaret A Honein, Carrie K Shapiro-Mendoza
BACKGROUND: Since the Zika virus epidemic in the Americas began in 2015, Zika virus transmission has occurred throughout the Americas. However, limited information exists regarding possible risks of transmission of Zika virus and other flaviviruses through breast feeding and human milk. We conducted a systematic review of the evidence regarding flaviviruses detection in and transmission through milk, specifically regarding Zika virus, Japanese encephalitis virus, tick-borne encephalitis virus, Powassan virus, West Nile virus, dengue virus, and yellow fever virus...
July 2018: Paediatric and Perinatal Epidemiology
Gail Woodward-Lopez, Janice Kao, Elena S Kuo, Suzanne Rauzon, Anthony C Taylor, Christina Goette, Carole Collins, Esmeralda P Gonzalez, Danielle R Ronshausen, Kathryn Boyle, Dana Williamson, Allen Cheadle
INTRODUCTION: From 2011 to 2014, small stores in three communities participated in a community-wide obesity prevention initiative. The study aimed to determine how participation in the initiative influenced store environments and consumer purchases. STUDY DESIGN: Pre- and post-intervention without control. Structured observations of the store environments and intercept surveys of adult shoppers at all stores, and of children at two stores, conducted at baseline and follow-up...
May 2018: American Journal of Preventive Medicine
Janice Connell, Jill Carlton, Andrew Grundy, Elizabeth Taylor Buck, Anju Devianee Keetharuth, Thomas Ricketts, Michael Barkham, Dan Robotham, Diana Rose, John Brazier
PURPOSE: Service user involvement in instrument development is increasingly recognised as important, but is often not done and seldom reported. This has adverse implications for the content validity of a measure. The aim of this paper is to identify the types of items that service users felt were important to be included or excluded from a new Recovering Quality of Life measure for people with mental health difficulties. METHODS: Potential items were presented to service users in face-to-face structured individual interviews and focus groups...
July 2018: Quality of Life Research
Afroditi Stathi, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Antonieta Medina-Lara, Colin Green, James Bilzon, Selena Gray, Heidi Johansen-Berg, Claire E Sexton, Max J Western, Jolanthe L de Koning, Jessica C Bollen, Sarah J Moorlock, Naiara Demnitz, Poppy Seager, Jack M Guralnik, W Jack Rejeski, Ken R Fox
BACKGROUND: The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/DESIGN: A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention...
April 17, 2018: Trials
Aude Nicolas, Kevin P Kenna, Alan E Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A Dominov, Brendan J Kenna, Mike A Nalls, Pamela Keagle, Alberto M Rivera, Wouter van Rheenen, Natalie A Murphy, Joke J F A van Vugt, Joshua T Geiger, Rick A Van der Spek, Hannah A Pliner, Shankaracharya, Bradley N Smith, Giuseppe Marangi, Simon D Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D Eicher, Aoife Kenna, Gabriele Mora, Andrea Calvo, Letizia Mazzini, Nilo Riva, Jessica Mandrioli, Claudia Caponnetto, Stefania Battistini, Paolo Volanti, Vincenzo La Bella, Francesca L Conforti, Giuseppe Borghero, Sonia Messina, Isabella L Simone, Francesca Trojsi, Fabrizio Salvi, Francesco O Logullo, Sandra D'Alfonso, Lucia Corrado, Margherita Capasso, Luigi Ferrucci, Cristiane de Araujo Martins Moreno, Sitharthan Kamalakaran, David B Goldstein, Aaron D Gitler, Tim Harris, Richard M Myers, Hemali Phatnani, Rajeeva Lochan Musunuri, Uday Shankar Evani, Avinash Abhyankar, Michael C Zody, Julia Kaye, Steven Finkbeiner, Stacia K Wyman, Alex LeNail, Leandro Lima, Ernest Fraenkel, Clive N Svendsen, Leslie M Thompson, Jennifer E Van Eyk, James D Berry, Timothy M Miller, Stephen J Kolb, Merit Cudkowicz, Emily Baxi, Michael Benatar, J Paul Taylor, Evadnie Rampersaud, Gang Wu, Joanne Wuu, Giuseppe Lauria, Federico Verde, Isabella Fogh, Cinzia Tiloca, Giacomo P Comi, Gianni Sorarù, Cristina Cereda, Philippe Corcia, Hannu Laaksovirta, Liisa Myllykangas, Lilja Jansson, Miko Valori, John Ealing, Hisham Hamdalla, Sara Rollinson, Stuart Pickering-Brown, Richard W Orrell, Katie C Sidle, Andrea Malaspina, John Hardy, Andrew B Singleton, Janel O Johnson, Sampath Arepalli, Peter C Sapp, Diane McKenna-Yasek, Meraida Polak, Seneshaw Asress, Safa Al-Sarraj, Andrew King, Claire Troakes, Caroline Vance, Jacqueline de Belleroche, Frank Baas, Anneloor L M A Ten Asbroek, José Luis Muñoz-Blanco, Dena G Hernandez, Jinhui Ding, J Raphael Gibbs, Sonja W Scholz, Mary Kay Floeter, Roy H Campbell, Francesco Landi, Robert Bowser, Stefan M Pulst, John M Ravits, Daniel J L MacGowan, Janine Kirby, Erik P Pioro, Roger Pamphlett, James Broach, Glenn Gerhard, Travis L Dunckley, Christopher B Brady, Neil W Kowall, Juan C Troncoso, Isabelle Le Ber, Kevin Mouzat, Serge Lumbroso, Terry D Heiman-Patterson, Freya Kamel, Ludo Van Den Bosch, Robert H Baloh, Tim M Strom, Thomas Meitinger, Aleksey Shatunov, Kristel R Van Eijk, Mamede de Carvalho, Maarten Kooyman, Bas Middelkoop, Matthieu Moisse, Russell L McLaughlin, Michael A Van Es, Markus Weber, Kevin B Boylan, Marka Van Blitterswijk, Rosa Rademakers, Karen E Morrison, A Nazli Basak, Jesús S Mora, Vivian E Drory, Pamela J Shaw, Martin R Turner, Kevin Talbot, Orla Hardiman, Kelly L Williams, Jennifer A Fifita, Garth A Nicholson, Ian P Blair, Guy A Rouleau, Jesús Esteban-Pérez, Alberto García-Redondo, Ammar Al-Chalabi, Ekaterina Rogaeva, Lorne Zinman, Lyle W Ostrow, Nicholas J Maragakis, Jeffrey D Rothstein, Zachary Simmons, Johnathan Cooper-Knock, Alexis Brice, Stephen A Goutman, Eva L Feldman, Summer B Gibson, Franco Taroni, Antonia Ratti, Cinzia Gellera, Philip Van Damme, Wim Robberecht, Pietro Fratta, Mario Sabatelli, Christian Lunetta, Albert C Ludolph, Peter M Andersen, Jochen H Weishaupt, William Camu, John Q Trojanowski, Vivianna M Van Deerlin, Robert H Brown, Leonard H van den Berg, Jan H Veldink, Matthew B Harms, Jonathan D Glass, David J Stone, Pentti Tienari, Vincenzo Silani, Adriano Chiò, Christopher E Shaw, Bryan J Traynor, John E Landers
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2)...
March 21, 2018: Neuron
Keliana L O'Mara, Saleem Islam, Janice A Taylor, Daniel Solomon, Michael D Weiss
Feeding intolerance, poor oral feeding skills, and retching are common symptoms seen in medically complex infants with a history of abdominal disorders and surgical interventions, such as gastrostomy tube placement and Nissen fundoplication. Visceral hyperalgesia may play a role in the underlying pathophysiology. We report the use of orally administered gabapentin in 3 infants with presumed visceral hyperalgesia presenting as poor tolerance of enteral and oral feeds. Retching and outward discomfort associated with feeds was resolved within 2 to 3 days of initiation of therapy...
January 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Kush Kapur, Rebecca S Taylor, Kristin Qi, Janice A Nagy, Jia Li, Benjamin Sanchez, Seward B Rutkove
INTRODUCTION: Electrical impedance can be used to estimate cellular characteristics. We sought to determine whether it could be used to approximate myofiber size using standard prediction modeling approaches. METHODS: Forty-four C57BL/6J wild-type immature mice of varying ages underwent electrical impedance myography (EIM) with a needle electrode array placed in the gastrocnemius. Animals were then humanely killed and muscle fixed, stained, and myofiber size quantified...
February 24, 2018: Muscle & Nerve
Karen Kelly, Jeffrey R Infante, Matthew H Taylor, Manish R Patel, Deborah J Wong, Nicholas Iannotti, Janice M Mehnert, Anja H Loos, Helga Koch, Isabell Speit, James L Gulley
BACKGROUND: Antibodies targeting the programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) checkpoint may cause adverse events (AEs) that are linked to the mechanism of action of this therapeutic class and unique from those observed with conventional chemotherapy. METHODS: Patients with advanced solid tumors who were enrolled in the phase 1 JAVELIN Solid Tumor (1650 patients) and phase 2 JAVELIN Merkel 200 (88 patients) trials received avelumab, a human anti-PD-L1 IgG1 antibody at a dose of 10 mg/kg every 2 weeks...
May 1, 2018: Cancer
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